Re–evaluation of the effects of high PEEP with recruitment manoeuvres versus low PEEP without recruitment manoeuvres during general anaesthesia for surgery – Protocol and statistical analysis plan for an individual patient data meta–analysis of PROVHILO, iPROVE and PROBESE

Campos, N.S.; Bluth, T.; Hemmes, S.N.T.; Librero, J.; Pozo, N.; Ferrando, C.; Ball, L.; Mazzinari, G.; Pelosi, P.; Gama de Abreu, M.; Schultz, M.J.; Serpa Neto, A.

doi:10.1016/j.redare.2019.08.003

ISSN: 2341-1929

Revista Española de Anestesiología y Reanimación (REDAR) -the Spanish Journal of Anesthesiology and Resuscitation- is the scientific body of the Spanish Society of Anesthesiology, Resuscitation and Pain Therapy. This is a monthly journal (10 issues) that publishes scientific articles of all areas within its specialty: clinical anesthesia, resuscitation-intensive medicine and critical care, diagnosis and treatment of acute and chronic pain, urgent care and emergencies and studies on basic science and related fields. The journal accepts work in both Spanish and English.

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Vol. 67. Issue 2.

Pages 76-89 (February 2020)

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Vol. 67. Issue 2.

Pages 76-89 (February 2020)

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DOI: 10.1016/j.redare.2019.08.003

Re–evaluation of the effects of high PEEP with recruitment manoeuvres versus low PEEP without recruitment manoeuvres during general anaesthesia for surgery – Protocol and statistical analysis plan for an individual patient data meta–analysis of PROVHILO, iPROVE and PROBESE

Reevaluación de los efectos de PEEP alta con maniobras de reclutamiento vs. PEEP baja sin maniobras de reclutamiento durante la anestesia general para cirugía: protocolo y plan de análisis estadístico para un metaanálisis de los datos de pacientes individuales de PROVHILO, iPROVE y PROBESE

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N.S. Camposa,b, T. Bluthc, S.N.T. Hemmesd,e, J. Librerof, N. Pozog, C. Ferrandog,h, L. Balli,j, G. Mazzinarik, P. Pelosii,j, M. Gama de Abreuc, M.J. Schultzd,l,m, A. Serpa Netoa,b,d,

Corresponding author

ary.neto2@einstein.br

Corresponding author.

, on behalf of PROVHILO iPROVE and PROBESE network researches 1

a Deptartment of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil

b Cardio-Pulmonary Department, Pulmonary Division, Instituto do Coração, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

c Pulmonary Engineering Group, Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

d Department of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

e Department of Anaesthesiology, Amsterdam UMC location ‘AMC’, University of Amsterdam, Amsterdam, The Netherlands

f Navarrabiomed-Fundación Miguel Servet, Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Pamplona, Navarra, Spain

g Department of Anesthesiology and Critical Care, Hospital Clinic de Barcelona, Barcelona, Spain

h CIBER of Respiratory Disease, Instituto de Salud Carlos III, Madrid, Spain

i IRCCS San Martino Policlinico Hospital, Genoa, Italy

j Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy

k Department of Anesthesiology and Pain Medicine, Hospital de Manises, Valencia, Spain

l Research Group in Perioperative Medicine, Instituto de Investigación Sanitaria La Fe, Valencia, Spain

m Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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Tables (3)

Table 1. Characteristics of the included trials.

Table 2. Dataset specification and harmonization.

Table 3. Definitions of the outcomes.

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