Clinics

SIGLEC9 is highly expressed in cervical cancer and linked to poor prognosis.

Bioinformatics show SIGLEC9 correlates with macrophages and T-cells.

SIGLEC9+ TAMs and T-cells are highly enriched in the cervical cancer microenvironment.

High SIGLEC9+ TAM expression correlates with poor prognosis in cervical cancer.

Prematurity is a risk factor for lifelong hearing damage.

Hearing monitoring is necessary until around 3-years of age.

Hearing monitoring after peri-intraventricular hemorrhage is essential.

Establishes the first cephalic index standards for multi-ethnic Malaysian subadults.

Reports a negative correlation between age and CI, with a decline of 0.026 yearly.

Shows higher CI values in Malaysians than in Caucasians and other Asian groups.

Provides a validated tool (ICC > 0.93) to track cranial growth and deformity severity.

Two diagnostic criteria diagnose cancer cachexia in HNSCC patients.

Disease-free HNSCC patients present cancer cachexia after long-term follow-up.

Cachexia is not associated with dysphagia.

Uterine carcinosarcoma is treated with no histology-based management.

Heterologous sarcomatous component has a negative impact on overall survival.

First study to report a negative prognostic impact in FIGO I‒IVA in Latin America.

There is a need to reconsider the role of sarcomatous component to tailor treatment.

Fibromyalgia patients have thinner skin on ultrasound.

Trapezius muscle is thicker and stiffer in fibromyalgia.

Muscle stiffness is correlated with pain severity.

Reduced skin thickness may drive peripheral sensitization.

Uterine carcinosarcoma is treated with no histology-based management.

Heterologous sarcomatous component has a negative impact on overall survival.

First study to report a negative prognostic impact in FIGO I-IVA in Latin America.

There is a need to reconsider the role of the sarcomatous component to tailor treatment.

ML model uses VCG-derived GEH to predict tertiary care (AUC 68 %, Sens 94 %) for triage.

Interpretable XGBoost prioritizes GEH and prior PCI, matching clinical risk factors.

High sensitivity and low specificity highlight its use as a screening support tool.

SHAP confirms robustness of SVG, QTc, and age across several sensitivity scenarios.

VCG biomarker extraction enables low-cost, scalable support for clinical triage use.

PSE occurred in approximately one-third of IgAV patients at disease onset.

IgAV painful subcutaneous edema was mainly located on the lower and upper limbs.

IgAV painful subcutaneous edema was identified predominantly at an early age.

+2767, +781, and −251 polymorphisms were associated with cancer risk.

−251 variant may directly influence IL-8 expression in prostate cancer patients.

These polymorphisms represent promising candidate biomarkers of cancer detection.

Obinutuzumab safety evaluated using FAERS data from 2013–2024.

Blood and lymphatic disorders show the highest signal strength in both sexes.

Women show a higher risk of severe hematologic toxicities with Obinutuzumab.

Novel signals for pure red cell aplasia and enteroviral meningitis in women.

Healthy nighttime sleep may be linked to lower odds of ADLD.

Healthy sleep is linked to reduced risk of ADLD in the elderly with sufficient PA.

Benefits of sufficient PA and healthy sleep on reducing the risk of ADLD is unclear.

37.4 % of emergency patients were eligible for palliative care.

Public EDs had 9-fold higher odds of palliative care eligibility.

Pain was the most reported symptom among eligible patients.

Opioid use was low despite high symptom burden in PC patients.

SPICT-BR™ and PPS tools revealed unmet needs in emergency care.

Describes the co-design and pilot implementation of a one-stop clinic for DDH.

Introduces a novel grouping of Graf subtypes to guide a structured three-phase treatment.

Presents collaboratively designed algorithms for clinic workflow and evidence-based treatment.

In the pilot phase, 22 of 98 infants were treated with a Pavlik harness, showing feasibility.

Aims to standardize care and serve as a model for implementation in similar healthcare settings.

TBL1XR1 and MFAP5 are highly expressed in the serum of patients with PCa.

TBL1XR1 and MFAP5 expression levels are positively related to PSA concentration.

Combination of TBL1XR1, MFAP5 and PSA improves the accuracy of PCa diagnosis.

Renal amyloidosis is the dominant lesion in this Chinese MGRS cohort.

Amyloidosis MGRS shows a distinct clinical phenotype at presentation.

Cardiac involvement is a key predictor of end-stage kidney disease.

Therapy response (hematologic/renal) is linked to better survival.

Early clone-directed therapy is critical for amyloidosis MGRS.

Cross-regional validation of IgAN tubulointerstitial lesion prediction nomogram in China.

eGFRcr and eGFRcr-cys perform equally, supporting use in low-resource settings.

