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21490
The impact of folic acid supplementation on gestational and long term health: Critical temporal windows, benefits and risks
Carla Silva, Elisa Keating, Elisabete Pinto
Porto Biomed J. 2017;2:315-32
21490
Highlights

  • Associations between FA supplementation in pregnancy and effects on offspring's NTDs, allergy/respiratory problems, cancer and behaviour problems as been studied.

  • There is growing concern about the effects of excessive FA supplementation, whether in terms of doses or times of exposure.

  • FA supplementation in the periconceptional period is protective against NTDs while in later periods it could be deleterious.

  • A daily dose of 0.4mg FA in the periconceptional period seems to be effective and safe.

Open access
19208
Comparison between effects of antibiotics, NSAIDs and their mixture on the growth of microorganisms
S. Bhattacharya, Y. Akula, G.M. Mitongo, Q. Khorram
Porto Biomed J. 2017;2:176-7
19208
Open access
14471
Rituximab in generalized myasthenia gravis: Clinical, quality of life and cost–utility analysis
João Peres, Rita Martins, José Delgado Alves, Ana Valverde
Porto Biomed J. 2017;2:81-5
14471
Highlights

  • Rituximab use in MG patients lead to the reduction of relapses and to a lesser use of immunosuppressive agents in our series.

  • Rituximab use in our MG patients decreased healthcare costs after treatment, comparing to the pre-treatment period.

  • Rituximab is a clinical effective treatment for B cell-related diseases like MG and seems to be a cost–saving intervention.

Open access
12550
Recognition of chronic hypoxia and pre-existing foetal injury on the cardiotocograph (CTG): Urgent need to think beyond the guidelines
Susana Pereira, Edwin Chandraharan
Porto Biomed J. 2017;2:124-9
12550
Open access
12092
The importance of outdoor play for young children's healthy development
Gabriela Bento, Gisela Dias
Porto Biomed J. 2017;2:157-60
12092
Open access
11805
Role of platelets in immune system and inflammation
Ozge Sonmez, Mehmet Sonmez
Porto Biomed J. 2017;2:311-4
11805
Open access
10467
Botulinum toxin improves pain in chronic anal fissure
Hugo Amorim, José Santoalha, Rui Cadilha, Maria-José Festas, Paula Barbosa, Armanda Gomes
Porto Biomed J. 2017;2:273-6
10467
Highlights

  • Chronic anal fissure is a common condition associated with intense pain.

  • Local botulinum toxin injection is a valid option in its management.

  • Pain intensity scores significantly improved after BoNT injection.

  • Side effects were rare and mild.

  • Our results support the inclusion of BoNT in the management algorithm of chronic anal fissure.

Open access
8765
Congenital dacryocystocele in infant: A rare cause of eye swelling
Fábio Barroso, Renato Silva, Catarina Mendes
Porto Biomed J. 2017;2:28-9
8765
Open access
7784
Family physicians’ opinions on and difficulties with breaking bad news
José António Ferraz Gonçalves, Carla Almeida, Joana Amorim, Rita Baltasar, Joana Batista, Yusianmar Borrero, João Pedro Fallé, Igor Faria, ... Rita Xavier
Porto Biomed J. 2017;2:277-81
7784
Highlights

  • Breaking bad news is still deemed a difficult task by family physicians.

  • Family physicians feel they need training in breaking bad news.

  • The family physicians’ attitude to this issue is different from what they would wish if they themselves had a life-threatening disease.

Open access
7550
Public and patient participation in health policy, care and research
Cláudia de Freitas
Porto Biomed J. 2017;2:31-2
7550
Open access
7281
Topical use of probiotics: The natural balance
Freni Kekhasharú Tavaria
Porto Biomed J. 2017;2:69-70
7281
Open access
7198
The effects of cannabinoids in exemestane-resistant breast cancer cells
C. Almeida, T. Augusto, G. Correia-da-Silva, N. Teixeira, C. Amaral
Porto Biomed J. 2017;2:221-2
7198
Open access
6937
Statins as anti-inflammatory agents: A potential therapeutic role in sight-threatening non-infectious uveitis
Rose Gilbert, Ahmed Al-Janabi, Oren Tomkins-Netzer, Sue Lightman
Porto Biomed J. 2017;2:33-9
6937
Open access
6860
Quality of life after gastric sleeve and gastric bypass for morbid obesity
Gil Filipe Ramada Faria, Jorge Manuel Nunes Santos, Donald C. Simonson
Porto Biomed J. 2017;2:40-6
6860
Highlights

  • Quality-of-life measures improve as early as 3 months after bariatric surgery.

  • There is wide variability in reporting that renders direct comparisons difficult.

  • The available comparisons between RYGB and sleeve gastrectomy could not detect any difference.

  • Improvement in PRO measures might be related to weight loss.

  • Larger and better designed studies are required to achieve discrimination in PRO measures.

Open access
6785
The impact of exercise training on adipose tissue remodelling in cancer cachexia
Rita Ferreira, Rita Nogueira-Ferreira, Rui Vitorino, Lúcio Lara Santos, Daniel Moreira-Gonçalves
Porto Biomed J. 2017;2:333-9
6785
Open access
6550
Comorbidities impact on the prognosis of severe acute community-acquired pneumonia
Ana Vidal, Lurdes Santos
Porto Biomed J. 2017;2:265-72
6550
Highlights

  • Host comorbidities impact on prognosis of severe community-acquired pneumonia.

  • Association of severity indexes, clinical and analytic parameters at admission and patient comorbidities with mortality.

  • Characterization of severe community-acquired pneumonia patients admitted to ICU.

Open access
6454
Iron pill-induced gastroduodenopathy
Rui Morais, Armando Ribeiro, David Paiva, Elisabete Rios, Susana Rodrigues, Guilherme Macedo
Porto Biomed J. 2017;2:344-6
6454
Open access
6272
Information of patients with life-threatening diseases: A survey of the attitude of Portuguese family practitioners
José A. Ferraz Gonçalves, Carla Almeida, Joana Amorim, Rita Baltasar, Joana Batista, Yusianmar Borrero, João Pedro Fallé, Igor Faria, ... Rita Xavier
Porto Biomed J. 2017;2:250-3
6272
Highlights

  • The attitudes of family physicians regarding breaking bad news are heterogeneous.

  • Younger doctors seem to see the delivery of bad news more positively.

  • This trend suggests that there will be a more open communication in the future.

Open access
6168
Cosmos caudatus extract/fractions reduce smooth muscle cells migration and invasion in vitro: A potential benefit of suppressing atherosclerosis
Said Moshawih, Manraj S. Cheema, Zaid O. Ibraheem, Nirmala Devi Tailan, Muhammad Nazrul Hakim
Porto Biomed J. 2017;2:293-300
6168
Highlights

  • Cosmos caudatus Ethanolic extract fractionation by n-butanol produced a phenolics-saponin rich fraction.

  • Cosmos caudatus butanol fraction was the most potent in all antioxidant and MTT assays.

  • High concentrations of all fractions increased cells migration and invasion in vitro.

  • Butanol fraction intermediate concentration maximally inhibited VSMC migration and invasion.

  • Mild concentrations of crude and butanol fractions showed the best invasion inhibition index.

Open access
6139
Monitoring the extracorporeal photopheresis by immunophenotyping in a Sézary syndrome patient
Tânia Rodrigues, Sérgio Lopes, Catarina Pinho, Susana Roncon
Porto Biomed J. 2017;2:340-3
6139
Open access
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos