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Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) FDG-PET/CT and new radiopharmaceuticals in patients with multiple myeloma
Journal Information
Vol. 42. Issue 2.
Pages 129-135 (March - April 2023)
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61
Vol. 42. Issue 2.
Pages 129-135 (March - April 2023)
Continuing Education
FDG-PET/CT and new radiopharmaceuticals in patients with multiple myeloma
PET/CT con FDG y nuevos radiofármacos en pacientes con mieloma múltiple
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61
María Isabel Morales Lozano, María José García-Velloso
Corresponding author
mjgarciave@unav.es

Corresponding author.
Universidad Clínica de Navarra, Pamplona, Spain
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Tables (3)
Table 1. Diagnostic criteria of MGUS, QMM and MM.
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Table 2. IMPETUS criteria adapted by Nanni and cols. 27.
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Table 3. Deauville scale28.
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Abstract

Multiple myeloma is a monoclonal gammopathy, a clonal proliferative disorder of plasma cells that produces a protein called M or myeloma protein in the bone marrow, usually IgG or IgA. It accounts for 1% in the general cancer statistics and represents 10% of all hematologic tumours, with a cumulative incidence in Spain of about 5/100,000/year. The incidence increases with age, so that 50% of cases are diagnosed in patients over 75 years of age, being infrequent in the population under 40 years of age. This publication details the indications of FDG PET/CT for the staging and response assessment in patients with MM, accepted by the international working group on myeloma, as well as new molecular imaging radiopharmaceuticals with potential value for personalised medicine.

Keywords:
PET/CT
FDG
Mieloma múltiple
Criterios de interpretación
Radiofármacos
Resumen

El mieloma múltiple es un desorden proliferativo clonal de células plasmáticas, dentro del grupo de las gammapatías monoclonales, que producen una proteína llamada M o proteína de mieloma, generalmente IgG o IgA, en la médula ósea. Supone un 1% en las estadísticas generales del cáncer y un 13% en las series de neoplasias hematológicas, con una incidencia acumulada en España de aproximadamente 5 personas por 100,000 personas-año. Dicha incidencia aumenta con la edad, de forma que un 50% de los casos se diagnostican en pacientes de edades superiores a 75 años, siendo infrecuente en la población menor de 40 años. En esta publicación se detallan las indicaciones de la PET/CT con FDG, para el diagnóstico de extensión y la valoración de respuesta en pacientes con MM, aceptadas por el grupo internacional de trabajo en mieloma, así como nuevos radiofármacos de imagen molecular con valor potencial para una medicina personalizada.

Palabras clave:
PET/CT
Multiple myeloma
Interpretation criteria
Radiopharmaceuticals

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