The expression of DLGAP1-AS1 expression is increased in glioma.

DLGAP1-AS1 promotes the malignancy of glioma via modulating miR-628-5p/DDX59 axis.

OUES analysis is useful for assessing functional capacity in refractory angina.

O2 pulse curve is correlated with contractile alterations in exercise echocardiogram.

Cardiopulmonary exercise test is useful toll in patients with refractory angina.

In infants gestational age ≥ 36 weeks the readmission rate is 4.0%.

Most common causes are respiratory infections, jaundice, and feeding problems.

Initial care in special care or NICU setting showed reduced readmission rates.

GM1 and erythropoietin bring neurological improvement in mice with blunt spinal cord injury.

Fatigue of the ankle's stabilizing muscles does influence the performance.

Functional jump tests are low cost and useful for clinical practice.

Functional jump tests can evaluate of the effects of muscle fatigue.

Anti-SARS-CoV-2 antibodies in blood donors in the state of São Paulo.

High prevalence of anti-SARS-CoV-2 antibodies in donors using public transport.

FRAX without BD moderately to strongly correlates to FRAX with BD and tends to superestime 10-year fracture risk prediction.

FRAX without BD is reliable and sensitive as a screening tool even in multimorbid patients.

The aim of the research is to explore the clinical value of preferred ultrasound endoscopic guided biliary drainage in patients with extrahepatic biliary obstruction with intrahepatic biliary ectasis.

A prospective randomized controlled study was randomized into EUS-AG and ERCP-BD, with 28 patients in EUS-AG and 30 in ERCP-BD.

The authors found the EUS-AG operation can be done in a short time, low incidence of complications, is safe, effective, and can be used as the preferred treatment plan for patients with extrahepatic biliary duct malignant obstruction.

Lacticaseibacillus rhamnosus prevents lung neutrophilia.

Lacticaseibacillus rhamnosus attenuates bronchial hyperreactivity.

Lacticaseibacillus rhamnosus reduces pulmonary oedema.

Incidental thyroid carcinomas are diagnosed by pathological study of the surgical specimen, with no previous suspicion by other diagnostic methods before surgery.

Incidental thyroid cancer has been found at high rates in men and young people, usually, but not always, with more favorable histopathological characteristics and better prognosis.

The better understanding of incidental thyroid cancer can improve decisions towards active surveillance strategies for the management of papillary thyroid carcinoma.

We observed that miR-128b regulated LPS-induced apoptosis of HPMECs and identified its mechanism.

LPS induced apoptosis and ROS production and upregulated miR-128b and caspase-3 expressions in HPMECs.

miR-128b has a potential therapeutic target for the treatment of ARDS.

""H4AE"": warning signs for hereditary angioedema identification.

Hereditary angioedema is unknown and underdiagnosed.

Hereditary angioedema has high morbidity and may be fatal.

miR-181a-5p expression was found to be decreased in retinoblastoma tissues and cell lines.

miR-181a-5p reduced retinoblastoma cell proliferation, migration, and invasion while enhancing apoptosis.

NRAS is a direct target of miR-181a-5p.

Predicting placenta accreta spectrum disorder with magnetic resonance imaging.

Estimating probability of placenta accreta spectrum disorder.

Circ_0075825 is highly expressed in gastric cancer tissues.

Circ_0075825 promotes the malignant biological behaviors of gastric cancer cells.

Circ_0075825 functions as a molecular sponge to repress miR-432-5p and up-regulate SOX9.

Phytosterols supplementation reduced total cholesterol, LDL-C, apo B, and triglycerides.

Phytosterols supplementation increased plasma lathosterol as well as campesterol and sitosterol, indicating compliance to the diets.

Lathosterol-to-cholesterol ratio predicted the cholesterol response to phytosterols feeding.

High basal cholesterol synthesis is associated with a lack of response to plasma cholesterol.

IRF4 is a negative regulator during the osteogenic differentiation of BM-MSCs.

IRF4 can transcriptionally activate microRNA-636 in BM-MSCs.

