Vol. 30.Issue. 1. January - June 2025

Brain reserve in hepatic encephalopathy: Pathways of damage and preventive strategies through lifestyle and therapeutic interventions

Jacqueline Cordova-Gallardo, Andres Manuel Vargas-Beltran, Samantha Melanie Armendariz-Pineda, Jesus Ruiz-Manriquez, Javier Ampuero, Aldo Torre

Ann Hepatol. 2025;30:101740

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The burden of hepatic encephalopathy and the use of albumin as a potential treatment

Jasmohan S. Bajaj, Enrico Pompili, Paolo Caraceni

Ann Hepatol. 2025;30:101751

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From gut to liver: Exploring the crosstalk between gut-liver axis and oxidative stress in metabolic dysfunction-associated steatotic liver disease

Mi Zhou, Jianyu Lv, Xinli Chen, Yujie Shi, Guanqun Chao, Shuo Zhang

Ann Hepatol. 2025;30:101777

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Mechanisms and therapeutic targets of mitochondria in the progression of metabolic dysfunction-associated steatotic liver disease

Chenyang Mu, Sijie Wang, Zenghan Wang, Jian Tan, Haozan Yin, Yuefan Wang, Zhihui Dai, Dongyang Ding, Fu Yang

Ann Hepatol. 2025;30:101774

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The role of inflammasomes in hepatocellular carcinoma: Mechanisms and therapeutic insights

Valentina Arrè, Roberto Negro, Gianluigi Giannelli

Ann Hepatol. 2025;30:101772

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Energy metabolism: An emerging therapeutic frontier in liver fibrosis

Iram Irshad, Saleh A Alqahtani, Kenichi Ikejima, Ming-Lung Yu, Manuel Romero-Gomez, Mohammed Eslam

Ann Hepatol. 2025;30:101896

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Does the hepatologist still need to rely on aminotransferases in clinical practice? A reappraisal of the role of a classic biomarker in the diagnosis and clinical management of chronic liver diseases

Patrizia Burra, Calogero Cammà, Pietro Invernizzi, Fabio Marra, Maurizio Pompili

Ann Hepatol. 2025;30:101900

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Evaluation of four chatbots in autoimmune liver disease: A comparative analysis

Jimmy Daza, Lucas Soares Bezerra, Laura Santamaría, Roberto Rueda-Esteban, Heike Bantel, Marcos Girala, Matthias Ebert, Florian Van Bömmel, ... Andreas Teufel

Ann Hepatol. 2025;30:101537

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Characterizing outcomes in a large cohort of latinx patients with autoimmune hepatitis

Eleanor Belilos, Jessica Strzepka, Ethan Ritz, Nancy Reau, Costica Aloman

Ann Hepatol. 2025;30:101570

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Clinically significant portal hypertension in patients with primary biliary cholangitis: Clinicopathological features and prognostic value

Ying Zhang, Huaying Lai, Jing Chen, Ruimin Lai, Xiaoyu Lin, Shan Lin, Bingping Liu, Qiuxiang Lin, ... Qi Zheng

Ann Hepatol. 2025;30:101577

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The Toulouse algorithm identifies patients with increased risk of cardiac decompensation only in patients with TIPS for refractory ascites

Emma Vanderschueren, Youri Bekhuis, Jan Clerick, Jappe Decock, Philippe Meersseman, Alexander Wilmer, Eveline Claus, Lawrence Bonne, ... Wim Laleman

Ann Hepatol. 2025;30:101568

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Ethanol with thioacetamide murine model of alcoholic liver disease identifies hepatic pathways as targets for the human disease

Ashi Mittal, Nishu Choudhary, Sudrishti Chaudhary, Anupama Kumari, Archana Rastogi, Guresh Kumar, Jaswinder Singh Maras, Shiv K Sarin, Shvetank Sharma

Ann Hepatol. 2025;30:101565

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Camila Marques de Alcântara Barreto, Eliane Almeida do Valle, Jessica Pronestino de Lima Moreira, Katia Farias e Silva, Siane Lopes Bittencourt Rosas, Patrícia Teixeira Santana, Ana Maria Pittella, Gustavo Pereira, ... Heitor Siffert Pereira de Souza

Ann Hepatol. 2025;30:101567

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EIF3B affects the invasion and metastasis of hepatocellular carcinoma cells via the TGFBI/MAPK/ERK pathway

Ling Wang, Chuanzhong Huang, Wansong Lin, Zhifeng Zhou, Jieyu Li, Mingshui Chen, Lingyu Zhang, Yunbin Ye

Ann Hepatol. 2025;30:101564

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Soft drink consumption and increased risk of nonalcoholic fatty liver disease: Results from the health workers cohort study

Edgar Denova-Gutiérrez, Berenice Rivera-Paredez, Amado D. Quezada-Sánchez, Brianda I. Armenta-Guirado, Paloma Muñoz-Aguirre, Yvonne N. Flores, Rafael Velázquez-Cruz, Jorge Salmerón

Ann Hepatol. 2025;30:101566

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Knowledge about metabolic dysfunction-associated steatotic liver disease among the medical professionals from countries in the MENA region

Saleh A. Alqahtani, Yusuf Yilmaz, Mohamed El-Kassas, Khalid Alswat, Mohamed Mawardi, Faisal M. Sanai, Faisal Abaakhail, Saad Alghamdi, ... Global NASH Council

Ann Hepatol. 2025;30:101569

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Epidemiology and natural history of chronic Hepatitis B in the Canadian province of Alberta from 2012 to 2021: A population-based study

Golasa Samadi Kochaksaraei, Fengjuan Yang, Cynthia H. Seow, Herman W Barkema, Carla S Coffin, Abdel-Aziz Shaheen

Ann Hepatol. 2025;30:101576

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Efficacy of prophylactic antibiotics in the adjuvant treatment of alcohol-related liver disease (ALD): A systematic review and meta-analysisProphylactic antibiotics in ALD

Xiuyan Wang, Endian Zheng, Haoyue Sun, Beibei Xu, Liang Zheng, Yi Huang

Ann Hepatol. 2025;30:101571

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Integrated analyses and a novel nomogram for the prediction of significant fibrosis in patients

Mengxin Lu, Shuai Tao, Xinyan Li, Qunling Yang, Cong Du, Weijia Lin, Shuangshuang Sun, Conglin Zhao, ... Liang Chen

Ann Hepatol. 2025;30:101744

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Exosomal linc00152 intensifies the crosstalk between cholangiocarcinoma cells and cancer-associated fibroblasts

Min Hu, Yaxuan Niu, Jinlin Wang, Xiao Chen, Gang Li

Ann Hepatol. 2025;30:101745

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HLA-G liver expression in chronically HIV/hepatitis C-coinfected individuals.

Fernando Crivelenti Vilar, Eduardo Donadi, Benedito Antônio Lopes da Fonseca, Janaina Cristiana de Oliveira Crispim Freitas, Ana Letícia Gomide Zanin Borducchi, Rodrigo de Carvalho Santana

Ann Hepatol. 2025;30:101755

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A social media listening study of patients’ experiences relating to metabolic dysfunction-associated steatotic liver disease: The LISTEN-MASLD study

Jeffrey V. Lazarus, William Alazawi, Ron Basuroy, Laurent Castera, Dmitry Estulin, Yiannoula Koulla, Preethy Prasad, Manuel Romero-Gomez, ... Jörn M. Schattenberg

Ann Hepatol. 2025;30:101741

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Free fatty acid-induced DDX3 inhibits autophagy via miR-141 upregulation in diet-induced MASLD mice model system

Md. Musa Hossain, Amit K. Mishra, Ajay K. Yadav, Md. Ismail, Teja Naveen Sata, Amrendra K. Sah, Arnab Banik, Gopal Sharma, Senthil K. Venugopal

Ann Hepatol. 2025;30:101758

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Factors associated with obtaining lower IQR-CAP values in the detection of hepatic steatosis by transient elastography

Iván López-Mendez, Juan Luis Romero-Flores, Graciela Castro-Narro, Misael Uribe, Eva Juárez-Hernández

Ann Hepatol. 2025;30:101762

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Clinical usefulness of an ultra-high-sensitivity hepatitis B surface antigen assay to determine the cessation of treatment for HBV reactivation

Takanori Suzuki, Akihiro Tamori, Kentaro Matsuura, Takako Inoue, Shigeru Kusumoto, Shinya Hagiwara, Haruka Sagi, Atsushi Kaneko, ... Yasuhito Tanaka

