Buscar en
Neurología (English Edition)
Toda la web
Inicio Neurología (English Edition) Music therapy and Alzheimer's disease: Cognitive, psychological, and behavio...
Journal Information
Vol. 32. Issue 5.
Pages 300-308 (June 2017)
Vol. 32. Issue 5.
Pages 300-308 (June 2017)
Original article
DOI: 10.1016/j.nrleng.2015.12.001
Open Access
Music therapy and Alzheimer's disease: Cognitive, psychological, and behavioural effects
Musicoterapia en la enfermedad de Alzheimer: efectos cognitivos, psicológicos y conductuales
M. Gómez Gallegoa,
Corresponding author

Corresponding author.
, J. Gómez Garcíab
a Departamento de Terapia Ocupacional, Facultad de Ciencias de la Salud, Universidad Católica San Antonio de Murcia, Murcia, Spain
b Departamento de Métodos Cuantitativos, Facultad de Economía, Universidad de Murcia, Murcia, Spain
Article information
Full Text
Download PDF
Figures (3)
Show moreShow less
Tables (3)
Table 1. Descriptive statistics for our sample.
Table 2. Changes in scores after 6 and 12 sessions of music therapy (repeated measures ANOVA).
Table 3. Changes in scores by disease severity.
Show moreShow less

Music therapy is one of the types of active ageing programmes which are offered to elderly people. The usefulness of this programme in the field of dementia is beginning to be recognised by the scientific community, since studies have reported physical, cognitive, and psychological benefits. Further studies detailing the changes resulting from the use of music therapy with Alzheimer patients are needed.


To determine the clinical improvement profile of Alzheimer patients who have undergone music therapy.

Patients and methods

Forty-two patients with mild to moderate Alzheimer disease (AD) underwent music therapy for 6 weeks. The changes in results on the Mini-Mental State Examination, Neuropsychiatric Inventory, Hospital Anxiety and Depression Scale and Barthel Index scores were studied. We also analysed whether or not these changes were influenced by the degree of dementia severity.


Significant improvement was observed in memory, orientation, depression and anxiety (HAD scale) in both mild and moderate cases; in anxiety (NPI scale) in mild cases; and in delirium, hallucinations, agitation, irritability, and language disorders in the group with moderate AD. The effect on cognitive measures was appreciable after only 4 music therapy sessions.


In the sample studied, music therapy improved some cognitive, psychological, and behavioural alterations in patients with AD. Combining music therapy with dance therapy to improve motor and functional impairment would be an interesting line of research.

Music therapy
Alzheimer disease
Neuropsychiatric symptoms

La musicoterapia forma parte de los programas de envejecimiento activo que se ofrecen a las personas mayores. Su utilidad en el campo de las demencias empieza a ser valorada por la comunidad científica, ya que se han reportado efectos positivos a nivel físico, cognitivo y psicológico. Son necesarios más estudios que perfilen el alcance de tales cambios en la enfermedad de Alzheimer.


Conocer el perfil de mejoría clínica que experimentan los pacientes con enfermedad de Alzheimer con la aplicación de una intervención de musicoterapia.

Pacientes y métodos

Se aplicó un tratamiento con musicoterapia durante 6 semanas a 42 pacientes con enfermedad de Alzheimer en estadio leve-moderado. Se estudiaron los cambios en las puntuaciones de Mini-examen del estado mental, Inventario de síntomas neuropsiquiátricos, Escala hospitalaria de ansiedad y depresión, e índice de Barthel. Se estudió si estos cambios se influían por el grado de severidad de la demencia.


Se observó una mejoría significativa de memoria, orientación, depresión y ansiedad (escala HAD) en pacientes leves y moderados; de ansiedad (escala NPI) en pacientes leves; de los delirios, alucinaciones, agitación, irritabilidad y trastornos del lenguaje en el grupo con demencia moderada. El efecto sobre las medidas cognitivas es ya apreciable a las 4 sesiones de musicoterapia.


En la muestra estudiada, la musicoterapia mejoró algunas alteraciones cognitivas, psicológicas y conductuales de los pacientes con enfermedad de Alzheimer. Sería interesante complementar la musicoterapia con intervenciones de danzaterapia a fin de mejorar los aspectos motores y funcionales.