High-altitude IgAN subgroup shows improved nomogram predictive performance.

Sleep apnea in Down syndrome may relate to obesity and body fat distribution.

Abdominal fat and neck size are linked to sleep apnea in Down syndrome.

Sleep apnea may be related to metabolic changes in adults with Down syndrome.

Obstructive sleep apnea may impair memory and cognition in Down syndrome.

Obstructive sleep apnea in Down syndrome is linked to poor memory performance.

First study of NF1 patient experiences in the health systems of Brazil and Portugal.

Portuguese patients showed lower genetic and health literacy than Brazilians.

Access to neurologists and psychiatrists was a key barrier in both countries.

Despite economic differences, both nations face similar barriers in multidisciplinary care.

Findings highlight urgent need for national NF1 data and structured care pathways.

Serum hsa_circ_0005075 is significantly elevated in patients with Recurrent Spontaneous Abortion (RSA).

Hsa_circ_0005075 exhibits high diagnostic value (AUC = 0.820) for distinguishing RSA patients from healthy controls.

Overexpression of hsa_circ_0005075 suppresses trophoblast cell proliferation, invasion, and cell cycle progression while promoting apoptosis.

Hsa_circ_0005075 exerts its functional effects by inhibiting the activation of the Wnt/β-catenin signaling pathway.

Targeting hsa_circ_0005075 may represent a novel diagnostic and therapeutic strategy for RSA.

Acupuncture could improve the physical function and reduce pain of knee.

Acupuncture improving the life quality of patients.

Electroacupuncture showed the strongest effects.

A machine learning nomogram predicts in-hospital mortality in sepsis.

Seven clinical parameters were identified as independent mortality predictors.

The nomogram showed excellent discrimination with an AUC of 0.900.

SHAP analysis offers interpretability to the machine learning model.

The tool facilitates early risk stratification of high-risk patients.

Limb RIPC decreases plasma CC16, a key biomarker of lung epithelial injury.

RIPC attenuates systemic Inflammation (IL-6) and oxidative stress (MDA).

A simple, non-invasive intervention for molecular lung protection.

No short-term improvement in oxygenation indices was observed postoperatively.

GALAD model shows high accuracy in diagnosing HBV-related HCC in Chinese patients.

GALAD outperforms AFP, AFP-L3 %, and DCP in diagnostic performance.

GALAD is a cost-effective tool for HCC screening in HBV-endemic and in resource-limited regions.

Study found 53.15% prevalence of IBS in women with Chronic Pelvic Pain (CPP).

No significant differences in sociodemographic factors between IBS and non-IBS patients.

IBS patients had higher rates of myofascial pain, neuropathic pain, and sensitization.

Multiple assessment tools were used, including the Rome IV criteria for IBS diagnosis.

Results highlight the link between IBS and chronic pelvic pain, necessitating better care.

Resveratrol studied for protection against isoflurane-induced testicular damage.

Sixty C57BL/6 mice were divided into control, isoflurane, and resveratrol groups.

Isoflurane reduced testicular volume, tubular structures, and altered cells.

Resveratrol modulated apoptotic markers and boosted antioxidant gene expression.

Resveratrol shows potential in preventing isoflurane-induced testicular toxicity.

Zumba lowers TSH and triglycerides in postmenopausal obese women.

Zumba improves body composition and blood pressure after menopause.

Zumba is a non-drug strategy to boost postmenopausal women's health.

Dance-based training helps regulate thyroid and lipid levels postmenopause.

Screened 177 Chinese GDM women (FBG ≥5.1 mmoL/L) for GCK variants.

Identified 8 rare GCK variants in 9 individuals (1.9 % prevalence).

No confirmed GCK-MODY cases found among variant carriers.

Limited utility of FBG-based GCK-MODY screening in Chinese GDM.

Totally Laparoscopic Gastrectomy (TLG) has been used for the treatment of gastric cancer.

Compared with Laparoscopy-Assisted Gastrectomy (LAG), TLG has a shorter operative time and less intraoperative blood loss.

TLG contributes to faster recovery and shorter time of hospitalization than LAG.

Eustachian tube dysfunction prevalence does not differ across chronic sinusitis subtypes.

Serum IgE levels correlate with eustachian tube dysfunction in CRSwNP.

Total IgE and age correlate with ETD in EosCRSwNP, IgE as a risk factor.

ET function assessment shows moderate-good consistency between ETDQ-7 and ETS results.

The private sector performs the majority of procedures despite serving a minority of the population.

National procedure volume more than doubled (140% increase) in almost a decade.

The Southeast region is responsible for 70% of all private procedures.

