covid
Buscar en
Angiología
Toda la web
Inicio Angiología Fiabilidad de los tests diagnósticos no invasivos en la recurrencia de la tromb...
Información de la revista
Vol. 59. Núm. 2.
Páginas 155-172 (enero 2007)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 59. Núm. 2.
Páginas 155-172 (enero 2007)
Acceso a texto completo
Fiabilidad de los tests diagnósticos no invasivos en la recurrencia de la trombosis venosa profunda
The reliability of non-invasive diagnostic tests in recurring deep vein thrombosis
Visitas
2800
J.M. Fontcuberta-Garcíaa,
Autor para correspondencia
juanfontcuberta@telefonica.net

Correspondencia: Gran Vía de San Francisco, 8, esc. A, 1.° izq. E-28005 Madrid
, I. Leala, A. Flores-Herreroa, A. Orgaz Pérez-Gruesoa, M. Bermúdezb, J.M. Benitob, M. Doblas-Domíngueza
a Servicio de Angiología, Cirugía Vascular y Endovascular
b Laboratorio Vascular. Hospital Virgen de la Salud. Toledo, España
Este artículo ha recibido
Información del artículo
Resumen
Bibliografía
Descargar PDF
Estadísticas
Resumen
Introducción

Los síntomas y signos clínicos de la trombosis venosa profunda recurrente (TVPR) pueden ser muy anodinos, confundiéndose con la sintomatología producida por un síndrome postrombótico. Los errores diagnósticos tienen gran trascendencia, ya que los falsos positivos suponen realizar un tratamiento posiblemente indefinido con anticoagulantes, y los falsos negativos exponen al paciente a nuevos episodios de TVPR y/o a un embolismo pulmonar.

Desarrollo

En esta revisión se discutirán los mecanismos fisiopatológicos de la TVPR y se realizará una valoración de los diferentes tests diagnósticos y su fiabilidad.

Palabras clave:
Doppler
Flebografía
Síndrome postflebítico
Tromboflebitis
Trombosis venosa
Ultrasonografía
Summary
Introduction

The clinical signs and symptoms of recurring deep vein thrombosis (RDVT) can be very anodyne, and may easily be confused with the symptomatology produced by a post-thrombotic syndrome. Diagnostic errors have very important effects because false positives mean carrying out a possibly indefinite treatment with anticoagulant drugs and false negatives expose the patient to new episodes of RDVT and/or a pulmonary embolism.

Development

In this review the pathophysiological mechanisms of RDVT will be discussed and we will also evaluate the different diagnostic tests and their reliability.

Key words:
Doppler
Phlebography
Postphlebitic syndrome
Thrombophlebitis
Ultrasonography
Venous thrombosis
El Texto completo está disponible en PDF
Bibliografía
[1.]
Koopman M.M., Buller H.R., Ten Cate J.W..
Diagnosis of recurrent deep vein thrombosis.
Haemostasis, 25 (1995), pp. 49-57
[2.]
Büller H.R., Lensing A.W.A., Hirsh J., Ten Cate J.W..
Deep vein thrombosis: new noninvasive diagnostic tests.
Thromb Haemost, 66 (1991), pp. 133-137
[3.]
Hull R.D., Carter C.J., Jay R.M., Ockelford P.A., Hirsch J., Turpie A.G., et al.
The diagnosis of acute, recurrent, deep-vein thrombosis: a diagnostic challenge.
Circulation, 67 (1983), pp. 901-906
[4.]
Meissner M.H., Caps M.T., Bergelin R.O., Manzo R.A., Strandness E..
Propagation, rethrombosis and new thrombus formation after acute deep venous thrombosis.
J Vasc Surg., 22 (1995), pp. 558-567
[5.]
Prandoni P., Lensing A.W.A., Cogo A., Cuppini S., Villalta S., Carta M., et al.
The long-term clinical course of acute deep venous thrombosis.
Ann Intern Med., 125 (1996), pp. 1-7
[6.]
