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203
C-reactive protein in adult sepsis: systematic review and meta-analysis
Antonio Silvinato, Clara Lucato dos Santos, Eliane Amorim, Idevaldo Floriano, Luís Eduardo Miranda Paciência, Luca Schiliró Tristão, Wanderley Marques Bernardo
Clinics. 2026;81C:100848
203
Highlights

  • CRP shows high sensitivity but low specificity for adult sepsis diagnosis.

  • Diagnostic accuracy of CRP in sepsis is limited by high heterogeneity.

  • Prognostic value of CRP for mortality in sepsis remains uncertain.

  • False-positive rate of CRP in sepsis diagnosis reaches about 44 %.

  • Overall quality of evidence on CRP use in sepsis is low.

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98
The role of SIGLEC9 in immunosuppression and prognosis in cervical cancer
Bihui Wang, Yuejie Zhu, Zhenyu Ru, Yulian Zhang, Mingkai Yu, Pingfen Li, Manli Zhang, Jianbing Ding, Zhifang Chen
Clinics. 2026;81C:100849
98
Highlights

  • SIGLEC9 is highly expressed in cervical cancer and linked to poor prognosis.

  • Bioinformatics show SIGLEC9 correlates with macrophages and T-cells.

  • SIGLEC9+ TAMs and T-cells are highly enriched in the cervical cancer microenvironment.

  • High SIGLEC9+ TAM expression correlates with poor prognosis in cervical cancer.

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94
New population-specific cephalic index standards for Malaysian subadults: prevalence, growth patterns, and clinical implications from a CT imaging study
Sharifah Nabilah Syed Mohd Hamdan, Rabi’ah Al-Adawiyah Rahmat, Selva Malar Munusamy, Norliza Ibrahim
Clinics. 2026;81C:100855
94
Highlights

  • Establishes the first cephalic index standards for multi-ethnic Malaysian subadults.

  • Reports a negative correlation between age and CI, with a decline of 0.026 yearly.

  • Shows higher CI values in Malaysians than in Caucasians and other Asian groups.

  • Provides a validated tool (ICC > 0.93) to track cranial growth and deformity severity.

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85
Electrophysiological evaluation of the auditory pathway in newborns and infants with peri-intraventricular hemorrhage and/or periventricular leukomalacia
Rosanna Giaffredo Angrisani, Natalia Olival Balzarini, Carla Regina Tragante, Valdenise Martins Laurindo Tuma Calil, Werther Brunow de Carvalho, Carla Gentile Matas
Clinics. 2026;81C:100853
85
Highlights

  • Prematurity is a risk factor for lifelong hearing damage.

  • Hearing monitoring is necessary until around 3-years of age.

  • Hearing monitoring after peri-intraventricular hemorrhage is essential.

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71
Head and neck cancer patients present late cancer cachexia two years after curative chemoradiotherapy
Willian das Neves, Thomás Giollo Rivelli, Eduardo Furquim Simão, Marco Aurélio Vamondes Kulcsar, Gilberto de Castro Junior
Clinics. 2026;81C:100851
71
Highlights

  • Two diagnostic criteria diagnose cancer cachexia in HNSCC patients.

  • Disease-free HNSCC patients present cancer cachexia after long-term follow-up.

  • Cachexia is not associated with dysphagia.

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