Palabras clave:
Enfermedad de Alzheimer
Síntomas neuropsiquiátricos
Full Text

The prevalence of dementia is increasing worldwide.1 With this in mind, and since dementia requires a substantial share of the total healthcare and social resources, it is recognised as a priority in research. The most frequent cause of dementia in developed countries is Alzheimer disease (AD).2 Current research aims to halt cognitive decline through pharmacological treatment.3 Anticholinesterase drugs and memantine have demonstrated moderate effects on cognitive function. These drugs are effective for managing neuropsychiatric symptoms only at high doses and do not work in some cases.4 These symptoms are usually treated with neuroleptic and anxiolytic drugs, which worsen motor function and result in premature death.5 Non-pharmacological treatment provides a promising alternative for improving behaviour and cognitive function.6–8 One such intervention is music therapy, which uses music to improve communication, learning, mobility, and other mental and physical functions.9 Numerous music therapy techniques have been developed.9 Active techniques are based on direct interaction with the patient, whereas receptive techniques require a lower level of participation. Interventions may be tailored to a specific subject and carried out with individuals or in groups. In patients with dementia, music therapy has been shown to improve neuropsychiatric symptoms and, to a lesser extent, cognitive function.10,11 However, we have yet to determine the symptoms most likely to improve with music therapy and whether clinical improvement depends on the stage of the disease. Our study included patients with AD, who were classified in 2 groups according to disease severity (mild or moderate). Our purpose was to determine whether music therapy can improve patients’ cognitive function, neuropsychiatric symptoms, and functional capacity and, if so, to evaluate whether these changes depend on dementia severity.

Patients and methodsPatients

We selected patients from 2 geriatric residences in the Region of Murcia and included those who met the diagnostic criteria for probable AD proposed by the National Institute of Neurological and Communicative Disorders,12 in a mild or moderate stage according to the Clinical Dementia Rating (CDR) scale.13 We excluded deaf or aphasic patients who might have difficulty understanding instructions during the intervention. Patients and their relatives and carers at the geriatric residences signed informed consent forms prior to inclusion in the study. The study was approved by the ethics committee at Universidad de Murcia.


Questionnaire of musical preferences.14 This tool gathers data on patients’ musical preferences. It enquires about patients’ favourite instruments and musical genres as well as about their dislikes.

Mini-Mental State Examination (MMSE).15 This quick-to-administer questionnaire evaluates orientation in time and place, attention, verbal memory, language, and motor skills. Total scores range from 0 to 30 points (orientation [0-10], memory [0-6], attention [0-5], and language–motor skills [0-9]).

Neuropsychiatric Inventory (NPI).16 This tool assesses 10 domains of behavioural function: delusions, hallucinations, depression, agitation, irritability, aberrant motor behaviour, anxiety, aggressiveness, apathy, and disinhibition. Frequency of each of these symptoms is scored on a 4-point scale whereas severity is scored on a 3-point scale.

Hospital Anxiety and Depression Scale (HADS).17 This 14-item questionnaire includes 2 subscales containing 7 items each (anxiety and depression). Frequency of each item is scored on a 4-point Likert scale (0-3); each subscale is scored from 0 to 21 points, with higher scores indicating greater symptom severity.

Barthel Index (BI).18 This is a useful tool for evaluating patients’ ability to complete 10 basic activities of daily living (feeding, bathing, grooming, dressing, bowels, bladder, toilet use, transfers, mobility, and stairs). Scores range from 0 (completely dependent) to 100 (independent).


Our patients underwent cognitive, neuropsychiatric, and functional assessment; the MMSE, NPI, and HADS were administered by a neurologist specialising in dementia and the BI was given by an occupational therapist. In each geriatric residence, participants were divided in 2 groups (fewer than 12 patients per group). Musical preferences were subsequently analysed using the questionnaire on musical preferences; our purpose was to choose songs that most of the participants would like and rule out music genres that they would regard as unpleasant. Patients did not use headphones; rather, music was played on a high-quality stereo system with the speakers placed in the room in such a way as to avoid echo. Patients attended 2 weekly sessions of music therapy lasting 45min. Each session included several activities: welcome song (in which patients greeted each other and introduced themselves), rhythmic accompaniment by clapping hands or playing music instruments (triangle, tambourine, maracas), moving to background music (patients were instructed to move their arms and legs to rhythm of a song, including dance therapy with hoops and balls once a week), guessing songs and interpreters (music bingo, plus playing name-that-tune using drawings once a week), and farewell song (in which patients said goodbye). Sessions were designed and led by 2 music therapists. The rooms in which sessions took place were large enough for patients to be comfortable yet focused on the task (40-48m2). Rooms were sound-proof, well-lit, and far from any sources of noise or distress; they had wooden floors and thermal insulation to ensure a pleasant temperature.