Douketis J.D., Kearon C.B., Bates S., Duku E., Ginsberg J.S..
The risk of fatal pulmonary embolism in patients with treated venous thromboembolism.
JAMA, 279 (1998), pp. 458-462
[7.]
Prandoni P., Lensing A.W.A., Cogo R., Cuppini S., Villalta S., Carta M., et al.
The long-term clinical course of acute deep vein thrombosis.
[8.]
Heit J.A., Mohr D.N., Silverstein M.D., Petterson T.M., O'Fallon W.M., Melton LJ I.I.I..
Predictors of recurrence after deep vein thrombosis and pulmonary embolism: a population-based cohort study.
Arch Intern Med., 160 (2000), pp. 761-768
[9.]
Schulman S., Granqvist S., Holmstrom M., Carlsson A., Lindmarker P., Nicol P., et al.
The duration of oral anticoagulant therapy after a second episode of venous thromboembolism.
N Engl J Med., 336 (1997), pp. 393-398
[10.]
Trujillo-Santos J., Herrera S., Page A., Soto J., Raventós A., Sánchez R., et al.
Predicting adverse outcome in outpatients with acute deep vein thrombosis. Findings from the RIETE registry.
J Vasc Surg., 44 (2006), pp. 789-793
[11.]
Christiansen S.C., Cannegieter S., Koster T., Vandenbroucke J.P., Rosendaal F.R..
Thrombophilia, clinical factors, and recurrent venous thrombotic events.
JAMA, 293 (2005), pp. 2352-2361
[12.]
De Stefano V., Simioni P., Rossi E., Tormene D., Za T., Pagnan A., et al.
The risk of recurrent venous thromboembolism in patients with inherited deficiency of natural anticoagulants antithrombin, protein C, and protein S.
Haematologica, 91 (2006), pp. 695
[13.]
Asherson R.A., Bagulay E., Pal C., Hughes G.R..
Antiphospholipid syndrome: five year follow-up.
Ann Rheum Dis, 50 (1991), pp. 805-810
[14.]
Long A.A., Ginsgerg J.S., Brill-Edwards P., Johnston M., Turner C., Denburg J.A., et al.
The relation of antiphosphoplipid antibodies to thromboembolic disease in systemic lupus erythematosus:A cross-sectional study.
Thromb Haemost, 66 (1991), pp. 520-524
[15.]
Rosolve M.H., Brewer P.M.C..
Antiphospholipid thrombosis: clinical course after the first thrombolic event in 70 patients.
Ann Intern Med., 117 (1992), pp. 303-308
[16.]
Derksen R.H.W.M., De Groot P.H.G., Kater L..
Patients with antiphospholipid antibodies and venous thrombosis should receive long-term anticoagulant treatment.
Ann Rheum Dis, 52 (1993), pp. 689-692
[17.]
Viana J.L., Khamashta M.A., Ordi-Ros J., Font J., Cervera R., López-Soto A., et al.
Comparison of the primary and secondary antiphospholipid syndrome: a European multicenter study in 114 patients.
Am J Med., 96 (1994), pp. 3-9
[18.]
Khamashta M.A., Cuadrado M.J., Mujic F..
The management of thrombosis in antiphospholipid antibodies syndrome.
N Engl J Med., 332 (1995), pp. 993-997
[19.]
Rickles F.R., Edwards L.E..
Activation of blood coagulation in cancer: Trousseau's syndrome revisited.
Blood, 62 (1983), pp. 14-31
[20.]
Prandoni P., Lensing A.W.A., Piccioli A., Bernardi E., Simioni P., Girolami B., et al.
Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis.
Blood, 100 (2002), pp. 3484-3488
[21.]
Prandoni P..
Risk factors of recurrent venous thromboembolism: the role of residual vein thrombosis.
Pathophysiol Haemost Thromb 2003, 33 (2004), pp. 351-353
[22.]
Hansson P.O., Sorbo J., Eriksson H..
