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DOI: 10.1016/j.aller.2019.06.004
Available online 2 September 2019
Pro-inflammatory immunological effects of adipose tissue and risk of food allergy in obesity: Focus on immunological mechanisms
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X. Guoa,b, L. Chenga,b, S. Yanga,b, H. Chea,b,
Corresponding author
chehuilian@cau.edu.cn

Corresponding author.
a College of Food Science and Nutritional Engineering, China Agricultural University, China
b Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, China
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Abstract

Over the past three decades, the number of obese people has risen steadily. The chronic low-grade inflammatory state and the non-specific activation of the immune system have contributed greatly to the development of obesity-related immunology. Food allergy as a kind of inflammatory disease with abnormal immune response may be associated with obesity. This review begins with the pro-inflammatory immunological effects of adipose tissue in obesity, and explains the possible effects of obesity on food allergy. In short, obesity not only directly causes imbalance of allergic-related immune cells in adipose tissue, but also indirectly causes this consequence through affecting expression of adipocytokines and peroxisome proliferator-activated receptor gamma (PPARγ) in adipose tissue. As a result, circulating levels of pro-inflammatory factors which are partly derived from adipose tissue increase, which might cause intestinal barrier injury. Therefore, obesity may increase the risk of food allergy.

Keywords:
Obesity
Pro-inflammatory
Immunological effects
Adipose tissue
Food allergy
Abbreviations:
PPARγ
Treg cells
IgE
BMI
CD4+T cells/Th cells
CD8+T cells/Tc cells
Breg cells
iNKT cells
TNF-α
IL-6
NF-κB
Th1
Th2
PAR-2
ERK1/2
IL-12
MHC
IL-10
CLA
CLNA
STAT
JAK
iNOS

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