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Allergologia et Immunopathologia
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Inicio Allergologia et Immunopathologia Farnesol, a sesquiterpene alcohol in essential oils, ameliorates serum allergic ...
Journal Information
Vol. 44. Num. 2.March - April 2016
Pages 97-188
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Vol. 44. Num. 2.March - April 2016
Pages 97-188
Original Article
DOI: 10.1016/j.aller.2015.05.009
Farnesol, a sesquiterpene alcohol in essential oils, ameliorates serum allergic antibody titres and lipid profiles in ovalbumin-challenged mice
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C.-M. Ku, J.-Y. Lin
Corresponding author
jinlin@nchu.edu.tw

Corresponding author.
Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuokuang Road, Taichung 40227, Taiwan, ROC
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Tables (6)
Table 1. Effects of farnesol supplementation with different doses for 5 weeks on serum farnesol concentrations of OVA/AL-sensitised and challenged BALB/c asthmatic mice.
Table 2. Effects of farnesol supplementation with different doses for 5 weeks on serum OVA-specific IgG1, IgG2a as well as IgE antibody titres of OVA/AL-sensitised and challenged BALB/c asthmatic mice.
Table 3. Effects of farnesol supplementation with different doses for 5 weeks on serum non-specific IgE, IgA, IgM, and IgG antibody titres of OVA/AL-sensitised and challenged BALB/c asthmatic mice.
Table 4. Effects of farnesol supplementation with different doses for 5 weeks on serum lipid profiles of OVA/AL-sensitised and challenged BALB/c asthmatic mice.
Table 5. Effects of farnesol supplementation with different doses for 5 weeks on total cell number and differential cell distribution in BALF from OVA/AL-sensitised and challenged BALB/c asthmatic mice.
Table 6. Effects of farnesol supplementation with different doses for 5 weeks on Th1/Th2 cytokine levels in BALF from OVA/AL-sensitised and challenged BALB/c asthmatic mice.
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Abstract
Background

Farnesol, a natural sesquiterpene alcohol in essential oils, was found to have potential for alleviating massive inflammation, oxidative stress and lung injury. However, effects of farnesol supplementation on allergic asthma remain unclear.

Objectives

To clarify the puzzle, this work investigates the effects of farnesol on allergic asthma using an ovalbumin (OVA)-sensitised and challenged mouse model.

Methods

Farnesol was administered to OVA-sensitised and challenged mice for 5 weeks. Three farnesol doses, namely 5, 25 and 100mg farnesol/kg BW/day, non-sensitised control, dietary control, and positive control (dexamethasone 3mg/kg BW by gavage) were included. Sera and bronchoalveolar lavage fluids from the experimental mice were collected to measure farnesol concentrations, serum lipid profiles, antibody titres, differential cell counts or Th1/Th2 cytokines levels.

Results

The results showed that farnesol supplementation increased serum farnesol concentration dose-dependently, significantly increased (P<0.05) OVA-specific IgG2a/IgE antibody titre ratios, but decreased total IgE levels. Farnesol supplementation markedly reversed the aberrated LDL-c/HDL-c and HDL-c/TC ratios in the sera of asthmatic mice, suggesting that farnesol supplementation might ameliorate serum lipid profiles in the OVA-sensitised and challenged mice.

Conclusion

Our results evidenced that farnesol supplementation might improve serum allergic antibody titres and lipid profiles in asthmatic mice.

Keywords:
Allergic asthmatic inflammation
Farnesol
IgE
Serum lipid profiles
Sesquiterpene alcohol

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