Recurrent venous thromboembolism after deep vein thrombosis. Incidence and risk factors.
Arch Intern Med., 1260 (2000), pp. 769-774
[23.]
Anderson F.A. Jr, Wheeler H.B., Goldberg R.J., Hosmer D.W., Patwardhan N.A., Jovanovic B., et al.
A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT study.
Arch Intern Med., 151 (1991), pp. 933-938
[24.]
Prandoni P., Lensing A.W.A., Büller H.R..
Comparison of subcutaneous low molecular weight heparin with intravenous stan- dard heparin in proximal deep vein thrombosis.
Lancet, 339 (1992), pp. 441-445
[25.]
Hull R., Raskob G.E., Pineo G.F..
Subcutaneous low molecular weight heparin compared with continuous intravenous heparin in the treatment of proximal vein thrombosis.
N Engl J Med., 326 (1992), pp. 975-982
[26.]
Hull R., Delmore T., Genton E..
Warfarin sodium versus low-dose heparin in the long-term treatment of venous thrombosis.
N Engl J Med., 301 (1979), pp. 855-858
[27.]
Hull R., Delmore T., Carter C..
Adjusted subcutaneous heparin versus warfarin sodium in the long-term treatment of venous thrombosis.
N Engl J Med., 306 (1982), pp. 189-194
[28.]
Fink A.M., Mayer W., Steiner A..
Extent of thrombus evaluated in patients with recurrent and first deep vein thrombosis.
J Vasc Surg., 36 (2002), pp. 357-360
[29.]
Douketis J.D., Crowther M.A., Foster G.A., Ginsberg J.S..
Does the location of thrombosis determine the risk of disease recurrence in patients with proximal deep vein thrombosis?.
Am J Med., 110 (2001), pp. 515-519
[30.]
Lensing A.W., Prandoni P., Brandjes D.P.M..
Detection of deep-vein thrombosis by real-time B-mode ultrasonography.
N Engl J Med., 320 (1989), pp. 342-345
[31.]
Heijboer H., Buller H.R., Lensing A.W.A., Turpie A.G.G., Colly L.P., Ten Cate J.W..
A comparison of real-time compression ultrasonography with impedance plethysmography for the diagnosis of deep-vein thrombosis in symptomatic outpatients.
N Engl J Med., 329 (1993), pp. 1365-1369
[32.]
Anand S.S., Wells P.S., Hunt D., Brill-Edwards P., Cook D., Ginsberg J.S..
Does this patient have deep vein thrombosis?.
JAMA, 279 (1998), pp. 1094-1099
[33.]
Rabinov K., Paulin S..
Roentgen diagnosis of venous thrombosis in the leg.
Arch Surg., 104 (1972), pp. 134-144
[34.]
Kahn S.R., Joseph L., Grover S.A., Leclerc J.R..
A randomized management study of impedance plethysmography vs contrast venography in patients with a first episode of clinically suspected deep vein thrombosis.
Thromb Res, 102 (2001), pp. 15-24
[35.]
Fraser D.G., Moody A.R., Morgan P.S., Martel A.L., Davidson I..
Diagnosis of lower-limb deep venous thrombosis: a prospective blinded study of magnetic resonance direct thrombus imaging.
Ann Intern Med., 136 (2002), pp. 89-98
[36.]
Couson F., Bounameaux C., Didier D., Geiser D., Meyerovitz M.F., Schmitt H.E., et al.
Influence of variability of interpretation of contrast venography for screening of postoperative deep venous thrombosis on the results of a thromboprophylactic study.
Thromb Haemost, 70 (1993), pp. 573-575
[37.]
Illescas F.F., Lerclerc J., Rosenthall L., Wolfson C., Rush C., Herba M.J., et al.
Interobserver variability in the interpretation of contrast venography, technetium-99m red blood cell venography and impedance plethysmography for deep vein thrombosis.
Can Assoc Radiol J., 41 (1990), pp. 264-269
[38.]
Coel M.N..
