High level of Pan Lysine Lactylation (Pan-Kla) is found in pancreatic cancer tissues.

H3K18la levels are increased in pancreatic cancer tissues.

H3K18la is related to the severity and prognosis of pancreatic cancer.

Hormone measurement in FNA washout fluid is an accessible method for improving accuracy.

Thyroglobulin (TG) dosage can enhance the accuracy of detecting well-differentiated thyroid carcinomas.

Calcitonin dosage complements cytology in detecting medullary thyroid carcinoma cervical metastasis.

Post-thyroidectoby bed dosages help to determine non-thyroid/parathyroid lesions.

The main cause of hilar obstruction was cholangiocarcinoma (32.9 %) followed by lymph node metastasis (23.2 %).

Technical success was achieved in 91.5 %, clinical success in 60 %.

A significant correlation between clinical success rate was found when at least 50 % of viable parenchyma was drained (p = 0.016; OR = 4.15, 95 % CI 1.4–12.5).

Considering liver sectors, higher clinical success rates were found when at least 2 sectors were drained (p < 0.001; OR = 8.50, 95 % CI 2.7–26.7).

Correlation between unilateral versus bilateral drainage and clinical success was not statistically significant.

Analyzing complaints is essential for identifying areas for improvement.

79 % of the complaints were related to communication issues with the patient.

Improving communication with the patient will help reduce the number of complaints filed.

Using a web application simplifies the management of complaints in primary care.

Most surgeons underestimate the positional and numerical variations of the Facial Nerve.

About 50% of the Marginal Nerves of the Mandible have more than one subdivision.

Just over half of the branches of the Mandibular Marginal Nerve are found below the lower border of the mandible.

The great anatomical variation of the Mandibular Marginal Nerve is responsible for the majority of postoperative motor sequelae.

Harvesting abdominal fat for mFAt knee injection is a safe procedure.

Minor events, such as ecchymosis, mild abdominal discomfort, and mild discomfort at the infiltrated knee are common.

The procedure can be done under local anesthesia, without sedation after single-time preparation.

Despite the efficacy of reconstructive surgeries and Montgomery T-tube, clinical and neurological instability significantly impact outcomes and prolong tracheostomy use.

Treatment for post-intubation tracheal or laryngotracheal stenosis requires a multidisciplinary and personalized approach.

Dysphagia is a significant factor linked to poorer clinical outcomes and extended tracheostomy use.

Photodynamic Therapy (PDT) significantly increased HPV clearance rates in cervical HPV-infected patients.

PDT treatment augmented CD3+ and CD4+ T-cell levels, with sustained elevation observed up to 6 months post-treatment.

A higher CD4+/CD8+ ratio was noted in the PDT group, indicating an enhanced cellular immune response.

Pro-inflammatory cytokines IL-6, IL-8, and TNF-α levels decreased post-PDT, suggesting reduced inflammation.

The total effective rate of treatment in the observation group was higher than that in the control group.

The middle ear resonance frequency of the children in the observation group was higher than that of the control group at weeks 4, 8 and 12 of treatment, and the air-conduction hearing threshold was lower than that of the control group.

The total effective rate of the observation group after 12 weeks of treatment was 92.11 %, which was significantly higher than that of the control group (73.68 %).

The T-ETDQ score of the observation group was lower than that of the control group after treatment.

According to imaging findings of CEUS, TLN was associated with enhanced concentric performance in the arterial phase and heterogeneous enhancement pattern in lymph nodes.

Peak Intensity (PI) of lesions was higher in MLN patients.

Increased age-enhanced concentric performance in the arterial phase, increased PI, and serum PCT above 5.39 ng/mL were independent risk factors for MLN.

The prediction model of serum PCT combined with CEUS had a higher diagnostic value for MLN.

LCA has the ability to suppress the growth, movement, and invasion of glioma cells.

It can also counteract resistance to TMZ drugs.

This opens up new possibilities for identifying clinical drugs to treat glioma patients who are resistant to TMZ.

Eight-section brocade exercises enhance exercise endurance and lung function of COPD patients.

Eight-section brocade exercises improve the physical function of COPD patients.

Eight-section brocade exercises improve patient emotions, nursing efficiency, and satisfaction.

Comparison of the invasive capabilities.

Comparison of the metastatic capabilities.

Effect of CST1 and AKT mRNA in gastric cancer.

Effect of CST1 and AKT protein in gastric cancer.

GpS ameliorates Sev-induced cognitive deficits in rats.

GpS ameliorates Sev-induced neuronal cell damage in rats.

GpS promotes activation of the PI3K/AKT/mTOR pathway.

PI3K/AKT/mTOR pathway inhibitor reduces the amelioration of cognitive deficits in Sev-anesthetized rats by high-dose GpS.

PI3K/AKT/mTOR pathway inhibitor impairs the ameliorative effect of high-dose GpS on neuronal cell damage in Sev-anesthetized rats.

Perioperative Neurocognitive Disorders (PND) can occur in patients submitted to elective surgical procedures under general or regional anesthesia, especially the elderly.

Circadian rhythm disruptions have harmful effects on cognition and may also play a role in the development of PND.

Melatonin 10 mg administered in the perioperative period of TURP surgery for elderly patients hasn&apos;t shown any protective effect against postoperative cognitive decline, mainly because the patients have shown a significant improvement in cognitive functions after the surgery.

SARCCalf is better than SARC-F in screening the risk of sarcopenia in PLHIV.

Low CD4+ count, the presence of opportunistic infections, and AIDS status are associated with the risk of sarcopenia in PLHIV, regardless of the tool used.

Lung granulomas have been associated with mycobacteria and fungal infections.

The largest cohort of pulmonary granulomatous lesions in Brazil was studied.

FFPE specimens are a valuable source of material for molecular methods.

Molecular methods contribute to the fast diagnosis of all mycobacteria species.

The findings of the study indicate that Centchroman led to a notable reduction in fibroadenoma size, with a significant proportion of patients experiencing more than 50 % regression in their fibroadenomas.

Patients experienced significant relief from breast pain (mastalgia), showcasing the efficacy of Centchroman in alleviating associated physical discomfort.

Centchroman led to a significant improvement in anxiety and depression scores, highlighting its positive impact on the psychological health and overall well-being of patients.

Electrographic seizures did not have predictive value for adverse neurodevelopmental outcomes at 12‒24 months of age.

The incidence of neurodevelopmental impairment or death was significantly higher in the clinical seizure group.

Only cord blood pH and abnormal brain MRI findings were consistently associated with long-term neurodevelopmental outcomes in a multivariate analysis.

Antithrombotics are the cornerstone for acute Pulmonary Embolism (APE) treatment.

Patients hospitalized with APE in Brazil had a high prevalence of bleeding.

The major bleeding increased the one-year mortality rate.

The bleeding predictive scores assessed showed limited accuracy in identifying high bleeding-risk patients.

Restless legs syndrome is associated with lower information processing speed.

Obstructive sleep apnea is not associated with lower information processing speed.

Managing sleep disorders is critical for improving cognition in multiple sclerosis.

Renal Doppler marker variations within the initial 24 h in sepsis patients.

RRI reduction after 24h of ICU treatment can be used for early detection of SA-AKI.

Critical ultrasound for dynamic monitoring of renal perfusion.

Adverse effects of lenalidomide for Newly Diagnosed Multiple Myeloma (NDMM) cannot be ignored.

Lower-dose PLD administered with dexamethasone and subcutaneous bortezomib is associated with a good durable response.

Lenalidomide is retained as maintenance or salvage therapy if the DVD regimen fails.

After cataract surgery, the prevalence rate of Descemet membrane Detachment was significantly higher in the group with keratome incisions (63.2 %) compared to that with femtolaser incisions (22.2 %).

OSVE and multiple-choice tests can be used interchangeably in the context of formative assessment.

OSVE and multiple-choice tests as effective tools to enhance intern training and monitoring.

OSVE holds promise as a transformative tool, capable of ensuring the continuity and integrity of clinical skills assessment in medical education.

Question – Extension of the biliopancreatic loop increases l-cell activity after surgery bariatric?

Findings – l-cell activity increased independent of extension of the biliopancreatic limb.

Meaning – The additional beneficial effects of long BPL may be due to more rapid delivery of food and bile salts to more distal portions of the intestine.

We identified a distinctive pattern of serum metabolic signatures in juvenile idiopathic arthritis patients under methotrexate therapy.

Methotrexate use is associated with a more efficient mitochondrial function.

A decreased mitochondrial metabolism was observed in polyarticular and systemic JIA subtypes, with a decrease of several acylcarnitines’ concentrations.

Incidence of frailty in elderly patients varies widely among different tools.

FP and FS could be employed as tools for predicting frail conditions.

Different tools had low consistency in predicting frail conditions.

Guidelines recommended pulmonary rehabilitation in COPD.

Self-driven pulmonary rehabilitation is an undertreatment for COPD patients in China.

Chinese patients with COPD have worse clinical conditions.

Treatment with pulmonary rehabilitation at institutes improves clinical outcomes.

Chinese COPD patients are required to be treated as per proper guidelines.

Respiratory symptoms of PACS are associated with high serum Myl9 levels.

Patients who have had COVID-19 can be divided into two groups according to their serum Myl9 levels.

The neutrophil count is correlated with the Myl9 level at 6 months after infection.

circLOC375190 reduction ameliorates neuronal autophagy and apoptosis in tMCAO mice.

circLOC375190 knockdown improves OGD/R-mediated neuronal autophagy and apoptosis.

circLOC375190 affects OGD/R-mediated neuronal apoptosis and autophagy by adsorbing miR-93-5p.

circLOC375190 affects OGD/R-mediated neuronal apoptosis and autophagy by regulating the miR-93-5p/MKNK2 axis.

circLOC375190 affects AIS autophagy by regulating the mTORC1/TFEB axis.

hsa_circ_0000105 modulates malignancy of NPC cells.

hsa_circ_0000105 influences the malignant behavior of NPC via downstream miR-541-3p.

hsa_circ_0000105 positively regulates S100A11 to accelerate the malignant behavior of NPC.

hsa_circ_0000105 inhibits NPC tumor growth in vivo.

Dry eye is more frequent in the urban than in the rural population.

Dry eye is associated with dyslipidemia, visual display terminal, and ocular surface problems.

Dry eye is more frequent in women and the associated factors are associated with antiallergics, chronic pelvic pain, and fibromyalgia.

Dry eye in the elderly has distinct clinical associated factors.

Stem cell therapy is a promising alternative in the spinal cord injury arsenal.

Challenges in stem cell treatment in SCI: phase uncertainty and cell type controversy.

Umbilical cord mononuclear cells may enhance recovery via multiple mechanisms.

Umbilical cord mononuclear cells can promote histological improvement after SCI.

Construction of a personalized risk prediction model for in-hospital mortality in patients with acute myocardial infarction undergoing Percutaneous Coronary Intervention (PCI).

Identification of risk factors associated with in-hospital mortality in AMI patients who underwent PCI.

Development of a nomogram prediction model for in-hospital mortality in AMI patients after emergency PCI.

Evaluation of the nomogram model&apos;s effectiveness through c-index, internal validation, Hosmer-Lemeshow test, and calibration curve analysis.

NHANES data from 1999 to 2006 show a positive link between serum CRP levels and low muscle mass risk in US adults.

An inverse J-shaped pattern emerges, indicating a non-linear association between CRP levels and low muscle mass risk, with critical points at 0.273 mg/dL for the overall population, 0.172 mg/dL for males, and 0.296 mg/dL for females.

This nationally representative study underscores the crucial role of inflammation in muscle function and advocates for future research and clinical strategies to address inflammation&apos;s impact on muscle mass and function.

Correlation between pathologic complete response and endoluminal complete response.

Half of pathologic complete responses do not achieve an endoluminal complete response.

Gross findings do not perfectly reflect microscopic findings.

ADSCs increased the viability (significantly less necrosis) of a TRAM flap in rats.

Vessel formation in the ischemic segment of the flap was also enhanced by the ADSCs.

Fluorescence microscopy indicated no differentiation of ADSCs into endothelial cells.

Educational value of health expeditions assessed via surveys.

No significant clinical or empathy gains observed.

80 % reported positive career influence from participation.

60 % intend to work within the public health system.

Practical experiences deemed crucial for shaping careers.

Risk factors for depression in peritoneal dialysis patients identified.

Nomogram predicts depression risk in peritoneal dialysis patients.

Gender, income, and comorbidities influence depression risk in dialysis.

Low hemoglobin and uric acid levels are linked to higher depression risk.

Developed nomogram shows strong clinical applicability and accuracy.

The use of LARCs reduces unplanned pregnancies.

Single-visit placements of LARCs increase access and uptake.

Train and allowed nurses on the placement of LARCs is important to women access and uptake.

Expand the knowledge of non-contraceptive benefits of LARCs is important among providers and users.

The original variant was responsible for most of the cases that evolved with death, omicron seems to be responsible for milder symptoms when compared to delta.

Children between 1‒6-months of age account for most of the cases, which concerns since there is no vaccination coverage.

Receptors have chemotactic property cells and are characterized as inflammatory markers.

Monocyte subtypes can play an important role in the Chronic Venous Disease scenario.

Receptors that act by recruiting monocytes include CCR2, CCR5, and CX3CR1.

Chronic Venous Insufficiency changes the monocyte phenotype.

The chemokine receptors might be changed by the Chronic Venous Insufficiency.

Multi-omics study is promising to improve the sensitivity and specificity of screening for NSCLC.

The risk score of Metabonomics, radiomics and multi-omics had different levels of performance in different risk groups.

Multi-omics model is more effective in the non-invasive diagnosis of pulmonary malignant nodules.

miR-519d-3p affects the antitumor effect of 5-FU on CRC cells.

miR-519d-3p could regulate PFKFB3 and could have a significant effect on CRC.

PFKFB3 attenuated 5-FU sensitivity in CRC cells and enhanced glycolysis.

History of venous thromboembolism, d-Dimer as well as ETP, APTT coagulation indices, and Wells score were significantly higher in the AECOPD with PE group, and ttpeak, ALB and TP were lower.

Wells score had a positive correlation with ETP and APTT and a negative correlation with ttpeak, which were all independent risk factors for PE in AECOPD.

Wells score, ETP, APTT and ttpeak had the efficacy of predicting PE by ROC curve analysis.

Power Doppler as a Predictor: In hand ultrasound of women with early rheumatoid arthritis, Power Doppler was a significant predictor of therapeutic failures.

Important Power Doppler Scores: The total Power Doppler score, wrist Power Doppler score, and metacarpophalangeal Power Doppler score were the most critical predictors of therapeutic failures.

Clinical Implications of Power Doppler: The use of Power Doppler can help clinicians identify the risk of therapeutic failures in women with early rheumatoid arthritis, allowing for early intervention and treatment adjustments to improve patient outcomes.

Pembrolizumab is effective for GTN multi-drug resistant treatment.

Pembrolizumab seems also effective for PSTT/ETT treatment.

Pembrolizumab efficacy is similar in cases of resistance or GTN relapse.

Fibroids are tumors that can cause important symptoms that reduce women&apos;s quality of life.

The gold standard treatment for symptomatic fibroids is hysterectomy.

Myomectomy is the treatment of choice for women with reproductive desire.

Magnetic resonance-guided focused ultrasound for uterine fibroids is a minimally invasive treatment alternative for symptomatic women.

Magnetic resonance-guided focused ultrasound for uterine fibroids proves to be a good alternative to improve the symptoms and quality of life of symptomatic women.

Adding Lymphocyte to Monocyte Ratio (LMR) to CHA2DS2-VASc score improves its reclassification ability and is comparable with the ABC score in predicting stroke.

Adding a systemic inflammation score (using LMR, albumin and fibrinogen) to CHA2DS2-VASc score improves its predictive and reclassification ability and is comparable with the ABC score in predicting death.

Because traditional inflammatory biomarkers are more readily available and less expensive, they may be used to improve decision support for AF.

High levels of HMGB1 in AOSC bile are associated with the risk of septic shock.

AOSC bile HMGB1 is significantly correlated with blood CRP.

Elevated HMGB1 in AOSC bile increases the risk of postoperative complications.

Abnormal Uterine Bleeding (AUB) is the leading cause of seeking gynecological care, with data showing that 3 in 10 Brazilian women have this condition, with intermenstrual bleeding standing out.

According to the International Federation of Gynecology and Obstetrics (FIGO), cycles lasting less than 24 days or more than 38 days, with menstrual flow lasting eight days or more and blood loss reported by the woman as intense, are considered abnormal.

The main causes of AUB are summarized in the mnemonic PALM-COEIN, dividing them into structural and non-structural causes.

Diagnosing the etiology of AUB is essential to establish specific treatments, directed at the cause, which can be clinical or surgical, aiming not only to control the amount of blood loss, but also to improve the quality of life of women with AUB.

In general, the first line of treatment for AUB is medication, with surgical treatment being intended for failure or contraindication to clinical treatment or in cases of significant hemodynamic instability.

Uterine fibroids adversely impact maternal and neonatal outcomes.

UAD parameters and PAPP-A levels do not markedly associate with the fibroid size.

UAD and PAPP-A play functional roles in determining the outcomes of pregnancies carrying fibroids.

Normal ranges of fetal weight as a function of gestational age was created.

New parameter, days before birth, was incorporated for normal ranges of fetal weight.

Parameter days before birth is useful for estimating fetal weight at scheduled birth.

A newly developed tool, featuring a virtual reality immersion headset combined with software created in collaboration with a Brazilian company, enables students to immerse themselves in a simulated surgical theater environment.

The study demonstrated that virtual reality learning was equivalent to textbook training and scored higher than traditional training in satisfaction ratings.

The use of virtual reality offers a practical and appealing alternative to conventional instrumentation classes.

Uptake of 18F-FAPI in the myocardium can detect fibrosis and predict LV dyssynchrony.

There are different distributions of FAPI-uptake in CAD and DMVR patients.

FAPI-uptake in the anterior, septal and inferior walls can detect cardiac dysfunction.

SUVmean of FAPI in the lateral wall can determine the progression of cardiac dysfunction.

FAPI-uptake in the basal inferospetal/basal inferior walls can assess the level of MR.

Eugenol significantly lessens renal injury and oxidative stress in ischemia-reperfusion.

Eugenol&apos;s protection is enhanced by increasing Sestrin2 expression, crucial for its benefits.

Eugenol protects kidneys by modulating oxidative and endoplasmic reticulum stress via Sestrin2.

Slow induction of BD affects male and female organs differently.

Reduced lung function was observed in females with higher leukocyte infiltration.

Greater kidney injury was observed in males, with higher plasma creatinine levels.

Systemically identify risk factors for PAH among IIM patients in southern China.

Anti-SRP antibody and Interleukin (IL)−17A are correlated with IIM-related PAH.

The BAIMS model is valuable in prediction and early-identification of PAH in IIM.

This study addresses the critical prognostic factors for SARS-CoV-2 complications in hematological patients, a high-risk population with reported mortality rates up to 31 %.

