metricas
covid
Buscar en
Cirugía Española (English Edition)
Toda la web
Inicio Cirugía Española (English Edition) Current Use of Molecular Profiling for Indeterminate Thyroid Nodules
Journal Information
Share
Share
Download PDF
More article options
Visits
3000
Review article
Current Use of Molecular Profiling for Indeterminate Thyroid Nodules
Utilidad del estudio molecular de nódulos tiroideos con citología indeterminada
Visits
3000
Irene López Rojoa,
Corresponding author
irene.lrojo@quironsalud.es

Corresponding author.
, Adela Gómez Valdazoa, Joaquín Gómez Ramirezb
a Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
b Hospital Universitario Ramón y Cajal, Madrid, Spain
This item has received
Received 25 February 2018. Accepted 18 April 2018
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Tables (1)
Table 1. Comparison of Main Characteristics of the Molecular Panels Available.
Abstract

Even though cytology remains the gold standard to assess the nature of thyroid nodules, up to 30% of the results are indeterminate (Bethesda III and IV). In these cases, current guidelines recommend performing diagnostic surgery, which proves malignancy in only 15%–30% of cases. A more precise method is needed to avoid unnecessary surgeries, surgical complications and costs in the process of diagnosing indeterminate nodules. Complementary use of molecular profiling tests seems to help in this complex scenario. We present a review of the current literature on the usefulness of molecular profiling of thyroid nodules so as to define its indications, costs and usability for clinical practice.

Keywords:
Molecular diagnosis
Bethesda III
Bethesda IV
Indeterminate cytology
Thyroid nodule
Afirma test
Thyroseq test
Resumen

El análisis citológico tiene un papel fundamental en el estudio de los nódulos tiroideos. Sin embargo, hasta un 30% de estos muestran citologías indeterminadas (BethesdaIII o IV). En estos casos, se realizan cirugías diagnósticas que únicamente demuestran malignidad en un 15–35% de los pacientes. Se precisa una herramienta de mayor precisión para determinar la benignidad o malignidad del nódulo tiroideo con citología indeterminada sin precisar cirugías diagnósticas, evitando así posibles complicaciones y/o costes innecesarios. El uso complementario de paneles moleculares junto con la citología ha sido, de momento, la única herramienta que parece ayudar en este difícil escenario. Se realiza una revisión de la bibliografía sobre el estudio molecular complementario de los nódulos tiroideos para tratar de resumir las características intrínsecas de cada uno de los test disponibles, su coste-efectividad, y determinar sus indicaciones y su aplicabilidad en la práctica clínica habitual.

Palabras clave:
Diagnóstico molecular
Bethesda III
Bethesda IV
Citología indeterminada
Nódulo tiroideo
Afirma
Thyroseq

Article

These are the options to access the full texts of the publication Cirugía Española (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Cirugía Española (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos