metricas

Revista Española de Patología

Sugerencias
Revista Española de Patología Liposarcomas. Aspectos clínico-patológicos y moleculares
Información de la revista
Vol. 39. Núm. 3.
Páginas 133-198 (Julio - Septiembre 2006)
Cita
Cita
Compartir
Descargar PDF
Más opciones de artículo
Vol. 39. Núm. 3.
Páginas 133-198 (Julio - Septiembre 2006)
Revisiones

Liposarcomas. Aspectos clínico-patológicos y moleculares

Liposarcomas. Clinicopathological and molecular aspects
Visitas
5251
Juan Segura Sánchez1, María Jesús Pareja Megía2, Antonio García Escudero2, María Teresa Vargas De Los Monteros2, Ricardo González-Cámpora2
Este artículo ha recibido
Información del artículo
Resumen
Bibliografía
Descargar PDF
Estadísticas
Resumen

Los liposarcomas constituyen el grupo más numeroso de sarcomas del adulto. Su interés actual radica fundamentalmente en los cambios conceptuales y clasificatorios que han acontecido en los últimos años merced a la aplicación de las técnicas de citogenética y de biología molecular. En la presente revisión se lleva a cabo una correlación clínico patológica de los cinco tipos básicos de liposarcomas y se comentan los aspectos citogenéticos y de biología molecular que han permitido la elaboración de la nueva clasificación de la OMS.

Palabras clave:
Liposarcomas
citogenética
biología molecular
Summary

Liposarcomas are the most common sarcoma of the adult life. Their current interest is based on the recent molecular and cytogenetic changes that have allowed the new WHO classification. In the present report we carried out a clinicopathological correlation in the five distinctive groups of the current classification and described the most relevant cytogenetics and molecular findings in each group.

Key words:
Liposarcoma
cytogenetics
molecular biology
PDF

Artículo

Opciones para acceder a los textos completos de la publicación Revista Española de Patología
Suscriptor
Suscriptor de la revista

Si ya tiene sus datos de acceso, clique aquí.

