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Annals of Hepatology
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Special Issue on Genomic Medicine in Obesity and Chronic Liver Damage

Edited by Sonia Roman

Obesity is a complex disease comprising multiple genetic and environmental factors causing important metabolic dysfunctionalities in body organs including the liver. Currently, the aim is to provide personalized medicine and nutrition strategies to detect, manage and treat obesity-related liver damage at earlier stages and avoid end-stage liver disease. Basic and clinical research are needed to guide and reinforce the capacities of regional health care systems to respond according to the biological characteristics of the population.

Based on the Aim and Scope of Annals of Hepatology, we enthusiastically announce our Special Issue "Obesity and Liver Damage" for authors to contribute with original articles and reviews. We welcome studies focusing on strategies for early detection, prevention, medical or nutritional therapies using "omics" methodologies either accessed exclusively or in combination with lifestyle factors (diet, physical activity, mental health). Large cohort prospective/retrospective epidemiological studies could be considered. We hope that these contributions aid in increasing our insights on the prevention of obesity and chronic liver damage in populations of Latin America and other regions around the world.

Keywords: Obesity, liver damage, insulin resistance, NAFLD, inflammation, fibrosis, cirrhosis, lifestyle factors.

Non-alcoholic fatty liver disease prevalence in Latin America: A systematic review and meta-analysis
Yesmi A. Ortega Rojas, Claudia L. Vidal Cuellar, Karina M. Aparicio Barrón, Juan Pablo Arab, Adelina Lozano Miranda
Open access
Available online 22 June 2022
Abdominal obesity, chronic inflammation and the risk of non-alcoholic fatty liver disease
Dongna Zhao, Haozhe Cui, Zhiqiang Shao, Liying Cao
Open access
Available online 12 June 2022
African genetic ancestry is associated with lower frequency of PNPLA3 G allele in non-alcoholic fatty liver in an admixed population
Lourianne Nascimento Cavalcante, Jun Porto, Daniel Mazo, Adhemar Longatto-Filho, José Tadeu Stefano, Andre Castro Lyra, Flair Jose Carrilho, Rui Manuel Reis, Venâncio A.F. Alves, Arun J. Sanyal, Claudia P Oliveira
Open access
Available online 7 July 2022
Late evening snack and oral amino acid capsules improved respiratory quotient and Fischer ratio in patients with alcoholic liver cirrhosis
Juan Zhao, Jing Wu, Juan Li, Zhong-Ying Wang, Qing-Hua Meng
Open access
Available online 26 September 2022
Body weight loss and glycemic control on the outcomes of patients with NAFLD. The role of new antidiabetic agents
Diego García-Compeán, Ramesh Kumar, Ángel Noe del Cueto-Aguilera, Héctor Jesús Maldonado-Garza, Jesús Zacarías Villarreal-Pérez
Open access
Available online 25 September 2022
NAFLD VS MAFLD. The evidence-based debate has come. Time to change?
Diego García-Compeán, Alan Rafael Jiménez-Rodríguez
Open access
Available online 9 October 2022
Anti-hepatitis B virus activity of food nutrients and potential mechanisms of action
Alexis Jose-Abrego, Ingrid Rivera-Iñiguez, Luis A. Torres-Reyes, Sonia Roman
Open access
Available online 6 October 2022
Whole-Exome Sequencing identified Olfactory Receptor genes as a key contributor to extreme obesity with progression to nonalcoholic steatohepatitis in Mexican patients
LA Torres-Reyes, K Gonzalez-Aldaco, A Panduro, A Jose-Abrego, S Roman

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    Variants in olfactory receptor genes are highly enriched in Mexican extreme obese/NASH patients

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    Mexican extreme obese/NASH patients present genetic susceptibility to developing liver cancer

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    Identifying genetic susceptibility to extreme obesity/NASH might facilitate the implementation of precision medicine

Open access
Pre-proof. Available online 11 October 2022
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