Lenvatinib was associated with a higher incidence of ascites and bilirubin elevation, highlighting the need for vigilant liver function monitoring.

Lenvatinib’s inhibition of VEGFR, FGFR, and PDGFR pathways contributes to its superior anti-angiogenic and anti-proliferative effects.

Preclinical evidence suggests lenvatinib may synergize with immunotherapy by modifying the tumor microenvironment, offering novel therapeutic avenues.

Economic analyses indicate lenvatinib is more cost-effective than sorafenib, supporting its adoption in resource-limited settings.

Executive functions components behave differently during aerobic exercise.

Inhibitory control improves during moderate and vigorous exercise.

No effect of moderate or vigorous exercise on working memory or cognitive flexibility.

Δ9-THC/CBD reduced TMD pain from 7.35 to 3.50 on the VAS scale.

Functional gain: mouth opening increased from 45.9 mm to 49.9 mm.

Significant improvement in mandibular protrusion and laterality.

∼90 % reduction in functional pain; allodynia and hyperalgesia nearly absent.

Superior analgesic effect vs. placebo, with large effect size (d > 0.8).

Infertility affects around 15 % of couples around the world.

The quality of eggs and the chances of pregnancy in IVF treatment decrease with maternal age.

Preimplantation genetic diagnosis can help select euploid embryos for embryo transfer.

The indication of preimplantation genetic diagnosis in IVF treatment does not seem to reduce treatment costs.

Preimplantation genetic diagnosis does not seem to ALTER miscarriage or pregnancy rates in good prognosis fertile couples.

Elevated serum creatinine at ICU admission independently predicted in-hospital mortality.

Viral load correlated with disease severity but was not an independent predictor after adjustment.

Advanced age and chronic respiratory disease were associated with reduced survival.

Non-survivors showed higher D-dimer, leukocyte counts, and greater multiorgan dysfunction.

This study provides a historical record of early COVID-19 mortality in a Brazilian ICU.

Education years predicted global cognitive performance in older men.

Serum testosterone levels inversely correlated with depression scores.

Higher BMI was associated with lower MMSE scores in bivariate analysis.

BMI was negatively correlated with serum testosterone levels.

Endometriosis was found in 61.5 % of women with chronic pelvic pain and confirmed pelvic varicosities.

Multiparametric MRI allows non-invasive, simultaneous detection of vascular and gynecological abnormalities.

Integrated imaging may improve diagnostic workup in women with chronic pelvic pain.

Gynecologist and obstetrician availability in Brazil shows significant inequalities.

Mammography and cervical biopsy service provision shows significant inequalities.

These inequalities exist across regions and between the public and private sectors.

The inequalities create barriers to breast and cervical cancer diagnosis.

The inequalities lead to increased health inequities in North and Northeast Brazil.

First large cohort study to identify high muscle mass as a novel and independent risk factor for incident CKD.

Reveals a body composition paradox: both high adiposity and high muscle mass increase CKD risk.

Gender-specific adipokine roles: Leptin (women) is a stronger predictor than adiponectin.

Metabolic syndrome confers a 5-fold higher risk of developing CKD over 10-years.

Findings challenge the traditional focus solely on fat and highlight muscle mass as a key prognostic factor.

Average ICU costs tripled during COVID-19 compared to the pre-pandemic period.

Human resources drove ICU costs, accounting for over 78 % during the pandemic.

Patients needing ventilation, dialysis or surgery had significantly higher ICU costs.

The study offers a replicable micro and macro-costing method for economic evaluations.

Novel comparative analysis of ICU costs before and during the COVID-19 pandemic.

Surpassing organizational frontiers through listening in regular harmonization forums.

Fostering interdisciplinary connections through listening in harmonization forums.

Harmonization working forums as a strategy for regular listening.

Harmonization working forums to enhance interdisciplinary connections.

Interdisciplinary connectivity to understanding organizational processes.

Treat-to-close benefits atrial septal defect with pulmonary hypertension.

Invasive hemodynamic tests identify patients who benefit from treat-to-close.

Most drug-sensitive patients close within one year of targeted drug therapy.

Early fall in pulmonary artery pressure with drug therapy shows a response.

AHP and K-Means enable prioritizing surgical patients using biopsychosocial criteria.

Expert knowledge and clustering identify clinically relevant patient groups.

Structured prioritization boosts clinical outcomes and operational efficiency.

Model validation shows significant improvements in clinical risk, hospitalization rates, and waiting times for high-priority patients.

Burn injuries affect approximately 8.4 million people annually, with 90% occurring in low- and middle-income countries.

The study introduced a gamified learning model that combined a lecture and an interactive trivia game to educate Brazilian students on burn classification and prevention.

