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Associations between FA supplementation in pregnancy and effects on offspring's NTDs, allergy/respiratory problems, cancer and behaviour problems as been studied.

There is growing concern about the effects of excessive FA supplementation, whether in terms of doses or times of exposure.

FA supplementation in the periconceptional period is protective against NTDs while in later periods it could be deleterious.

A daily dose of 0.4mg FA in the periconceptional period seems to be effective and safe.

Chronic anal fissure is a common condition associated with intense pain.

Local botulinum toxin injection is a valid option in its management.

Pain intensity scores significantly improved after BoNT injection.

Side effects were rare and mild.

Our results support the inclusion of BoNT in the management algorithm of chronic anal fissure.

Breaking bad news is still deemed a difficult task by family physicians.

Family physicians feel they need training in breaking bad news.

The family physicians’ attitude to this issue is different from what they would wish if they themselves had a life-threatening disease.

Host comorbidities impact on prognosis of severe community-acquired pneumonia.

Association of severity indexes, clinical and analytic parameters at admission and patient comorbidities with mortality.

Characterization of severe community-acquired pneumonia patients admitted to ICU.

The attitudes of family physicians regarding breaking bad news are heterogeneous.

Younger doctors seem to see the delivery of bad news more positively.

This trend suggests that there will be a more open communication in the future.

Cosmos caudatus Ethanolic extract fractionation by n-butanol produced a phenolics-saponin rich fraction.

Cosmos caudatus butanol fraction was the most potent in all antioxidant and MTT assays.

High concentrations of all fractions increased cells migration and invasion in vitro.

Butanol fraction intermediate concentration maximally inhibited VSMC migration and invasion.

Mild concentrations of crude and butanol fractions showed the best invasion inhibition index.

The association between body image, body composition and school bullying was evaluated.

409 children with 11.14 years in high social vulnerability in Brazil participated.

Victim–aggressor bullying participants are dissatisfied with thinness.

Girls aged 8–10 years and with high fat % have dissatisfaction with excess.

Body dissatisfaction showed associations with body composition and bullying.

A statistically significant and moderate positive correlation was verified between systolic blood pressure and plasma phosphate concentration in the whole sample (diabetic and non-diabetic), due to the diabetic chronic kidney disease group.

A statistically significant and moderate positive correlation was verified between the diastolic blood pressure and plasma phosphate concentration in the whole sample (diabetic and non-diabetic), due to the diabetic chronic kidney disease group.

A statistically significant and strong negative correlation was found between diastolic blood pressure and estimated glomerular filtration rate in the diabetic chronic kidney disease group, but there was no statistically significant correlation in the whole sample (diabetic and non-diabetic).

Urine proteomics allows the identification of the pathways modulated in neonates.

Up-regulated pathways in preterm include immunity, metabolism and oxidative stress.

Some of these pathways seem to be modulated by the nutritional support.

AGT and RBP4 might be related to the development of cardiovascular diseases.

The increased incidence of dementia places the family in the role of caregiver.

It is important to create, to implement and to validate training programmes for family caregivers of people with dementia living at home.

The programme “Living together with dementia” addressed in this protocol seeks to be a response to empower these caregivers.

Specific mind-brain processes are associated with political attitudes.

The risks of a T.R.U.M.P. mindset are highlighted.

An alternative G.A.N.D.H.I. mindset is suggested.

This paper identifies a set of constraints experienced by FC in the caregiver role.

This paper identifies difficulties experienced by FC.

Urgent care nurses should address the FC constraints and difficulties.