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Clinics Most cited
Journal Information

Most cited

Data available in articles published since the year 2017

20
Screening and diagnostic tools for autism spectrum disorder: Systematic review and meta-analysis
Clara Lucato dos Santos, Indyanara Inacio Barreto, Idevaldo Floriano, Luca Schiliró Tristão, Antonio Silvinato, Wanderley Marques Bernardo
Clinics. 2024;79C:100323
20
Highlights

  • Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder.

  • Autism spectrum disorder has a significant impact on the patient and their family.

  • To provide adequate advice is to carry out screening and diagnosis correctly and accurately.

  • Screening test must be applied, M-CHAT-R/F is recommended.

  • For diagnosis CARS and ADOS are the most recommended tools.

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16
Pharmacological treatment for obstructive sleep apnea: A systematic review and meta-analysis
Maria Luísa Nobre, Ayane Cristine Alves Sarmento, Priscila Farias de Oliveira, Felipe Ferreira Wanderley, José Diniz Júnior, Ana Katherine Gonçalves
Clinics. 2024;79C:100330
16
Highlights

  • Obstructive sleep apnea affects one billion people worldwide and is associated with cardiometabolic risk and cognitive impairment.

  • Drug therapy for the management of sleep apnea has been investigated, but no robust evidence that supports its benefits has been found to date.

  • The combination of noradrenergic and antimuscarinic drugs shows promising results.

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11
Firmicutes/Bacteroidetes and Firmicutes/Proteobacteria ratios are associated with worse prognosis in a cohort of Latin American patients with cirrhosis
Augusto Mantovani, Larisse Longo, Rutiane Ullmann Thoen, Pabulo Henrique Rampelotto, Raul Salinas, Gabriel Tayguara Silveira Guerreiro, Mário Reis Álvares-da-Silva
Clinics. 2024;79C:100471
11
Highlights

  • Gut Microbiota (GM) has an important role in liver diseases progression.

  • Notable differences in GM and diversity exist between healthy individuals and cirrhosis patients.

  • Changes in GM are associated with an increased risk of mortality within 90 days.

  • Firmicutes/Bacteroidetes and Firmicutes/Proteobacteria predict hepatic decompensation and mortality.

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10
Esketamine alleviates hypoxia/reoxygenation injury of cardiomyocytes by regulating TRPV1 expression and inhibiting intracellular Ca2+ concentration
Ying Zhang, QuanMei Lu, HanChun Hu, ChunChen Yang, QiHong Zhao
Clinics. 2024;79C:100363
10
Highlights

  • ESK treatment can increase H9c2 cell viability and reduce apoptosis and intracellular Ca2+ concentration.

  • CAP treatment decreases H9c2 cell viability and increases apoptosis and intracellular Ca2+ concentration.

  • TRPV1 upregulation decreases H9c2 cell viability and increases cell apoptosis and intracellular Ca2+ concentration.

  • After overexpressing TRPV1, the protective effect of ESK on H/R injury of H9c2 cells is weakened.

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9
Tanshinone IIA alleviates IL-1β-induced chondrocyte apoptosis and inflammation by regulating FBXO11 expression
Jin Xu, XiaoCheng Zhi, YunHui Zhang, Ren Ding
Clinics. 2024;79C:100365
9
Highlights

  • TAN IIA inhibits IL-1β from inducing apoptosis and inflammation in CHON-001 cells.

  • FBXO11 overexpression inhibits the protective effect of TAN IIA on apoptosis and inflammation of CHON-001 cells.

  • Suppressing PI3K/AKT and NF-κB pathways protects against apoptosis and inflammation of CHON-001 cells.

  • TAN IIA treatment improves apoptosis and inflammation of chondrocytes in OA rats.

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9
Targeted saliva metabolomics in Sjögren's syndrome
Giovanna Piacenza Florezi, Felippe Pereira Barone, Mario Augusto Izidoro, José Maria Soares-Jr, Claudia Malheiros Coutinho-Camillo, Silvia Vanessa Lourenço
Clinics. 2024;79C:100459
9
Highlights

  • The role of metabolism in Sjögren's Syndrome (SS) is still under discussion.

  • Saliva can reflect the metabolic state of the microenvironments of salivary glands affected by SS.

  • An increase in metabolites associated with oxidative stress can be observed.

  • An increase in metabolites involved in the growth and proliferation of T-cells was also observed.

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9
Serum procalcitonin as a marker of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD)
Tao Jiang, Wen-Xian Ouyang, Yan-Fang Tan, Ying Yu, Xiao-Mei Qin, Hai-Yan Luo, Lian Tang, Hui Zhang, Shuang-Jie Li
Clinics. 2024;79C:100383
9
Highlights

  • PCT was a highly sensitive marker to differentiate NICCD from cholestatic hepatitis patients.

  • PCT was reduced when NICCD was treated.

  • PCT is a much more effective marker to differentiate NICCD than the inflammatory markers.

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9
Reduced HDL-cholesterol in long COVID-19: A key metabolic risk factor tied to disease severity
Jamila Al-Zadjali, Amal Al-Lawati, Nafila Al Riyami, Koukab Al Farsi, Najwa Al Jarradi, Ammar Boudaka, Ali Al Barhoumi, Mohsen Al Lawati, ... Jumana Saleh
Clinics. 2024;79C:100344
9
Highlights

  • Low HDL-C and high ferritin are linked to increased Long-COVID-19 severity.

  • Changes in HDL-C levels, significantly impact Long-COVID-19 progression.

  • Ferritin may exacerbate disease progression by increasing oxidative stress.

  • HDL-C and ferritin levels may serve as markers and therapeutic targets for Long-COVID-19.

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8
Low-level red-light therapy for myopia control in children: A systematic review and meta-analysis
Dillan Cunha Amaral, Sávio Batista, Edson dos Santos-Neto, José Eduardo Ferreira Manso, Márcio Penha Morterá Rodrigues, Mário Luiz Ribeiro Monteiro, Milton Ruiz Alves, Ricardo Noguera Louzada
Clinics. 2024;79C:100375
8
Highlights

  • There is a global increase in childhood myopia and current treatments are limited.

  • LLRL non-invasive therapy shows promise in myopia control.

  • LLRL is promising and requires further studies for standardization and safety.

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8
The effects of art therapy interventions on anxiety in children and adolescents: A meta-analysis
Bo Zhang, Jiahua Wang, Azizah binti Abdullah
Clinics. 2024;79C:100404
8
Highlights

  • This meta-analysis aimed to evaluate the impact of art therapy on reducing anxiety symptoms among children and adolescents. A comprehensive search was conducted across several databases, including PubMed, Web of Science, Embase, PsychINFO, The Cochrane Library, CNKI, and Wan Fang Data, resulting in the inclusion of six studies with a total of 422 participants. The findings demonstrated a significant decrease in anxiety symptoms through art therapy interventions, with a Standardized Mean Difference (SMD) of -1.42, 95% Confidence Interval (-2.33, -0.51), p < 0.002. This indicates that art therapy is an effective method for treating anxiety in this demographic. Moreover, the analysis revealed that art therapy had a more pronounced effect on state anxiety than on trait anxiety, suggesting that art therapy may be particularly beneficial in helping children and adolescents manage anxiety in specific situations. These insights underscore the importance of integrating art therapy into mental health care, especially for managing anxiety among young individuals, and have significant implications for clinical practice and policy making.

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