Adequacy of lower limb venous opacification: comparison of supine and upright phlebography.
AJR Am J Roentgenol., 134 (1980), pp. 163-165
[39.]
Rabinov K., Paulin S..
Roentgen diagnosis of venous thrombosis in the leg.
Arch Surg., 104 (1972), pp. 134-144
[40.]
Huisman M.V., Büller H.R., Ten Cate J.W..
Serial impedance plethysmography for suspected deep venous thrombosis in outpatients. The Amsterdam General Practitioner Study.
N Engl J Med., 314 (1986), pp. 823-828
[41.]
Bates S.M., Lister-James J., Julian J.A., Taillefer R., Moyer B.R., Ginsberg J.S..
Imaging characteristics of a novel technetium Tc 99m-labeled platelet glycoprotein IIb/IIIa receptor antagonist in patients with acute deep vein thrombosis or a history of deep vein thrombosis.
Arch Intern Med., 163 (2003), pp. 452-456
[42.]
Bosson J.L., Barro C., Satger B., Carpentier P.H., Polack B., Pernod G..
Quantitative high D-dimer value is predictive of pulmonary embolism occurrence independently of clinical score in a well-defined low risk factor population.
J Thromb Haemost, 3 (2005), pp. 93-99
[43.]
Bosson J.L., Labarere J., Sevestre M.A..
Deep vein thrombosis in elderly patients hospitalized in subacute care facilities. A multicenter cross-sectional study of risk factors, prophylaxis and prevalence.
Arch Intern Med., 163 (2003), pp. 2613-2618
[44.]
Righini M., Goehring C., Bounameaux H., Perrier A..
Effects of age on the performance of common diagnostic tests for pulmonary embolism.
Am J Med., 109 (2000), pp. 357-361
[45.]
Kovacs M.J., MacKinnon K.M., Anderson D.R..
A comparison of three rapid D-dimer methods for the diagnosis of venous thromboembolism.
Br J Haematol, 115 (2001), pp. 140-144
[46.]
Heim S.W., Schectman J.M., Siadaty M.S., Philbrick J.T..
D-dimer testing for deep venous thrombosis: a metaanalysis.
Clin Chem, 50 (2004), pp. 1136-1147
[47.]
Sie P., Cadroy Y., Elias A., Boccalon H., Boneu B..
D-dimer levels in patients with long-term antecedents of deep venous thrombosis.
Thromb Haemost, 72 (1994), pp. 161-162
[48.]
D'Angelo A., D'Alessandro G., Tomassini L., Pittet J.L., Dupuy G., Crippa L..
Evaluation of a new rapid quantitative D-dimer assay in patients with clinically suspected deep vein thrombosis.
Thromb Haemost, 75 (1996), pp. 412-416
[49.]
Bernardi E., Prandoni P., Lensing A.W., Agnelli G., Guazzaloca G., Scannapieco G., et al.
D-dimer testing as an adjunct to ultrasonography in patients with clinically suspected deep vein thrombosis: prospective cohort study. The Multicentre Italian D-dimer Ultrasound Study Investigators Group.
BMJ, 317 (1998), pp. 1037-1040
[50.]
Perrier A., Desmarais S., Miron M.J., de Moerloose P., Lepage R., Slosman D., et al.
Non-invasive diagnosis of venous thromboembolism in outpatients.
[51.]
Bates S.M., Kearon C., Crowther M., Linkins L., O'Donnell M., Douketis J., et al.
A diagnostic strategy involving a quantitative latex D-dimer assay reliably excludes deep venous thrombosis.
Ann Intern Med., 138 (2003), pp. 787-794
[52.]
Rathbun S.W., Whitsett T.L., Raskob G.E..
Negative D-dimer result to exclude recurrent deep venous thrombosis: a management trial.
Ann Intern Med., 141 (2004), pp. 839-845
[53.]
Van der Graaf F., Van den Borne H., Van der Kolk M., De Wild P.J., Janssen G.W., Van Uum S.H..