This study showed a significant improvement in student knowledge, 98% of the students showed improved scores after the intervention.

High school students demonstrated the highest gain of knowledge, surpassing vocational school students, confirming the effectiveness of the gamified strategy across different educational settings.

The incidence of intrabdominal hypertension was low in this study.

IAH was linked to a greater need for mechanical ventilation.

IAH was linked to a greater need for hemodialysis.

No cases of abdominal compartment syndrome were observed.

Mendelian randomization reveals causal plasma proteins for idiopathic pulmonary fibrosis.

MASP1 and S100A11 are novel therapeutic targets lowering IPF risk.

WFIKKN2 is a potential therapeutic target that increases IPF risk.

Evaluated the association between the Cardiometabolic Index (CMI) and sarcopenia prevalence among U.S. adults using NHANES data (2011‒2018).

Found significantly higher CMI values in sarcopenia patients compared to non-sarcopenia patients (0.82 vs. 0.43, p < 0.0001).

Identified a significant positive correlation between increased CMI and sarcopenia prevalence (adjusted OR = 1.39, 95 % CI = 1.05–1.91, p = 0.005).

Confirmed a nonlinear positive correlation between CMI and sarcopenia, with an optimal threshold effect at CMI = 0.899.

Highlighted the significance of this association in males, younger adults (20‒39 years), non-Hispanic Black individuals, hypertensive, non-obese, and non-diabetic individuals.

Emphasized the importance of considering CMI as a potential risk factor for sarcopenia and the need for targeted interventions.

Patients trust and satisfaction with healthcare are closely linked.

Patient-doctor communication relates to patient satisfaction and trust with care.

Factors mediate the relationship between communication, satisfaction, and trust.

Doctors clinical and relational competencies are important mediators.

Patients expectations and healthcare context play a critical role as mediators too.

PGE2 seems to have a role in hypertrophic osteoarthropathy/clubbing of different causes.

The measurement of PGE2 and bone turnover markers may be useful for monitoring disease activity.

The use of COX-2 inhibitors can be useful for managing the symptoms related to this entity.

Nine-week HIIT program improved body composition in obese adolescent females.

HIIT did not affect serum creatinine, urea, and eGFR in obese adolescent females.

HIIT resulted in non-clinically meaningful decreases in plasma sodium and chloride.

Exercise improves cardiorespiratory fitness.

Enhance QoL.

Reduce AF recurrence.

Sofosbuvir improved cardiac function in chronic HCV patients with heart disease.

Ejection fraction and left atrial volume improved, boosting heart performance.

Liver stiffness significantly reduced after HCV eradication.

Warfarin dosage was increased to optimize INR, maintaining stable anticoagulation.

circ-RERE is augmented in AML.

Silencing circ-RERE can inhibit autophagy and immune escape in AML cells.

circ-RERE is a molecular sponge for miR-128–3p.

miR-128–3p can block autophagy and immune escape in AML cells.

Up-regulation of ZEB1 reverses the effect of down-regulation of circ-RERE on AML cells.

The study addresses a gap in IC validation for the Brazilian elderly.

Age-stratified analysis tailors screening to high-risk groups.

ADL, IADL, frailty, and urinary incontinence enrich the IC evaluation.

The better survival of preterm infants in recent years raises concerns about the risk of Intraventricular Hemorrhage (IVH).

The incidence of IVH was 32% and more frequent in those < 1000g (50.5%) compared with those ≥ 1000 g (21.5%).

In preterm infants < 1000 g, gestational age and patent ductus arteriosus were associated with IVH, and severe IVH.

In preterm infants ≥ 1000 g, IVH was associated with preeclampsia, first-minute Apgar, use of vasoactive drugs and surfactant.

C-PLAN integrates CRP, lymphocytes, nutrition, and NLR for prognosis in esophageal cancer.

Nonlinear link between C-PLAN and survival (p < 0.001) shown via spline analysis.

C-PLAN outperforms NLR in predicting OS/PFS (AUC 0.897 vs. 0.740).

Independent predictor of mortality, enabling tailored immunotherapy decisions.

ABSI positively and nonlinearly associates with AAC and SAAC.

ABSI outperforms BMI, WWI, WHtR and WC in predicting AAC/SAAC.

The ABSI-AAC/SAAC association is consistent across subgroups.

First successful living-donor uterus transplantation in Latin America is reported.

Proactive, multimodal pain control is crucial for the healthy living donor.

Hemodynamic stability in the recipient is paramount during graft reperfusion.

A proactive anesthetic strategy is a critical pillar for a successful outcome.

M2-exo facilitated osteogenic differentiation of hPDLSCs.

