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4881
The impact of folic acid supplementation on gestational and long term health: Critical temporal windows, benefits and risks
Carla Silva, Elisa Keating, Elisabete Pinto
Porto Biomed J 2017;2:315-32
4881

  • Associations between FA supplementation in pregnancy and effects on offspring's NTDs, allergy/respiratory problems, cancer and behaviour problems as been studied.

  • There is growing concern about the effects of excessive FA supplementation, whether in terms of doses or times of exposure.

  • FA supplementation in the periconceptional period is protective against NTDs while in later periods it could be deleterious.

  • A daily dose of 0.4mg FA in the periconceptional period seems to be effective and safe.

Open access
4088
Melkersson-Rosenthal syndrome – delay in the diagnosis of an early-onset oligosymptomatic variant
Fabrícia Carolino, Margarida Fernandes, José Luís Plácido
Porto Biomed J 2016;1:43-5
4088
Open access
3828
Regulation of colonic epithelial butyrate transport: Focus on colorectal cancer
Pedro Gonçalves, Fátima Martel
Porto Biomed J 2016;1:83-91
3828

  • Fermentation of the dietary fiber by intestinal microflora results in production of butyrate.

  • Butyrate possesses anticarcinogenic effect at the colonic level.

  • Three transporters (MCT1, SMCT1 and BCRP) regulate the intracellular concentration of BT in colonic epithelial cells.

  • Changes in the expression of these transporters occur in colorectal cancer.

Open access
3468
Reversible cerebral vasoconstriction syndrome – A narrative revision of the literature
Laura Santos, Elsa Azevedo
Porto Biomed J 2016;1:65-71
3468
Open access
3296
Sodium intake and Helicobacter pylori infection in the early stages of life
Catarina Monteiro, Ana Rute Costa, Bárbara Peleteiro
Porto Biomed J 2016;1:52-8
3296

  • H. pylori was observed in 30% of children and 26% had excessive sodium intake.

  • No association was found between sodium intake and H. pylori infection in early life.

  • This is the first study testing sodium effect in H. pylori infection in children.

Open access
3232
Family physicians’ opinions on and difficulties with breaking bad news
José António Ferraz Gonçalves, Carla Almeida, Joana Amorim, Rita Baltasar, Joana Batista, Yusianmar Borrero, João Pedro Fallé, Igor Faria, Manuel Henriques, Helena Maia, Teresa Fernandes, Mariana Moreira, Susana Moreira, Camila Neves, Ana Ribeiro, Ana Santos, Filipa Silva, Susana Soares, Cristina Sousa, Joana Vicente, Rita Xavier
Porto Biomed J 2017;2:277-81
3232

  • Breaking bad news is still deemed a difficult task by family physicians.

  • Family physicians feel they need training in breaking bad news.

  • The family physicians’ attitude to this issue is different from what they would wish if they themselves had a life-threatening disease.

Open access
2999
A biopsychosocial approach to the interrelation between motherhood and women's excessive weight
Ana Henriques, Ana Azevedo
Porto Biomed J 2016;1:59-64
2999
Open access
2918
Statins as anti-inflammatory agents: A potential therapeutic role in sight-threatening non-infectious uveitis
Rose Gilbert, Ahmed Al-Janabi, Oren Tomkins-Netzer, Sue Lightman
Porto Biomed J 2017;2:33-9
2918
Open access
2816
Probiotics for the control of obesity – Its effect on weight change
Ana Lídia Rouxinol-Dias, Ana Raquel Pinto, Catarina Janeiro, Daniel Rodrigues, Marta Moreira, João Dias, Pedro Pereira
Porto Biomed J 2016;1:12-24
2816
Open access
2796
Pulsed electromagnetic field therapy effectiveness in low back pain: A systematic review of randomized controlled trials
Renato Andrade, Hugo Duarte, Rogério Pereira, Isabel Lopes, Hélder Pereira, Rui Rocha, João Espregueira-Mendes
Porto Biomed J 2016;1:156-63
2796
Open access
2759
Cervical cancer screening opportunities for Guinea-Bissau
Ivo Julião, Joana Savva-Bordalo, Nuno Lunet
Porto Biomed J 2017;2:306-10
2759
Open access
2587
Cognitive and emotional impairments in obsessive–compulsive disorder: Evidence from functional brain alterations
Óscar F. Gonçalves, Sandra Carvalho, Jorge Leite, Ana Fernandes-Gonçalves, Angel Carracedo, Adriana Sampaio
Porto Biomed J 2016;1:92-105
2587
Open access
2506
Kidney cancer. Heavy metals as a risk factor
Isabel Sá, Mariana Semedo, Mónica Elisabete Cunha
Porto Biomed J 2016;1:25-8
2506
Open access
2459
Indoor air quality and atopic sensitization in primary schools: A follow-up study
João Cavaleiro Rufo, Joana Madureira, Inês Paciência, Lívia Aguiar, João Paulo Teixeira, André Moreira, Eduardo de Oliveira Fernandes
Porto Biomed J 2016;1:142-6
2459

  • The SINPHONIE guidelines were successful in reducing PM2.5 and PM10 in schools.

  • The schools failed to reduce the levels of other IAQ pollutants.

  • No significant changes were observed in the prevalence of atopy.

Open access
2416
Relevance of peroxynitrite formation and 3-nitrotyrosine on spermatozoa physiology
Daniel Filipe Cruz, Margarida Fardilha
Porto Biomed J 2016;1:129-35
2416

  • Male fertility decline has been attributed, in part, to increased oxidative stress.

  • Here we will focus on spermatozoa ROS, namely O2•−, NO and ONOO and their contribution to protein tyrosine nitration, namely by 3-NT formation.

  • An in depth review will be made on the methods used to detect protein oxidation.

  • Detecting 3-NT in sperm proteins will have a crucial clinical impact, namely on the follow up of anti-oxidant therapies.

Open access
2360
Comorbidities impact on the prognosis of severe acute community-acquired pneumonia
Ana Vidal, Lurdes Santos
Porto Biomed J 2017;2:265-72
2360

  • Host comorbidities impact on prognosis of severe community-acquired pneumonia.

  • Association of severity indexes, clinical and analytic parameters at admission and patient comorbidities with mortality.

  • Characterization of severe community-acquired pneumonia patients admitted to ICU.

Open access
2345
Cosmos caudatus extract/fractions reduce smooth muscle cells migration and invasion in vitro: A potential benefit of suppressing atherosclerosis
Said Moshawih, Manraj S. Cheema, Zaid O. Ibraheem, Nirmala Devi Tailan, Muhammad Nazrul Hakim
Porto Biomed J 2017;2:293-300
2345

  • Cosmos caudatus Ethanolic extract fractionation by n-butanol produced a phenolics-saponin rich fraction.

  • Cosmos caudatus butanol fraction was the most potent in all antioxidant and MTT assays.

  • High concentrations of all fractions increased cells migration and invasion in vitro.

  • Butanol fraction intermediate concentration maximally inhibited VSMC migration and invasion.

  • Mild concentrations of crude and butanol fractions showed the best invasion inhibition index.

Open access
es en pt

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Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
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