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2017 FI

1.644
© Thomson Reuters, Journal Citation Reports, 2017

Indexed in:

Index Medicus/Medline, Excerpta Medica/EMBASE, IBECS, IME Cancerlit, Bibliomed, CabHealth, Scisearch, HealthStar, Scopus, Prous, Science Intergews, Science Citation Index Expanded.

Metrics

  • Impact Factor: 1.644 (2017)
  • CiteScore 2017: 1.24
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  • SCImago Journal Rank (SJR):0,504
  • Source Normalized Impact per Paper (SNIP):0,791

© Clarivate Analytics, Journal Citation Reports 2017

Allergol Immunopathol (Madr) 2018;46:76-81 - DOI: 10.1016/j.aller.2017.03.004
Original Article
Helicobacter pylori seropositivity protects against childhood asthma and inversely correlates to its clinical and functional severity
E.M. Foudaa,, , T.B. Kamela, E.S. Nabihb, A.A. Abdelazema
a Department of Pediatrics, Ain Shams University, Egypt
b Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Egypt
Received 19 January 2017, Accepted 30 March 2017
Abstract
Background

In recent years, the prevalence of asthma has risen in developed countries, and its extent related to a change in our indigenous microbiota. Helicobacter pylori disappearance across the population represents a fundamental change in our human microbiota and has preceded the rise in asthma prevalence.

Objective

To assess the relationship between childhood asthma and Helicobacter pylori infection.

Methods

Quantitative determination of Helicobacter pylori IgG among 90 asthmatic children and 90 – age and gender – matched non-atopic, non-asthmatic healthy children was performed using ELISA in serum of all participants.

Results

Helicobacter pylori IgG seropositivity was found in 25.6% of asthmatics compared to 44.4% of controls. Asthmatics showed lower median Helicobacter pylori IgG titre compared to healthy controls. We also detected a significant inverse relationship between Helicobacter pylori IgG titre and asthma severity.

Conclusion

Helicobacter pylori seropositivity protects against childhood asthma and inversely correlates to its clinical and functional severity.

Keywords
Bronchial asthma, Helicobacter pylori, Childhood, Microbiota
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