Si olvidó su clave de acceso puede recuperarla clicando aquí y seleccionando la opción "He olvidado mi contraseña".
Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Comprar ahora
Contactar
Teléfono para suscripciones e incidencias
De lunes a viernes de 9h a 18h (GMT+1) excepto los meses de julio y agosto que será de 9 a 15h
Llamadas desde España
932 415 960
Llamadas desde fuera de España
+34 932 415 960
E-mail
Bibliografía
[1.]
S.W. Weiss, J.R. Goldblum.
Enzinger and Weiss's Soft Tissue Tumours.
4th ed., Mosby, (2001),
[2.]
A.P. Dei Tos.
Liposarcoma new entities and evolving concepts.
Ann Diagn Pathol, 4 (2000), pp. 252-266
[3.]
Adipocytic tumors. World Health Organization Classification of tumors. Pathology and genetics of tumors of soft tissue and bone, pp. 19-46
[4.]
S.W. Weiss.
Histological Typing of soft tissue tumours.
World Health Organization Histological Classification of Tumours,
[5.]
C.D.M. Fletcher.
Soft tissue tumours.
Diagnostic histopathology of tumours, pp. 1474-1485
[6.]
T. Mentzel.
Biological continuum of benign, atypical, and malignant mesenchymal neoplasms -does it exist?.
[7.]
B.M. Shmookler, F.M. Enzinger.
Liposarcoma occurring in children. An analysis of 17 cases and review of the literature.
Cancer, 52 (1983), pp. 567-574
[8.]
Kempson R, Fletcher CDM, Evans H, Henrickson MR, Sibley RK. Lipomatous Tumors. In Tumors of the Soft Tissues. Atlas of Tumor Pathology. Third edition; n.° 30. Washington DC: AFIP; 2001. p. 187-237.
[9.]
S.W. Weiss, V.K. Rao.
Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellaneous sites. A follow-up study of 92 cases with analysis of the incidence of «dedifferentiation».
Am J Surg Pathol, 16 (1992), pp. 1051-1058
[10.]
H.L. Evans, E.H. Soule, R.K. Winkelman.
Atypical lipoma, atypical intramuscular lipoma, and well differentiated retroperitoneal liposarcoma: a reappraisal of 30 cases formely classified as well differentiated liposarcoma.
Cancer, 43 (1979), pp. 1150
[11.]
B.M. Wenig, D.K. Heffner.
Liposarcomas of the larynx and hypopharynx: a clinicopathologic study of eight new cases and a review of the literature.
Laryngoscope, 105 (1995), pp. 747-756
[12.]
R.M. Austin, W.B. Dupree.
Liposarcoma of the breast: a clinicopathologic study of 20 cases.
Hum Pathol, 17 (1986), pp. 906-913
[13.]
G. Tallini, R.A. Erlandson, M.F. Brennan, J.M. Woodruff.
Divergent myosarcomatous differentiation in retroperitoneal liposarcoma.
Am J Surg Pathol, 17 (1993), pp. 546-556
[14.]
M.D. Kraus, L. Guillou, C.D. Fletcher.
Well-differentiated inflammatory liposarcoma: an uncommon and easily overlooked variant of a common sarcoma.
Am J Surg Pathol, 21 (1997), pp. 518-527
[15.]
A.F. Nascimento, C.D.M. Fletcher.
Spindle cell liposarcoma/Atypical lipomatous tumor. A clinicopathologic study of 120 cases. 94th Annual meeting. United States and Canadian Academy of Pathology.
Modern Pathol, 18 (2005), pp. 19A
[16.]
F. Pedeutour, R.F. SuijkeRBuijk, A. Forus, J. Van Gaal, W. Van de Klundert, J.M. Coindre, G. Nicolo, F. Collin, U. Van Haelst, K. Huffermann, et al.
Complex composition and coamplification of SAS and MDM2 in ring and giant rod marker chromosomes in well-differentiated liposarcoma.
Genes Chromosomes Cancer, 10 (1994), pp. 85-94
[17.]
A.A. Sandberg.
Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: liposarcoma.
Cancer Genet Cytogenet, 155 (2004), pp. 1-24
[18.]
S. Pilotti, G. Della Torre, C. Lavarino, G. Sozzi, F. Minoletti, B. Vergani, A. Azzarelli, F. Rilke, M.A. Pierotti.
Molecular abnormalities in liposarcoma: role of MDM2 and CDK4-containing amplicons at 12q13-22.
[19.]
A.P. Dei Tos, C. Doglioni, S. Piccinin, R. Sciot, A. Furlanetto, M. Boiocchi, P. Dal Cin, R. Maestro, C.D. Fletcher, G. Tallini.
Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours.
[20.]
S. Pilotti, G. Della Torre, A. Mezzelani, E. Tamborini, A. Azzarelli, G. Sozzi, M.A. Pierotti.
The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma.
Br J Cancer, 82 (2000), pp. 1271-1275
[21.]
