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4635
The impact of folic acid supplementation on gestational and long term health: Critical temporal windows, benefits and risks
Carla Silva, Elisa Keating, Elisabete Pinto
Porto Biomed J 2017;2:315-32
4635

  • Associations between FA supplementation in pregnancy and effects on offspring's NTDs, allergy/respiratory problems, cancer and behaviour problems as been studied.

  • There is growing concern about the effects of excessive FA supplementation, whether in terms of doses or times of exposure.

  • FA supplementation in the periconceptional period is protective against NTDs while in later periods it could be deleterious.

  • A daily dose of 0.4mg FA in the periconceptional period seems to be effective and safe.

Open access
3034
Family physicians’ opinions on and difficulties with breaking bad news
José António Ferraz Gonçalves, Carla Almeida, Joana Amorim, Rita Baltasar, Joana Batista, Yusianmar Borrero, João Pedro Fallé, Igor Faria, Manuel Henriques, Helena Maia, Teresa Fernandes, Mariana Moreira, Susana Moreira, Camila Neves, Ana Ribeiro, Ana Santos, Filipa Silva, Susana Soares, Cristina Sousa, Joana Vicente, Rita Xavier
Porto Biomed J 2017;2:277-81
3034

  • Breaking bad news is still deemed a difficult task by family physicians.

  • Family physicians feel they need training in breaking bad news.

  • The family physicians’ attitude to this issue is different from what they would wish if they themselves had a life-threatening disease.

Open access
2791
Statins as anti-inflammatory agents: A potential therapeutic role in sight-threatening non-infectious uveitis
Rose Gilbert, Ahmed Al-Janabi, Oren Tomkins-Netzer, Sue Lightman
Porto Biomed J 2017;2:33-9
2791
Open access
2630
Cervical cancer screening opportunities for Guinea-Bissau
Ivo Julião, Joana Savva-Bordalo, Nuno Lunet
Porto Biomed J 2017;2:306-10
2630
Open access
2259
Cosmos caudatus extract/fractions reduce smooth muscle cells migration and invasion in vitro: A potential benefit of suppressing atherosclerosis
Said Moshawih, Manraj S. Cheema, Zaid O. Ibraheem, Nirmala Devi Tailan, Muhammad Nazrul Hakim
Porto Biomed J 2017;2:293-300
2259

  • Cosmos caudatus Ethanolic extract fractionation by n-butanol produced a phenolics-saponin rich fraction.

  • Cosmos caudatus butanol fraction was the most potent in all antioxidant and MTT assays.

  • High concentrations of all fractions increased cells migration and invasion in vitro.

  • Butanol fraction intermediate concentration maximally inhibited VSMC migration and invasion.

  • Mild concentrations of crude and butanol fractions showed the best invasion inhibition index.

Open access
2212
Comorbidities impact on the prognosis of severe acute community-acquired pneumonia
Ana Vidal, Lurdes Santos
Porto Biomed J 2017;2:265-72
2212

  • Host comorbidities impact on prognosis of severe community-acquired pneumonia.

  • Association of severity indexes, clinical and analytic parameters at admission and patient comorbidities with mortality.

  • Characterization of severe community-acquired pneumonia patients admitted to ICU.

Open access
2209
The influence of inspiratory muscle training on lung function in female basketball players - a randomized controlled trial
Tiago Vasconcelos, Andreia Hall, Rui Viana
Porto Biomed J 2017;2:86-9
2209
Open access
2136
Monitoring the extracorporeal photopheresis by immunophenotyping in a Sézary syndrome patient
Tânia Rodrigues, Sérgio Lopes, Catarina Pinho, Susana Roncon
Porto Biomed J 2017;2:340-3
2136
Open access
2002
Rituximab in generalized myasthenia gravis: Clinical, quality of life and cost–utility analysis
João Peres, Rita Martins, José Delgado Alves, Ana Valverde
Porto Biomed J 2017;2:81-5
2002

  • Rituximab use in MG patients lead to the reduction of relapses and to a lesser use of immunosuppressive agents in our series.

  • Rituximab use in our MG patients decreased healthcare costs after treatment, comparing to the pre-treatment period.

  • Rituximab is a clinical effective treatment for B cell-related diseases like MG and seems to be a cost–saving intervention.

Open access
1981
Prediction of cardiovascular risk in preterm neonates through urinary proteomics: An exploratory study
Estela Cabral, Henrique Soares, Hercília Guimarães, Rui Vitorino, Rita Ferreira, Tiago Henriques-Coelho
Porto Biomed J 2017;2:287-92
1981

  • Urine proteomics allows the identification of the pathways modulated in neonates.