Exclusion of deep venous thrombosis with D-dimer testingcomparison of 13 D-dimer methods in 99 outpatients suspected of deep venous thrombosis using venography as reference standard.
Thromb Haemost, 83 (2000), pp. 191-198
[54.]
Oger E., Leroyer C., Bressollette L., Nonent M., Le Moigne E., Bizais Y., et al.
Evaluation of a new, rapid, and quantitative D-Dimer test in patients with suspected pulmonary embolism.
Am J Respir Crit Care Med., 158 (1998), pp. 65-70
[55.]
Kearon C., Julian J.A., Newman T.E., Ginsberg J.S..
Noninvasive diagnosis of deep venous thrombosis. McMaster diagnostic imaging practice guidelines initiative.
Ann Inter Med., 128 (1998), pp. 663-677
[56.]
Blaivas M., Lambert M.J., Harwood R.A., Wood J.P., Konicki J..
Lower-extremity Doppler for deep venous thrombosis –can emergency physicians be accurate and fast?.
Acad Emerg Med., 7 (2000), pp. 120-126
[57.]
Atri M., Herba M.J., Reinhold C., Leclerc J., Ye S., Illescas F.F., et al.
Accuracy of sonography in the evaluation of calf deep vein thrombosis in both postoperative surveillance and symptomatic patients.
AJR Am J Roentgenol., 166 (1996), pp. 1361-1367
[58.]
Levine M.N., Hirsh J., Gent M..
Optimal duration of oral anticoagulant therapy: a randomized trial comparing four weeks with three months of warfarin in patients with deep vein thrombosis [abstract].
Thromb Haemost, 69 (1993), pp. 982
[59.]
Heijboer H., Jongbloets L.M.M., Büller H.R., Lensing A.W.A., Ten Cate J.W..
The clinical utility of real-time compression ultraso-nography in the diagnostic management of patients with recurrent venous thrombosis.
Acta Radiol Scand, 33 (1992), pp. 297-300
[60.]
Murphy T.P., Cronan J.J..
Evolution of deep venous thrombosis: a prospective evaluation with US.
Radiology, 177 (1990), pp. 543-548
[61.]
Koopman M.M.W., Jongbloets L.M.M., Lensing A.W.A., Büller H.R., Ten Cate J.W..
Clinical utility of a quantitative B-mode ultraso-nography method in patients with suspected recurrent deep vein thrombosis [abstract].
Thromb Haemost, 69 (1993), pp. 623
[62.]
Prandoni P., Cogo A., Bernardi E., Villalta S., Polistena P., Simioni P., et al.
A simple ultrasound approach for detection of recurrent proximalvein thrombosis.
Circulation, 88 (1993), pp. 1730-1735
[63.]
Cogo A., Lensing A.W.A., Koopman M.M.W., Piovella F., Siragusa S., Wells P.S., et al.
Compression ultrasonography for diagnostic management of patients with clinically suspected deep vein thrombosis: prospective cohort study.
BMJ, 316 (1998), pp. 17-20
[64.]
Caprini J.A., Arcelus J.I., Hoffman K.N., Size G., Laubach M., Traverso C.I., et al.
Venous duplex imaging follow up of acute symptomatic deep vein thrombosis of the leg.
J Vasc Surg., 21 (1995), pp. 472-476
[65.]
Rosfors S., Eriksson M., Leijd B., Nordstrom B..
A prospective follow up study of acute deep venous thrombosis using color duplex ultrasound, phlebography and venous occlusion plethysmography.
Int Angiol., 16 (1997), pp. 39-44
[66.]
Cronan J.J., Leen V..
Recurrent deep vein thrombosis. Limitations of US.
Radiology, 170 (1989), pp. 739-742
[67.]
Lim A.C., Roth E.J., Green D..
Lower limb paralysis: its effect on the recanalization of deep-vein thrombosis.
Arch Phys Med Rehabil, 73 (1992), pp. 331-333
[68.]
Mantoni M..
