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2016 FI

© Thomson Reuters, Journal Citation Reports, 2016

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Index Medicus/Medline, Excerpta Medica/EMBASE, IBECS, IME Cancerlit, Bibliomed, CabHealth, Scisearch, HealthStar, Scopus, Prous, Science Intergews, Science Citation Index Expanded.


  • Impact Factor: 1.439 (2016)
  • SCImago Journal Rank (SJR):0,38
  • Source Normalized Impact per Paper (SNIP):0,591

© Thomson Reuters, Journal Citation Reports, 2016

Allergol Immunopathol (Madr) 2017;45:87-92 - DOI: 10.1016/j.aller.2016.06.008
Original Article
Allergen-specific IgE to food molecular components and age: From early childhood to adulthood
M.A. Toscaa, M. Silvestria, R. Olcesea, O. Saccoa, A. Pistoriob, G.A. Rossia, G. Ciprandic,,
a Pediatric Pulmonology, Allergy Unit and Cystic Fibrosis Center, Istituto Giannina Gaslini, Genoa, Italy
b Epidemiology and Biostatistics Unit, Istituto Giannina Gaslini, Genoa, Italy
c Internal Medicine Department, IRCCS-AOU San Martino, Genoa, Italy
Received 23 March 2016, Accepted 13 June 2016

Respiratory allergy is characterised by an IgE-mediated reaction. The immune system functions, including IgE production, progressively decline over time with growing up and ageing. Molecular-based allergy diagnostic defines sensitisation profile. This study aimed to evaluate the impact of age on serum allergen-specific IgE to molecular component levels in a large sample of subjects.


Serum IgE to: rCor a11, rPru p3, nJug r3, rAra h8, rGly m4, rCor a8, nPen m1, nAct d8, Bos d 8, and nGal d2 were assessed by ISAC method. Sera from 2795 patients, 1234 males (44.1%) and 1561 females (55.9%), median age 23 years (1st and 3rd quartiles: 9.7–43.7 years; age range: 1 month-103 years) were analysed.


The number of positive tests (i.e. sensitisation) tended to increase between birth and school-age until young adulthood and then decreased. A similar age-dependent trend was observed considering the levels of each allergen components: the levels of each allergen component tended to increase until early adulthood, but Gal d 2 and Bos d 8 (rapidly diminishing), and then to decrease over time. However, the pattern is significantly dependent on each single tested food.


Allergen-specific IgE production to food molecular components tend to reduce with ageing, but with differences between allergens. This phenomenon should be adequately evaluated managing allergic patients.

Allergen-specific IgE, Age, Food allergen, Molecular component, ISAC, Serum
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