CCL18 was upregulated in M2-exo and M2-exo treated hPDLSCs.

CCL18 knockdown reversed the impact of M2-exo in hPDLSCs.

MR analysis shows AS causally linked to hypertension & heart failure.

No causal effects of AS on atrial fibrillation, AMI, CA, or angina.

Inflammation may mediate AS-CVD relationship.

Oral midazolam and esketamine together provide satisfactory sedation in children.

Oral administration of 0.41 mg/kg midazolam and 4.1 mg/kg esketamine is safe.

A higher esketamine ratio can cause more adverse events.

The 1-minute sit-to-stand test and 6-minute walk test are key tools for evaluating exercise capacity in COPD patients.

A smartphone-based 1-minute sit-to-stand test predicts the 6-minute walk distance.

Combines inertial motion unit sensor data with machine learning for accurate estimation.

Enables remote COPD management using smartphone sensors and advanced algorithms.

Telesurgery was feasible over SUS infrastructure in a dry lab setting.

Private 5 G delivered higher latency and jitter than wired connections.

All 5 G sessions completed all tasks successfully.

Surgeons rated safety and suitability for complex procedures highly.

Initial multivariate analysis showed inverse DII-LTBI association (OR = 0.93, p = 0.011).

Association became non-significant after adjusting for country of birth (OR = 0.96).

No significant link found in US-born or non-US-born subgroup analyses.

Country of birth is identified as a key confounder in the diet-LTBI relationship.

ROMA showed higher accuracy (AUC: 0.93–0.95) than HE4 and CA-125 for ovarian cancer.

ROMA, HE4 discriminated cancer vs benign (AUC ≥ 0.93), unlike CA-125 (0.60).

ROMA validated as a specific triage tool for ovarian cancer in low-resource settings.

Study provides key biomarker performance data from a Bangladeshi cohort.

First nomogram integrates 5-HT and oxidative stress markers for vertigo treatment.

Model shows high accuracy (C-index 0.86‒0.87) and identifies key predictive factors.

Facilitates personalized therapy by early detection of flunarizine poor responders.

Music therapy has a positive impact on adult patients with different endocrinopathies.

Music therapy decreases anxiety and depression in hospitalized patients.

A single session of music therapy enables patients to reconnect with their sense of self.

•Music therapy improves hospital adjustment for patients with endocrinopathies.

First clinical evidence linking serum Slit3 to both RA disease activity and RA-associated Interstitial Lung Disease (RA-ILD).

Slit3 as an independent predictor of RA-ILD, alongside male gender, disease duration, and ACPA positivity.

High Slit3 levels correlate with increased systemic inflammation (ESR, CRP, IL-6) and higher composite Disease Activity Scores (DAS28, SDAI).

Weak-to-moderate correlation with HRCT lung involvement suggests Slit3 may reflect ‒ but not strongly drive ‒ ILD severity.

Potential dual role as a diagnostic biomarker and future therapeutic target in RA-ILD pathogenesis.

The timed Up and Go test (TUG) execution time is significantly slower in lower-limb amputees than in healthy volunteers.

Older age, lower scores on the Amputee Mobility Predictor (AMP), and non-use of a prosthesis were key factors associated with slower TUG times.

For each additional year of age, TUG time increased by 0.14 seconds in the amputee cohort.

The TUG test is a practical tool that can be standardized in clinical practice to guide rehabilitation strategies for amputees.

Comparable 90-day survival: In 2590 sepsis patients, short (2–7 days) and long (8–14 days) antibiotic courses showed similar outcomes (∼41%, p = 0.98).

High-risk subgroups identified: Extended therapy reduced mortality in patients > 65-years, severe hypoxemia, renal replacement therapy, or infections with Staphylococcus aureus or Pseudomonas aeruginosa.

Supports antimicrobial stewardship: Short-course therapy is safe in lower-risk patients, aiding in efforts to minimize antibiotic overuse.

Advocates for personalized treatment: Findings suggest antibiotic duration should be tailored based on patient factors, pathogen, and severity.

Genetics establishes smoking as a cause of Carpal Tunnel Syndrome.

Genetic predisposition to smoking raises the risk of Carpal Tunnel Syndrome.

Finding is robust to genetic confounding.

Quitting smoking is key to preventing Carpal Tunnel Syndrome.

Data on LUNGguard indicate stable hypothermic conditions; reported short-term survival is high but based on limited studies.

A single study on MYTEMP 65 HC reported a lower PGD3 incidence but longer ventilator times.

Significant evidence gaps exist for most commercial devices, underscoring the critical need for comparative studies.

Weak evidence suggests varied clinical outcomes across devices.