  • Up-regulated pathways in preterm include immunity, metabolism and oxidative stress.

  • Some of these pathways seem to be modulated by the nutritional support.

  • AGT and RBP4 might be related to the development of cardiovascular diseases.

Open access
1980
“Living together with dementia”: Training programme for family caregivers – A study protocol
Lia Sousa, Carlos Sequeira, Carme Ferré-Grau, Pedro Neves, Mar Lleixá-Fortuño, Ana Monteiro, Joana Meireles, Madalena Pinto, Tiago Gomes
Porto Biomed J 2017;2:282-6
1980

  • The increased incidence of dementia places the family in the role of caregiver.

  • It is important to create, to implement and to validate training programmes for family caregivers of people with dementia living at home.

  • The programme “Living together with dementia” addressed in this protocol seeks to be a response to empower these caregivers.

Open access
1979
Association between body dissatisfaction and bullying in children of socioeconomically vulnerable areas
Marcela Almeida Zequinão, Pâmella de Medeiros, Helena Rafaela Vieira do Rosário, Andreia Pelegrini, Luis Lopes, Beatriz Pereira, Fernando Luiz Cardoso
Porto Biomed J 2017;2:260-4
1979

  • The association between body image, body composition and school bullying was evaluated.

  • 409 children with 11.14 years in high social vulnerability in Brazil participated.

  • Victim–aggressor bullying participants are dissatisfied with thinness.

  • Girls aged 8–10 years and with high fat % have dissatisfaction with excess.

  • Body dissatisfaction showed associations with body composition and bullying.

Open access
1975
Evaluation of spinal posture using Microsoft Kinect™: A preliminary case-study with 98 volunteers
A.P.G. Castro, J.D. Pacheco, C. Lourenço, S. Queirós, A.H.J. Moreira, N.F. Rodrigues, J.L. Vilaça
Porto Biomed J 2017;2:18-22
1975
Open access
1950
Role of platelets in immune system and inflammation
Ozge Sonmez, Mehmet Sonmez
Porto Biomed J 2017;2:311-4
1950
Open access
1877
Effects of oculomotor and gaze stability exercises on balance after stroke: Clinical trial protocol
Carla Pimenta, Anabela Correia, Marta Alves, Daniel Virella
Porto Biomed J 2017;2:76-80
1877

  • Balance problems after stroke are an important risk factor for falling.

  • The inability to maintain balance decreased potential for recovery.

  • This trial assesses the effect of oculomotor and gaze stability training on balance.

Open access
1865
Prevalence of abacavir-associated hypersensitivity syndrome and HLA-B*5701 allele in a Portuguese HIV-positive population
Fabrícia Carolino, Natacha Santos, Carmela Piñeiro, Ana Sofia Santos, Pedro Soares, António Sarmento, Josefina Rodrigues Cernadas
Porto Biomed J 2017;2:59-62
1865
Open access
1832
Comfort, well-being and quality of life: Discussion of the differences and similarities among the concepts
Sara Pinto, Laís Fumincelli, Alessandra Mazzo, Sílvia Caldeira, José Carlos Martins
Porto Biomed J 2017;2:6-12
1832

  • The distinction among the concepts of comfort, well-being and QoL is often unclear.

  • This ambiguity can lead to redundancies, gaps, and knowledge dispersion.

  • The concepts are not surrogate terms but related concepts sharing common attributes.

Open access
1831
The impact of exercise training on adipose tissue remodelling in cancer cachexia
Rita Ferreira, Rita Nogueira-Ferreira, Rui Vitorino, Lúcio Lara Santos, Daniel Moreira-Gonçalves
Porto Biomed J 2017;2:333-9
1831
Open access
1822
Information of patients with life-threatening diseases: A survey of the attitude of Portuguese family practitioners
José A. Ferraz Gonçalves, Carla Almeida, Joana Amorim, Rita Baltasar, Joana Batista, Yusianmar Borrero, João Pedro Fallé, Igor Faria, Manuel Henriques, Helena Maia, Teresa Fernandes, Mariana Moreira, Susana Moreira, Camila Neves, Ana Ribeiro, Ana Santos, Filipa Silva, Susana Soares, Cristina Sousa, Joana Vicente, Rita Xavier
Porto Biomed J 2017;2:250-3
1822

  • The attitudes of family physicians regarding breaking bad news are heterogeneous.

  • Younger doctors seem to see the delivery of bad news more positively.

  • This trend suggests that there will be a more open communication in the future.

Open access
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