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Barrientos Guzmán, A.I. Sánchez Fructuoso" "autores" => array:2 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Barrientos Guzmán" ] 1 => array:2 [ "nombre" => "A.I." "apellidos" => "Sánchez Fructuoso" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1889183700710713?idApp=UINPBA00004N" "url" => "/18891837/0000001700000007/v1_201307261511/S1889183700710713/v1_201307261511/es/main.assets" ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Seguridad y efectividad de amlodipino en pacientes hipertensos no controlados farmacológicamente en el ámbito de Atención Primaria" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "296" "paginaFinal" => "301" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "A. Gil de Miguel, R. Jiménez García, P. Carrasco Garrido" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Gil de Miguel" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Jiménez García" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Carrasco Garrido" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Facultad de Ciencias de la Salud. Universidad Rey Juan Carlos" ] ] ] 1 => array:3 [ "autoresLista" => "J. Martínez González, I. Fernández González, J. Espejo Martínez" "autores" => array:3 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Martínez González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "I." "apellidos" => "Fernández González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Espejo Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "División Médica de Pfizer España. Madrid" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evaluar la seguridad de amlodipino en el tratamiento del paciente hipertenso no controlado con otros agentes hipotensores.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional, abierto, de cohortes, prospectivo, controlado, paralelo comparativo de farmacovigilancia. Se incluyeron 3.018 pacientes ambulatorios diagnosticados de hipertensión arterial grados I o II, según criterios del V Informe del JNC, y que no estaban controlados con su tratamiento farmacológico. El médico de Atención Primaria decidía en cada caso la asignación de un tratamiento de monoterapia con amlodipino o la administración del mismo en terapia combinada.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El 28,6 % de los pacientes alcanzaron el objetivo terapéutico óptimo. Descendieron significativamente los niveles medios de presión arterial sistólica y diastólica desde el inicio al final del estudio (p < 0,05). Un 5,9 % (157) de los pacientes presentaron acontecimientos adversos. No se mostraron diferencias estadísticamente significativas en cuanto a la frecuencia de acontecimientos adversos entre el grupo de monoterapia y el que recibió terapia combinada. La dosis de 5 mg consigue un control óptimo del 30 %, control que puede incrementarse en un 23,2 % adicional si se sube a 10 mg.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Amlodipino es un fármaco seguro y eficaz en el tratamiento de la hipertensión arterial en pacientes no controlados con otros fármacos hipotensores, tanto en monoterapia como en terapia combinada; el incremento de dosis no aumenta la frecuencia de acontecimientos adversos y amplía el porcentaje de pacientes controlados.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "por el Grupo Multicéntrico Encuesta de Actuaciones en Hipertensión Arterial. 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Seguridad y efectividad de amlodipino en pacientes hipertensos no controlados farmacológicamente en el ámbito de Atención Primaria