Patients underwent cognitive, neuropsychiatric, and functional assessment after 3 weeks (6 sessions) and at the end of the study period (12 sessions). Tests were administered by the same professionals as at baseline. Statistical analysis was performed by a professional blinded to patient data (mild/moderate AD), and to time-related data (baseline/follow-up/end-of-study assessment).

Statistical analysis

We used repeated measures ANOVA to evaluate changes in outcome variables throughout the intervention period; effect size was estimated with the partial η2 coefficient. We tested for normality and sphericity of the variance matrix before conducting repeated measures ANOVA. When sphericity was violated, a correction factor (epsilon) was applied to the F-value. For those symptoms responding to music therapy, we analysed whether the effect was present in both groups (paired samples t test). Statistical analysis was performed using SPSS version 19.


Our sample included 42 patients (27 women) with a mean age of 77.5±8.3 years. Dementia was mild in 25 patients (CDR=1) and moderate in 17 (CDR=2). Regarding our patients’ education level, 3 had no schooling, 32 had completed primary school, and 7 had finished secondary school. The most frequent comorbidities were bone diseases (83.33%), heart diseases (21.42% heart failure and 14.28% ischaemic heart disease), endocrine and metabolic disorders (71.42% arterial hypertension, 33.33% diabetes mellitus, and 52.38% dyslipidaemia), and 28.57% chronic obstructive pulmonary disease. Table 1 shows descriptive statistics for our sample, including drugs for AD. No significant differences in drug use were found between groups (CDR1 and CDR2) (P>.1). Table 2 shows the results of the repeated measures ANOVA. Music therapy significantly increased MMSE scores, especially in the domains of orientation, language, and memory. Effect size was large for orientation and memory. Cognitive function improved progressively throughout the study period (Fig. 1). Regarding language, differences were significant only between baseline and final scores (P=.047). We observed a marked decrease in total NPI scores, with scores decreasing in most of the domains (Table 2). However, decreases between baseline and follow-up scores were not significant for any of the symptoms assessed with the NPI (P>.05 for all symptoms). Scores on the anxiety and depression subscales of the HADS improved; the effect size was large in the latter case. Depression did not improve after 6 sessions (P>.05). Music therapy had no significant effects on BI scores (P=.338). Significant differences were also detected in total MMSE scores and in the domains of memory and orientation between groups CDR1 and CDR2 (Table 3). Only the group with moderate dementia displayed significant improvements in language. Regarding neuropsychiatric symptoms, delusions, hallucinations, irritability, and agitation improved significantly in the group with moderate dementia (Table 3). Patients in the CDR2 group displayed higher baseline scores in the domains of delusions, hallucinations, and irritability than did those in the CDR1 group (P<.005); the effect on disinhibition was significant in both groups. According to HADS scores, music therapy had a positive effect on anxiety and depression in both groups. Anxiety as measured on the NPI improved significantly in the mild dementia group; improvements were less marked in the group with moderate dementia (P=.080). Depression did not improve significantly in patients with moderate dementia and lessened only slightly in those with mild dementia (P=.087) (Figs. 2 and 3).

Table 1.

Descriptive statistics for our sample.