MicroRNA-636 can suppress the osteogenic differentiationof BM-MSCs by directly targeting DOCK9.

The morbidity and mortality associated with cardiovascular diseases may be higher in patients with chronic inflammatory diseases.

The lipid paradox has to be studied in all chronic inflammatory diseases.

The performance of scores of cardiovascular risk may underestimate the real risk in patients with chronic inflammatory diseases.

Development of a novel standard set to be pursued in IIM follow-up, including main outcome concerns of patients and rheumatologists.

Additional important outcomes only indicated by patients such as controlling pain, fatigue and skin lesions were also included in this standard set.

The proposed IIM standard set evaluation consists of MOYACT, MMT8, fatigue and pain VAS, HAQ, and level of physical activity.

MECP2 was downregulated in elderly patients with hip fracture.

MECP2 was correlated with inflammatory factors in hip fractures.

Lower MECP2 predicted poor clinical outcomes of hip fractures.

Lower MECP2 predicted higher mortality and postoperative complications.

There is a positive correlation between temperature and neuropathological damage caused by RFA at different temperatures.

There is a positive correlation between nerve conduction velocity and temperature.

Nerve injury occurs when the temperature reaches 67°C, and the main pathogenesis is closely related to the expression of SCN9A, SCN3B and NFASC protein in sciatic nerve tissue caused by heat transfer injury.

Brain metastasis aberrantly expresses L1CAM.

L1CAM high expression is associated with poor prognosis in brain metastases.

The authors translated and cross-culturally adapted the TEAM tool into Brazilian Portuguese.

The Brazilian Portuguese TEAM version proved to be a consistent and reliable tool.

Aging process increases postural oscillations, worsening the postural balance.

Poor postural balance is more evident in the elderly over 80-years old.

Deterioration of the postural control systems and the increased risk of falls.

Important identify factors related to falls and postural balance.

Over-expression of CLEC14A was in HCC.

CLEC14A may function as a potential diagnostic biomarker for HCC.

Over-expression of CLEC14A was in HCC cells.

Knockdown of CLEC14A decreased the viability and increased the apoptosis of HuH-7 cell.

The frequency of iNKT cells in general and their subtype double-negative are related to endometriosis.

The expression of IL-17 and CCR7 by iNKT cells are related to endometriosis-associated pain symptoms.

iNKT cells are numerically and functionally altered in women with endometriosis.

IPO7 remarkably enhanced pancreatic cancer cell proliferation, migration and invasion and suppressed apoptosis.

IPO7 facilitated the malignant phenotype of pancreatic cancer cells by up-regulating ERBB2.

Knockdown of IPO7 inhibited tumor growth and lung metastasis in vivo.

• APOO was highly expressed in the left ventricle of mice with myocardial infarction.

• Increasing of APOO may activate autophagy and apoptosis in myocardial infarction.

• The regulation of APOO in autophagy and apoptosis was regulated by p38MAPK signaling pathway.

• Checklists avoid human errors and are commonly used in high-reliability industries.

• The “InCor Checklist” was associated with decreased mortality over time.

• Adherence, completeness, and sustainability within public policies are necessary.

The authors The authors have described three novel rearrangements between chromosomes 5 and 2, 5 and 18, and 5 and Y with chromosomal breakpoints and overlapped phenotypes that were not previously described.

One of the main atypical features for 5p- syndrome that the authors report was the presence of seizures that was found in the three patients with rearrangements between different chromosomes and in a patient with a deletion followed by duplication in 5p.

The authors suggest physicians conduct further molecular investigation in the presence of atypical clinical features for patients with 5p- syndrome suspicion.

LINC01857 is upregulated in PAAD and promotes malignant cellular behaviors.

LINC01857 interacts with miR-19a-3p to regulate SMOC2 expression.

LINC01857 promotes malignant cellular phenotypes by upregulating SMOC2.

SNHG22 in downregulated in placentas from PE patients.

Overexpression of SNHG22 promotes the migration and invasion of trophoblasts.

SNHG22 works as a sponger of microRNA-128-3p to increase PCDH11X expression in trophoblasts.

