metricas

Radiología

Sugerencias
Radiología Miocarditis: diagnóstico y seguimiento con resonancia magnética
Información de la revista
Vol. 55. Núm. 4.
Páginas 279-370 (Julio - Agosto 2013)
Cita
Cita
Compartir
Descargar PDF
Más opciones de artículo
Visitas
19214
Vol. 55. Núm. 4.
Páginas 279-370 (Julio - Agosto 2013)
Actualización

Miocarditis: diagnóstico y seguimiento con resonancia magnética

Myocarditis: magnetic resonance imaging diagnosis and follow-up
Visitas
19214
A. Bustos García de Castroa,
Autor para correspondencia
abustos.hcsc@salud.madrid.org

Autor para correspondencia.
, B. Cabeza Martíneza, J. Ferreirós Domíngueza, C. García Villafañea, C. Fernández-Golfínb
a Servicio de Radiodiagnóstico, Hospital Clínico San Carlos, Madrid, España
b Instituto Cardiovascular, Hospital Clínico San Carlos, Madrid, España
Este artículo ha recibido
Información del artículo
Resumen
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Resumen

La miocarditis consiste en la inflamación del miocardio, producida la mayoría de las veces por una infección viral. La confirmación diagnóstica en la práctica clínica habitual es difícil porque la historia clínica y la exploración física, las alteraciones en el electrocardiograma, la determinación de las enzimas cardiacas y el ecocardiograma ofrecen escasa precisión diagnóstica, y no es infrecuente que se plantee el diagnóstico diferencial con el infarto agudo de miocardio. La resonancia magnética (RM) cardiaca se ha convertido en el método de imagen de elección para el diagnóstico de la miocarditis. En este trabajo se describen los hallazgos de imagen en la RM en el momento del diagnóstico y en el seguimiento de los pacientes con miocarditis, el diagnóstico diferencial con otros procesos agudos como el infarto de miocardio, y los factores pronósticos estudiados mediante RM.

Palabras clave:
Miocarditis
Resonancia magnética
Imagen cardiaca
Abstract

Myocarditis, inflammation of the myocardium, is usually due to viral infection. Diagnostic confirmation in ordinary clinical practice is difficult because the findings on the clinical history, physical examination, electrocardiogram, and laboratory tests offer scant diagnostic accuracy, and the differential diagnosis is often done with acute myocardial infarction. Cardiac magnetic resonance imaging (CMR) has become the method of choice for the diagnosis of myocarditis. In this article, we describe the CMR findings at diagnosis and during the follow-up of patients with myocarditis, the differential diagnosis with other acute processes like myocardial infarction, and the prognostic factors studied with CMR.

Keywords:
Myocarditis
Magnetic resonance imaging
Cardiac imaging

Artículo

Opciones para acceder a los textos completos de la publicación Radiología
Suscriptor
Suscriptor de la revista

Si ya tiene sus datos de acceso, clique aquí.