  Mean±SD  Mean±SD  Mean±SD 
Age (years)  84±8.30    83.87±7.75    77.5±8.3   
Sex (women)    60    70.58    64.28 
Education level
No schooling      17.64    7.14 
Primary education    80    70.58    76.19 
Secondary education    20    11.76    16.66 
Attention  0.50±0.51    1.37±1.52    1.02±1.30   
Orientation  4.33±2.25    3.87±2.47    6.42±2.30   
Language  7.16±1.16    5.86±1.12    3.35±1.28   
Memory  3.30±1.86    3.37±1.40    1.02±1.54   
Total  18.33±5.84    12.50±3.02    15.02±5.40   
Delusions  0.67±0.51    3.88±2.99    2.29±2.92   
Hallucinations  0.33±0.49    3.75±2.25    2.29±2.43   
Agitation  1.33±1.64    2.50±1.85    2.00±1.79   
Anxiety  2.67±1.63    1.75±2.18    2.14±1.95   
Apathy  1.04±1.67    1.50±2.33    1.29±2.01   
Irritability  0.67±0.82    3.25±2.82    2.14±2.55   
Depression  4.01±4.41    1.13±1.36    2.21±3.19   
AMB  0.17±0.38    0.75±2.02    0.50±1.60   
Disinhibition  1.00±1.57    9.75±0.98    0.86±1.29   
Aggressiveness  1.54±1.32    2.20±3.14    1.86±2.62   
Total  12±5.75    22±12.59    17.71±11.59   
Depression  9.00±1.54    9.62±3.20    9.35±2.56   
Anxiety  12.66±2.70    13.37±1.43    13.07±2.17   
Total  21.67±3.02    23.00±1.52    22.43±3.34   
BI  44.10±20.58    18.18±12.62    29.29±25.18   
Anticholinesterase drugs    64    82.35    71.42 
Memantine    16    11.76    14.28 
Neuroleptics    24    23.53    23.80 
Antidepressants    56    58.82    57.14 
Benzodiazepines    48    52.94    50 

AMB: aberrant motor behaviour; SD: standard deviation; HADS: Hospital Anxiety and Depression Scale; BI: Barthel Index; MMSE: Mini-Mental State Examination; NPI: Neuropsychiatric Inventory.

Table 2.

Changes in scores after 6 and 12 sessions of music therapy (repeated measures ANOVA).

  Baseline6 sessions12 sessionsWithin-subjects effects
  Mean  SD  Mean  SD  Mean  SD  F  P  Partial η2 
Orientation  4.07  2.30  5.00  2.48  5.85  2.21  40.42  .000  0.76 
Language  6.42  1.28  6.64  1.23  7.43  1.34  4.79  .047  0.27 
Memory  3.35  1.54  3.64  1.21  4.71  1.26  29.89  .000  0.69 
Attention  1.02  1.30  1.43  1.50  1.64  1.33  2.98  .108  0.19 
Total  15.02  5.40  16.71  5.51  19.64  4.84  34.65  .000  0.72 
Delusions  2.29  2.92  2.26  2.89  1.07  1.20  7.75  .015  0.37 
Hallucinations  2.29  2.43  2.21  2.42  1.21  1.25  6.34  .026  0.33 
Agitation  2.00  1.79  2.07  1.77  1.00  0.78  9.10  .010  0.41 
Depression  2.21  3.19  2.29  3.14  0.93  1.07  4.36  .057  0.25 
Anxiety  2.14  1.95  2.10  1.94  0.64  0.63  14.89  .002  0.53 
Euphoria  1.86  2.62  1.79  2.71  1.14  1.09  2.51  .136  0.16 
Apathy  1.29  2.01  1.20  2.08  0.43  0.75  5.63  .034  0.30 
Disinhibition  0.86  1.29  0.76  1.18  0.36  0.63  3.95  .068  0.23 
Irritability  2.14  2.55  2.09  2.37  0.64  0.62  6.44  .025  0.33 
AMB  0.50  1.60  0.32  1.62  0.14  0.53  1.52  .239  0.10 
Total  17.71  11.59  17.60  11.46  7.57  5.01  28.29  .000  0.68 
Anxiety  13.07  2.17  11.57  2.65  10.71  3.49  15.98  .000  0.28 
Depression  9.35  2.56  8.07  2.16  5.71  1.81  21.33  .000  0.62 
Total  22.43  3.34  19.64  4.12  17.14  4.09  18.95  .001  0.69 
BI  29.29  25.18  29.64  24.76  33.21  28.52  1.13  .338  0.08 

AMB: aberrant motor behaviour; SD: standard deviation; HADS: Hospital Anxiety and Depression Scale; BI: Barthel Index; MMSE: Mini-Mental State Examination; NPI: Neuropsychiatric Inventory.

Figure 1.

Changes in MMSE scores by domain.

Table 3.