SNHG22 modulates PCDH11X-activated PI3K/Akt signaling to drive migration and invasion of trophoblasts.

Two novel inflammation-related markers, LMR and MHR are associated with Chronic Heart Failure (CHF).

LMR and MHR were first proposed to be the predictors of a diagnosis of CHF in this study, which suggested that inflammation was associated with CHF, and anti-inflammation therapy might be a potential target for future therapeutic interventions.

Compared with special inflammatory indicators such as TNF or IL-1, LMR and MHR are routinely measured in clinical practice and less time-consuming, which makes them suitable for popularization.

32% of the patients visited an emergency room after COVID-19 hospitalization.

The rate of hospital readmission after COVID-19 hospitalization is high, in the present sample 10% of patients needed a second hospitalization in 6-months

Patients with persistent diarrhea after COVID-19 discharge had two times more chance to have another hospitalization in the next 6-months.

Indwelling pleural catheter represents a suitable option for patients with malignant pleural effusion and short life expectancy. It relieves respiratory symptoms without compromising the quality of life, and the complication rate is low, even in an emerging country, with a low socioeconomic and under-educated patient population. The rate of spontaneous pleurodesis was 45%. The analysis of the visual analog scale showed significant control of dyspnea (p = 0.001), but pain and quality of life did not change significantly.

miR-146b was downregulated in Inflammatory Bowel Disease (IBD) mice and LPS-induced macrophages.

Fibrinogen Like 2 (FGL2) was identified as the target gene of miR-146b.

miR-146b ameliorated the inflammation and blocked M1 macrophage polarization via inhibiting FGL2.

miR-146b ameliorated the symptoms and pathological injury of IBD via inhibiting FGL2.

RT3D-STE and exosome miRNAs can be used as a hierarchical diagnostic system in AMI.

Exosomal miR-152-5p and miR-3681-5p function as potential biomarkers for ST-segment elevation myocardial infarction.

Deccanulation indicators were investigated in patients who were submitted to a tracheostomy procedure.

Early swallowing evaluation and rehabilitation were associated with a successful decannulation process.

Low swallowing functional levels were negatively associated with the success of decannulation.

In unvaccinated pregnant and postpartum women, any need for oxygen supply increases the risk of invasive ventilation.

Obesity, smoking and chronic arterial hypertension proved to be risk factors for the use of oxygen in pregnant and postpartum women with COVID-19.

The combination of C-reactive protein ≥ 21 mg/L, hemoglobin < 11.0 g/dL, and lymphopenia < 1500 mm3 on hospital admission and the presence of ground glass ≥ 50% in computer tomography increased the risk of O2 use by 4.97 and 5.33 times respectively in pregnant and postpartum women with COVID-19.

Individuals previously infected with SARS-CoV-2 ancestral strain do not develop neutralizing antibodies against the Omicron variant.

Omicron variant escapes immune response after SARS CoV-2 previous infection with the SARS CoV-2 Gamma variant.

Individuals previously infected with SARS-CoV-2 ancestral strain or with SARS-CoV-2 Gamma variant will likely have little protection if subsequently exposed to the Omicron variant.

Acetate was able to exacerbate the production of TNF-α in microglia.

Acetate administered as pre-treatment to LPS acts as an anti-inflammatory.

Histone deacetylase decreased TNF-α production in Acetate- and LPS-treated cells.

Depending on the time of administration, Acetate modulates microglia's activation.

Acetate may threaten neurodegenerative and neuropsychiatric diseases.

The scaffold-based delivery therapy with adipose tissue-derived stem cells in the rat ovarian autografts seems to be the best option when compared to direct injection or systemic route.

Ovarian grafts treated with adipose tissue-derived stem cells showed the highest number of genes over-regulated in the apoptosis pathway, compared to inflammation cytokines and angiogenesis pathway.

Capsase14 was the most over-regulated gene in the apoptosis pathway.

The treatment with adipose tissue-derived stem cells in ovarian grafts treated didn't compromise the ovary graft morphology and viability for short time.