Data were derived from the China Health and Retirement Longitudinal Study (CHARLS).

Both cross-sectional and longitudinal analyses were performed.

Sarcopenia and possible sarcopenia were positively associated with KOA prevalence.

Participants developing sarcopenia during follow-up had a higher risk of KOA.

Men show higher lactate, pain, dyspnea, and perceived exertion than women at CV.

CV reflects severe-intensity domain and should not replace maximal lactate steady state.

Critical Swimming Velocity (CV) values differ significantly by protocol choice.

Four-distance protocol produces higher CV than two- and three-distance methods.

92% of 400-m test underestimates CV in male and female triathletes.

The authors developed a high-accuracy RA-ILD diagnostic model by integrating multi-omics, radiomics and machine learning approaches.

The clinical-radiomics nomogram shows robust diagnostic performance in both internal and multicenter external validation.

Key biomarkers were identified that link molecular changes to inflammatory activation and pulmonary function impairment.

Multi-omics integration outperforms single-omics strategies for RA-ILD diagnosis and reflects disease severity progression.

Secondary Cardiovascular Events (SCEs) occurred in 27.9% of older CAP inpatients.

Nearly 70% of SCEs developed within 72-hours of hospital admission.

Clinical Frailty (CFS ≥ 5) independently predicted in-hospital SCEs.

Adding CFS, hs-cTn and NT-proBNP to PSI raised AUC from 0.68 to 0.79.

Cumulative SCE incidence reached 33.7% at 30-days and 37.8% at 90-days.

Both Onlay and Inlay techniques of LTT transfer effectively improved shoulder function in patients with irreparable posterosuperior rotator cuff tears.

The Onlay technique resulted in better AHD at the final follow-up.

This study provides evidence to guide surgical decision-making of the Onlay technique for LTT transfer in this patient population.

LAR is a strong predictor of mortality in ICU patients with hypertensive heart failure.

Threshold effect identified: LAR >2.4 indicates ultra-high-risk patients.

Risk increases stepwise across LAR quartiles in Kaplan-Meier survival analysis.

LAR offers a simple, low-cost prognostic tool from routine lab values.

Stronger predictive value observed in males and patients with chronic pulmonary disease.

CT imaging grading combined with PCT/CRP effectively predicts conservative treatment prognosis for acute appendicitis.

Higher CT grades correlate with elevated PCT/CRP and poorer antibiotic therapy outcomes in acute appendicitis patients.

CT grade is an independent risk factor for relapse, with higher grades shortening relapse-free survival time.

NLR, white blood cell/neutrophil counts also link to increased conservative treatment failure risk in acute appendicitis.

Low CT grades suit conservative treatment; high grades warrant prioritized surgical intervention for acute appendicitis.

Genetically predicted hemoglobin levels show a weak potential association with increased osteoarthritis risk.

Neutrophil count is not significantly associated with osteoarthritis risk after correction for multiple testing.

The effect size for hemoglobin is clinically negligible, suggesting an exploratory rather than definitive causal link.

Significant heterogeneity and potential pleiotropy suggest these findings should be interpreted with caution.

Diabetes‑associated LUTS were associated with higher BMI and inflammatory indices.

CRP and WBC count were higher in the diabetes‑associated LUTS group.

WBC count was an independent risk factor in diabetes‑associated LUTS patients.

Anticholinergic burden was detected in over 50% of fibromyalgia patients.

Pain medications made up nearly 73% of all drugs prescribed in the study.

Medication alerts highlight risks of CNS depression and cognitive impairment.

Pharmacological reviews help align treatment with clinical guidelines.

Personalized drug therapy may reduce fibro-fog and enhance patient outcomes.

SII is a cost-effective indicator for Metabolic Syndrome (MetS).

MetS patients exhibit significantly higher SII scores than healthy peers.

High SII predicts increased all-cause and CVD mortality in MetS.

A J-shaped relationship exists between SII and MetS mortality risks.

SII mortality prediction is strongest in MetS patients aged ≥60.

Seven emotions are linked to traditional Chinese medicine syndromes in lung cancer.

Emotional states correlate with inflammation markers IL-6 and IFN-γ in patients.

Findings suggest mind-body connections may inform future lung cancer care.

Restrictive lung disease is common after severe COVID-19.

Lung function improves over one year, but impairment often persists.

Physical performance improves, especially in restrictive lung disease.

Functional limitations persist in some patients after one year.

Long-term follow-up and rehabilitation are essential after COVID-19 hospitalization.

CLIC3 and MST1R are overexpressed and linked to pancreatic cancer progression.

Mendelian randomization confirms a causal role of CLIC3 and MST1R in PC.

