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Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Unusual presentation of sarcoid-like reaction on bone marrow level associated wi...
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Vol. 31. Issue 4.
Pages 207-209 (July - August 2012)
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Vol. 31. Issue 4.
Pages 207-209 (July - August 2012)
Clinical note
Unusual presentation of sarcoid-like reaction on bone marrow level associated with mediastinal lymphadenopathy on 18F-FDG-PET/CT resembling an early recurrence of Hodgkin's Lymphoma
Presentación inusual de reacción sarcoidea en médula ósea asociada a adenopatía mediastínica en estudio PET-TAC con 18F-FDG simulando recidiva precoz de Linfoma de Hodgkin
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F. Fallancaa, M. Picchioa,b, C. Crivellaroc, P. Mapellic,
Corresponding author
mapelli.paola@gmail.com

Corresponding author.
, A.M. Samanes Gajatea, E. Sabattinid, L. Gianollia, C. Messab,c,e
a Nuclear Medicine Department, San Raffaele Scientific Institute, Milan, Italy
b Institute for Bioimaging and Molecular Physiology, National Research Council, Milan, Italy
c Center for Molecular Bioimaging, University of Milano-Bicocca, Milan, Italy
d Unit of Haematopathology, Department of Haematology and Oncological Sciences “L. & A. Seràgnoli”, Bologna University, Policlinico S. Orsola, Bologna, Italy
e Nuclear Medicine Department, San Gerardo Hospital, Monza, Italy
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Abstract

18F-FDG-PET/CT is widely employed to evaluate lymphoma patients. False positive results are quite frequent, generally due to active phase of inflammation. We describe an unusual PET/CT presentation of a sarcoid-like reaction (SLR) in a patient monitored for Hodgkin Lymphoma characterized by an intense uptake in lymph nodes and multiple bone foci in a PET/CT study. The final diagnosis was obtained by biopsy. This study draws attention to the fact that multifocal bone marrow uptakes due to a sarcoideal reaction may be a possible cause of false positive results in 18F-FDG-PET/CT studies in oncology patients.

Keywords:
Positron emission tomography
18F-fluorodeoxyglucose
Hodgkin's disease
Sarcoid-like reaction
False positive
Resumen

La PET-TAC con 18F-FDG se usa habitualmente en la evaluación de pacientes con linfoma. Son frecuentes los falsos positivos, generalmente debidos a inflamación en fase activa. Describimos una presentación inusual de una reacción sarcoidea, caracterizada por una captación intensa en ganglios y en múltiples huesos, en un estudio PET en paciente en seguimiento por linfoma de Hodgkin. El diagnóstico final se obtuvo mediante biopsia. Este trabajo hace notar que captaciones múltiples óseas debidas a reacción sarcoidea pueden ser una posible causa de resultado falso positivo en estudios PET en pacientes oncológicos.

Palabras clave:
Tomografia por emisión de positrones
18F-fuorodesoxiglucosa
linfoma de Hodgkin
reacción sarcoidea
falso positivo

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