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Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) The usefulness of 18F-fluorocholine PET/CT in the detection of recurrence of cen...
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Vol. 36. Issue 4.
Pages 227-232 (July - August 2017)
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Vol. 36. Issue 4.
Pages 227-232 (July - August 2017)
Original Article
The usefulness of 18F-fluorocholine PET/CT in the detection of recurrence of central nervous system primary neoplasms
Valor de la PET/TC cerebral con 18F-fluorocolina en la detección de recurrencias de neoplasias primarias del sistema nervioso central
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A. Montesa,
Corresponding author
amontegr7@gmail.com

Corresponding author.
, A. Fernándeza, V. Camachoa, C. de Quintanab, O. Gallegoc, J. Craven-Bartled, D. Lópeza, J. Moletb, B. Gómez-Ansóne, I. Carrióa
a Servicio de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
b Servicio de Neurocirugía, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
c Servicio de Oncología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
d Servicio de Oncología Radioterápica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
e Servicio de Radiología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
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Table 1. Initial diagnosis, age, sex, PET/CT results and diagnosis of the patients included in this study.
Abstract
Aim

To study the usefulness of 18F-fluorocholine (FCH) in detecting the recurrence of primary brain tumors.

Materials and methods

A prospective study was conducted on brain PET/CT with FCH for compassionate use in 21 patients with suspected recurrence of a primary brain tumor. The distribution by pathology was: three grade ii astrocytomas, three grade iii astrocytomas, one grade ii oligodendroglioma, three grade iii oligodendrogliomas, one grade iii oligoastrocytoma, four glioblastoma multiform, one gliomatosis cerebri, and five meningiomas. Studies in which there was a visually significant uptake in the brain parenchyma were classified as positive.

Results

A total of 17 patients were classified as positive, with the results being confirmed by histology (10 cases) or clinical follow-up and imaging, with no false positives or negatives. The mean SUVmax for positive patients was 8.02 and 0.94 for the negative ones, which was significantly different (P=.003)

Conclusion

PET/CT with FCH shows encouraging results in the evaluation of patients with suspected recurrence of primary brain neoplasms.

Keywords:
18F-fluorocholine
Brain tumor
Neuro-oncology
Recurrence
Brain PET/CT
Resumen
Objetivo

Estudiar el impacto clínico en el manejo de los pacientes de la 18F-fluorocolina (18F-COL) en la recurrencia de neoplasias cerebrales primarias.

Material y métodos

Se estudió prospectivamente a 21 pacientes con sospecha de recidiva de neoplasia cerebral primaria mediante PET/TC cerebral con 18F-COL en uso compasivo. La distribución por patología de los pacientes estudiados fue: 3 astrocitomas grado ii, 3 astrocitomas grado iii, un oligodendroglioma grado ii, 3 oligodendrogliomas grado iii, un oligoastrocitoma grado iii, 4 glioblastomas multiformes, una gliomatosis cerebri y 5 meningiomas. Se consideraron positivos los estudios en los que había una captación visualmente significativa respecto al fondo del parénquima cerebral.

Resultados

Diecisiete de los pacientes fueron positivos, comprobándose dicho resultado por histología (10 de ellos) o seguimiento clínico y por neuroimagen, sin hallarse falsos positivos o negativos. El índice target to backgroud ratio medio para los positivos fue de 8,02 y para los negativos de 0,94, lo que representa una diferencia significativa (p=0,003).

Conclusión

La PET/TC con 18F-COL presenta resultados alentadores en la valoración de pacientes con sospecha de recidiva.

Palabras clave:
18F-fluorocolina
Tumor cerebral
Neurooncología
Recidiva
PET/TC cerebral

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