Higher education, prior experience, and being women improved the odds of identifying stroke warning signs and symptoms as associated risk factors

Improving knowledge, skills, and attitude on acute stroke in the school community may represent a significant advance in public health management

Future stroke awareness campaigns and educational efforts should focus on schoolchildren and adolescents, especially in low-income countries

Adaptations in validated methods are a recurrent trend due to limited budgets which does not diminish their functionality.

Scintigraphy with 99mTcO4 is effective in evaluating the functionality of thyroid grafts after cryopreservation in rats.

It is possible to adapt human SPECT for other animals for clinical and research purposes.

COVID-19 increases the rates of adverse pregnancy and neonatal outcomes.

Serious cases are associated with oligohydramnios, fetal distress, prematurity, neonatal ICU admission, maternal and neonatal deaths.

The maternal clinical status dictates obstetric and neonatal outcomes.

The implantation of endometrial cells in the pelvic cavity has been related to some factors such as a receptive environment that allows the implantation and proliferation of these cells.

Several studies have shown the participation of the Ezrin protein in the process of invasion of malignant cells.

The expression of Ezrin and its activated form was observed in endometriotic lesions providing great evidence that these proteins can play an important role in the migration and attachment of endometriotic lesions.

Positivity for strongyloidiasis in coproscopic exam was low in diabetic patients.

PCR is more sensitive for detecting S. stercoralis infection in diabetic patients.

Molecular diagnosis is an important tool for the detection of S. stercoralis.

Ambulation capacity, race, age, and immunosuppression increase the risk of in-hospital death. How might it impact clinical practice in the future?

People with ambulation disabilities should be treated more carefully when they present the first symptoms of COVID-19, due to the high risk of developing a worse prognosis.

Pandemic control recommendations should include the population with ambulation disability as a priority group in vaccination against COVID-19

Hands osteoarthritis treatment.

Intra-articular corticosteroid injection.

Group cognitive-behavioral therapy (CBT) have a positive influence on women's sexuality.

Group CBT was shown to be an effective tool for treating Hypoactive Sexual desire disorder in women.

Group CBT can be a short-term focal intervention carried out by gynecologists specialized in sexual health.

Group CBT can be used in a high-complexity care setting.

Analysis of changes in hepatectomies during the last 2 decades.

The surgical treatment of liver tumors needs a multidisciplinary approach.

Clinical variability within a large family with a slowly progressive form of MPS II.

Despite being safe, ERT with α or β-Idursulfase might not prevent disease progression.

FOXP3 variants are associated with susceptibility to IBD.

GAGA haplotype is associated with reduced TGF-γ plasma levels in IBD.

G/C haplotypes have a protective effect on susceptibility in CD.

MicroRNA-448 expression decreased in Breast Cancer (BC) tissues and BC cells.

Zinc finger E-box Binding Homeobox 1 (ZEB1) was upregulated in BC tissues and cells.

Upregulation of miR-448 expression could inhibit the malignant behaviors of BC cells.

Upregulated miR-448 expression could enhance BC cells’ sensitivity to PTX or 5-FU.

TRAS is the most common vascular complication after kidney transplantation.

Delayed graft function increases more than 3 times the chance of developing TRAS.

Diabetes mellitus and DGF are independent risk factors for post-anastomotic TRAS.

Resveratrol can effectively improve pulmonary thromboembolism-induced PAEC injury.

Resveratrol can reduce pulmonary arterial pressure through a variety of mechanisms.

These findings may contribute to the treatment of PH in the future.

The main determinants for depression after lacunar and non-lacunar stroke were different.

Infarctions in the frontal cortex were significantly associated with post-stroke depression.

For patients of lacunar stroke, the location of the infarction was not associated with the presence of post-stroke depression.

Important etiologies of chronic liver disease are viral hepatitis.

Viral hepatitis B and C causes 1.1 million deaths per year.

Hepatic steatosis (liver fat accumulation) is a metabolic complication of hepatitis C.

The underlying mechanisms involving steatosis include genetic polymorphisms.

-493G/T and I128T polymorphisms in the MTTP gene are relevant in hepatic steatosis.