Through a retrospective analysis of 71 hematology inpatients (November 2022–March 2023), elevated ferritin levels emerged as a robust predictor of COVID-19 pneumonia development (p = 0.016), while heightened serum interferon-γ concentrations correlated strongly with disease severity (p = 0.048).

Mortality risk was significantly associated with elevated neutrophil counts, ferritin, D-dimer, and fibrin degradation products (p < 0.05). Notably, patients with myeloid malignancies in complete remission exhibited increased pneumonia susceptibility (p = 0.012), suggesting post-treatment immune vulnerability.

Conversely, B-cell-targeted therapy or cytotoxic chemotherapy markedly reduced severe infection rates (p = 0.024).

These findings fill critical gaps in prognostic assessment for hematological patients with SARS-CoV-2 co-infection and establish a scientific foundation for personalized monitoring through multidimensional biomarker analysis (e.g., iron metabolism, coagulation profiles, cytokine dynamics), directly informing optimized management strategies for high-risk populations.CLINICS-D-23–00783_Original Article.

Superior capsule reconstruction with an autologous iliotibial band, dermal allograft, and long head of biceps tendon has been proposed to treat massive irreparable posterosuperior rotator cuff tears.

Superior capsule reconstruction with dermal allograft combined with autologous long head of biceps tendon demonstrates significant improvements in shoulder function and pain relief over two years for patients with irreparable posterosuperior rotator cuff tears.

The indications for this method included painful irreparable posterosuperior massive rotator cuff tears less or equal to Hamada grade 2 rotator cuff tear arthropathy, supraspinatus tendon retraction at Patte stage III, no preoperative pseudoparesis, supraspinatus fatty infiltration equal to or more than Goutallier stage 2, and presence of long head of the biceps tendon.

Leukoreduction decreases the adverse effects of blood component transfusion.

Leukoreduction by pre-storage filtration reduced the length of hospital stay.

Leukoreduction by pre-storage filtration reduced hospital deaths.

No effect of leukoreduction filtration moment on adverse transfusion reaction.

No effect of leukoreduction filtration moment on healthcare-associated infection.

In OSCC patients, p53 expression in oral mucosal tissues was downregulated.

The concentration of CagA in the serum of OSCC patients was increased.

A correlation was observed between p53 expression and the tumor stage in OSCC.

The decreased p53 expression may be related to the progression of OSCC.

Elevated serum CagA levels could potentially serve as a factor for OSCC diagnosis.

Cisplatin induces RBBP4 in A549 cells, higher in cisplatin-resistant A549/DDP.

Downregulating RBBP4 with siRNA increased cisplatin sensitivity in A549 and A549/DDP.

Overexpressing RBBP4 reduced sensitivity, while downregulation inhibited cyclinD1.

CyclinD1 overexpression reversed this effect in A549, A549/DDP, and HeLa/DDP cells.

Brugada syndrome presents with a dynamic ECG pattern during autonomic stimulation.

Tilt table test can provide different autonomic situations during the exam.

High precordial leads can be used during the test to enhance ECG information.

circLRRC4C is highly expressed in periodontitis tissues.

circLRRC4C acts as a sponge for miR-485-3p.

•THBS1 is a target gene of miR-485-3p.

Knockdown of circLRRC4C ameliorates periodontitis in mice.

This study explores imaging assessment of pelvic floor function after hysterectomy.

The TAH can cause more significant damage to the pelvic floor structure and function.

Transperineal ultrasound and SWE assess pelvic floor function in multiple dimensions.

Supramolecular Polymer-Related Genes (SPRGs) was associated with Gastric Cancer (GC).

A prognostic signature was constructed based on SPRGs for GC patients.

A nomogram was constructed for prognostic evaluation in GC patients.

KLC1 was confirmed to promote proliferation, metastasis, and invasion in GC cells.

SBP was lower in the SMM (−4.1 mmHg) and the LMM (−5.6 mmHg) vs. control.

No statistical difference between SMM and LMM was observed.

DBP did not change over a period of 24 h in response to SMM or LMM involved.

Isometric exercise caused lower SBP, but not DBP, regardless of the mass of muscle.

Evidence-Based Care Program improves decision-making in a large Brazilian hospital.

95 reviews conducted, including 55 rapid and 40 scoping reviews in 40 months.

High satisfaction: 99 % of requestors reported a positive impact on decision-making.

Most frequent topics: medical devices, drugs, and scale assessments.

Rapid reviews were critical for updating policies and guiding clinical decisions.

Kynurenine suppressed T-cell activation and promoted immune escape.

Kynurenine promoted NAT10-mediated ac4C mRNA modification.

NAT10 inhibition improved T-cell activation and suppressed immune escape.

CircNOLC1 and IGF1R are upregulated while miR-140–5p is downregulated in TGCT.

CircNOLC1 can act as a sponge of miR-140–5p to up-regulate IGF1R.

Silencing circNOLC1 or overexpressing miR-140–5p inhibits TGCT cell proliferation, colony formation, and invasion, and promotes cell apoptosis.

CircNOLC1 promotes the progression of TGCT by modulating the miR-140–5p/IGF1R axis.

ω−3 PUFAs had no significant effect on endometriosis symptoms, such as pain, etc.

ω−3 PUFAs could reduce the inflammatory response in patients with endometriosis.

The local environment of implants exhibits pre-inflammatory tissue characteristics.

Upregulated circPOLA2 in BC is associated with poor prognosis.

circPOLA2 triggers BC cell malignant phenotype.

circPOLA2 directly interacts with miR-1224–5p in cells.

Depleting miR-1224–5p reverses si-circPOLA2-mediated inhibition of malignant behavior in BC cells.

COVID-19 and functional disability.

combined training as a treatment for COVID-19 symptoms.

Therapeutic approach to patients with COVID-19.

Direct-acting antivirals are highly efficacious for hepatitis C virus cure.

Access to specialized care and antivirals are difficult in some areas.

Simplifying delivery and follow-up of therapy can facilitate hepatitis C cure.

A single-day visit protocol achieved acceptable cure rates in this study.

This strategy.

Laryngeal carcinoma may be treated clinically or surgically as an initial therapeutic option.

Differences in terms of costs and outcomes has not been evaluated in Brazil.

Clinical and surgical therapeutic modalities for laryngeal carcinoma showed similar total costs.

Overall survival of laryngeal carcinoma patients was better in the surgical group.

Further studies should consider implementing cost-effectiveness analysis.

The COVID-19 pandemic impacts global physical and mental health.

Parkinson&apos;s disease is the second most common age-related neurodegenerative disease.