High expression of both genes alters immune infiltration, especially CD8+ T-cells.

CLIC3 and MST1R correlate with poor prognosis in pancreatic cancer patients.

Both genes are potential targets for precision and immune-based PC therapies.

Interdisciplinary model assessed over 350 post-COVID patients.

Over 30 assessments generated ∼11,000 patient evaluations.

Integrated dataset strongly supports interdisciplinary research.

Hybrid model optimized patient time and study logistics.

Standardized ultrasound protocol for TMD asymmetry assessment.

Quantitative indices for muscle and TMJ asymmetry analysis.

Ultrasound asymmetry linked to TMD symptoms (exploratory).

Feasibility of multimodal ultrasound in the masticatory system study.

Vitamin D and exercise may benefit muscle health.

Changes in body composition and bone health may require time.

Vitamin D and exercise regulate biochemical parameters.

FTP strongly correlates with power at the respiratory compensation point.

The FTP-RCP relationship is consistent in male and female triathletes.

FTP and RCP show poor agreement and should not be used interchangeably.

FTP consistently underestimates the power associated with RCP.

Sex differences disappear when power is normalized to lean mass.

CTI correlates with increased asthma risk in NHANES and CHNS cohorts.

No nonlinear relationship found between CTI and asthma risk.

CTI integrates inflammation and metabolism for asthma risk assessment.

Two-sample MR confirms hypothyroidism causally elevates osteomyelitis risk.

Hyperthyroidism-osteomyelitis link is confounded by lifestyle and BMI factors.

No reverse causality from osteomyelitis to thyroid dysfunction detected.

Hypothyroidism patients need closer infection monitoring in orthopedic care.

HIV care remained stable in patients retained during COVID-19.

Viral suppression and CD4 counts were maintained over time.

Telemedicine and ART dispensing were used during the pandemic.

Anxiety and depressive symptoms were frequently reported.

Findings reflect outcomes in a selected cohort with follow-up.

miR-1180–3p is significantly overexpressed in the serum of patients with OSAHS.

miR-1180–3p acts as a potential diagnostic biomarker for OSAHS.

miR-1180–3p is an independent risk factor for the occurrence of OSAHS.

Downregulation of miR-1180–3p alleviates CIH-induced injury in HUVECs.

miR-1180–3p targets CERS1 to regulate CIH-induced injury in HUVECs.

VCE and BAE have changed the management of small bowel lesions.

VCE is a noninvasive method allowing examination of the entire small bowel.

BAE enables therapeutic interventions.

This is the first Brazilian consensus addressing SBE.

This consensus may assist the medical team in the decision-making process.

Telemedicine showed high patient satisfaction in gynecologic oncology care.

Remote visits reduced travel, costs, and time compared to in-person visits.

Telephone-based care was feasible despite limitations in physical examination.

Patients and providers supported telemedicine as a complementary care strategy.

Educational and digital access disparities may influence telemedicine adoption.

Multiple methods exist to extract Adipose-Derived Stem Cells (ASCs) and fat derivatives for medical use.

Saline solution 0.9% was the washing solution that showed the lowest rate of cell death; lidocaine, ropivacaine, and epinephrine caused similar levels of cell death, and passing fat through a 2.4 mm Luer-to-Luer connector up to 20 times did not affect cell viability.

ASC proliferation and differentiation capability into adipocytes, osteocytes, and chondrocytes remained intact with saline and 20 × passages.

These findings may enhance fat graft viability.

A triple-marker strategy synergizes fecal DNA and serum tests for CRC screening.

This combination achieves near-complete (96.9%) sensitivity for colorectal cancer.

Half of precancerous advanced adenomas are identified by the combined approach.

The method surpasses standard blood tests in early detection capability.

Population-based study of 1202 pregnant women in Paraná, Brazil.

Anti-HCV antibody seroprevalence was 0.75%, with no active infections detected.

Over half of seropositive women were unaware of prior HCV exposure.

Findings support universal prenatal HCV screening as a postpartum care opportunity, even in low-prevalence settings.

Regional heterogeneity underscores the need for equitable screening policies in Brazil.

Genetically predicted TTK inhibition is causally associated with a significant decrease in breast cancer risk.

No gut microbial taxa remained significantly associated with TTK inhibition or breast cancer after FDR correction.

An exploratory mediation analysis of Genus Anaerostipes did not yield statistically significant results.

The findings reinforce TTK as a promising therapeutic target for breast cancer.

First evidence that miR-628–3p is upregulated in AR patients and cell models.

miR-628–3p promotes inflammatory response and apoptosis in nasal epithelial cells.

Mechanistic validation shows CELF2 is a direct target of miR-628–3p.

