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Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Complete hormonal and metabolic response after iodine-131 metaiodobenzylguanidin...
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Vol. 32. Issue 6.
Pages 390-393 (November - December 2013)
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Vol. 32. Issue 6.
Pages 390-393 (November - December 2013)
Clinical note
Complete hormonal and metabolic response after iodine-131 metaiodobenzylguanidine treatment in a patient diagnosed of malignant pheochromocytoma
Respuesta hormonal y metabólica completa tras el tratamiento con yodo-131 metayodobencilguanidina en un caso de feocromocitoma maligno
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M.P. García Alonso
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pilargarciaalonso@yahoo.es

Corresponding author.
, M.A. Balsa Bretón, C. Paniagua Correa, L. Castillejos Rodríguez, E. Rodríguez Pelayo, A. Mendoza Paulini, A. Ortega Valle, J. Penín González
Servicio de Medicina Nuclear, Hospital Universitario de Getafe, Getafe, Madrid, Spain
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Table 1. Analytical evolution along the disease.
Abstract

Radiolabeled metaiodobenzylguanidine is an analog of norepinephrine used to localize tumors that express the neurohormone transporters, specifically those derived from the neural crest having a neuroendocrine origin. It is also used to treat non-surgical metastases derived from them. A review of the literature revealed symptomatic improvements associated to a decrease in hormone levels in a significant percentage of patients after 131I-MIBG treatment. However, complete tumor remission has been described only in very few cases and hardly ever when bone metastases exist.

We present a case of a patient diagnosed of malignant pheochromocytoma who achieved complete hormonal and metabolic response after 131I-MIBG treatment (600mCi) in spite of the presence of bone metastases.

Keywords:
Malignant pheochromocytoma
Treatment
Metaiodobenzylguanidine
Resumen

La metayodobencilguanidina radiomarcada es un análogo de la norepinefrina que se utiliza en la localización de tumores que expresan transportadores de dicha neurohormona, especialmente los derivados de la cresta neural y de origen neuroendocrino, y en el tratamiento de sus metástasis cuando estas no son quirúrgicas. En la literatura revisada se encuentran mejorías sintomáticas, asociadas a un descenso de los niveles hormonales, en un porcentaje no despreciable de casos tras el tratamiento con 131I-MIBG. Sin embargo, la remisión tumoral completa se ha descrito en muy pocas ocasiones y casi nunca en presencia de metástasis óseas.

Presentamos un caso de feocromocitoma maligno que tras el tratamiento con 131I-MIBG (600mCi) alcanzó una respuesta hormonal y metabólica completa a pesar de la existencia de metástasis óseas.

Palabras clave:
Feocromocitoma maligno
Tratamiento
Metayodobencilguanidina

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