The study's objective was to identify the risk factors for the development of post-pleurodesis empyema in order to better select patients for this procedure and minimize its morbidity. The study suggests that antibiotic therapy prior to pleurodesis may increase the risk of developing empyema. Furthermore, pleurodesis should be carefully considered in patients with long-duration chest tube and incomplete lung expansion.

Obesity and its related complications are rapidly changing the epidemiology of many types of cancer, including HCC. As a result of this dynamic epidemiology, NAFLD and NASH-related HCC have risen ‒ more rapidly than HCV, HBV, and other HCC's causes.

The evaluation of HCC development, the role of screening, treatment, and outcomes on HCC-NAFLD patients is still controversial and not well described.

Metabolic risk factors for NAFLD were present in the majority of the patients, even though a small percentage were in HCC screening programs before.

Cumulative survival at the end of the first year was 72%, second year 52%, and fifth-year 32%. The independent factors associated with shorter general survival were BCLC C-D, and the size of the largest nodule > 42 mm.

Body composition is considered an important predictor in different clinical and health promotion scenarios.

This is the first study to describe the reference values of body composition composed of a sample of Brazilians stratified by different life cycles, sex, and race.

This is the first study that includes the evaluation of all parameters of body composition assessed from electrical bioimpedance.

• Beclin-1 gene silencing could reduce the autophagy level of BPH-1 cells.

• Beclin-1 gene silencing could promote the apoptosis of BPH-1 cells.

• There is an antagonisc relationship between autophagy and apoptosis in BPH-1 cells.

lncRNA SNHG1 played an oncogenic role in bladder cancer, indicating poor prognosis.

SNHG1 competitively bound miR-137-3p to promote EZH2 expression in the cytoplasm.

SNHG1 could interact with EZH2 to inhibit KLF2 transcription in the nucleus.

Total CTCs and MCTCs in post-treatment is strongly relative to PFS and OS of patients.

The PFS of >6 CTCs or 5 MCTCs/5 mL blood was shorter than that in ≤ 6 CTCs or 5 MCTCs.

Detection of CTCs in CRC patients is a critical biomarker for their prognosis.

SP-A induced pathological damage to placenta by promoting STOX1.

SP-A inhibited the activities of antioxidant enzymes through STOX1.

SP-A promoted the ROS production in placenta by promoting STOX1.

SP-A inhibited protein levels of NOS3 and ARG2 in placenta.

Anterior cruciate ligament injury is disabling in several sports.

nterior cruciate ligament injury causes knee instability and functional deficit.

Usually, surgical treatments produce best functional outcomes.

Incidence of Hemodynamic Depression was 54.4% in 237 carotid surgeries.

Asymptomatic carotid stenosis and endovascular surgery were predictors of HD.

Hypotension requiring continuous vasopressor infusion was associated with MACE.

LHX1 is highly upregulated in the cells and tissues of Uterine Corpus Endometrial Carcinoma (UCEC).

Upregulation of LHX1 is correlated with poor prognosis of UCEC patients.

LHX1 may regulate UCEC progression at least partly by modulating EMT induction.

Natural antigen ELISA detected saliva IgG or IgA against respiratory viruses in asymptomatic people from Influenza and COVID.

Samples with specific influenza IgG were more frequent than COVID IgG, probably due to long time exposure to influenza, but samples positive for specific IgA had same proportion for both viruses.

POCD has a significant impact on patients' physical and mental health.

Postoperative models of tibial fracture in aged rats were established.

Postoperative central inflammation in rats with lower limb fracture induced POCD through the GBA molecular mechanism.

Lower incidence of incisional hernias in pediatric patients.

Greater proliferation of fibroblasts in younger rats.

Lox gene is more expressed in weaning rats.

Breast stiffness severely affects clinical- and self-examination of the breast.

Development of subjective stiffness scale based on expert examination.

Objective stratification based on interval of increment of strain energy density.

Proposed scale correlates with subjective clinical examination in 92%.

Women with stiff breasts may benefit from frequent checkup procedures.

Relationship of plasma miR-423-5p expression in COPD patients as well as smoking history.

9 miRNAs were dysregulated in COPD patients.

miR-423-5p has potential value as a clinical diagnosis of COPD.

Radiofrequency is effective in flaccidity.

Radiofrequency provokes collagen remodeling.

Higher Adiposity Index (VAI) tertile shows higher rates of Abdominal Aortic Calcification (AAC).

Each unit increase in VAI was associated with 4% higher likelihood of severe AAC.

Increased visceral adiposity evaluating by VAI associated with a higher AAC score.

This positive relationship was more significant in normal weight population.

High lipoprotein (a) levels increase the risk of carotid plaques presence in asymptomatic subjects.

Carotid intima-media thickness is not affected by plasma lipoprotein (a) levels.

Age and race are directly associated with lipoprotein (a) levels, suggesting an important influence even in a highly miscegenated population.

Vaccination with any vaccine was effective in preventing confirmed COVID-19 cases.

CoronaVac was effective in preventing COVID-19 related hospitalizations.

Vaccination had a significant impact in reducing cases and hospitalizations.

Predominance of mild cases, with respiratory symptoms, myalgia, and headache.

Vaccine protection waned over time.

The study evaluated seroconverted asymptomatic COVID-19 in pediatric Autoimmune Rheumatic Diseases (ARDs) patients.

Pediatric rheumatic disease patients were infected at the same rate as healthy ones.

Neither the underlying pathology nor its immunosuppressive treatment seemed to interfere with contagion risk.

Melatonin (MT) plays a similar role in ovarian damage as 3-MA does.

MT confers protection against ovarian damage in vivo and in vitro.

MT exerts its protective effects by inhibiting the PI3K/AKT/mTOR signaling pathway.

Prospective, double-blind, randomized pilot study.

Compares efficacy of oxytocin and promestriene in Genitourinary Menopause Syndrome.

The two medications improved the three domains of the FSFI scales scores evaluated.

Both medications showed an increase in the thickness of the vaginal epithelium (p < 0.05).

Oxytocin and promestriene were both effective in Genitourinary Menopause Syndrome.

Central auditory processing disorder was detected in all the individuals in the study group.

The study group had worse performance with a statistically significant difference.

The changes especially are in auditory closure and temporal processing as compared to the control group.

MiR-135a-5p was significantly down-regulated and BAG3 expression was significantly raised in BC tissues.

MiR-135a-5p overexpression inhibited the viability, migration and aggressiveness of BC cells, and blocked cell cycle progression in G0/G1 phase.

Over-expression of BAG3 reversed the impacts of miR-135a-5p on BC cells.

miRNA-223 was downregulated in endometrial stromal ells from endometriosis patients.

miRNA-223 upregulation repressed malignant behaviors of endometrial stromal cells.

miRNA-223 might serve as a potential therapeutic target for endometriosis.

Profound changes in lipid profile have been described in septic patients.

Lipid profile was equivalent between septic and control groups.

Septic shock group showed lower TG, HDLc, monocytes and M/H ratio and higher CRP, IL-6, IL-8 and IL-10 levels at admission.

All lipid variables decreased from D0 to D3 in the shock group.

M/H ratio and non-HDL cholesterol were predictors of shock in septic newborns.

Critically ill patients with COVID-19 can have secondary infections.

Some of them are caused by Multidrug-Resistant (MDR) Gram-Negative Bacteria (GNB).

To know the risk factors related to MDR-GNB is essential to analyze if it is possible to prevent them.

Hospital of admission for patients with COVID-19 posed as high risk for MDR-GNB.

This is a modifiable risk factor.

Knockdown of TRIM47 suppressed proliferation of ovarian cancer cells.

Knockdown of TRIM47 inhibited ovarian cancer cell migration and invasion.

TRIM47 promoted ovarian cancer cell proliferation and invasion via STAT3 signaling.

The multigenic panel effectively diagnoses patients with endocrine diseases.

It is the first panel to diagnose a broad spectrum of endocrine diseases using TMPS.

