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2016 FI

© Thomson Reuters, Journal Citation Reports, 2016

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  • Impact Factor: 1.439 (2016)
  • CiteScore 2017: 1.24
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  • SCImago Journal Rank (SJR):0,504
  • Source Normalized Impact per Paper (SNIP):0,791

© Thomson Reuters, Journal Citation Reports, 2017

Allergol Immunopathol (Madr) 2018;46:39-44 - DOI: 10.1016/j.aller.2017.03.005
Original Article
Correlation between serum vitamin D status and immunological changes in children affected by gastrointestinal food allergy
H. Guo1, Y. Zheng1, X. Cai, H. Yang, Y. Zhang, L. Hao, Y. Jin, G. Yang,
Gastroenterology Unit, Nanjing Children's Hospital Affiliated with Nanjing Medical University, 72 Guangzhou Road, Nanjing, Jiangsu 210008, China
Received 09 January 2017, Accepted 30 March 2017

Low vitamin D status is linked to increased incidence of food allergy and intestinal inflammation. Whether vitamin D status is associated with immunological changes in children with gastrointestinal food allergy (GFA) remains unclear.


Forty-nine GFA children (aged 2–11 years old) were enrolled in this study. Serum 25-hydroxyvitamin D (25OHD) level, total immunoglobulin E (IgE), specific IgE against allergens, circulating regulatory T lymphocytes (Tregs), and blood eosinophil numbers were measured.


Levels of serum 25OHD in the GFA children ranged 35.5–156.4nmol/L, with a mean value similar to that of the healthy controls. Compared to those with normal 25OHD (≥75nmol/L), GFA children with low 25OHD (<75nmol/L) had increased total IgE (84% vs. 54%, P<0.05), persistent blood eosinophilia (56% vs. 25%, P<0.05), and delayed resolution of symptoms after food allergen elimination (odds ratio 3.51, 95% CI 1.00–12.36, P<0.05). Among the GFA children with elevated total IgE, those with low 25OHD had lower circulatory Tregs (8.79±2.4% vs. 10.21±1.37%, P<0.05), higher total IgE (1197.5±1209.8 vs. 418.5±304.6kU/L, P<0.05), and persistent eosinophilia (0.61±0.52 vs. 0.31±0.15×109cells/L, P<0.05) compared to those with normal 25OHD. In addition, serum 25OHD concentrations inversely correlated with total IgE (R=−0.434, P<0.05), and positively with Treg population (R=0.356, P<0.05).


Low serum vitamin D status correlates with stronger allergic immune response in GFA children.

Eosinophilia, Gastrointestinal food allergy, Regulatory T cells, Total immunoglobulin E, Vitamin D
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