COVID-19 quarantine worsened Parkinson&apos;s severity and quality of life.

Improved care, support, and activity plans are needed for Parkinson&apos;s patients during pandemics.

Primary congenital glaucoma is a leading cause of childhood blindness.

Eyes with primary congenital glaucoma often require multiple surgeries to control pressure.

Pediatric glaucoma drainage device studies show declining surgical success rates by year 3 due to complications.

The Susanna UF Glaucoma Drainage Device has a published complication rate under 6 % in adults.

No published data is available on the Susanna UF Glaucoma Drainage Device in pediatrics.

CRP levels in patients with PU with UGIB were significantly higher than those without UGIB.

PU patients with UGIB had a higher CLR compared to those without UGIB.

HP infection is an independent risk factor for UGIB.

Inflammation in SARS-CoV-2 has an extrapulmonary alteration in 20 % of cases.

Intestinal damage is a direct action of the virus.

Enterocyte damage is lower to tight junction alteration.

During the Omicron wave, hospitalized patients with COVID-19 were mainly older adults.

Disorders of the cardiovascular system were the most prevalent comorbidities.

More COVID-19 cases were unvaccinated individuals compared to the controls.

Most COVID-19 cases were moderate, but in-hospital deaths occurred in ∼20 % of cases.

SLT cost-effective for glaucoma in SUS.

SLT reduces costs & improves outcomes.

Economic analysis of SLT in Brazil.

SLT as alternative to eye drops.

Early Morphine in Septic CHF Patients Reduces 30-Day Mortality (HR = 0.539).

Morphine Dose < 15 mg Lowers Mortality in Septic CHF Patients (HR = 0.233).

Analysis of 7424 Septic CHF Patients from MIMIC-IV Database.

NSUN3 levels were up-regulated in NSCLC.

Inhibition of NSUN3 promotes CD8+ T-cell cytotoxicity against NSCLC cells.

NSUN3 inhibition suppresses the tumor growth.

Heart failure cohort analysis using the MIMIC-III database of 6094 patients.

Impact of clinical factors on heart failure prognosis and patient outcomes.

Exploring biomarkers associated with heart failure progression and mortality.

Data-driven insights into heart failure management from ICU patient data.

Predictive modeling of heart failure outcomes based on the MIMIC-III dataset.

A novel Group IPT was developed for Generalized Anxiety Disorder (GAD).

Reduction in GAD symptoms highlights the potential efficacy of Group IPT for GAD.

N Group IPT effectively addresses mental health care access barriers.

Focal disruption of the anterior margin of IMC was significantly associated with malignancy.

Both small and large thyroid nodules with IMC had a lower intermediate risk of malignancy.

Interruption of IMC is more often seen in malignant nodules.

Inactivation of the ATRX tumor suppressor in MYCN non-amplified neuroblastoma.

ATRX mutations have been associated with complete loss of protein expression.

ATRX mutations in neuroblastoma tend to have a progressive course of disease.

ATRX mutations are associated with age at diagnosis in patients with neuroblastoma.

Non-invasive ctDNA monitoring shows promise for sarcoma patient management.

ddPCR identified IDH2 and TP53 mutations in bone sarcoma plasma samples.

Liquid biopsy could improve bone sarcoma diagnosis.

Study highlights the detection of a novel IDH2 mutation in osteosarcoma.

This study aimed to analyze factors affecting acute fatigue in acute ischemic stroke patients. A single-center convenience sample of 420 patients was used.

Female gender, chronic comorbidities, etc. were identified as risk factors for acute fatigue, while social support was a protective factor, guiding clinical interventions.

There was a positive correlation between fear of disease progression and acute fatigue. Alleviating fear may improve patients&apos; fatigue and quality of life.

The incidence of acute fatigue in acute ischemic stroke patients was 37.4 %, which affected rehabilitation. It&apos;s crucial to intervene for better rehabilitation outcomes.

Computerized optokinetic nystagmus testing improves pediatric vision accuracy.

Non-invasive OKN analyzer enables early detection of vision impairments in children.

Innovative OKN technology advances pediatric ophthalmology diagnostic methods.

Elastography can be used to measure liver stiffness after transplantation.

Elastography had good accuracy in predicting allograft loss.

Elastography has the advantage of prediction dysfunction on the first day.

This study aimed to identify prognostic biomarkers for Endometrioid Endometrial Carcinoma (EEC) regulated by estradiol.

miR-142–5p and miR-30a-5p exhibited high sensitivity to estradiol stimulation and a strong association with EEC prognosis.

SACS and GPR157 were identified as potential biomarkers for EEC prognosis.

miR-142–5p–SACS and miR-30a-5p–GPR157 are novel therapeutic targets for EEC.

PA training is allied to assessing, knowledge, and recognizing skills in PA counseling.

Training on PA is the key for physicians to be confident in their counseling abilities.

High self-efficacy for PA counseling is associated with willingness to prescribe PA.

Major gaps in physicians’ knowledge of PA recommendations were identified.

NAT10 mediated ac4C modification by interacting with HK1.

The levels of ac4C and NAT10 were increased in cancer tissues and RB cell lines.

NAT10 knockdown inhibited the glycolysis in RB cell lines.

Weighted logistic regression examined Body Fat percentage (BF%) obesity associated with osteopenia across gender and Body Mass Index (BMI) levels.

In females, compared to BMI obesity combined with BF% obesity, BF% obesity or non-obesity was respectively associated with higher osteopenia odds.

In males, BMI obesity was linked to lower osteopenia odds compared to both BMI and BF% obesity.

MTX in lipid core nanoparticles (LDE) shows low toxicity and reduces inflammation.

LDE-MTX treatment reduces microglial activation and macrophage count in rats.

LDE-MTX boosts neuroprotection, increasing neuronal survival by 319 %.

LDE-MTX reduces ischemic stroke damage in rat models.

Potential novel treatment for ischemic stroke patients.

Olive oil has more obvious effects in improving muscle strength than soybean oil.

Patients with high TyG exhibit more improvements in biomarkers to interventions.

The TyG index is a valuable tool for clinically screening and categorizing patients.

TyG index can be used for personalized precision treatment of diabetes.

Real-time tissue elastography has excellent diagnostic performance in prostate cancer.

A blue area on elastography has significant diagnostic value for prostate cancer.

Multiparametric ultrasound can accurately diagnose prostate cancer.

Gender gap in cancer research improved with more female authors/articles last decade.