Ann Hepatol. 2025;30:101764

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Assessing liver fibrosis in chronic liver disease: Comparison of diffusion-weighted MR elastography and two-dimensional shear-wave elastography using histopathologic assessment as the reference standard

Li Yang, Guofeng Zhou, Liheng Liu, Shengxiang Rao, Wentao Wang, Kaipu Jin, Caixia Fu, Mengsu Zeng, Ying Ding

Ann Hepatol. 2025;30:101743

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Effect of bariatric endoscopy on liver fibrosis and steatosis and the course of NAFLD – a prospective interventional study

Adam Vašura, Evžen Machytka, Ondřej Urban, Jitka Macháčková, Lubomír Pavliska, Zdeněk Berka, Zdeněk Švagera, Marek Bužga

Ann Hepatol. 2025;30:101765

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Lipocalin-2 silencing alleviates sepsis-induced liver injury through inhibition of ferroptosis

Yuping Li, Lu Li, Yuming Zhang, Qi Yun, Ruoli Du, Hongwei Ye, Zhenghong Li, Qin Gao

Ann Hepatol. 2025;30:101756

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Diagnostic performance of FibroTouch® in assessing hepatic steatosis and fibrosis in patients with metabolic dysfunction-associated steatotic liver disease: An Asian experience

Thanikan Sukaram, Soe Thiha Maung, Yuda Chongpison, Tassanan Jaihan, Chonlada Phathong, Roongruedee Chaiteerakij

Ann Hepatol. 2025;30:101753

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PNPLA3 and SAMM50 variants are associated with lean nonalcoholic fatty liver disease in Asian population

Chia-Wen Lu, Tzu-Jung Chou, Tsan-Yu Wu, Yi-Hsuan Lee, Hung-Jen Yang, Kuo-Chin Huang

Ann Hepatol. 2025;30:101761

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Racial and ethnic disparities in alcohol-associated liver disease hospitalizations in Brazil before and after the COVID-19 pandemic

Daniel L Heringer, Gabriel P.A. Costa, Jeremy Weleff, Victor Rodrigues, Shreya Sengupta, Akhil Anand

Ann Hepatol. 2025;30:101742

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An exploratory machine learning model for predicting advanced liver fibrosis in autoimmune hepatitis patients: A preliminary study

Qinglin Wei, Wen Li, Shubei He, Hongbo Wu, Qiaoling Xie, Ying Peng, Xingyue Zhang

Ann Hepatol. 2025;30:101754

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Tumor-associated macrophages contribute to cholangiocarcinoma progression and chemoresistance through activation of ID1

Yinghao Guo, Shuangda Miao, Yun Jin, Qi Li, Yihang Wang, Xiaoxiao Zhang, Jiangtao Li

Ann Hepatol. 2025;30:101773

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Role of waist circumference, body mass index and high-sensitivity C-reactive protein in pediatric steatotic liver disease: A cross-sectional study

Qiaoling Wu, Yongmei Peng, Chundan Gong

Ann Hepatol. 2025;30:101759

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Metabolic dysfunction-associated steatotic liver disease and risk of four intrahepatic and extrahepatic diseases

Yiyuan Xiao, Sihua Xu, Wenyan Hu, Jiapeng Huang, Deke Jiang, Rong Na, Zhaoqing Yin, Jingjing Zhang, Haitao Chen

Ann Hepatol. 2025;30:101750

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Examining the prevalence of hepatic steatosis and advanced fibrosis using non-invasive measures across Canada: A national estimate using the Canadian Health Measures Survey (CHMS) from 2009-2019

Jacob Romano, Jessica Burnside, Giada Sebastiani, Alnoor Ramji, Keyur Patel, Mark Swain, Sahar Saeed

Ann Hepatol. 2025;30:101757

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FLI and FIB-4 in diagnosing metabolic dysfunction-associated steatotic liver disease in primary care: High prevalence and risk of significant disease

Mário Reis Álvares-da-Silva, Márcia da Silva Vargas, Soheyla Mohd Souza Rabie, Gabriella Jonko, Patricia Gabriela Riedel, Larisse Longo, Marcelo Rodrigues Gonçalves, Vivian Cristine Luft, Dvora Joveleviths

Ann Hepatol. 2025;30:101584

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Rifaximin treatment in patients with severe alcohol-associated hepatitis: A multicenter, randomized controlled, open-label, pilot trial

