SUMMARY: Selective Sentinel Lymph Node Biopsy (SSLNB) in breast cancer for residents

Caratini, R.; Segarra, A.; Garcia, E.; Quintero, K.; Cordon, J.; Vega, M.; Cases, J.; Cebrecos, I.; Ribera-Perianes, J.; Vidal-Sicart, S.

doi:10.1016/j.remnie.2025.500261

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)

ISSN: 2253-8089

The Revista Española de Medicina Nuclear e Imagen Molecular (Spanish Journal of Nuclear Medicine and Molecular Imaging), was founded in 1982, and is the official journal of the Spanish Society of Nuclear Medicine and Molecular Imaging.
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DOI: 10.1016/j.remnie.2025.500261

Uncorrected Proof. Available online 17 December 2025

SUMMARY: Selective Sentinel Lymph Node Biopsy (SSLNB) in breast cancer for residents

RESUMEN: Biopsia Selectiva de Ganglio Centinela (BSGC) en cáncer de mama para residentes

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R. Caratinia,

Corresponding author

caratini@clinic.cat

Corresponding author.

, A. Segarraa, E. Garciaa, K. Quinteroa, J. Cordona, M. Vegaa, J. Casesa, I. Cebrecosb,c, J. Ribera-Perianesa, S. Vidal-Sicarta,c

a Servei de Medicina Nuclear, Centre de Diagnòstic per la imatge (CDI), Clínic Barcelona, Barcelona, Spain

b Servei de Ginecologia i Obstetricia (ICGON), Clínic Barcelona, Barcelona, Spain

c Institut d’Investigacions Biomèdiques August Pi i SUnyer (IDIBAPS), Barcelona, Spain

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Tables (11)

Table 1. Classification according to the 8th edition of the breast cancer staging system of the American Joint Committee on Cancer.5

Table 2. Molecular subtypes of breast cancer according to immunohistochemical studies and their principal clinical-pathological. ER: estrogen receptor; PR: progesterone receptor; HER2: human epidermal growth factor receptor 2.6.

Table 3. Definitions taken from the Spanish Society of Senology and Breast Disease (SESPM) 2022 consensus on SSLNB and axillary management.10

Table 4. Indications and contraindications of SSLNB according to the Spanish Society of Senology and Breast Disease (SESPM) on SSLNB and axillary management in breast cancer (2022).10

Table 5. Radiopharmaceuticals most commonly used worldwide for performing SSLNB.

Table 6. Types of radiopharmaceutical injections for performing SSLNB in patients with breast cancer.

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Abstract

This work presents the key aspects of the sentinel lymph node biopsy (SLNB) procedure in breast cancer, based on the protocol used at Hospital Clínic de Barcelona. The aim is to facilitate its generalization in other hospital settings and training environments, promoting the standardization of the technique. It is also intended to serve as a useful resource for resident physicians and other medical trainees.

Keywords:

Selective sentinel lymph node biopsy

Breast cáncer

Radioguided surgery

Lymphatic drainage

Resumen

Este trabajo presenta los aspectos clave del procedimiento de biopsia selectiva del ganglio centinela (BSGC) en el cáncer de mama, basado en el protocolo utilizado en el Hospital Clínic de Barcelona. El objetivo es facilitar su generalización en otros contextos hospitalarios y entornos de formación, promoviendo la estandarización de la técnica. Asimismo, se pretende que sea un recurso útil para médicos residentes y otros profesionales en formación.

Palabras clave:

Biopsia selectiva de ganglio centinela

Cáncer de mama

Cirugía radioguiada

Drenaje linfático

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