Changes in scores by disease severity.

  Mild dementiaModerate dementia
  BaselineEnd of studyt  P  BaselineEnd of studyt  P 
  Mean  SD  Mean  SD      Mean  SD  Mean  SD     
Orientation  4.33  2.25  6.16  2.56  −3.84  .012  3.87  2.47  5.62  2.06  −4.78  .002 
Language  7.16  1.16  7.01  0.08  0.35  .741  5.86  1.12  7.75  1.75  −3.42  .011 
Memory  3.30  1.86  4.33  1.36  −3.87  .012  3.37  1.40  5.03  1.19  −4.33  .003 
Total  18.33  5.84  22  4.64  −6.83  .000  12.50  3.02  17.88  4.03  −8.48  .000 
Delusions  0.67  0.51  0.17  0.43  1.58  .175  3.88  2.99  1.75  1.16  2.86  .024 
Hallucinations  0.33  0.49  0.19  0.47  1.00  .363  3.75  2.25  2.00  1.07  2.70  .031 
Agitation  1.33  1.64  0.67  0.81  −1.34  .235  2.50  1.85  1.25  0.71  −2.76  .028 
Anxiety  2.67  1.63  0.63  0.74  −3.87  .012  1.75  2.18  0.63  0.74  −2.05  .080 
Apathy  1.04  1.67  0.33  0.51  1.35  .235  1.50  2.33  0.50  0.93  1.87  .104 
Irritability  0.67  0.82  0.33  0.57  1.58  .180  3.25  2.82  0.88  0.64  1.00  .037 
Depression  4.01  4.41  1.01  1.54  2.12  .087  1.13  1.36  0.75  0.71  2.57  .351 
Aggressiveness  1.54  1.32  0.83  0.95  1.84  .082  2.20  3.14  1.38  1.24  1.19  .246 
Disinhibition  1.57  0.33  0.48  2.48  .024  0.75  0.99  0.38  0.71  2.58  .017 
AMB  0.17  0.38  1.84  .083  0.75  2.02  0.25  0.67  1.81  .083 
Total  12  5.75  4.66  2.63  8.11  .000  22  25.59  9.75  5.07  7.46  .000 
Depression  9.00  1.54  5.66  1.86  3.78  .013  9.62  3.20  5.75  1.90  3.08  .018 
Anxiety  12.66  2.70  11.33  4.18  2.49  .024  13.37  1.43  11.50  2.93  2.94  .007 
Total  21.67  3.49  17  5.41  5.74  .000  23  3.02  17.25  2.59  6.96  .000 
BI  44.10  20.58  40  21.62  0.58  .560  18.18  12.62  21.88  23.39  −0.68  .503 

AMB: aberrant motor behaviour; SD: standard deviation; HADS: Hospital Anxiety and Depression Scale; BI: Barthel Index; MMSE: Mini-Mental State Examination; NPI: Neuropsychiatric Inventory.

Figure 2.

Changes in NPI scores in the group with mild dementia, broken down by symptom.

Figure 3.

Changes in NPI scores in the group with moderate dementia, broken down by symptom.


This study analysed the effects of music therapy on cognitive, psychological, and behavioural problems in patients with AD. According to our results, this type of intervention has a positive impact on symptoms in these patients. Music therapy lessened symptoms of most neuropsychiatric disorders, especially anxiety and depression; similar results have been reported in a recent study by Raglio et al.19 However, depression as measured on the NPI did not improve significantly. HADS and NPI measure different aspects of depression and were administered to different individuals (patients and carers, respectively). Furthermore, HADS focuses on symptoms of anhedonia and only evaluates symptom severity, whereas the NPI assesses frequency and intensity of physical symptoms.

Music therapy was found to improve delusions, hallucinations, irritability, and agitation in the group with moderate dementia, probably due to the higher intensity of symptoms in this group. This type of intervention has been found to reduce levels of agitation, leading to a decrease in the prescription of psychotropic drugs.20 According to Hall and Buckwalter,21 progressive cognitive impairment lowers the stress threshold. Thus, under stressful conditions, patients may display such behavioural problems as agitation or aggressiveness. Music therapy increases the level of tolerance to stressful environmental stimuli that may trigger such symptoms.22 In our study, music was found to have a major impact on anxiety and depression. Music is a pleasant stimulus, especially when it is adapted to one's personal preferences, and it can evoke positive emotions. It also affects the endocrine and autonomic nervous systems by decreasing stress-related activation of the adrenomedullary and parasympathetic nervous systems.23 Furthermore, holding interactive group sessions promote social relationships and improve the subjects’ moods.24 Groups were small in our study, which promoted participation, social interaction, and intimacy. Patients were familiar with the songs used during the intervention; as a result, they participated actively and their sense of competence increased.

