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Clinics
Journal Information
Issue
portada-S1807593225X00028Vol. 81. (In progress)
(January - December 2026)
This issue is in progress but contains articles that are final and fully citable.
Original articles
The role of SIGLEC9 in immunosuppression and prognosis in cervical cancer
Bihui Wang, Yuejie Zhu, Zhenyu Ru, Yulian Zhang, Mingkai Yu, Pingfen Li, Manli Zhang, Jianbing Ding, Zhifang Chen
Clinics. 2026;81C:100849
Highlights

  • SIGLEC9 is highly expressed in cervical cancer and linked to poor prognosis.

  • Bioinformatics show SIGLEC9 correlates with macrophages and T-cells.

  • SIGLEC9+ TAMs and T-cells are highly enriched in the cervical cancer microenvironment.

  • High SIGLEC9+ TAM expression correlates with poor prognosis in cervical cancer.

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Electrophysiological evaluation of the auditory pathway in newborns and infants with peri-intraventricular hemorrhage and/or periventricular leukomalacia
Rosanna Giaffredo Angrisani, Natalia Olival Balzarini, Carla Regina Tragante, Valdenise Martins Laurindo Tuma Calil, Werther Brunow de Carvalho, Carla Gentile Matas
Clinics. 2026;81C:100853
Highlights

  • Prematurity is a risk factor for lifelong hearing damage.

  • Hearing monitoring is necessary until around 3-years of age.

  • Hearing monitoring after peri-intraventricular hemorrhage is essential.

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New population-specific cephalic index standards for Malaysian subadults: prevalence, growth patterns, and clinical implications from a CT imaging study
Sharifah Nabilah Syed Mohd Hamdan, Rabi’ah Al-Adawiyah Rahmat, Selva Malar Munusamy, Norliza Ibrahim
Clinics. 2026;81C:100855
Highlights

  • Establishes the first cephalic index standards for multi-ethnic Malaysian subadults.

  • Reports a negative correlation between age and CI, with a decline of 0.026 yearly.

  • Shows higher CI values in Malaysians than in Caucasians and other Asian groups.

  • Provides a validated tool (ICC > 0.93) to track cranial growth and deformity severity.

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Head and neck cancer patients present late cancer cachexia two years after curative chemoradiotherapy
Willian das Neves, Thomás Giollo Rivelli, Eduardo Furquim Simão, Marco Aurélio Vamondes Kulcsar, Gilberto de Castro Junior
Clinics. 2026;81C:100851
Highlights

  • Two diagnostic criteria diagnose cancer cachexia in HNSCC patients.

  • Disease-free HNSCC patients present cancer cachexia after long-term follow-up.

  • Cachexia is not associated with dysphagia.

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Prognostic impact of sarcomatous component in patients with localized and locally advanced uterine carcinosarcoma: a retrospective study in Latin America
Daniel Santos Rocha Sobral Filho, Giulia Mazaro de Oliveira, Letícia Vecchi Leis, Mariana de Paiva Batista, Vanessa da Costa Miranda, Renata Colombo Bonadio, Maria del Pilar Estevez Diz, Samantha Cabral Severino da Costa
Clinics. 2026;81C:100854
Highlights

  • Uterine carcinosarcoma is treated with no histology-based management.

  • Heterologous sarcomatous component has a negative impact on overall survival.

  • First study to report a negative prognostic impact in FIGO I‒IVA in Latin America.

  • There is a need to reconsider the role of sarcomatous component to tailor treatment.

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Skin layer thickness, muscle elasticity and their effects on pain level in fibromyalgia patients
Selçuk Akan, Mehtap Balaban, Ahmet Kor, Bahadir Erturk
Clinics. 2026;81C:100858
Highlights

  • Fibromyalgia patients have thinner skin on ultrasound.

  • Trapezius muscle is thicker and stiffer in fibromyalgia.

  • Muscle stiffness is correlated with pain severity.

  • Reduced skin thickness may drive peripheral sensitization.

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Predictive value of serum chitinase 3-like 1 for dysfunctional autogenous arteriovenous fistulas in patients with chronic kidney disease stage G5
You Wen Lin, Qing Zhang, Ying Sheng Xu, Ting Qu
Clinics. 2026;81C:100852
Highlights

  • Uterine carcinosarcoma is treated with no histology-based management.

  • Heterologous sarcomatous component has a negative impact on overall survival.

  • First study to report a negative prognostic impact in FIGO I-IVA in Latin America.

  • There is a need to reconsider the role of the sarcomatous component to tailor treatment.

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Review articles
C-reactive protein in adult sepsis: systematic review and meta-analysis
Antonio Silvinato, Clara Lucato dos Santos, Eliane Amorim, Idevaldo Floriano, Luís Eduardo Miranda Paciência, Luca Schiliró Tristão, Wanderley Marques Bernardo
Clinics. 2026;81C:100848
Highlights

  • CRP shows high sensitivity but low specificity for adult sepsis diagnosis.

  • Diagnostic accuracy of CRP in sepsis is limited by high heterogeneity.

  • Prognostic value of CRP for mortality in sepsis remains uncertain.

  • False-positive rate of CRP in sepsis diagnosis reaches about 44 %.

  • Overall quality of evidence on CRP use in sepsis is low.

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