Si olvidó su clave de acceso puede recuperarla clicando aquí y seleccionando la opción "He olvidado mi contraseña".
Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Comprar ahora
Contactar
Teléfono para suscripciones e incidencias
De lunes a viernes de 9h a 18h (GMT+1) excepto los meses de julio y agosto que será de 9 a 15h
Llamadas desde España
932 415 960
Llamadas desde fuera de España
+34 932 415 960
E-mail
Bibliografía
[1]
B.J. Maron, J.A. Towbin, G. Thiene, C. Antzelevitch, D. Corrado, D. Arnett, American Heart Association; Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; Council on Epidemiology and Prevention, et al.
Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology. Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention.
Circulation, 113 (2006), pp. 1807-1816
[2]
P. Elliott, B. Andersson, E. Arbustini, Z. Bilinska, F. Cecchi, P. Charron, et al.
Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases.
Eur Heart J, 29 (2008), pp. 270-276
[3]
S. Machado, F. Roubille, G. Gahide, H. Vernhet-Kovacsik, L. Cornillet, T.T. Cung, et al.
Can troponin elevation predict worse prognosis in patients with acute pericarditis?.
Ann Cardiol Angeiol (Paris), 59 (2010), pp. 1-7
[4]
A. Doolan, N. Langlois, C. Semsarian.
Causes of sudden cardiac death in young Australians.
Med J Aust, 180 (2004), pp. 110-112
[5]
Y. Drory, Y. Turetz, Y. Hiss, B. Lev, E.Z. Fisman, A. Pines, et al.
Sudden unexpected death in persons less than 40 years of age.
Am J Cardiol, 68 (1991), pp. 388-392
[6]
H. Mahrholdt, A. Wagner, C.C. Deluigi, E. Kispert, S. Hager, G. Meinhardt, et al.
Presentation, patterns of myocardial damage, and clinical course of viral myocarditis.
Circulation, 114 (2006), pp. 1581-1590
[7]
M.T. Arrigan, R.P. Killeen, J.D. Dodd, W.C. Torreggiani.
Imaging spectrum of sudden athlete cardiac death.
Clin Radiol, 66 (2011), pp. 203-223
[8]
P.J. Sparrow, N. Merchant, Y.L. Provost, D.J. Doyle, E.T. Nguyen, N.S. Paul.
CT and MR imaging findings in patients with acquired heart disease at risk for sudden cardiac death.
Radiographics, 29 (2009), pp. 805-823
[9]
C. Roubille, A.S. Brunel, G. Gahide, K.H. Vernhet, A. Le Quellec.
Cytomegalovirus (CMV) and acute myocarditis in an immunocompetent patient.
Intern Med, 49 (2010), pp. 131-133
[10]
V. Raj, S. Joshi, D.J. Pennell.
Images in Cardiovascular Medicine. Cardiac magnetic resonance of acute myocarditis in an human immunodeficiency virus patient presenting with acute chest pain syndrome.
Circulation, 121 (2010), pp. 2777-2779
[11]
E.T. Hoey, G.S. Gulati, A. Ganeshan, R.W. Watkin, H. Simpson, S. Sharma.
Cardiovascular MRI for assessment of infectious and inflammatory conditions of the heart.
AJR Am J Roentgenol, 197 (2011), pp. 103-112
[12]
C.E. Rochitte, P.F. Oliveira, J.M. Andrade, B.M. Ianni, J.R. Parga, L.F. Avila, et al.
Myocardial delayed enhancement by magnetic resonance imaging in patients with Chagas’ disease: a marker of disease severity.
J Am Coll Cardiol, 46 (2005), pp. 1553-1558
[13]
S. Sagar, P.P. Liu, L.T. Cooper Jr..
Myocarditis.
[14]
H. Mahrholdt, C. Goedecke, A. Wagner, G. Meinhardt, A. Athanasiadis, H. Vogelsberg, et al.
Cardiovascular magnetic resonance assessment of human myocarditis: a comparison to histology and molecular pathology.
Circulation, 109 (2004), pp. 1250-1258
[15]
H.T. Aretz, M.E. Billingham, W.D. Edwards, S.M. Factor, J.T. Fallon, J.J. Fenoglio Jr., et al.
Myocarditis. A histopathologic definition and classification.
Am J Cardiovasc Pathol, 1 (1987), pp. 3-14
[16]
L. Sarda, P. Colin, F. Boccara, D. Daou, R. Lebtahi, M. Faraggi, et al.
Myocarditis in patients with clinical presentation of myocardial infarction and normal coronary angiograms.
J Am Coll Cardiol, 37 (2001), pp. 786-792
[17]
G.M. Felker, R.E. Thompson, J.M. Hare, R.H. Hruban, D.E. Clemetson, D.L. Howard, et al.
Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy.
N Engl J Med, 342 (2000), pp. 1077-1084
[18]
R.J. Kim, A. Farzaneh-Far.
