Clinics

SIGLEC9 is highly expressed in cervical cancer and linked to poor prognosis.

Bioinformatics show SIGLEC9 correlates with macrophages and T-cells.

SIGLEC9+ TAMs and T-cells are highly enriched in the cervical cancer microenvironment.

High SIGLEC9+ TAM expression correlates with poor prognosis in cervical cancer.

Prematurity is a risk factor for lifelong hearing damage.

Hearing monitoring is necessary until around 3-years of age.

Hearing monitoring after peri-intraventricular hemorrhage is essential.

Establishes the first cephalic index standards for multi-ethnic Malaysian subadults.

Reports a negative correlation between age and CI, with a decline of 0.026 yearly.

Shows higher CI values in Malaysians than in Caucasians and other Asian groups.

Provides a validated tool (ICC > 0.93) to track cranial growth and deformity severity.

Two diagnostic criteria diagnose cancer cachexia in HNSCC patients.

Disease-free HNSCC patients present cancer cachexia after long-term follow-up.

Cachexia is not associated with dysphagia.

Uterine carcinosarcoma is treated with no histology-based management.

Heterologous sarcomatous component has a negative impact on overall survival.

First study to report a negative prognostic impact in FIGO I‒IVA in Latin America.

There is a need to reconsider the role of sarcomatous component to tailor treatment.

Fibromyalgia patients have thinner skin on ultrasound.

Trapezius muscle is thicker and stiffer in fibromyalgia.

Muscle stiffness is correlated with pain severity.

Reduced skin thickness may drive peripheral sensitization.

Uterine carcinosarcoma is treated with no histology-based management.

Heterologous sarcomatous component has a negative impact on overall survival.

First study to report a negative prognostic impact in FIGO I-IVA in Latin America.

There is a need to reconsider the role of the sarcomatous component to tailor treatment.

ML model uses VCG-derived GEH to predict tertiary care (AUC 68 %, Sens 94 %) for triage.

Interpretable XGBoost prioritizes GEH and prior PCI, matching clinical risk factors.

High sensitivity and low specificity highlight its use as a screening support tool.

SHAP confirms robustness of SVG, QTc, and age across several sensitivity scenarios.

VCG biomarker extraction enables low-cost, scalable support for clinical triage use.

PSE occurred in approximately one-third of IgAV patients at disease onset.

IgAV painful subcutaneous edema was mainly located on the lower and upper limbs.

IgAV painful subcutaneous edema was identified predominantly at an early age.

+2767, +781, and −251 polymorphisms were associated with cancer risk.

−251 variant may directly influence IL-8 expression in prostate cancer patients.

These polymorphisms represent promising candidate biomarkers of cancer detection.

Obinutuzumab safety evaluated using FAERS data from 2013–2024.

Blood and lymphatic disorders show the highest signal strength in both sexes.

Women show a higher risk of severe hematologic toxicities with Obinutuzumab.

Novel signals for pure red cell aplasia and enteroviral meningitis in women.

Healthy nighttime sleep may be linked to lower odds of ADLD.

Healthy sleep is linked to reduced risk of ADLD in the elderly with sufficient PA.

Benefits of sufficient PA and healthy sleep on reducing the risk of ADLD is unclear.

37.4 % of emergency patients were eligible for palliative care.

Public EDs had 9-fold higher odds of palliative care eligibility.

Pain was the most reported symptom among eligible patients.

Opioid use was low despite high symptom burden in PC patients.

SPICT-BR™ and PPS tools revealed unmet needs in emergency care.

Describes the co-design and pilot implementation of a one-stop clinic for DDH.

Introduces a novel grouping of Graf subtypes to guide a structured three-phase treatment.

Presents collaboratively designed algorithms for clinic workflow and evidence-based treatment.

In the pilot phase, 22 of 98 infants were treated with a Pavlik harness, showing feasibility.

Aims to standardize care and serve as a model for implementation in similar healthcare settings.

TBL1XR1 and MFAP5 are highly expressed in the serum of patients with PCa.

TBL1XR1 and MFAP5 expression levels are positively related to PSA concentration.

Combination of TBL1XR1, MFAP5 and PSA improves the accuracy of PCa diagnosis.

Renal amyloidosis is the dominant lesion in this Chinese MGRS cohort.

Amyloidosis MGRS shows a distinct clinical phenotype at presentation.

Cardiac involvement is a key predictor of end-stage kidney disease.

Therapy response (hematologic/renal) is linked to better survival.

Early clone-directed therapy is critical for amyloidosis MGRS.

Cross-regional validation of IgAN tubulointerstitial lesion prediction nomogram in China.

eGFRcr and eGFRcr-cys perform equally, supporting use in low-resource settings.

High-altitude IgAN subgroup shows improved nomogram predictive performance.

Sleep apnea in Down syndrome may relate to obesity and body fat distribution.

Abdominal fat and neck size are linked to sleep apnea in Down syndrome.

Sleep apnea may be related to metabolic changes in adults with Down syndrome.

Obstructive sleep apnea may impair memory and cognition in Down syndrome.

Obstructive sleep apnea in Down syndrome is linked to poor memory performance.

First study of NF1 patient experiences in the health systems of Brazil and Portugal.

Portuguese patients showed lower genetic and health literacy than Brazilians.

Access to neurologists and psychiatrists was a key barrier in both countries.

Despite economic differences, both nations face similar barriers in multidisciplinary care.

Findings highlight urgent need for national NF1 data and structured care pathways.

Serum hsa_circ_0005075 is significantly elevated in patients with Recurrent Spontaneous Abortion (RSA).

Hsa_circ_0005075 exhibits high diagnostic value (AUC = 0.820) for distinguishing RSA patients from healthy controls.

Overexpression of hsa_circ_0005075 suppresses trophoblast cell proliferation, invasion, and cell cycle progression while promoting apoptosis.

Hsa_circ_0005075 exerts its functional effects by inhibiting the activation of the Wnt/β-catenin signaling pathway.

Targeting hsa_circ_0005075 may represent a novel diagnostic and therapeutic strategy for RSA.

Acupuncture could improve the physical function and reduce pain of knee.

Acupuncture improving the life quality of patients.

Electroacupuncture showed the strongest effects.

A machine learning nomogram predicts in-hospital mortality in sepsis.

Seven clinical parameters were identified as independent mortality predictors.

The nomogram showed excellent discrimination with an AUC of 0.900.

SHAP analysis offers interpretability to the machine learning model.

The tool facilitates early risk stratification of high-risk patients.

Limb RIPC decreases plasma CC16, a key biomarker of lung epithelial injury.

RIPC attenuates systemic Inflammation (IL-6) and oxidative stress (MDA).

A simple, non-invasive intervention for molecular lung protection.

No short-term improvement in oxygenation indices was observed postoperatively.

GALAD model shows high accuracy in diagnosing HBV-related HCC in Chinese patients.

GALAD outperforms AFP, AFP-L3 %, and DCP in diagnostic performance.

GALAD is a cost-effective tool for HCC screening in HBV-endemic and in resource-limited regions.

Study found 53.15% prevalence of IBS in women with Chronic Pelvic Pain (CPP).

No significant differences in sociodemographic factors between IBS and non-IBS patients.

IBS patients had higher rates of myofascial pain, neuropathic pain, and sensitization.

Multiple assessment tools were used, including the Rome IV criteria for IBS diagnosis.

Results highlight the link between IBS and chronic pelvic pain, necessitating better care.

Resveratrol studied for protection against isoflurane-induced testicular damage.

Sixty C57BL/6 mice were divided into control, isoflurane, and resveratrol groups.

Isoflurane reduced testicular volume, tubular structures, and altered cells.

Resveratrol modulated apoptotic markers and boosted antioxidant gene expression.

Resveratrol shows potential in preventing isoflurane-induced testicular toxicity.

Zumba lowers TSH and triglycerides in postmenopausal obese women.

Zumba improves body composition and blood pressure after menopause.

Zumba is a non-drug strategy to boost postmenopausal women's health.

Dance-based training helps regulate thyroid and lipid levels postmenopause.

Screened 177 Chinese GDM women (FBG ≥5.1 mmoL/L) for GCK variants.

Identified 8 rare GCK variants in 9 individuals (1.9 % prevalence).