This panel helps the visualization of molecular pathways behind endocrine conditions.

Untreated obstructive sleep apnoea in children may result in severe health consequences, including cardiovascular, metabolic, endocrine and growth abnormalities.

Other sleep impairments may be associated with obstructive sleep apnoea, affecting children's quality of life.

Polysomnography is the gold standard for diagnosis, but it is costly and not widely available.

Other studies that contribute to the diagnosis process are relevant and of great importance.

The objective of this review was to evaluate the effect of L-carnitine compared to placebo or Usual Care (UC) on the mortality rate in hospitalized adult septic shock patients. •Two Randomized Controlled Trials were selected for inclusion in this review •There is low-quality evidence that L-carnitine has no significant effect on 28-day mortality of septic shock patients

Older men are stronger than older women.

Higher torque variability in older men.

Adaptation to the isokinetics evaluation.

Different muscles need different numbers of sets.

Different muscles need different numbers of trials.

One out of every two pregnant adolescents (50.5%) followed in prenatal care were positive for high-risk HPV and about 1 in 6 pregnant women (17.5%) had an abnormal Pap smear.

Positivity for oncogenic HPV was an important risk factor for colpocytological alterations, especially for Low-grade Squamous epithelial Lesion (LSIL), increasing the risk by nine times.

Higher education, fewer lifetime partners, and profession of religion were associated with the diagnosis of oncogenic HPV in pregnancy.

Higher concentrations of Activin A in pleural effusion were associated with days of admission in PPE patients.

Elevated levels of Activin A in pleural effusion exhibited 93% sensitivity and 84% specificity in the diagnosis of PPE.

Pleural fluid Activin A level had higher AUC and better accuracy in the diagnosis of PPE.

This study's main objective is to describe the clinical characteristics and evolution from birth to discharge of 71 neonates born to unvaccinated women with COVID-19 with RT-PCR for SARS-CoV-2 positive within fourteen days prior to delivery in a Brazilian hospital.

The neonatal SARS-CoV-2 positivity rate was 2.8% and these newborns had few clinical symptoms.

The prematurity rate was 63.4%, indicating that maternal disease may lead to neonatal complications associated with a higher prematurity rate.

Dry syndrome can increase the risk of spontaneous abortion and preterm delivery.

Dry syndrome can increase the risk of low birth weight and birth defects.

Clinics should provide comprehensive prenatal counseling and testing for the patients.

P4HA2 is highly expressed in LUAD tumor cells, especially for the BM subtype.

P4HA2 is a valuable prognostic indicator for LUAD.

P4HA2 is related to biological processes promoting metastasis.

Adolescents’ knowledge of HPV.

Adolescents’ knowledge of sexually transmitted diseases.

Female adolescents’ knowledge of HPV and sexually transmitted diseases.

Male adolescents’ knowledge of HPV and sexually transmitted diseases.

The protein analysis reveals dynamic changes in the three different phases in response to allo-HSCT.

The most identified proteins were involved with the regulation of body fluid levels and mucosal immune response.

The allo-HSCT patients presented a decreased salivary flow rate at 30 and 100 days post-transplant.

MB improved septic shock biomarkers associated with microcirculation, however, did not improve blood pressure.

The MB was not associated with pulmonary hypertension and respiratory clinical repercussions.

The MB did not decrease the heart inotropic or chronotropic aspects.

Children with hemoglobinopathies have less severe conditions with Coronavirus 2019 Disease (COVID-19) compared to adults, which is similar to that observed in the general population

In the H1N1 pandemic, patients with hemoglobinopathies behaved as the group most susceptible to complications, with increased morbidity and mortality

Ischemic stroke in COVID-19 is multifactorial but predominantly embolic.

Ischemic stroke in COVID-19 predominantly affects males and the anterior circulation.

Frequency of ischemic stroke has not increased since the outbreak of the pandemic.

The increase of arterial stiffness at younger ages has been considered a strong predictor of cardiovascular outcomes.

Elevated “pulsatile load”, which translates into elevated arterial stiffness, would lead to a cascade of phenomena (left atrium distension, neurohormonal activation and inflammatory response), that in their final common path would lead to the development of atrial fibrillation.