The diagnostic utility of cardiovascular magnetic resonance in patients with chest pain, elevated cardiac enzymes and non-obstructed coronary arteries.
Rev Esp Cardiol, 62 (2009), pp. 966-971
[19]
H. Steen, M. Madadi-Schroeder, S. Lehrke, D. Lossnitzer, E. Giannitsis, H.A. Katus.
Staged cardiovascular magnetic resonance for differential diagnosis of troponin T positive patients with low likelihood for acute coronary syndrome.
J Cardiovasc Magn Reson, 12 (2010), pp. 51
[20]
L.T. Cooper, K.L. Baughman, A.M. Feldman, A. Frustaci, M. Jessup, U. Kuhl, et al.
The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology.
Circulation, 116 (2007), pp. 2216-2233
[21]
A.J. Hauck, D.L. Kearney, W.D. Edwards.
Evaluation of postmortem endomyocardial biopsy specimens from 38 patients with lymphocytic myocarditis: implications for role of sampling error.
Mayo Clin Proc, 64 (1989), pp. 1235-1245
[22]
A. Yilmaz, I. Kindermann, M. Kindermann, F. Mahfoud, C. Ukena, A. Athanasiadis, et al.
Comparative evaluation of left and right ventricular endomyocardial biopsy: differences in complication rate and diagnostic performance.
Circulation, 122 (2010), pp. 900-909
[23]
I. Kindermann, M. Kindermann, R. Kandolf, K. Klingel, B. Bultmann, T. Muller, et al.
Predictors of outcome in patients with suspected myocarditis.
Circulation, 118 (2008), pp. 639-648
[24]
O. Goitein, S. Matetzky, R. Beinart, E. Di Segni, H. Hod, A. Bentancur, et al.
Acute myocarditis: noninvasive evaluation with cardiac MRI and transthoracic echocardiography.
AJR Am J Roentgenol, 192 (2009), pp. 254-258
[25]
H.N. Skouri, G.W. Dec, M.G. Friedrich, L.T. Cooper.
Noninvasive imaging in myocarditis.
J Am Coll Cardiol, 48 (2006), pp. 2085-2093
[26]
M.G. Gagliardi, M. Bevilacqua, P. Di Renzi, S. Picardo, R. Passariello, C. Marcelletti.
Usefulness of magnetic resonance imaging for diagnosis of acute myocarditis in infants and children, and comparison with endomyocardial biopsy.
Am J Cardiol, 68 (1991), pp. 1089-1091
[27]
M.G. Friedrich, O. Strohm, J. Schulz-Menger, H. Marciniak, F.C. Luft, R. Dietz.
Contrast media-enhanced magnetic resonance imaging visualizes myocardial changes in the course of viral myocarditis.
Circulation, 97 (1998), pp. 1802-1809
[28]
A. Zagrosek, R. Wassmuth, H. Abdel-Aty, A. Rudolph, R. Dietz, J. Schulz-Menger.
Relation between myocardial edema and myocardial mass during the acute and convalescent phase of myocarditis--a CMR study.
J Cardiovasc Magn Reson, 10 (2008), pp. 19
[29]
K.G. Ordovas, G.P. Reddy, C.B. Higgins.
MRI in nonischemic acquired heart disease.
J Magn Reson Imaging, 27 (2008), pp. 1195-1213
[30]
H. Abdel-Aty, P. Boye, A. Zagrosek, R. Wassmuth, A. Kumar, D. Messroghli, et al.
Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches.
J Am Coll Cardiol, 45 (2005), pp. 1815-1822
[31]
H. Abdel-Aty, M. Cocker, C. Meek, J.V. Tyberg, M.G. Friedrich.
Edema as a very early marker for acute myocardial ischemia: a cardiovascular magnetic resonance study.
J Am Coll Cardiol, 53 (2009), pp. 1194-1201
[32]
K.H. Stensaeth, P. Hoffmann, E. Fossum, A. Mangschau, L. Sandvik, N.E. Klow.
Cardiac magnetic resonance visualizes acute and chronic myocardial injuries in myocarditis.
Int J Cardiovasc Imaging, 28 (2012), pp. 327-335
[33]
M. Jeserich, M. Olschewski, T. Bley, N. Merkle, J. Kirchberger, G. Pavlik, et al.
Cardiac involvement after respiratory tract viral infection--detection by cardiac magnetic resonance.
J Comput Assist Tomogr, 33 (2009), pp. 15-19
[34]
A. Stork, K. Muellerleile, P.M. Bansmann, J. Graessner, M. Kaul, J. Kemper, et al.
Value of T2-weighted, first-pass and delayed enhancement, and cine CMR to differentiate between acute and chronic myocardial infarction.
Eur Radiol, 17 (2007), pp. 610-617
[35]
A. Wagner, J. Schulz-Menger, R. Dietz, M.G. Friedrich.
Long-term follow-up of patients paragraph sign with acute myocarditis by magnetic paragraph sign resonance imaging.
[36]
N.S. Yelgec, S. Dymarkowski, J. Ganame, J. Bogaert.
Value of MRI in patients with a clinical suspicion of acute myocarditis.
Eur Radiol, 17 (2007), pp. 2211-2217
[37]
G. Gahide, D. Bertrand, F. Roubille, C. Tron, S. Skaik, C. Piot, et al.
MR delayed enhancement imaging findings in suspected acute myocarditis.
Eur Radiol, 20 (2010), pp. 65-72
[38]
M.L. Shehata, E.B. Turkbey, J. Vogel-Claussen, D.A. Bluemke.
Role of cardiac magnetic resonance imaging in assessment of nonischemic cardiomyopathies.
Top Magn Reson Imaging, 19 (2008), pp. 43-57
[39]
V. Hombach, N. Merkle, H.A. Kestler, J. Torzewski, M. Kochs, N. Marx, et al.
Characterization of patients with acute chest pain using cardiac magnetic resonance imaging.
Clin Res Cardiol, 97 (2008), pp. 760-767
[40]
H. Mahrholdt, A. Wagner, R.M. Judd, U. Sechtem, R.J. Kim.
Delayed enhancement cardiovascular magnetic resonance assessment of non ischaemic cardiomyopathies.
Eur Heart J, 26 (2005), pp. 1461-1474
[41]
J.P. Laissy, F. Hyafil, L.J. Feldman, J.M. Juliard, E. Schouman-Claeys, P.G. Steg, et al.
Differentiating acute myocardial infarction from myocarditis: diagnostic value of early- and delayed-perfusion cardiac MR imaging.
Radiology, 237 (2005), pp. 75-82
[42]
L. Boussel, D. Gamondes, P. Staat, B.M. Elicker, D. Revel, P. Douek.
Acute chest pain with normal coronary angiogram: role of contrast-enhanced multidetector computed tomography in the differential diagnosis between myocarditis and myocardial infarction.
J Comput Assist Tomogr, 32 (2008), pp. 228-232
[43]
H. Baccouche, H. Mahrholdt, G. Meinhardt, R. Merher, M. Voehringer, S. Hill, et al.
Diagnostic synergy of non-invasive cardiovascular magnetic resonance and invasive endomyocardial biopsy in troponin-positive patients without coronary artery disease.
Eur Heart J, 30 (2009), pp. 2869-2879
[44]
G.S. Camastra, L. Cacciotti, F. Marconi, S. Sbarbati, B. Pironi, G. Ansalone.
Late enhancement detected by cardiac magnetic resonance imaging in acute myocarditis mimicking acute myocardial infarction: location patterns and lack of correlation with systolic function.
J Cardiovasc Med (Hagerstown), 8 (2007), pp. 1029-1033
[45]
M.G. Friedrich, U. Sechtem, J. Schulz-Menger, G. Holmvang, P. Alakija, L.T. Cooper, et al.
Cardiovascular magnetic resonance in myocarditis: A JACC White Paper.
J Am Coll Cardiol, 53 (2009), pp. 1475-1487
[46]
M. Gutberlet, B. Spors, T. Thoma, H. Bertram, T. Denecke, R. Felix, et al.
Suspected chronic myocarditis at cardiac MR: diagnostic accuracy and association with immunohistologically detected inflammation and viral persistence.
Radiology, 246 (2008), pp. 401-409
[47]
F. De Cobelli, M. Pieroni, A. Esposito, C. Chimenti, E. Belloni, R. Mellone, et al.
Delayed gadolinium-enhanced cardiac magnetic resonance in patients with chronic myocarditis presenting with heart failure or recurrent arrhythmias.
J Am Coll Cardiol, 47 (2006), pp. 1649-1654
[48]
A. Zagrosek, H. Abdel-Aty, P. Boye, R. Wassmuth, D. Messroghli, W. Utz, et al.
Cardiac magnetic resonance monitors reversible and irreversible myocardial injury in myocarditis.
JACC Cardiovasc Imaging, 2 (2009), pp. 131-138
[49]
M. Danti, S. Sbarbati, N. Alsadi, A. Di Filippo, G. Gangitano, L. Giglio, et al.
Cardiac magnetic resonance imaging: diagnostic value and utility in the follow-up of patients with acute myocarditis mimicking myocardial infarction.
Radiol Med, 114 (2009), pp. 229-238
[50]
D.A. Bluemke.
MRI of nonischemic cardiomyopathy.
AJR Am J Roentgenol, 195 (2010), pp. 935-940
[51]
F. Escher, D. Westermann, R. Gaub, J. Pronk, T. Bock, N. Al-Saadi, et al.
Development of diastolic heart failure in a 6-year follow-up study in patients after acute myocarditis.
Heart, 97 (2011), pp. 709-714
[52]
L.A. Mendes, G.W. Dec, M.H. Picard, I.F. Palacios, J. Newell, R. Davidoff.
Right ventricular dysfunction: an independent predictor of adverse outcome in patients with myocarditis.
Am Heart J, 128 (1994), pp. 301-307
asdasdasd
Opciones de artículo
Herramientas