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Allergologia et Immunopathologia
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Inicio Allergologia et Immunopathologia Association between ADAM33 S2 and V4 polymorphisms and susceptibility to allergi...
Journal Information
Vol. 44. Num. 2.March - April 2016
Pages 97-188
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Vol. 44. Num. 2.March - April 2016
Pages 97-188
Original Article
DOI: 10.1016/j.aller.2015.05.013
Association between ADAM33 S2 and V4 polymorphisms and susceptibility to allergic rhinitis: A meta-analysis
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Zewen Lia,
Corresponding author
ent_lizewen@126.com

Corresponding author.
, Fubo Yana, Zhimin Yangb, Jie Zhoua, Yingchao Chena, Zhuhua Dingb
a Department of Otolaryngology, The Central Hospital of Xiaogan, Tongji Medical College, Huazhong University of Science Technology, Xiaogan, Hubei, China
b Department of Otolaryngology, The First People's Hospital of Xiaogan, Zhongnan Hospital of Wuhan University, Xiaogan, Hubei, China
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Table 1. Characteristics of studies included in the meta-analysis.
Table 2. Analysis of the association between the ADAM33 S2 and V4 polymorphisms and AR.
Table 3. Analysis of the association between the ADAM33 T+1, T1 and T2 polymorphisms and AR.
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Abstract
Background

It has been reported that ADAM33 (a disintegrin and metalloproteinase domain 33) polymorphisms might be associated with susceptibility to allergic rhinitis (AR).

Objective

Owing to mixed and inconclusive results, we conducted a meta-analysis to systematically summarise and clarify the association between ADAM33 S2, V4, T1, T2 and T+1 polymorphisms and AR risk.

Methods/results

A systematic search of studies on the association of ADAM33 polymorphisms with susceptibility to AR was conducted in Pubmed and Embase. A total of five case–control studies with 1251 patients and 1634 controls were included. Meta-analysis indicated an association between the ADAM33 S2 and AR in allele comparison (G/C:OR=1.40, 95% CI 1.08–1.82, P=0.012), heterozygote comparison (CG/CC:OR=1.24, 95% CI 1.04–1.48, P=0.015), and dominant comparison (CG+GG/CC:OR=1.39, 95% CI 1.05–1.85, P=0.023). The meta-analysis also revealed an association between the ADAM33 V4 and AR in allele comparison (G/C:OR=1.67, 95% CI 1.01–2.75, P=0.044). However, no association was found between AR and the ADAM33 T1, T2 and T+1 polymorphisms in any gene model comparison.

Conclusions

This meta-analysis demonstrates that the ADAM33 S2 and V4 polymorphisms confer susceptibility to AR. However, these results should be interpreted with caution due to limited sample and heterogeneity. Large-scale and well-designed studies are needed to validate our findings.

Keywords:
ADAM33
Allergic rhinitis
Meta-analysis
Polymorphisms
Susceptibility

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