Deep venous thrombosis. Longitudinal study with duplex US.
Radiology, 179 (1991), pp. 271-273
[69.]
Johnson B.F., Manzo R.A., Bergelin R.O., Strandness D.E. Jr.
Relationship between changes in the deep venous system and the development of the postthrombotic syndrome after an acute episode of lower limb deep vein thrombosis: a one- to six-year follow-up.
J Vasc Surg., 21 (1995), pp. 307-312
[70.]
Franzeck U.K., Schalch I., Jager K.A., Schneider E., Grimm J., Bollinger A..
Prospective 12-year follow-up study of clinical and hemodynamic sequelae after deep vein thrombosis in low-risk patients (Zurich study).
Circulation, 93 (1996), pp. 74-79
[71.]
Franzeck U.K., Schalch I., Bollinger A..
On the relationship between changes in the deep veins evaluated by duplex sonography and the postthrombotic syndrome 12 years after deep vein thrombosis.
Thromb Haemost, 77 (1997), pp. 1109-1112
[72.]
Baud J.M., Stephas L., Ribadeau-Dumas C., Louvet D., Lemasle P., Bosson J.L., et al.
Short- and medium-term duplex sonography follow-up of deep venous thrombosis of the lower limbs.
J Clin Ultrasound, 26 (1998), pp. 7-13
[73.]
Van Ramshorst B., Van Bemmelen P.S., Hoeneveld H., Faber J.A., Eikelboom B.C..
Thrombus regression in deep venous thrombosis. Quantification of spontaneous thrombolysis with duplex scanning.
Circulation, 86 (1992), pp. 414-419
[74.]
Piovella F., Crippa L., Barone M., D'Angelo S., Serafini S., Galli L., et al.
Normalization rates of compression ultrasonography in patients with a first episode of deep vein thrombosis of the lower limbs: association with DVT recurrence and new thrombosis.
Haematologica, 87 (2002), pp. 515-522
[75.]
Birdwell B.G., Raskob G.E., Whitsett T.L., Durica S.S., Comp P.C., George J., et al.
Predictive value of compression ultrasonography for deep vein thrombosis in symptomatic outpatients.
Ann Intern Med., 160 (2000), pp. 309-313
[76.]
Wells P.S., Anderson D.R., Bormanis J., Guy F., Mitchell M., Gray L., et al.
Value of assessment of pretest probability of deep-vein thrombosis in clinical management.
Lancet, 350 (1997), pp. 1795-1798
[77.]
Kraaijenhagen R.A., Piovella F., Bernardi E., Verlato F., Beckers E.A., Koopman M.M., et al.
Simplification of the diagnostic management of suspected deep vein thrombosis.
Arch Intern Med., 162 (2002), pp. 907-911
[78.]
Elias A., Maillard L., Elias M., Alquier C., Guidolin F., Gauthier B., et al.
A single complete ultrasound investigation of the venous network for the diagnostic management of patients with a clinically suspected first episode of deep venous thrombosis of the lower limbs.
Thromb Haemost, 89 (2003), pp. 221-227
[79.]
Schellong S.M., Schwarz T., Halbritter K., Beyer J., Oettler W., Schmidt B., et al.
Complete compression ultrasonography of the leg veins as a single test for the diagnosis of deep vein thrombosis.
Thromb Haemost, 89 (2003), pp. 228-234
[80.]
Wells P.S..
Advances in the diagnosis of venous thromboembolism.
J Thromb Thrombolysis, 21 (2006), pp. 31-40
[81.]
Wells P.S., Lensing A.W.A., Davidson B.L., Prins M.H., Hirsh J..
Accuracy of ultrasound for the diagnosis of deep venous thrombosis in asymptomatic patients after orthopedic surgery. A meta-analysis.
Ann Intern Med., 122 (1995), pp. 47-53
[82.]
Perone N., Bounameaux H., Perrier A..
Comparison of four strategies for diagnosing deep vein thrombosis: a cost-effectiveness analysis.