No confirmed GCK-MODY cases found among variant carriers.

Limited utility of FBG-based GCK-MODY screening in Chinese GDM.

Totally Laparoscopic Gastrectomy (TLG) has been used for the treatment of gastric cancer.

Compared with Laparoscopy-Assisted Gastrectomy (LAG), TLG has a shorter operative time and less intraoperative blood loss.

TLG contributes to faster recovery and shorter time of hospitalization than LAG.

Eustachian tube dysfunction prevalence does not differ across chronic sinusitis subtypes.

Serum IgE levels correlate with eustachian tube dysfunction in CRSwNP.

Total IgE and age correlate with ETD in EosCRSwNP, IgE as a risk factor.

ET function assessment shows moderate-good consistency between ETDQ-7 and ETS results.

The private sector performs the majority of procedures despite serving a minority of the population.

National procedure volume more than doubled (140% increase) in almost a decade.

The Southeast region is responsible for 70% of all private procedures.

Lenvatinib was associated with a higher incidence of ascites and bilirubin elevation, highlighting the need for vigilant liver function monitoring.

Lenvatinib’s inhibition of VEGFR, FGFR, and PDGFR pathways contributes to its superior anti-angiogenic and anti-proliferative effects.

Preclinical evidence suggests lenvatinib may synergize with immunotherapy by modifying the tumor microenvironment, offering novel therapeutic avenues.

Economic analyses indicate lenvatinib is more cost-effective than sorafenib, supporting its adoption in resource-limited settings.

Executive functions components behave differently during aerobic exercise.

Inhibitory control improves during moderate and vigorous exercise.

No effect of moderate or vigorous exercise on working memory or cognitive flexibility.

Δ9-THC/CBD reduced TMD pain from 7.35 to 3.50 on the VAS scale.

Functional gain: mouth opening increased from 45.9 mm to 49.9 mm.

Significant improvement in mandibular protrusion and laterality.

∼90 % reduction in functional pain; allodynia and hyperalgesia nearly absent.

Superior analgesic effect vs. placebo, with large effect size (d > 0.8).

Infertility affects around 15 % of couples around the world.

The quality of eggs and the chances of pregnancy in IVF treatment decrease with maternal age.

Preimplantation genetic diagnosis can help select euploid embryos for embryo transfer.

The indication of preimplantation genetic diagnosis in IVF treatment does not seem to reduce treatment costs.

Preimplantation genetic diagnosis does not seem to ALTER miscarriage or pregnancy rates in good prognosis fertile couples.

Elevated serum creatinine at ICU admission independently predicted in-hospital mortality.

Viral load correlated with disease severity but was not an independent predictor after adjustment.

Advanced age and chronic respiratory disease were associated with reduced survival.

Non-survivors showed higher D-dimer, leukocyte counts, and greater multiorgan dysfunction.

This study provides a historical record of early COVID-19 mortality in a Brazilian ICU.

Education years predicted global cognitive performance in older men.

Serum testosterone levels inversely correlated with depression scores.

Higher BMI was associated with lower MMSE scores in bivariate analysis.

BMI was negatively correlated with serum testosterone levels.

Endometriosis was found in 61.5 % of women with chronic pelvic pain and confirmed pelvic varicosities.

Multiparametric MRI allows non-invasive, simultaneous detection of vascular and gynecological abnormalities.

Integrated imaging may improve diagnostic workup in women with chronic pelvic pain.

Gynecologist and obstetrician availability in Brazil shows significant inequalities.

Mammography and cervical biopsy service provision shows significant inequalities.

These inequalities exist across regions and between the public and private sectors.

The inequalities create barriers to breast and cervical cancer diagnosis.

The inequalities lead to increased health inequities in North and Northeast Brazil.

First large cohort study to identify high muscle mass as a novel and independent risk factor for incident CKD.

Reveals a body composition paradox: both high adiposity and high muscle mass increase CKD risk.

Gender-specific adipokine roles: Leptin (women) is a stronger predictor than adiponectin.

Metabolic syndrome confers a 5-fold higher risk of developing CKD over 10-years.

Findings challenge the traditional focus solely on fat and highlight muscle mass as a key prognostic factor.