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Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Determination of the segmental hepatic clearance rate of 99mTc-mebrofenin and it...
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Vol. 40. Issue 6.
Pages 385-396 (November - December 2021)
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Vol. 40. Issue 6.
Pages 385-396 (November - December 2021)
Continuing Education
Determination of the segmental hepatic clearance rate of 99mTc-mebrofenin and its application in the functional assessment of future liver remnant after liver resection
Determinación de la tasa de aclaramiento hepático segmentario de 99mTcmebrofenina y su aplicación en la evaluación funcional del remanente hepático futuro tras resección hepática
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Jon Andoni Uña-Gorospe
Servicio de Medicina Nuclear, Hospital Universitario Nuestra Señora de Candelaria, Carretera del Rosario 145, 38010, Santa Cruz de Tenerife, Canarias, Spain
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Abstract

99mTc-mebrofenin hepatobiliary scintigraphy with SPECT/CT (HBS-M) has become an important quantitative method to evaluate global liver function and future liver remnant (FLR) function in patients who are candidates for resective liver surgery. The purpose of this work was to describe the method in the prediction of post-surgical liver failure.

The overall liver function and that of the FLR are obtained by analysis of the initial dynamic phase of the scan. Liver volume to be preserved is expressed as a percentage of the total liver volume measured in both CT sections.

HBS-M is able to accurately gauge regional liver function abnormalities that could be represented as normal liver tissue parenchyma in the CT study. This technique can provide very valuable prognostic information for the estimation of the postoperative risk of liver failure in all patients who are candidates for resective liver surgery.

Keywords:
99mTc-mebrophenin
Hepatobiliary scintigraphy
SPECT/CT
Functional remnant
Resumen

La gammagrafía hepatobiliar con 99mTc-mebrofenina con SPECT/TC (HBS-M) se ha convertido en un método cuantitativo importante para evaluar la función hepática global y la función remanente hepática futura (FLR) en pacientes candidatos a cirugía hepática resectiva. El propósito de este trabajo es describir el método para predecir la probabilidad de insuficiencia hepática posquirúrgica.

La función hepática general y la del futuro remanente hepático (FLR) se obtienen del análisis de la fase dinámica inicial de la exploración. El volumen hepático a conservar se expresa como un porcentaje del volumen hepático total medido en ambas secciones de TC.

La HBS-M es capaz de medir con precisión las anomalías regionales de la función hepática que podrían representarse como parénquima normal del tejido hepático en el estudio de TC. Esta técnica puede proporcionar información pronóstica muy valiosa para la estimación del riesgo postoperatorio de insuficiencia hepática en todos los pacientes candidatos a cirugía hepática resectiva.

Palabras clave:
99mTc-mebrofenina
Gammagrafía hepatobiliar
SPECT/TC
Remanente funcional

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