Slightly Reduction in Gender Bias in cancer publications between 2021 and 2011.

No gender perspective differences in research studies among female/male authorship.

Breast cancer was studied by female majority and Lung cancer by parity or male majority.

Chest wall reconstruction plays an important role in the outcomes of chest wall surgery. The ideal prosthesis characteristics are already established, even though, the best choice is not well decided.

The authors propose a new prosthesis for chest wall reconstruction.

This study is the first to assess patients with chest wall disease reconstructed with Vitagraft®. It is a synthetic, biocompatible, and absorbable material, which has never been found in thoracic surgery before.

Finally, the use of Vitagraft® has been shown to have good prosthesis biocompatibility.

Clock genes are linked to myocardial infarction, offering novel insights into its pathogenesis.

Ten differentially expressed clock genes suggest new pathways in myocardial infarction development.

RPS27A’s core role in myocardial infarction was validated via Lasso regression and qRT-PCR, showing elevated expression.

Gene enrichment analysis uncovers gap junction and circadian rhythm pathways in myocardial infarction.

RPS27A was identified as a potential molecular target for diagnosing myocardial infarction.

First research to investigate meditators’ profile for Gurusakásha meditation.

Meditators had higher levels of psychological well-being and quality of life.

Third phase meditation may impact stress, resilience, lifestyle, and quality of life.

Nude mice implantation experiment.

RNA FISH-immunofluorescence microscopy.

Cycloheximide (CHX) and protease inhibitor MG132 treatment assay.

Serum TNF-α, IL-1β, and IL-6 contents.

TLR4 and MyD88 expression levels in rat synovium.

TLR4 and MyD88 expression levels in rat synovium.

PIK3CA mutations involve exon 20 and 9 in breast cancer.

PIK3CA mutations are linked to tumor characteristics and NLR.

A tumor recurrence prediction model was established based tumor characteristics.

FOB with BAL enhances infection control and improves overall patient prognosis.

FOB with BAL provides a clear basis for pathogen diagnosis.

FOB with BAL aids in enhancing the effectiveness of antibiotic therapy.

FOB with BAL is safe for use in severe VAP patients.

A preoperative nomogram predicts Pancreatic Fistula (PF) after pancreatoduodenectomy.

Risk factors for PF: male gender, BMI, and pancreatic duct ≤ 3 mm.

Weight loss > 10 % is protective against PF development.

The nomogram shows strong predictive accuracy (AUC = 0.798).

This study proposes a new vision transformer to evaluate MRI from the ADNI dataset.

The proposed model captures global relationships between long-range pixels.

The suggested model achieves high accuracy in classifying AD classes.

EBUS enhances mediastinal lymph node evaluation with less invasiveness.

VGG19, EfficientNet, and DenseNet achieved top malignancy prediction (AUC = 0.96).

Model architecture plays a key role in selecting transfer learning approaches.

Cesarean rates were highest in GDM women from group 5 with prior uterine scars.

Spontaneous labor was the strongest predictor of vaginal delivery.

Prior C-section, fetal distress, and multiples reduced vaginal delivery odds.

Promoting safe spontaneous labor may lower C-sections in GDM cases.

More prospective studies are needed to confirm findings and guide practice.

High postoperative VTE incidence in women with adenomyosis after surgery.

Laparoscopic lesion excision shows higher VTE rates than hysterectomy.

Combined mechanical and pharmacological prophylaxis reduces VTE incidence.

Preoperative d-dimer levels significantly elevated in VTE cases.

The study emphasizes the need for VTE screening post-adenomyosis surgery.

A structured prioritization model was implemented for non-elective surgeries in a tertiary academic hospital in Brazil.

The intervention combined urgency classification, a Kanban dashboard, and daily multidisciplinary meetings.

Median surgical waiting time dropped from 17h20min to 8h52min after implementation (p < 0.001).

Compliance with acceptable waiting time windows improved from 60.5 % to 77.1 %.

The model enhanced surgical efficiency and was well-accepted by multidisciplinary teams.

Indobufen matches aspirin in preventing TVR for CAD patients post-DEB treatment.

Indobufen shows better safety with fewer adverse events in the trial.

Indobufen may cut GI bleeding and bruising, benefiting high-risk patients.

This trial fills the literature gap of indobufen post-DEB in CAD treatment.

New comparative evidence for post-PCI antiplatelet therapy is provided.

Significant differences in the expression of PLAUR in NSCLC tumor types.

PLAUR could serve as a prognostic biomarker for NSCLC patients.

MIRLET7BHG/hsa-miR-127–3p axis was the upstream pathway for PLAUR.

PLAUR-mediated carcinogenesis of NSCLC involves tumor immune escape.

Folate test ordering is rising in this large academic hospital.

Only 0.7 % of folate tests have results in the low range (< 3 ng/mL).

Most patients had more than one test ordered (74.8 %), many within three months.

Non-clinical guided test ordering suggests low-value testing of folate.

Almost $600 K dollars were spent on low-value folate ordering over 5-years.

IVR games can enhance cognitive and motor training in mild neurocognitive disorders.

IVR games support cognitive and motor function non-pharmacologically.

Combining fun and rehab to boost motivation and tech inclusion in older adults.

IVR games offer an affordable and accessible option for middle-income countries.

IVR Games may help delay Alzheimer’s in mild neurocognitive disorder.

valproic acid (Depakene) efficacy varies; a predictive model was developed.

86 genes linked to VPA response: 3 genes (NELL2, SNORD3A, mir-1974) in final model.

AUC of 0.70 indicates good predictive ability for VPA resistance.

qPCR validation confirms SNORD3A as a potential biomarker for VPA efficacy.

Oxytocin combined with cervical balloon dilators improves postpartum stress in high-risk pregnancies.

Oxytocin in combination with cervical balloon dilators improves postpartum inflammation in high-risk pregnancies.

Oxytocin in combination with cervical balloon dilators may improve hemodynamics in high-risk pregnancies.

Oxytocin combined with Cervical balloon dilators can shorten the duration of labor and improve the safety of delivery in high-risk pregnancies.

AngioPLUS is an innovative microvascular Doppler ultrasound technique for the evaluation of carotid IPN.

The IPN score is positively correlated with the IMVF grade on AngioPLUS.

FAR exhibits a strong association with both carotid IPN scores and IMVF grades.

A meta-analysis of 141 RCTs evaluated 12 PD-1/PD-L1 inhibitors in 18 cancer types.

PD-1/PD-L1 therapy has a higher incidence of serious Neurological Adverse Events (NAEs) compared to the control group.