Regarding cognitive function, orientation and memory improved regardless of dementia severity, which supports use of music therapy at different stages of the disease. Improvements in memory may have been favoured by using songs that were familiar to and appreciated by our patients. Recognition of the emotions associated with music seems to be preserved in patients with AD,25 which explains why these patients experience a rush of emotions and memories when they listen to familiar music.26 According to the literature, music enhances encoding of verbal information in healthy elderly individuals and in patients with AD.27,28 This may be explained by the fact that music alters the executive, associative, and auditory networks involved in brain plasticity and learning.29 Another possible explanation is that music increases arousal and reduces anxiety, states that promote attention and encoding in turn.30 Increased activation of brain plasticity mechanisms may also explain improved orientation in time and place. In line with this hypothesis, music has been suggested as a means of enhancing spatial reasoning skills.31 In addition, recalling music-associated memories is a technique used in reminiscence therapy.32 Our patients displayed language improvements, which is in line with results reported in the literature. Music has been observed to improve naming ability and speech fluency and content, as well as the drive to communicate, in patients with dementia.33,34 In fact, music training leads to recruitment of right hemisphere areas involved in speech processing, leading to improved language comprehension.35 We must stress that not all studies of music therapy for patients with dementia report significant improvements in cognitive function.24,36,37 Although some suggest that the effects of these interventions may remain in the long term,38 no studies have assessed whether gains persist after the intervention. Cognitive improvements may even be temporary and only present on the day following each music therapy session.39 In our study, cognitive function improved progressively throughout the intervention period; this finding may contradict the hypothesis that effects of music therapy are transient. Differences in results may stem from the type of intervention: active vs passive, individual vs group sessions, relaxation music vs pop music, etc. Further studies with large sample sizes and solid methodology should aim to explore the impact of these variables on treatment outcomes. Our results may have been influenced by the type of scale we used to assess cognitive function. The fact that we used short tests and administered them several times throughout the intervention period may have helped facilitate memory.

Despite changes in patients’ cognition and behaviour, music therapy had no impact on functional dependence, as the literature reports.40 Our results may be explained by the impact of certain factors. Our patients were severely dependent for activities of daily living. Combined motor and cognitive rehabilitation would therefore have been necessary to achieve any quantifiable improvements in function.

In summary, music therapy stimulates cognitive function, improves mood, and reduces behaviour problems triggered by stressful conditions. Music therapy, an inexpensive and pleasant intervention with no adverse effects, has emerged as a promising alternative for patients with dementia. Further controlled studies with homogeneous samples are necessary to support use of this technique. Results must be interpreted with caution due to the study's within-subjects design. Nevertheless, consistency and effect size underline the need for further controlled studies to rule out a placebo effect and analyse long-term residual benefits of music therapy sessions.

Conflicts of interest

The authors have no conflicts of interest to declare.