Knockdown of miR-628–3p alleviates inflammation via CELF2 upregulation.

Identifies miR-628–3p/CELF2 axis as a potential therapeutic target for AR.

Wearing full-body personal protective equipment does not reduce oxygen saturation.

Effects of full-body personal protective equipment are similar to wearing a facemask.

Human body acclimates to personal protective equipment within physiological limits.

The benefits of wearing respiratory protection outweigh any perceived risk.

First diabetes-related 8-gene signature for breast cancer prognosis and immunotherapy guidance.

Outperforms clinical variables (AUC=0.837) in predicting survival and stratifying risk.

Linked to immune microenvironment – high expression in CD4+ T-cells and regulatory T-cells.

Predicts chemotherapy sensitivity, identifying potential drugs for high- vs. low-risk patients.

Provides a translational bridge between diabetes biology and precision oncology in breast cancer.

Early low-dose terlipressin reduced norepinephrine dependence in septic shock.

Low-dose terlipressin increased vasopressor-free days within the first 7-days.

Earlier terlipressin improved hemodynamic stabilization and lactate clearance.

Low-dose terlipressin promoted faster renal, hepatic, and platelet recovery.

Early low-dose terlipressin was associated with fewer ischemic adverse events.

Lactate metabolism genes are closely linked to hepatocellular carcinoma prognosis.

Bioinformatics identifies ASPDH as a key lactate metabolism gene.

ASPDH effectively inhibits the proliferation, invasion, and migration of liver cancer cells.

ASPDH suppresses liver cancer progression via lactate metabolism and NF-κB/PD-L1 signaling.

Immunoinformatics-based design of a multi-epitope vaccine against Seoul virus (SEOV).

Designed Vaccine construct V2 showed 95.94% global coverage and strong antigenicity.

Docking and molecular dynamics simulations confirmed stable binding of V2 with the TLR4 receptor.

Immune simulations predicted strong IgG1, IFN-γ, and memory responses of V2.

Codon optimization and in silico cloning confirmed expression feasibility.

RA patients show significantly increased SSNHL risk.

Large-scale nationwide cohort strengthens validity.

Propensity matching reduces confounding bias.

RA increases SSNHL risk by approximately 2.7-fold.

Consistent findings across stratified and sensitivity analyses.

CRP shows high sensitivity but low specificity for adult sepsis diagnosis.

Diagnostic accuracy of CRP in sepsis is limited by high heterogeneity.

Prognostic value of CRP for mortality in sepsis remains uncertain.

False-positive rate of CRP in sepsis diagnosis reaches about 44 %.

Overall quality of evidence on CRP use in sepsis is low.

The high mortality rate associated with breast cancer makes it an important neoplasm.

Melatonin may modulate breast cancer progression, influencing proliferation and apoptosis.

Melatonin inhibited tumorigenesis in three studies with the lowest risk of bias.

Z-POEM achieves >90 % clinical success with durable symptom relief.

Technical variations (NiZ-POEM, tunnel-free) broaden clinical applicability.

Safety profile is favorable, with low rates of bleeding or perforation.

Z-POEM compares favorably to flexible septotomy in efficacy and safety.

Cost-effectiveness analyses support Z-POEM in specialized centers.

Meta-analysis evaluates thiamine’s efficacy for sepsis/septic shock.

Meta-analysis includes RCTs on intravenous thiamine for sepsis/septic shock.

Thiamine reduces the need for Renal Replacement Therapy (RRT).

Thiamine increases 24 h SOFA score changes and improves organ dysfunction.

Overall short-term mortality unchanged; subgroup has lower mortality.

Review of biopsychosocial factors in Surgical Waiting List prioritization (SWL).

Identification of frequent biopsychosocial factors in managing patients on SWL.

Association between biopsychosocial factors by clinical area in patients on SWL.

A holistic approach that balances both patient and physician perspectives.

First 30-year bibliometric map of Chemobrain-neuroinflammation research.

Neuroinflammation is the central, sustained mechanistic focus of the field.

Microglia, BBB, oxidative stress, and gut-brain axis are key research hotspots.

Multi-omics and clinical trials are urgently needed for translational breakthroughs.

Artificial intelligence can be used to detect lung cancer.

Convolutional Neural Networks (CNN) demonstrated the best performance.

Deep learning models lead to improved performance metrics.

Stepwise diagnostic algorithm for recurrent unexplained fever in adults.

Integrates infectious, autoimmune, neoplastic, and genetic causes.

Emphasizes Latin America epidemiology and endemic infections.

Combines basic tests with PET/CT and genomic sequencing.

Introduces SURF in persistent unexplained recurrent fever cases.