Six predominant NAEs showed higher incidence in the PD-1/PD-L1 group, including stroke and Guillain-Barré.

This analysis reveals a potential interaction between cancer immunotherapy and the nervous system.

IL-17, MIF, and PDGF-BB are causally linked to tic disorders.

IL-17 and MIF increase TD risk, while PDGF-BB is protective.

Study results are robust with strong statistical power.

Type 2 diabetes linked to reduced lung function, with smoking and high BP as mediators.

14 antidepressants show a significant seizure risk association in the FAERS analysis.

Bupropion shows the strongest seizure signal with the highest reporting odds ratio.

TCAs/tetracyclics elevate seizure risk, particularly clomipramine and maprotiline.

SSRIs/SNRIs require safety reconsideration as seizure risk persists.

Mirtazapine is linked to seizure risk despite low initial reports.

Identified an inverse association between serum haptoglobin levels and sepsis-associated AKI risk.

First evidence of haptoglobin as a predictive biomarker for AKI in septic ICU patients.

Highlights haptoglobin&apos;s potential for AKI prevention and intervention in sepsis.

Mechanical Ventilation (MV) significantly increases in-hospital mortality in Cardiac Intensive Care Unit (CICU) patients (OR = 4.16).

Propensity score matching confirmed that MV is independently associated with mortality risk (p < 0.001).

Patients with acute respiratory failure and shock had the highest mortality risk with MV (OR > 4).

Large-sample analysis based on the eICU database (n = 12,480), ensuring reliable results.

The study supports cautious use of MV in CICU and optimization of respiratory management strategies.

Baseline angiogenic biomarkers showed a weak predictive value by the ROC curve.

CRT changes VEGF-A, HB-EGF, angiopoietin-2, and HGF.

These alterations are not observed after NAC.

Biomarker patterns post-CRT were associated with improved outcomes by PCA.

ML may aid future stratification of angiogenesis profiles.

Complex fractures of the lower limbs, often resulting from traffic accidents, require extended periods of hospitalization and rehabilitation. These injuries are highly disabling and significantly impact the victims&apos; quality of life and work conditions.

Many individuals experience substantial physical limitations and a decreased quality of life. This suggests that, even after months of rehabilitation, many have not been able to return to their functional level before the accident.

The severity of the injuries influences the ability to return to work. Factors such as exposed fractures, multiple fractures, and long hospital stays are associated with poorer functional outcomes.

Used a hospital-based survey to assess healthcare professionals&apos; knowledge.

Many lacked a clear definition of organic foods and their health benefits.

High cost and uncertainty emerged as common consumption barriers.

Enhanced education could boost evidence-based dietary guidance.

Artificial intelligence based chest Computed Tomography (CT) is a diagnosis.

Eighty-seven patients with pulmonary nodules who underwent chest CT scanning.

Analysis shows 69 malignant (79.3 %) and 18 benign-nodules (20.7 %) with 87 patients.

Accuracy of combined diagnostic method is 96.55 % in discriminating these nodules.

Compared to AI, AI-based chest CT combined with the MDT model had greater value.

Randomized controlled trial with 4-week follow-up.

Supervised ACTs improve short-term outcomes in infants with AVB.

ACTs reduce clinical symptoms in viral bronchiolitis.

Respiratory rate and retractions improved with physiotherapy.

PSE showed greater ABSS and SpO2 improvements vs. AAD and control.

Hematological Malignancies (HM) did not increase in-hospital mortality after TAVR.

Prior stem cell transplantation was associated with an 8-fold increase in mortality.

TAVR patients with HM had slightly greater resource utilization.

Patients with HM had higher 30- and 90-day non-elective readmission rates.

Infection-related rehospitalizations were more frequent in patients with HM.

Elevated SII predicts increased CVD/all-cause mortality in US non-elderly adults with diabetes.

SII > 947.6 elevates CVD mortality risk 3.05-fold (95 % CI 1.85‒5.01).

Nonlinear SII-all-cause vs. linear SII-CVD mortality links in NHANES cohort.

Consistent SII-mortality associations across multi-subgroup analyses confirmed.

High temporal prevalence: 52.1 % (current), 93 % (past year), 77.4 % (lifetime) LBP in elderly Brazilians.

Key risk factors: Female sex, hypertension, lower BMI, and functional disability drive LBP burden.

Protective effect: Very active elderly had 74 % lower odds of current LBP (p < 0.05).

Novel associations: Widowhood and diabetes significantly increased lifetime LBP risk.

Clinical implication: Community-based exercise programs may reduce disability and healthcare costs.

The authors studied CIM variability across the cycle and its association with CVRFs.

The authors analyzed video CIMT imaging from 9546 ELSA-Brasil participants.

Median coefficients of variation were 2 % (far wall) to 5 %‒6 % (near wall).

CIMT varied ≥0.1 mm during the cycle in approximately 25 % of the exams.

Cardiac cycle had higher effects on CIMT in participants with CVRFs.

411 differentially expressed circRNAs found in lung cancer and paracarcinoma tissues by high ‒ throughput sequencing.

hsa_circ_0002872/hsa-miR-29b-1-5p/ZBTB46 axis predicted to affect lung cancer progression.

ZBTB46 expression in lung cancer correlates with prognosis, immune cell infiltration, and immune checkpoints.

Study suggests ZBTB46 as a potential biomarker and target for lung cancer immunotherapy.

Identified 4 diagnostic genes (APRT, ARG1, UMPS and LDHB) for sepsis prognosis.

ARG1 and age are independent prognostic factors for sepsis outcomes.

qRT-PCR confirmed diagnostic gene expression patterns in sepsis patients.

Adenomatous polyposis must be diagnosed and treated before colorectal cancer develops.

Screening and prophylactic surgery may improve quality of life and survival.

A review of a 40-year experience demonstrated excellent results and improvement in FAP management.

Long Noncoding RNAs (lncRNAs) played a role in Idiopathic Pulmonary Fibrosis (IPF).

Their specific functions and patterns of expression are still unclear.

The authors conducted a diagnostic study to study lncRNA functions in IPF.

lncRNAs were functionally active and potentially involved in inflammatory response.

Specific lncRNAs might be promising diagnostic biomarkers or therapeutic targets.

LA remodeling reversed after successful RFCA in HFpEF patients with persistent AF.

LA strain parameters effectively assess LA function in HFpEF patients with persistent AF.

Echocardiographic LA contractile function quantifies reverse remodeling post-RFCA.