Segura-Sánchez J, González-Cámpora R, Pareja-Megía MJ, García-Escudero A, Galera-Ruiz R, López-Beltrán A. Chromosome 12 copy number alterations and MDM2, CDK4 and TP53 expression in soft tissue liposarcoma. Anticancer Res. (aceptado).
[22.]
H.L. Evans.
Liposarcoma: a study of 55 cases with a reassessment of its classification.
Am J Surg Pathol, 3 (1979), pp. 507-523
[23.]
W.H. Henricks, Y.C. Chu, J.R. Goldblum, S.W. Weiss.
Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation.
Am J Surg Pathol, 21 (1997), pp. 271-281
[24.]
D. McCormick, T. Mentzel, A. Beham, C.D. Fletcher, et al.
Dedifferentiated liposarcoma. Clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas.
Am J Surg Pathol, 18 (1994), pp. 1213-1223
[25.]
J.M. Meiss-Kindblom, H. Sjögren, L.G. Kindblom, A. Peydro-Mellquist, E. Roijer, P. Aman, G. Stenman.
Cytogenetic and molecular genetic analysis of liposarcomas and its soft tissue simulators: recognition of a new variants and differential diagnosis.
Virchows Archiv, 439 (2001), pp. 141-151
[26.]
F. Mertens, C.D. Fletcher, P. Dal Cin, I. de Wever, N. Mandahl, F. Mitelman, J. Rosai, A. Rydholm, R. Sciot, G. Talini, H. vam den Berghe, R. Van, H. Willén.
Cytogenetics análisis of 46 pleomorphic soff tissue sarcomas and correlation with morphologic and clinical features: a report of the CHAMP study group.
Genes Chromosomes and Cancer, 22 (1998), pp. 16-25
[27.]
D.C. Dahlin, J.W. Beaubout.
Deddiferentiation of low-grade chondrosarcoma.
Cancer, 28 (1971), pp. 461-466
[28.]
M.B. Binh, X. Sastre-Garau, L. Guillou, G. de Pinieux, P. Terrier, R. Lagace, A. Aurias, I. Hostein, J.M. Coindre.
MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data.
Am J Surg Pathol, 29 (2005), pp. 1340-1347
[29.]
A.P. Dei Tos, C. Doglioni, S. Piccinin, R. Maestro, T. Mentzel, M. BaRBareschi, M. Boiocchi, C.D. Fletcher.
Molecular abnormalities of the TP53 pathway in dedifferentiated liposarcoma.
[30.]
C.R. Antonescu, A. Elahi, J.H. Healey, M.F. Brennan, M.Y. Lui, J. Lewis, S.C. Jhanwar, J.M. Woodruff, M. Ladanyi.
Monoclonality of multifocal myxoid liposarcoma: confirmation by analysis of TLS-CHOP or EWS-CHOP rearrangements.
Clin Cancer Res, 6 (2000), pp. 2788-2793
[31.]
S.E. Kilpatrick, J. Doyon, P.F. Choong, F.H. Sim, A.G. Nascimento.
The clinicopathologic spectrum of myxoid and round cell liposarcoma. A study of 95 cases.
[32.]
J.D. Siebert, R.P. Williams, D.R. Pulitzer.
Myxoid liposarcoma with cartilaginous differentiation.
Mod Pathol, 9 (1996), pp. 249-252
[33.]
J.H. Shanks, S.S. Banerjee, B.P. Eyden.
Focal rhabdomyosarcomatous differentiation in primary liposarcoma.
J Clin Pathol, 49 (1996), pp. 770-772
[34.]
H.L. Evans.
Liposarcomas. A study of 55 cases with reassessment of its classification.
Am J Surg Pathol, 3 (1979), pp. 507-523
[35.]
C.D.M. Fletcher.
Will we ever reliably predict prognosis in a patient with myxoid and round cell liposarcoma.
Adv Anat Pathol, 4 (1997), pp. 108-113
[36.]
R. Schneider-Stock, A. Ziegeler, C. Haeckel, D.S. Franke, J. Rys, A. Roessner.
Prognostic relevance of TP53 alterations and Mib-1 proliferation index in subgroups of primary liposarcomas.
Clin Cancer Res, 5 (1999), pp. 2830-2835
[37.]
A.J. Spillane, C. Fisher, J.M. Thomas.
Myxoid liposarcomathe frequency and the natural history of nonpulmonary soft tissue metastases.
Ann Surg Oncol, 6 (1999), pp. 389-394
[38.]
M. Miettinen, F.M. Enzinger.
Epithelioid variant of pleomorphic liposarcoma: a study of 12 cases of a distinctive variant of high-grade liposarcoma.
Mod Pathol, 12 (1999), pp. 722-728
[39.]
B.P. Rubin, C.D. Fletcher.
The cytogenetics of lipomatous tumours.
Histopathology, 30 (1997), pp. 507-511
[40.]
J.L. Hornick, M.W. Bosenberg, T. Mentzel, M.E. McMenamin, A.M. Oliveira, C.D. Fletcher.
Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases.
Am J Surg Pathol, 28 (2004), pp. 1257-1267
[41.]
T. Mentzel, C.D. Fletcher.
Dedifferentiated myxoid liposarcoma: a clinicopathological study suggesting a closer relationship between myxoid and well-differentiated liposarcoma.
Histopathology, 30 (1997), pp. 457-463
asdasdasd
Opciones de artículo
Herramientas