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Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Procedure update and interpretation guide for the brain 18F-FDG PET study
Journal Information
Vol. 44. Issue 4.
(July - August 2025)
Visits
27
Vol. 44. Issue 4.
(July - August 2025)
Continuing Education
Procedure update and interpretation guide for the brain 18F-FDG PET study
Actualización del procedimiento y guía de interpretación del estudio PET cerebral con 18F-FDG
Visits
27
C. Vigil Díaza,
Corresponding author
carmen.vigil@sespa.es

Corresponding author.
, P. Paredes Rodríguezb, A. Perissinottic, E. Fernando Guillénd, D.A. Diego Alfonsoe, J.A. Lojo Ramírezf, P. Aguiar Fernándezg,h, V. Camachoi, M. Nieves Cabrera-Martínj, por el grupo de Trabajo de Neuroimagen de la SEMNIM
a Servicio Medicina Nuclear, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Asturias, Spain
b Servicio de Medicina Nuclear, Hospital Universitario Ramón y Cajal, Madrid, Spain
c Servicio de Medicina Nuclear, Hospital Clínic Barcelona-IDIBAPS, Centro de Investigación Biomédica en red-Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), ISCIII, Barcelona, Spain
d Servicio de Medicina Nuclear. Clínica Universitaria de Navarra, Madrid, Spain
e Servicio de Medicina Nuclear, UDIAT - Centro Diagnóstico, Corporació Sanitària Parc Taulí, Sabadell, Spain
f Servicio de Medicina Nuclear, Hospital Universitario Virgen del Rocío, Sevilla, Spain
g Grupo de Imaxe Molecular e Física Médica, Departamento de Radioloxía, Facultade de Medicina, Universidade de Santiago de Compostela, Santiago de Compostela, La Coruña, Spain
h Servicio de Medicina Nuclear, Hospital Clínico de Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, La Coruña, Spain
i Servicio de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
j Servicio de Medicina Nuclear, Hospital Clínico San Carlos, Facultad de Medicina, Universidad Complutense de Madrid, Spain
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Table 1. Neurodegenerative diseases according to the presence of an anomalous protein, disease and associated syndromes and the different 18F-FDG PET imaging patterns related to the topography of the disease and allow differential diagnosis.
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Abstract

The increase in the prevalence of dementia in our clinical setting poses a diagnostic challenge for the Nuclear Medicine specialist. The aim of this study is to review the modifications in the procedure and to describe the usefulness of the use of brain PET with 18F-FDG in different clinical indications, both classic and emerging ones. The SEMNIM Neuroimaging working group has considered it appropriate to update the procedures available in Spanish in order to optimize the quality of this technique and the interpretation of its findings, both for the specialist in Nuclear Medicine and the rest of the professionals involved in the diagnosis and treatment of neurodegenerative diseases.

Keywords:
PET
18F-FDG
Dementia
Alzheimer’s disease
Frontotemporal degeneration
Synucleinopathies
Prion diseases
Neurology
Procedure
Resumen

El aumento en la prevalencia de la demencia en nuestro entorno supone un reto diagnóstico para el especialista en Medicina Nuclear. El objetivo de este trabajo es revisar las modificaciones en el procedimiento y describir la utilidad del uso de la PET cerebral con 18F-FDG en diferentes indicaciones clínicas, tanto clásicas como emergentes. Desde el grupo de trabajo de Neuroimagen de la SEMNIM se ha considerado procedente actualizar los procedimientos disponibles en castellano que permita optimizar la calidad de esta técnica y la interpretación de sus hallazgos, tanto para el especialista en Medicina Nuclear y el resto de los profesionales involucrados en el diagnóstico y tratamiento de las enfermedades neurodegenerativas.

Palabras clave:
PET
18F-FDG
Demencia
Enfermedad de Alzheimer
Degeneración frontotemporal
Sinucleinopatías
Enfermedades priónicas
Neurología
Procedimiento

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