A genetic predisposition for a higher arterial stiffness index was unidirectionally associated with an increase in incidence risk and prevalence of atrial fibrillation. These results are consistent with a causality association between arterial stiffness and atrial fibrillation.

A knowledge gap to be clarified is whether a reduction in arterial stiffness could lead to a decrease in atrial arrhythmia burden, from frequent atrial ectopic beats to atrial fibrillation. Another knowledge gap is the possible rule of arterial stiffness in the so-called “pre-fibrillatory stage”.

Dextrose injections promote deposition of collagen into injured structures through growth factors and inflammatory cells.

Dextrose-prolotherapy is a useful treatment method, but it is not superior or inferior to its counterparts.

Hyperthermia chemotherapy and cytoreductive surgery in patients with peritoneal pseudomyxoma.

This article defines medical errors and medical responsibility from a Brazilian perspective.

This article calls attention to the risks of medical liability and the unethical use of defensive medicine.

The authors propose some procedures and attitudes to avoid medical errors like the use of technology at the bedside and computer-based protocols.

The authors state that a good and ethical medical practice can avoid medical liability.

SARS-CoV-2 infections can be complicated by Guillain-Barre Syndrome (GBS).

The prevalence of SARS-CoV-2 associated GBS declined since the introduction of SARS-CoV-2 vaccines.

The outcome of SARS-CoV-2 associated GBS is worse among those with comorbidities compared to those without.

The efficacy of P-CAB-based triple therapy is superior to that of PPI-based triple therapy as a first-line approach to H. pylori eradication, particularly in Japanese patients.

P-CABs were not superior to PPIs as a salvage triple eradication therapy.

The safety and tolerability of P-CAB are comparable to PPI in H. pylori triple eradication therapies.

Further large RCTs conducted in multiple regions and countries are necessary.

The Coronavirus 19 (COVID-19) pandemic has dramatically impacted liver organ transplantation.

This study systematically reviewed the current knowledge regarding the Liver Transplantation (LT) time for patients after COVID-19.

Furthermore, the authors provide more knowledge to the transplant physicians with essential decision-making tools to manage these critically ill patients during the pandemic.

Screening and early detection programs are a cornerstone of cervical cancer prevention.

Human papillomavirus DNA-based testing reduced the incidence of CC below per capita GDP.

Cost-effectiveness of HPV testing versus cytology in Low- and Middle-Income Countries.

Human milk is an essential source of immunonutrients for the nursing infant.

Maternal vaccination provides specific IgA and IgG antibodies in breast milk.

Milk from vaccinated mothers contains anti-SARS-CoV-2 antibodies that may protect the infant.

Microbial agents and their metabolites are being tested to develop treatments that can reduce the tumor and are potentially preventable.

Microbiota is observed in all clinical and pathological stages of carcinogenesis, from its development, diagnosis, and treatment, including prognosis and survival.

There is a lack of studies on biliary microbiota and its relationship with hepatobiliopancreatic diseases.

Multivisceral liver resections have acceptable long-term oncologic outcomes.

Multivisceral liver resections are safe. They have similar rates of blood loss and postoperative complications.

Multivisceral liver resections are longer and may be associated with a longer length of hospital stay.

NMES may improve functional independence and decrease in adults with COPD.

NMES may decrease in duration of MV in adults with COPD.

More RCTs with a better methodological design are needed.

A meta-analysis was applied to understand the relationship between inhibition of Toll-like Receptor 4 and diabetic myocardial injury.

Inhibition of Toll-like Receptor 4 expression levels can improve the degree of cardiac impairment.

Toll-like Receptor 4 may become a new target for the treatment of diabetic cardiomyopathy.

Homeopathy employs the principle of therapeutic similitude as a method of treatment.

Primary action of drugs is followed by secondary and opposite reaction of the organism.

This secondary and opposite reaction of the organism is namely the rebound effect of drugs.

Homeopathy employs the rebound effect of drugs in a therapeutic way.