Identification of aberrantly expressed circRNAs in PMO.

Increased expression of hsa_circ_0004276 during OD of BMSCs.

ELAVL1 inhibits the OD of BMSCs.

Long-term pioglitazone therapy significantly reduces hepatic fat accumulation, as evidenced by reductions in CAP and FAST™ scores.

Pioglitazone demonstrated dual benefits by improving both liver parameters and glycemic control in MASLD patients.

Non-invasive tools, such as VCTE and FAST™ score, are valuable for monitoring treatment responses and reducing the need for liver biopsies.

The present work identifies modifiable risk factors (e.g., needle diameter, puncture frequency) and patient-specific predictors (BMI, lesion depth) to optimize procedural safety.

Methodological Rigor: The authors developed and validated a nomogram model (AUC: 0.875–0.897) using multicenter retrospective data (n = 383), incorporating Decision Curve Analysis (DCA) to confirm clinical utility.

Practical Impact: The model enables preoperative risk stratification, aiding surgeons in tailoring interventions to reduce pneumothorax rates (26.8 % in the studied cohort) and improve patient outcomes.

COVID-19 bivalent vaccine uptake in Korea is low at 12.95 %.

Cancer patients with no history of Omicron infection exhibit low antibody titers.

Hematologic cancer patients exhibit the lowest immune response.

These high-risk patients need additional vaccinations.

Stronger recommendations are needed for these individuals.

Sepsis patients with and without ARDS exhibited significantly different gene expression and immune cell profiles.

The number and proportion of lymphocytes, especially CD8+ T-cells, were lower in patients with sepsis-induced ARDS compared to those without ARDS. The recovery of CD8+ T-cells in these patients was also slow.

By the seventh day of hospitalization, sepsis patients with ARDS generally had a CD8+ T-cell count of less than 162.5.

As vaccination progressed, social risk factors emerged as increasingly important.

The first pandemic wave was marked by higher income and fewer comorbidities.

Low income, older age and black or brown ethnicity drove the last 2 epidemic waves.

Higher heart rate was an independent predictor of SARS-CoV-2 infection.

Black or brown ethnicity was an independent predictor of severe COVID-19.

BTV capsule alleviates the local inflammatory response of abdominal infection.

BTV capsule improves intestinal mucosal barrier function and immune function.

BTV capsules effectively corrected the dysbiosis of gut microbiota.

BTV capsule can reduce the IgA and IgG levels of patients.

Oxycodone alleviated the LPS-driven lung pathological injury both in vivo and in vitro.

Oxycodone pretreatment attenuated LPS-induced systemic inflammation and subsequent lung injury.

Oxycodone increases the expression of HO-1 while downregulating the mitophagy-related proteins.

HO-1 deficiency weakens the effect of oxycodone on the expression of mitophagy-related proteins.

Oxycodone attenuates LPS-induced cell injury by regulating mitophagy via the HO-1 pathway.

Oxidative and thiol balance is altered in AMI and HF.

Serum zinc levels are elevated in AMI.

Zinc and copper have the potential to be biomarkers in AMI and HF.

Examined patient and caregiver perceptions post-hospital discharge in Brazil.

Employed CTM-15 Brazil for data collection on transitional care quality.

Patients with chronic illnesses showed higher satisfaction with transitional care.

Hospital transitional care units play a vital role in patient reintegration.

Emphasized the importance of personalized care plans for enhancing outcomes

A classification method based on a vision transformer with a shifted window is proposed.

The proposed transformer model consists of two primary blocks and an attention unit.

The performance of this work outperforms state-of-the-art.

AASEQ is a self-efficacy tool with rigorous validation procedures.

AASEQ was translated and cross-culturally adapted to Brazilian Portuguese.

AASEQ shows good internal consistency and substantial test-retest reliability.

AASEQ fills a gap in assessing self-efficacy in Brazilian asthmatic adolescents.

Underreporting of chronic hepatitis C deaths was identified in Brazil.

In deaths in which Hepatitis C was the underlying cause of death, it was mentioned as an associated cause of death.

Multiple cause analysis revealed the true extent of hepatitis C mortality.

Study recommends reviewing the death cause recording processes in Brazil.

High ferritin levels are linked to increased all-cause mortality risk in CAD patients.

Elevated ferritin is associated with a 167.4 % higher risk of all-cause mortality.

Long follow-up ensures reliable findings, supporting ferritin as a risk stratification tool.

Question – Are early changes in glycemic and gut hormones similar after weight loss induced by VLCD and bariatric surgery?.

Findings – 50 % of patients had glycemic control after diet-induced weight loss. All patients had improved glycemic control after RYGB. There was an increase of GLP1 after weight loss by diet only in fasting and at all times after surgery.

Meaning – 50 % of patients had glycemic control after VLCD and 100 % after RYGB.

The preliminary data suggest an association between the FMR1 gene premutation and susceptibility to Fibromyalgia (FM), but larger studies with consistent designs are needed to confirm this hypothesis.

A sample definition focusing on FM prevalence among premutation carriers may offer a more effective approach to exploring this association.

The authors calculated the sample size needed to achieve statistical significance based on our pilot study.

Investigating this association could inform future clinical management and the identification of therapeutic targets.

Telomere length is associated with Graves&apos; disease risk in Europeans.

Telomere length is not associated with autoimmune thyroiditis risk in Europeans.

The impact of telomere length on autoimmune thyroid disease in Europeans is unequal.

First study to develop a model using total comorbidities and medication data.

Fill the gap in the readmission rate of critically ill HF pts in the 90-day vulnerable phase.

Model results suggest psychoanaleptics may be linked to HF readmissions.

Construct full & compact models with good performance for diverse clinical settings.

ML-based urine test enables screening for endometriosis (93 % sensitivity).

42 % reduction in unnecessary MRI referrals during endometriosis evaluation.

Same-day results support early triage of symptomatic gynecologic patients.

ATR-FTIR spectra combined with ML distinguish endometriosis biochemical profiles.

Decision-support tool for stratifying symptomatic patients before imaging.

The increase in SII level is associated with an increase in asthma incidence.

Age disparities may influence the relationship between inflammation and asthma.

Higher SII correlates with a 31 % increased asthma incidence.

Acupuncture improves cognitive and daily living abilities in VCI patients.

Long-term effects of acupuncture surpass those of donepezil and sham acupuncture.

Large-scale, multicenter trial enhances the reliability of acupuncture findings.

Minimal adverse reactions confirm the safety of acupuncture in VCI treatment.