Do Seon Song, Jin Mo Yang, Young Kul Jung, Hyung Joon Yim, Hee Yeon Kim, Chang Wook Kim, Soon Sun Kim, Jae Youn Cheong, ... Young Seok Kim

Ann Hepatol. 2025;30:101749

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Racial differences in primary sclerosing cholangitis: A retrospective cohort study leveraging a new ICD-10 code

Melinda Wang, Alyssa Harris, Charles E. McCulloch, Sharad I. Wadhwani, Jennifer C. Lai, Jessica B. Rubin

Ann Hepatol. 2025;30:101901

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Impact of parenchymal transection techniques on intraoperative blood loss during liver resection in a porcine model of elevated central venous pressure: A comparative study

Felicia Kneifel, Annika Mohr, Alexander D. Bungert, Tristan Wagner, Mazen Juratli, Haluk Morgul, Finnja Marie Krug, Tim-Gerald Kampmeier, ... Felix Becker

Ann Hepatol. 2025;30:101787

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MCM3 promotes hepatocellular carcinoma progression via Epithelial-mesenchymal Transition through AKT/Twist signaling pathway

Wei-Guo Tang, Jin-Feng Feng, Xian Li, Qi-Man Sun, Jin-Wu Hu, Xiao-Lu Ma, Yan-Yan Nie, Yang Xu, ... Qi-Meng Chang

Ann Hepatol. 2025;30:101785

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Outcomes and risk factors for de novo major depressive disorder after liver transplantation: Nested case-control study

Young Jin Yoo, Jinhee Lee, Deok-Gie Kim, Minyu Kang, Hwa-hee Koh, Eun-Ki Min, Jae Geun Lee, Myoung Soo Kim, Dong Jin Joo

Ann Hepatol. 2025;30:101779

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Liver stiffness measurement trajectory analysis for prognosis in patients with chronic hepatitis B and compensated advanced chronic liver disease

Hao Jiang, Hongsheng Yu, Can Hu, Yinan Huang, Bilan Yang, Xiaoli Xi, Yiming Lei, Bin Wu, Yidong Yang

Ann Hepatol. 2025;30:101788

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Clinical spectrum and long-term outcomes of non-cirrhotic portal venous system thrombosis in Hispanic population

Fernando Gil-López, Fausto Alfredo Rios-Olais, Roberta Demichelis-Gomez, Angel Vargas-Ruiz, Analy Mora-Cañas, Lydia A. Mercado, Denise M. Harnois, Juan Rangel-Patiño

Ann Hepatol. 2025;30:101786

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Body mass index and diabetes predict severity of liver fibrosis across the spectrum of steatotic liver disease

Eda Kaya, Eduardo Vilar-Gomez, Raj Vuppalanchi, Yusuf Yilmaz

Ann Hepatol. 2025;30:101907

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Development of a biodegradable prosthesis through tissue engineering: the lack of the physiological abstractions prevents bioengineering innovations

Ilya Klabukov, Anna Smirnova, Ekaterina Evstratova, Denis Baranovskii

Ann Hepatol. 2025;30:101587

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Development of a biodegradable prosthesis through tissue engineering, for the organ-replacement or substitution of the extrahepatic bile duct

Alan Isaac Valderrama-Treviño, Andrés E. Castell-Rodríguez, Rolando Hernández-Muñoz, Nadia A. Vázquez-Torres, Andrés Macari-Jorge, Baltazar Barrera-Mera, Alfredo Maciel-Cerda, Ricardo Vera-Graziano, Natalia Nuño-Lámbarri, Eduardo E. Montalvo-Javé

Ann Hepatol. 2025;30:101588

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The dual role of HCV protein expression in communication between host cells presents potential applications in the treatment of liver fibrosis

Junxi Liu, Boda Zhou

Ann Hepatol. 2025;30:101747

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Differentially expressed genes in Huh7 cells during co-culture with LX2 cells demonstrating dynamics of intercellular communication

Tania G. Heredia-Torres, Veronica Alvarado-Martínez, Ana R. Rincón-Sánchez, Sonia A. Lozano-Sepúlveda, Kame A. Galán-Huerta, Daniel Arellanos-Soto, Ana M. Rivas-Estilla

Ann Hepatol. 2025;30:101746

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Response to letter to the editor by Rodriguez S et al.

Carlos Moctezuma-Velazquez

Ann Hepatol. 2025;30:101770

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