M. Prince, R. Bryce, E. Albanese, A. Wimo, W. Ribeiro, C.P. Ferri.
The global prevalence of dementia: a systematic review and metaanalysis.
Alzheimers Dement, 9 (2013), pp. 63-75
F.J. García García, M.I. Sánchez Ayala, A. Pérez Martín, E. Martín Correa, C. Marsal Alonso, G. Rodríguez Ferrer, et al.
Prevalencia de demencia y de sus subtipos principales en sujetos mayores de 65 años: efecto de la educación y ocupación. Estudio Toledo.
Med Clin, 116 (2001), pp. 401-407
J.L. Conde-Sala, J. Garre-Olmo, J. Vilalta-Franch, J. Llinàs-Reglà, O. Turró-Garriga, M. Lozano-Gallego, et al.
Declive cognitivo en la enfermedad de Alzheimer. Seguimiento de más de tres años de una muestra de pacientes.
Rev Neurol, 56 (2013), pp. 593-600
C.C. Tan, J.T. Yu, H.F. Wang, M.S. Tan, X.F. Meng, C. Wang, et al.
Efficacy and safety of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease: a systematic review and meat-analysis.
J Alzheimer Dis, 41 (2014), pp. 615-631
J. Vilalta-Franch, S. Lopez-Pousa, J. Garre-Olmo, A. Turon-Estrada, I. Pericot-Nierga.
Mortalidad en pacientes con enfermedad de Alzheimer tratados con neurolépticos atípicos.
Rev Neurol, 46 (2008), pp. 129-134
J. Olazarán, B. Reisberg, L. Clare, I. Cruz, J. Peña-Casanova, T. del Ser, et al.
Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy.
Dement Geriatr Cogn Disord, 30 (2010), pp. 161-178
J. Olazarán-Rodríguez, L.F. Agüera-Ortiz, R. Muñiz-Schwochert.
Síntomas psicológicos y conductuales de la demencia: prevención, diagnóstico y tratamiento.
Rev Neurol, 55 (2012), pp. 598-608
D.P. Seitz, S. Brisbin, N. Herrmann, M.J. Rapoport, K. Wilson, S.S. Gill, et al.
Efficacy and feasibility of nonpharmacological interventions for neuropsychiatric symptoms of dementia in long term care: a systematic review.
J Am Med Dir Assoc, 13 (2012), pp. 503-506
A. Raglio, S. Filippi, D. Bellandi, M. Stramba-Badiale.
Global music approach to persons with dementia: evidence and practice.
Clin Interv Aging, 9 (2014), pp. 1669-1676
M. Gómez-Romero, M. Jiménez-Palomares, J. Rodríguez-Mansilla, A. Flores-Nieto, E.M. Garrido-Ardila, M.V. González-López.
Beneficios de la musicoterapia en las alteraciones conductuales de la demencia. Una revisión sistemática.
Neurología, 32 (2017), pp. 253-263
O. McDermott, N. Crellin, H.M. Ridder, M. Orrell.
Music therapy in dementia: a narrative synthesis systematic review.
Int J Geriatr Psychiatry, 28 (2013), pp. 781-794
G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price, E.M. Stadlan.
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.
Neurology, 34 (1984), pp. 939-944
C.P. Hughes, L. Berg, W.L. Danziger, L.A. Coben, R.L. Martin.
A new clinical scale for the staging of dementia.
Br J Psychiatry, 140 (1982), pp. 566-572
M. Mercadal-Brotons, P. Martí Augé.
Manual de musicoterapia en geriatría y demencias.
Instituto Monsa de Ediciones, (2008),
M.F. Folstein, S.E. Folstein, P.R. McHugh.
Mini-mental state. A practical method for grading the cognitive state of patients for the clinician.
J Psychiatr Res, 12 (1975), pp. 189-198
J.L. Cummings, M. Mega, K. Gray, S. Rosenberg-Thompson, D.A. Carusi, J. Gornbein.
The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia.
Neurology, 44 (1994), pp. 2308-2314
A.S. Zigmond, R.P. Snaith.
The Hospital Anxiety and Depression Scale.
Acta Psychiatr Scand, 67 (1983), pp. 361-370
F.I. Mahoney, D.W. Barthel.
Functional evaluation: the Barthel index.
Md State Med J, 14 (1965), pp. 61-65
A. Raglio, L. Attardo, G. Gontero, S. Rollino, E. Groppo, E. Granieri.
Effects of music and music therapy on mood in neurological patients.
World J Psychiatry, 5 (2015), pp. 68-78
H.M. Ridder, B. Stige, L.G. Qvale, C. Gold.
Individual music therapy for agitation in dementia: an exploratory randomized controlled trial.
Aging Ment Health, 17 (2013), pp. 667-678
G.R. Hall, K.C. Buckwalter.
