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DOI: 10.1016/j.aller.2019.10.003
Available online 11 February 2020
Interleukin 10: the critical role of a pleiotropic cytokine in food allergy
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Natalia Nedelkopouloua,b,
, Anil Dhawanc, Ioannis Xiniasd, Dimos Gidarise, Evangelia Farmakia,**
a Pediatric Immunology and Rheumatology Referral Center, 1stDepartment of Paediatrics, Hippokration General Hospital, Aristotle University, Thessaloniki, Greece
b Sheffield Children’s Hospital NHS Foundation Trust, Sheffield, UK
c King’s College Hospital NHS Foundation Trust and MowatLabs, London, UK
d 3rd Department of Paediatrics, Hippokration General Hospital, Aristotle University, Thessaloniki, Greece
e University of Nicosia, Cyprus
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Table 1. Effects of IL-10 on the immune components involved in allergic diseases.
Table 2. Studies on IL-10 gene polymorphisms associated with food allergy in pediatric patients.
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Abstract

Despite advances in research, the pathophysiology of food allergy has not yet been fully elucidated. IL-10 has both a pro- and anti-inflammatory effect on the development of food allergy and in order to understand its different immune-modulatory effects the factors that influence the inflammatory microenvironment need to be taken into account. Specific single nucleotide polymorphisms of the IL-10 gene seem to confer an increased risk of developing food allergy, but to date there is a substantial lack of genome- wide association studies regarding the genetic and epigenetic underpinnings of the disease. Special interest has been drawn to the development of allergen-specific regulatory CD4+CD25+ T-cells secreting IL-10 in the immunotherapy of allergic diseases. In addition, a distinct population of human tolerogenic dendritic cells (DC), DC-10 seems to hold great potential and could potentially serve as a therapeutic tool to improve the management of food allergy.

Keywords:
Food allergy
IL-10
IL-10 gene polymorphisms
Tregs
Dedritic cells

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