Associations between FA supplementation in pregnancy and effects on offspring's NTDs, allergy/respiratory problems, cancer and behaviour problems as been studied.

There is growing concern about the effects of excessive FA supplementation, whether in terms of doses or times of exposure.

FA supplementation in the periconceptional period is protective against NTDs while in later periods it could be deleterious.

A daily dose of 0.4mg FA in the periconceptional period seems to be effective and safe.

Rituximab use in MG patients lead to the reduction of relapses and to a lesser use of immunosuppressive agents in our series.

Rituximab use in our MG patients decreased healthcare costs after treatment, comparing to the pre-treatment period.

Rituximab is a clinical effective treatment for B cell-related diseases like MG and seems to be a cost–saving intervention.

Chronic anal fissure is a common condition associated with intense pain.

Local botulinum toxin injection is a valid option in its management.

Pain intensity scores significantly improved after BoNT injection.

Side effects were rare and mild.

Our results support the inclusion of BoNT in the management algorithm of chronic anal fissure.

Fermentation of the dietary fiber by intestinal microflora results in production of butyrate.

Butyrate possesses anticarcinogenic effect at the colonic level.

Three transporters (MCT1, SMCT1 and BCRP) regulate the intracellular concentration of BT in colonic epithelial cells.

Changes in the expression of these transporters occur in colorectal cancer.