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Vol. 43. Issue 2.
Pages 130-140 (March - April 2024)
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Vol. 43. Issue 2.
Pages 130-140 (March - April 2024)
Continuing Education
PET/CT FAPI: Procedure and evidence review in oncology
PET/TC con FAPI: Procedimiento y revisión de la evidencia en oncología
A.P. Caresiaa,
Corresponding author
, J. Jo Rosalesb, M. Rodríguez Fraileb, A. Arçay Öztürkc, C. Artigasc, On behalf of the Oncology Task Force of Spanish Nuclear Medicine and Molecular Imaging Society
a Servei e Medicina Nuclear, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
b Servicio de Medicina Nuclear, Clínica Universidad de Navarra, Pamplona, Spain
c Department of Nuclear Medicine, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium
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Table 1. Articles of theragnosis with radiopharmaceuticals of the FAPI family.

Neoplasms are composed of malignant tumor cells, which are surrounded by other non-tumor cellular elements, in what has been defined as the microenvironment or tumor stroma. Evidence on the importance of the tumor microenvironment has not stopped growing in recent years. It plays a central role in cell proliferation, tissue invasion, angiogenesis and cell migration.

The paradigm is the family of new FAPI radiopharmaceuticals that show the density of the fibroblast activation protein (FAP) which is overexpressed in the cell membrane of activated cancer-associated fibroblasts (CAF), and its presence is related to poor prognosis.

This educational document includes the procedure for performing PET/CT FAPI, biodistribution and the main potentially clinical applications in oncology to date.

Tumoral microenvironment

Las neoplasias se componen de células malignas tumorales, que se encuentran rodeadas de diversos elementos celulares no tumorales, que conforman el microambiente o estroma tumoral. La evidencia sobre la importancia del microambiente tumoral no ha parado de crecer en los últimos años ya que juega un papel necesario para la proliferación celular, invasión tisular, angiogénesis y migración celular.

El paradigma es la familia de los nuevos radiofármacos FAPI que nos muestran la densidad la proteína de activación de fibroblastos (FAP) que se encuentra sobreexpresada en la membrana celular de los fibroblastos activados asociados al cáncer (CAF), y su presencia está relacionada con un mal pronóstico.

En este documento de formación continuada se incluye el procedimiento para la realización de PET/TC con FAPI, la biodistribución y las potenciales aplicaciones clínicas en oncología publicadas hasta el momento.

Palabras clave:
Microambiente tumoral


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