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Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Role of FDG PET/CT in investigating the mechanisms underlying atherosclerotic pl...
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Vol. 32. Issue 4.
Pages 246-252 (July - August 2013)
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Vol. 32. Issue 4.
Pages 246-252 (July - August 2013)
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Role of FDG PET/CT in investigating the mechanisms underlying atherosclerotic plaque formation and evolution
Papel del FDG PET/CT en la investigación de los mecanismos subyacentes a la formación y evolución de la placa aterosclerótica
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M.C. Marzolaa, B. Sabouryb, S. Chondrogiannisa, L. Rampina, G. Grassettoa, A. Ferrettia,c, A. Alavib, D. Rubelloa,
Corresponding author
domenico.rubello@libero.it

Corresponding author.
a Department of Nuclear Medicine & PET/CT Centre, Santa Maria della Misericordia Hospital, Rovigo, Italy
b Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
c Medical Physics Unit, Santa Maria della Misericordia Hospital, Rovigo, Italy
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Abstract

This review article is focused on the role of FDG-PET/CT in visualizing atherosclerosis and on the relevance of inflammatory cells such as macrophages and T-lymphocytes in the formation of the atherosclerotic plaque. The vulnerability of the inflammatory plaque and the risk derived from the provocation of cardio- and cerebrovascular incidents independently from the presence of stenotic vessels are discussed as well as the evolution toward calcified plaque. The important role of FDG-PET/CT in early diagnosis of inflammatory plaque is discussed in both animal studies and in clinical setting. The possibility of curing inflammatory plaques, type of drugs, and the possibility of monitoring the anti-inflammatory treatment by FDG-PET/CT are also discussed.

Keywords:
Atherosclerosis
Etiology
Vulnerable plaque
Stable plaque
Inflammation cells
FDG PET/CT
Molecular imaging
Resumen

Este artículo se centra en el papel de la FDG PET/TC en la identificación de la aterosclerosis y en la relevancia de las células inflamatorias como los macrófagos y los linfocitos T en la formación de la placa aterosclerótica. Se discute también sobre la vulnerabilidad de la placa inflamatoria y el riesgo asociado a determinar incidentes cardio y cerebro-vasculares independientemente de la presencia de vasos estenóticos, así como sobre la evolución hacia la placa calcificada. El importante papel de la FDG PET/TC en el diagnóstico precoz de la placa inflamatoria se discute tanto en estudios con animales y en nivel clínico. Se discute, finalmente, la posibilidad de curar la placa inflamatoria, el tipo de fármacos utilizados y la posibilidad de controlar el tratamiento anti-inflamatorio a través de FDG PET/TC.

Palabras clave:
Aterosclerosis
Etiología
Placa vulnerable
Placa estable
Células inflamatorias
FDG PET/TC
Imagen molecular

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