Efectos de las estatinas sobre la presión arterial
V. Lahera, J. Navarro-Cid, N. de las Heras,, S. Vázquez-Pérez, E. Cediel, D. Sanz-Rosa, V. Cachofeiro
Departamento de Fisiología. Facultad de Medicina. Universidad Complutense. Madrid
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Cachofeiro" "autores" => array:7 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Lahera" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Navarro-Cid" ] 2 => array:2 [ "nombre" => "N." "apellidos" => "de las Heras," ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Vázquez-Pérez" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "Cediel" ] 5 => array:2 [ "nombre" => "D." "apellidos" => "Sanz-Rosa" ] 6 => array:2 [ "nombre" => "V." "apellidos" => "Cachofeiro" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Departamento de Fisiología. Facultad de Medicina. Universidad Complutense. Madrid" "identificador" => "aff0005" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Resumen</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Las estatinas han demostrado claramente su capacidad para disminuir la morbimortalidad cardiovascular debido principalmente a sus efectos sobre el colesterol sérico y las LDL, además de la estabilización de la placa y la reducción del riesgo trombótico. Sin embargo, en los últimos años diversos estudios indican que las estatinas tienen además efectos sobre la PA y la protección de órganos diana. Estos efectos pueden ser en parte dependientes de la reducción de la colesterolemia, pero otros mecanismos distintos a éste parecen intervenir en los efectos antihipertensivos de las estatinas. Entre ellos sus acciones sobre el manejo renal de sodio, la respuesta constrictora a diversos agentes, el remodelado vascular y diversas acciones sobre factores vasoactivos derivados del endotelio y el sistema renina angiotensina.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:58 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Statins and blockers of the renin-angiotensina system. Vascular protection beyond their primary mode of action" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Faggioto" 1 => "R. Paoletti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "1999" "volumen" => "34" "paginaInicial" => "987" "paginaFinal" => "996" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10523396" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The evolving role of statins in management of atherosclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.J. Vaughan" 1 => "A.M. Gotto" 2 => "C.T. Basson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2000" "volumen" => "35" "paginaInicial" => "1" "paginaFinal" => "10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10636252" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antiatherosclerotic activity of drugs in relation to nitric oxide function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Bult" 1 => "A.G. Herman" 2 => "K.E. Matthys" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Pharmacol" "fecha" => "1999" "volumen" => "375" "paginaInicial" => "157" "paginaFinal" => "176" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10443573" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma lipoprotein levels in treated and untreated hypertensive men and women: the National Heart Foundation of Australia Riks Factor Prevalence Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.W. MacMahon" 1 => "G.L. MacDonald" 2 => "R.B. Blacket" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arteriosclerosis" "fecha" => "1985" "volumen" => "5" "paginaInicial" => "391" "paginaFinal" => "396" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4015511" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple risk factors in hypertension: results from Gubbio study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "M. Laurenzim" 1 => "M. Mancini" 2 => "A. Menotti" 3 => "J. Stamler" 4 => "R. Stamler" 5 => "M. Trevisan" 6 => "A. Zanchetti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/HJH.0b013e3283642384" "Revista" => array:6 [ "tituloSerie" => "J Hypertens" "fecha" => "1990" "volumen" => "8(suppl 20" "paginaInicial" => "7" "paginaFinal" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23868088" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clofibrate prevents the development of hypertension in Dahl salt-sensitive rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.J. Roman" 1 => "T.H. Ma" 2 => "B. Frohlich" 3 => "B. Markham" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "1993" "volumen" => "21" "paginaInicial" => "985" "paginaFinal" => "988" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8505111" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lovastatin prevents development of hypertension in spontaneously hypertensive rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Jian" 1 => "R. Roman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "1997" "volumen" => "30" "paginaInicial" => "968" "paginaFinal" => "974" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9336402" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lovastatin but not enalapril reduces glomerular injury in Dahl salt-sensitive rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.P. O´Donnell" 1 => "B.L. Kasiske" 2 => "S.A. Katz" 3 => "P.G. Schmitz" 4 => "W.F. Keane" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "1992" "volumen" => "20" "paginaInicial" => "651" "paginaFinal" => "658" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1428116" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib005" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of cholesterol reduction on BP response to mental stress in patients with high cholesterol" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.H. Sung" 1 => "J.L. Izzo Jr." 2 => "M.F. Wilson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Hypertens" "fecha" => "1997" "volumen" => "10" "paginaInicial" => "592" "paginaFinal" => "599" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9194504" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of fluvastatin on serum lipid in essential hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Z. Jarai" 1 => "J. Kopocsi" 2 => "C. Farsang" 3 => "K. Detki" 4 => "G. Pados" 5 => "Z. Sebestyen" 6 => "J. Hollo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Orv Hetil" "fecha" => "1996" "volumen" => "137" "paginaInicial" => "1.857" "paginaFinal" => "1.859" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9254345" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypotensive effect of an inhibitor of cholesterol synthesis (fluvastatin): a pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Abetel" 1 => "P.N. Poget" 2 => "J.P. Bonnabry" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Schweiz Med Wochenschr" "fecha" => "1998" "volumen" => "128" "paginaInicial" => "272" "paginaFinal" => "277" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9540154" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Additional reduction in blood pressure after cholesterol- lowering treatment by statins (lovastatin or pravastatin) in hypercholesterolemic patients using angiotensin-converting enzyme inhibitors/enalapril or lisinopril" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.C. Sposito" 1 => "A.P. Mansur" 2 => "O.R. Coelho" 3 => "J.C. Nicolau" 4 => "J.A.F. Ramires" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "1999" "volumen" => "83" "paginaInicial" => "1.497" "paginaFinal" => "1.499" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10750596" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Glorioso" 1 => "C. Troffa" 2 => "F. Filigheddu" 3 => "F. Dettori" 4 => "A. Soro" 5 => "P. Pinna Parpaglia" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "1999" "volumen" => "34" "paginaInicial" => "1.281" "paginaFinal" => "1.286" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10601134" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Simvastatin treatment of hypercholesterolemia in patients with insulin dependent diabetes mellitus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "G. Sartor" 1 => "P. Katzman" 2 => "E. Eizyk" 3 => "J. Kalen" 4 => "A. Nilsson" 5 => "L. Ugander" 6 => "D. Ursing" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Clin Pharmacol Ther" "fecha" => "1995" "volumen" => "33" "paginaInicial" => "3" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7711988" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of lovastatin in hypercholesterolemia in patients with systemic hypertension.tolerability" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.B. D’Agostino" 1 => "W.B. Kannel" 2 => "M.N. Stepanians" 3 => "L.C. D’Agostino" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "1993" "volumen" => "71" "paginaInicial" => "82" "paginaFinal" => "87" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8093585" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Simvastatin in the treatment of hypercholesterolemia in elderly patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Antonicelli" 1 => "G. Onorato" 2 => "P. Pagelli" 3 => "L. Pierazzoli" 4 => "E. Paciaroni" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Ther" "fecha" => "1990" "volumen" => "12" "paginaInicial" => "165" "paginaFinal" => "171" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2354486" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does lowering of cholesterol levels influence functional properties of large arteries?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Kool" 1 => "F. Lustermans" 2 => "H. Kragten" 3 => "H. Struijker Biudier" 4 => "A. Hoeks" 5 => "R. Reneman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Pharmacol" "fecha" => "1995" "volumen" => "48" "paginaInicial" => "217" "paginaFinal" => "223" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7589044" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interactions of low density lipoprotein with rat mesangial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Wasserman" 1 => "A. Santiago" 2 => "H. Holthofer" 3 => "M. Epstein" 4 => "D. Schlondorff" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Kidney" "fecha" => "1989" "volumen" => "35" "paginaInicial" => "1.168" "paginaFinal" => "1.174" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Receptor mediated uptake of apo B and apo E rich lipoproteins by human glomerular epithelial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.J. Gröne" 1 => "A.K. Walli" 2 => "E. Gröne" 3 => "A. Krämer" 4 => "M.R. Clemens" 5 => "D. Seidel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "1990" "volumen" => "37" "paginaInicial" => "1.449" "paginaFinal" => "1.459" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2362410" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of low-density-lipoproteins on mesangial cell growth and viability in vitro" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.C. Wheeler" 1 => "J.W. Persuad" 2 => "R. Fernando" 3 => "P. Sweny" 4 => "Z. Varghese" 5 => "J.F. Moorhead" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nephrol Dial Transplant" "fecha" => "1990" "volumen" => "5" "paginaInicial" => "185" "paginaFinal" => "191" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2113645" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Injurious effects of low density lipoprotein (LDL) on human mesangial cells (MC" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "W.F. Keane" 1 => "J. Phillips" 2 => "B.L. Kasiske" 3 => "M.P. O’Donnell" 4 => "Y. Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Kidney Int" "fecha" => "1990" "volumen" => "37" "paginaInicial" => "509" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytotoxicity of low density lipoprotein (LDL) incultured rat mesangial cells (MC" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W.S. Mulcahy" 1 => "J.B. Smith" 2 => "M. Selak" 3 => "G.G. Krishna" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Kidney Int" "fecha" => "1990" "volumen" => "37" "paginaInicial" => "514" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lipids and progressive renal injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P.G. Schmitz" 1 => "B.L. Kasiske" 2 => "M.P. O’Donnell" 3 => "W.F. Keane" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Semin Nephrol" "fecha" => "1989" "volumen" => "9" "paginaInicial" => "354" "paginaFinal" => "369" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2688011" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combined antihypertensive and lipid-lowering therapy in experimental glomerulonephritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Rubin" 1 => "S. Silbiger" 2 => "L. Sablay" 3 => "J. Neugarten" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "1994" "volumen" => "23" "paginaInicial" => "92" "paginaFinal" => "95" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8282335" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Focal and segmental glomerulosclerosis: analogies to atherosclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.R. Diamond" 1 => "M.J. Karnovsky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "1988" "volumen" => "33" "paginaInicial" => "917" "paginaFinal" => "924" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3292816" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lipids and progressive glomerulosclerosis: a model analogous to atherosclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.F. Keane" 1 => "B.L. Kasiske" 2 => "M.P. O’Donnell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Nephrol" "fecha" => "1988" "volumen" => "8" "paginaInicial" => "261" "paginaFinal" => "271" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3055991" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of hyperlipidemia reduces glomerular injury in obese Zucker rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B.L. Kasiske" 1 => "M.P. O’Donnell" 2 => "M.P. Clery" 3 => "W.F. Keane" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "1988" "volumen" => "33" "paginaInicial" => "667" "paginaFinal" => "672" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3367557" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hemodynamic determinants of vascular changes in hypertension and atherosclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.D. Heistad" 1 => "A.G. López" 2 => "G.L. Baumbach" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/HYPERTENSIONAHA.113.01511" "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "1991" "volumen" => "17(suppl III" "paginaInicial" => "III7" "paginaFinal" => "III11" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23876476" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atherosclerosis and hypertension: mechanism and interrelationships" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V.J. Dzau" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/FJC.0b013e31829c9993" "Revista" => array:6 [ "tituloSerie" => "J Cardiovasc Pharmacol" "fecha" => "1990" "volumen" => "15(suppl 5" "paginaInicial" => "S59" "paginaFinal" => "S64" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23719093" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanism of the interaction of hypertension and hypercholesterolemia in atherogenesis: the effects of antihypertensive agents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V.J. Dzau" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ahj.2013.03.021" "Revista" => array:5 [ "tituloSerie" => "Am Heart J" "fecha" => "1988" "paginaInicial" => "1.725" "paginaFinal" => "1.728" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23816017" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Simvastatin inhibits cardiac hypertrophy and angiotensin enzyme activity in rats with aoritc stenosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.D. Luo" 1 => "W.W. Zhang" 2 => "G.P. Zhang" 3 => "J.X. Guan" 4 => "X. Chen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Pharmacol Physiol" "fecha" => "1999" "volumen" => "26" "paginaInicial" => "903" "paginaFinal" => "908" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10561812" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Abnormal pressure-diuresis-natriuresis response in spontaneously hypertensive rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.J. Roman" 1 => "A.W. Cowley Jr." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Physiol" "fecha" => "1985" "volumen" => "248" "paginaInicial" => "F199" "paginaFinal" => "F205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3970210" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal cortical and papillary blood flow in spontaneously hypertensive rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.J. Roman" 1 => "M.L. Kaldunski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "1988" "volumen" => "11" "paginaInicial" => "657" "paginaFinal" => "663" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3391676" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal medullary captopril delivery lowers blood pressure in spontaneously hypertensive rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.H. Lu" 1 => "D.L. Mattson" 2 => "A.W. Cowley Jr." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "1994" "volumen" => "23" "paginaInicial" => "337" "paginaFinal" => "345" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8125560" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Normalization of pressure-natriuresis by nisoldipine in spontaneously hypertensive rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F.J. Fenoy" 1 => "M.L. Kauker" 2 => "I. Milicic" 3 => "R.J. Roman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hypertension" "fecha" => "1992" "volumen" => "19" "paginaInicial" => "49" "paginaFinal" => "55" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1730439" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of simvastatin, an HMG-CoA reductase inhibitor, on plasma lipids and steroid hormones" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H. Ide" 1 => "S. Fujiya" 2 => "Y. Aanuma" 3 => "Y. Agishi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Ther" "fecha" => "1990" "volumen" => "12" "paginaInicial" => "410" "paginaFinal" => "420" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2268863" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3-OH-3-methyl-glutaryl CoA reductase inhibition modulates vasopressin stimulated calcium responses in rat A10 vascular smooth muscle cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.L. Ng" 1 => "J.E. Davies" 2 => "R.J. Wojcikiewicz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circ Res" "fecha" => "1994" "volumen" => "74" "paginaInicial" => "173" "paginaFinal" => "181" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8293556" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of pravastatin on cardiovascular reactivity to norepinephrine and angiotensin II in patients with hypercholesterolemia and systemic hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N.E. Straznicky" 1 => "L.G. Howes" 2 => "W. Lam" 3 => "W.J. Louis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "1995" "volumen" => "75" "paginaInicial" => "582" "paginaFinal" => "586" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7887382" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Release of contracting autacoids by aortae of normal and atherosclerosis rabbits" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Patrignani" 1 => "L. Daffonchio" 2 => "A. Hernández" 3 => "R. De Caterina" 4 => "G. Pelosi" 5 => "C. Patrono" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/FJC.0b013e3182927ea4" "Revista" => array:6 [ "tituloSerie" => "J Cardiovasc Pharmacol" "fecha" => "1992" "volumen" => "20 (suppl 12" "paginaInicial" => "S208" "paginaFinal" => "S210" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23846803" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physiological aspects of primary hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B. Folkow" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Physiol Rev" "fecha" => "1982" "volumen" => "62" "paginaInicial" => "347" "paginaFinal" => "504" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6461865" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of the new HmGCoA reductase inhibitor cerivastatin (BAY W6228) on migration, proliferation and cholesterol synthesis in arterial myocites" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "A. Corsini" 1 => "L. Arnaboldi" 2 => "M. Raiteri" 3 => "P. Quarato" 4 => "A. Faggiotto" 5 => "R. Paoletti" 6 => "R. Fumagalli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pharmacological Res" "fecha" => "1996" "volumen" => "33" "paginaInicial" => "55" "paginaFinal" => "61" ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recent advances in statins and the kidney" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Oda" 1 => "W.F. Keane" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ki.2013.210" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "1999" "volumen" => "56(suppl 71" "paginaInicial" => "S2" "paginaFinal" => "S5" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23739233" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lovastatin-induced inhibition of renal epithelial tubular cell proliferation involves a p21ras activated, Ap-1-dependent pathway" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F. Vrtovsnik" 1 => "S. Couette" 2 => "D. Prie" 3 => "D. Lallemand" 4 => "G. Friedlander" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "1997" "volumen" => "52" "paginaInicial" => "1.016" "paginaFinal" => "1.027" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9407519" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A cell cycle-regulated inhibitor of cyclin-dependent kinase" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Hengst" 1 => "V. Dulic" 2 => "J.M. Slingerland" 3 => "E. Lees" 4 => "S.T. Reed" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci USA" "fecha" => "1994" "volumen" => "91" "paginaInicial" => "5.291" "paginaFinal" => "5.295" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7809168" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Translational control of p27Kip1 accumulation during the cell cycle" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Hengst" 1 => "S.I. Reed" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1996" "volumen" => "271" "paginaInicial" => "1.861" "paginaFinal" => "1.864" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8596953" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.M. Bokoch" 1 => "V. Prossnitz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI115599" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1992" "volumen" => "89" "paginaInicial" => "402" "paginaFinal" => "408" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1310693" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preservation of endogenous antioxidant activity and inhibition of lipid peroxidation as common mechanism of antiatherosclerotic effects of vitamin E, lovastatin and amlodipine" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Chen" 1 => "W.H. Haught" 2 => "B. Yang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "1997" "volumen" => "30" "paginaInicial" => "569" "paginaFinal" => "575" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9247534" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhibitory effects of fluvastatin, a new HMG-CoA reductase