Progressively lowered stress threshold: a conceptual model for care of adults with Alzheimer's disease.
Arch Psychiatr Nurs, 1 (1987), pp. 399-406
L. Volicer, A.C. Hurley.
Management of behavioral symptoms in progressive degenerative dementias.
J Gerontol A Biol Sci Med Sci, 58 (2003), pp. 837-845
M. Suzuki, M. Kanamori, M. Watanabe, S. Nagasawa, E. Kojima, H. Ooshiro, et al.
Behavioral and endocrinological evaluation of music therapy for elderly patients with dementia.
Nurs Health Sci, 6 (2004), pp. 11-18
M. Sakamoto, H. Ando, A. Tsutou.
Comparing the effects of different individualized music interventions for elderly individuals with severe dementia.
Int Psychogeriatr, 25 (2013), pp. 775-784
J. Drapeau, N. Gosselin, L. Gagnon, I. Peretz, D. Lorrain.
Emotional recognition from face, voice, and music in dementia of the Alzheimer type.
Ann N Y Acad Sci, 1169 (2009), pp. 342-345
M. Irish, C.J. Cunningham, J.B. Walsh, D. Coakley, B.A. Lawlor, I.H. Robertson, et al.
Investigating the enhancing effect of music on autobiographical memory in mild Alzheimer's disease.
Dement Geriatr Cogn Disord, 22 (2006), pp. 108-120
N.R. Simmons-Stern, A.E. Budson, B.A. Ally.
Music as a memory enhancer in patients with Alzheimer's disease.
Neuropsychologia, 48 (2010), pp. 3164-3167
L. Ferreri, J.J. Aucouturier, M. Muthalib, E. Bigand, A. Bugaiska.
Music improves verbal memory encoding while decreasing prefrontal cortex activity: an fNIRS study.
Front Hum Neurosci, 7 (2013), pp. 779
L.J. Trainor, A.J. Shahin, L.E. Roberts.
Understanding the benefits of musical training: effects on oscillatory brain activity.
Ann N Y Acad Sci, 1169 (2009), pp. 133-142
G. Soria-Urios, P. Duque, J.M. Gracía-Moreno.
Música y cerebro (II): evidencias cerebrales del entrenamiento musical.
Rev Neurol, 53 (2011), pp. 739-746
F.H. Rauscher, G.L. Shaw, K.N. Ky.
Music and spatial task performance.
Nature, 365 (1993), pp. 611
B. Woods, A. Spector, C. Jones, M. Orrell, S. Davies.
Reminiscence therapy for dementia.
Cochrane Database Syst Rev, 2 (2005), pp. CD001120
M. Brotons, S.M. Koger.
The impact of music therapy on language functioning in dementia.
J Music Ther, 37 (2000), pp. 183-195
A. Dassa, D. Amir.
The role of singing familiar songs in encouraging conversation among people with middle to late stage Alzheimer's disease.
J Music Ther, 51 (2014), pp. 131-153
M.G. Jantzen, B.M. Howe, K.J. Jantzen.
Neurophysiological evidence that musical training influences the recruitment of right hemispheric homologues for speech perception.
Front Psychol, 5 (2014), pp. 171
P. Narme, S. Clément, N. Ehrlé, L. Schiaratura, S. Vachez, B. Courtaigne, et al.
Efficacy of musical interventions in dementia: evidence from a randomized controlled trial.
J Alzheimers Dis, 38 (2014), pp. 359-369
H.C. Li, H.H. Wang, F.H. Chou, K.M. Chen.
The effect of music therapy on cognitive functioning among older adults: a systematic review and meta-analysis.
J Am Med Dir Assoc, 16 (2015), pp. 71-77
T. Takahashi, H. Matsushita.
Long-term effects of music therapy on elderly with moderate/severe dementia.
J Music Ther, 43 (2006), pp. 317-333
R.A. Bruer, E. Spitznagel, C.R. Cloninger.
The temporal limits of cognitive change from music therapy in elderly persons with dementia or dementia-like cognitive impairment: a randomized controlled trial.
J Music Ther, 44 (2007), pp. 308-328
G. Berger, T. Bernhardt, U. Schramm, R. Müller, S. Landsiedel-Anders, J. Peters, et al.
No effects of a combination of caregivers support group and memory training/music therapy in dementia patients from a memory clinic population.
Int J Geriatr Psychiatry, 19 (2004), pp. 223-231

Please cite this article as: Gómez Gallego M, Gómez García J. Musicoterapia en la enfermedad de Alzheimer: efectos cognitivos, psicológicos y conductuales. Neurología. 2017;32:300–308.

Copyright © 2015. Sociedad Española de Neurología
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.