ISSN: 1807-5932
e-ISSN: 1980-5322

Clinics is a gold open access electronic international journal that publishes peer-reviewed research in continuous flow of interest to clinicians and researchers in medical and biomedical sciences based on its originality, importance, conclusions and interest to readers. CLINICS also publishes Comments and Editorials. The journal is committed to the principles of ethics, respect for the individual, humanization, honesty, pioneering spirit and excellence.Clinics is the Official Scientific journal of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP).

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Original articles

Methotrexate carried in lipid core nanoparticles reduces microglial activation and induces neuroprotection after cortical stroke induced in rats

Edmundo L.R. Pereiraa,b, Raul C. Maranhãob,

Corresponding author

ramarans@usp.br

Corresponding author.

, Michelle N.C. Diasc, Ijair R. dos Santosc, Carolina Ramos dos Santosa, Moisés Hamoyd, Danielle Cristine A. Feioe, Priscila O. Carvalhob, Jaqueline M. Baziolib, Aleksandra T. Morikawab, Walace Gomes-Leala

a Laboratory of Experimental Neuroprotection and Neuroregeneration, Institute of Collective Health, Universidade Federal do Oeste do Pará, Santarém, PA, Brazil

b Neurology Unity, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, PA, Brazil

c Laboratório de Metabolismo e Lípides, Instituto do Coração (InCor-HCMUSP), Department of Cardiopneumology of the Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil

d Laboratory of Toxicology and Natural Products, Institute of Biological Sciences, Universidade Federal do Pará, Belém, PA, Brazil

e Laboratory of Molecular Biology, Universidade Estadual do Pará, Belém, PA, Brazil

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ISSN: 18075932
Original language: English