inhibitor, on the increase in vascular ACE activity in cholesterol-fed rabbits" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Mitani" 1 => "T. Bandoh" 2 => "J. Ishikawa" 3 => "M. Kimura" 4 => "T. Totsuka" 5 => "S. Hayashi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Pharmacol" "fecha" => "1996" "volumen" => "119" "paginaInicial" => "1.269" "paginaFinal" => "1.275" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8982516" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Statin-sensitive dysregulated At1 receptor function and density in hypercholesterolemic men" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Nickenig" 1 => "A.T. Baumer" 2 => "Y. Temur" 3 => "D. Kebben" 4 => "F. Joceknjovel" 5 => "M. Bohm" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1999" "volumen" => "100" "paginaInicial" => "2.131" "paginaFinal" => "2.134" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10604893" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "U. Laufs" 1 => "V. La Fata" 2 => "J. Plutzky" 3 => "J.K. Liao" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation" "fecha" => "1998" "volumen" => "97" "paginaInicial" => "1.129" "paginaFinal" => "1.135" ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atrovastatin and simvastatin, on the expression of endothelin- 1 and endothelial nitric oxide synthase in vascular endothelial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "O. Hernández-Perera" 1 => "D. Pérez-Sala" 2 => "J. Navarro-Antolín" 3 => "R. Sánchez-Pascuala" 4 => "G. Hernández" 5 => "C. Díaz" 6 => "S. Lamas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI2821" "Revista" => array:7 [ "tituloSerie" => "J Clin Invest" "fecha" => "1998" "volumen" => "101" "paginaInicial" => "2.711" "paginaFinal" => "2.719" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9637723" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673600021401" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0260" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells: elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase activity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Rosenkranz-Weiss" 1 => "W.C. Sessa" 2 => "S. Milstein" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI117293" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1994" "volumen" => "93" "paginaInicial" => "2.236" "paginaFinal" => "2.243" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8201015" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0265" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Bustos" 1 => "M.A. Hernández-Presa" 2 => "M. Ortego" 3 => "J. Tuñón" 4 => "L. Ortega" 5 => "F. Pérez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "JACC" "fecha" => "1998" "volumen" => "32" "paginaInicial" => "2.057" "paginaFinal" => "2.064" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9857861" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673605745050" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0270" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does superoxide underlie the pathogenesis of hypertension?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K. Nakazono" 1 => "N. Watanabe" 2 => "J. Matsuno" 3 => "J. Sasaki" 4 => "T. Sato" 5 => "M. Inoue" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci" "fecha" => "1991" "volumen" => "88" "paginaInicial" => "10.045" "paginaFinal" => "10.048" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1837151" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0275" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lovastatin inhibits low-density lipoproteins oxidation and alters its fluidity and uptake by macrophages: in vitro and in vivo studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Aviram" 1 => "G. Danker" 2 => "U. Cogan" 3 => "E. Hochgraf" 4 => "J.G. Brook" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Metabolism" "fecha" => "1992" "volumen" => "41" "paginaInicial" => "229" "paginaFinal" => "237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1542259" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0967586899901911" "estado" => "S300" "issn" => "09675868" ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0280" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Cachofeiro V, Navarro-Cid J, Vázquez-Pérez S, De las Heras N, Cediel E, Sanz-Rosa D, et al. Papel de las especies reactivas de oxígeno en la disfunción endotelial en conejos dislipémicos. Efecto del tratamiento con atorvastatina. Clin Invest Arteriosclerosis 2000 (en prensa)." ] ] ] 56 => array:3 [ "identificador" => "bib0285" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of atorvastatin treatment on endothelial dysfunction and vascular structural associated with dyslipidaemia in rabbits" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "V. Cachofeiro" 1 => "R. Maeso" 2 => "J. Navarro-Cid" 3 => "G. Hernández" 4 => "C. Díaz" 5 => "L.M. Ruilope" 6 => "V. Lahera" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/eht257" "Revista" => array:5 [ "tituloSerie" => "Eur Heart J" "fecha" => "1999" "volumen" => "20(suppl" "paginaInicial" => "186" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23882067" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0290" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Cachofeiro V, Maeso R, Navarro-Cid J, Hernández G, Díaz C" ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/18891837/0000001700000008/v1_201307261511/S1889183700710865/v1_201307261511/es/main.assets" "Apartado" => array:4 [ "identificador" => "9106" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Revisiones" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/18891837/0000001700000008/v1_201307261511/S1889183700710865/v1_201307261511/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1889183700710865?idApp=UINPBA00004N" ]
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