Am J Med., 110 (2000), pp. 33-40
[83.]
Hillner B.E., Philbrick J.T., Becker D.M..
Optimal management of suspected lower-extremity deep vein thrombosis. An evaluation with cost assessment of 24 management strategies.
Arch Intern Med., 152 (1992), pp. 165-175
[84.]
Stevens S.M., Elliot C.G., Chan K.J., Egger M.J., Ahmed K.M..
Withholding anticoagulation after a negative result on duplex ultrasonography for suspected symptomatic deep venous thrombosis.
Ann Intern Med., 140 (2004), pp. 985-991
[85.]
Kearon C., Ginsberg J.S., Douketis J., Crowther M., Brill-Edwards P., Weitz J.I., et al.
Management of suspected deep venous thrombosis in outpatients by using clinical assessment and D-dimer testing.
Ann Intern Med., 135 (2001), pp. 108-111
[86.]
Schutgens R.E., Ackermark P., Haas F.J., Nieuwenhuis H.K., Peltenburg H.G., Pijlman A.H., et al.
Combination of a normal d-dimer concentration and a non-high pretest clinical probability score is a safe strategy to exclude deep venous thrombosis.
Circulation, 107 (2003), pp. 593-597
[87.]
Wells P.S., Anderson D.R., Rodger M., Forgie M., Kearon C., Dreyer J., et al.
Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis.
N Engl J Med., 349 (2003), pp. 1227-1235
[88.]
Hirsh J., Lee A.Y.Y..
How we diagnose and treat deep vein thrombosis.
Blood, 99 (2002), pp. 3102-3110
[89.]
Keeling D.M., Mackie I.J., Moody A., Watson H.G., The Haemostasis and Thrombosis Task Force of British Committee for Standards in Haematology.
The diagnosis of deep vein thrombosis in symptomatic outpatients and the potential for clinical assessment and D-dimer assays to reduce the need for diagnostic imaging.
Br J Haematol, 124 (2004), pp. 15-25
[90.]
Sampson F.C., Goodacre S.W., Thomas S.M., Van Beek E.J.R..
The accuracy of MRI in diagnosis of suspected deep vein thrombosis: systematic review and meta-analysis.
Eur Radiol., 17 (2007), pp. 175-181
[91.]
Downing L.J., Strieter R.M., Kadall A.M., Wilke C.A., Brown S.L., Wrobleski S.K..
Neutrophils are the initial cell type identified in deep venous thrombosis induced wall inflammation.
ASAIO J., 42 (1996), pp. 677-682
[92.]
Wakefield T.W., Greenfield L.F., Rolfe M.W., DeLucia A I.I.I., Strieter R.M., Abrams G.D., et al.
Inflammatory and procoagulant mediator interactions in an experimental baboon model of venous thrombosis.
Thromb Haemost, 69 (1993), pp. 164-172
[93.]
Froehlich J.B., Prince M.R., Greenfield L.J.D., Downing J., Shah N.L., Wakefield T.W..
‘Bull's eye' sign on gadolinium enhanced magnetic resonance venography determines thrombus presence and age: a preliminary study.
J Vasc Surg., 26 (1997), pp. 809-816
[94.]
Rubin J.M., Xie H., Kim K..
Sonographic elasticity imaging of acute and chronic deep venous thrombosis in humans.
J Ultrasound Med., 25 (2006), pp. 1179-1186
[95.]
Xie H., Kim K., Aglyamov S.R., Emelianov S.Y., O'Donnell M., Weitzel W.F., et al.
Mechanical measurement in aging DVT in rats.
Ultrasound Med Biol., 31 (2005), pp. 1351-1359
[96.]
Rubin J.M., Aglyamov S.R., Wakefield T.W., O'Donnell M., Emelianov S.Y..
Clinical application of sonographic elasticity imaging for aging of deep venous thrombosis.
J Ultrasound Med., 22 (2003), pp. 443-448
Copyright © 2007. SEACV
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos