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Inicio Vacunas (English Edition) Third booster vaccination and stopping the Omicron, a new variant of concern
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Vol. 23. Issue S2.
COVID 19 & vaccines: Development and practice
Pages S103-S110 (September - December 2022)
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Vol. 23. Issue S2.
COVID 19 & vaccines: Development and practice
Pages S103-S110 (September - December 2022)
Review article
Third booster vaccination and stopping the Omicron, a new variant of concern
Tercera vacuna de recuerdo y freno de ómicron, una nueva variante preocupante
Kiarash Ghazvinia,b,1, Mohsen Karbalaeic,1, Masoud Keikhaa,b,
Corresponding author
masoud.keykha90@gmail.com

Corresponding author at: Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
a Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
b Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
c Department of Microbiology and Virology, Faculty of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran
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Table 1. Characteristics of included studies.
Special issue
This article is part of special issue:
Vol. 23. Issue S2

COVID 19 & vaccines: Development and practice

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Abstract

The SARS-CoV-2 omicron variant is recent member of variant of concerns that confer neutralizing antibodies and escape immune system due to harboring more than 40 mutations. Current evidences suggest two dosages SARS-CoV-2 vaccine dose not efficient protects against new variants of SARS-CoV-2; however, recent studies declare that the third booster vaccination can elicit higher antibodies concentration as well as cross-reaction between neutralizing antibodies and new SARS-CoV-2 variants. On the other hand, although a third booster vaccination seems to be benefit in some immunocompromised patients such as recipients of solid-organ transplants or hemodialysis patients, but in other immunosuppressed patients, for instance patients with B cell lymphoproliferative disease partially respond to SARS-CoV-2. Herein, we evaluate the effectiveness of the third booster vaccination against Omicron variant using comprehensive literature review.

Keywords:
SARS-CoV-2
COVID-19
Omicron
Vaccine
Resumen

La variante ómicron de SARS-CoV-2 es un miembro reciente de variantes preocupantes, que confiere anticuerpos neutralizantes y escapa al sistema inmune debido a que alberga más de 40 mutaciones. Las evidencias actuales sugieren que dos dosis de la vacuna contra la SARS-CoV-2 no protegen eficientemente frente a las nuevas variantes de SARS-CoV-2. Sin embargo, los estudios recientes afirman que la tercera vacuna de refuerzo puede suscitar una mayor concentración de anticuerpos, así como una reacción cruzada entre los anticuerpos neutralizantes y las nuevas variantes de SARS-CoV-2. Por otro lado, aunque la tercera vacuna de refuerzo parece ser beneficiosa para algunos pacientes inmunocomprometidos, tales como los receptores de trasplantes de órganos sólidos, o los pacientes de hemodiálisis, otros pacientes inmunosuprimidos, como por ejemplo los pacientes con enfermedad linfoproliferativa de células B, responden parcialmente a la SARS-CoV-2. Por tanto, evaluamos la efectividad de la tercera vacuna de refuerzo frente a la variante ómicron, utilizando una revisión amplia de la literatura.

Palabras clave:
SARS-CoV-2
COVID-19
Ómicron
Vacuna

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