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Inicio Allergologia et Immunopathologia Association of interleukin-1 family gene polymorphisms with juvenile idiopathic ...
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Vol. 44. Issue 6.
Pages 542-546 (November - December 2016)
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Vol. 44. Issue 6.
Pages 542-546 (November - December 2016)
Original Article
DOI: 10.1016/j.aller.2016.07.002
Association of interleukin-1 family gene polymorphisms with juvenile idiopathic arthritis in Iranian population
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V. Ziaeea,b, M. Maddahb, S. Harsinic,d, A. Rezaeic, M. Sadre, S. Zoghid,e, M.H. Moradinejadb, N. Rezaeic,d,e,f,
Corresponding author
rezaei_nima@tums.ac.ir

Corresponding author.
a Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
b Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
c Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
d Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
e Molecular Immunology Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
f Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
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Table 1. Allele and genotype frequencies in Iranian patients with juvenile idiopathic arthritis and healthy individuals.
Abstract
Background

Cytokines, including interleukin-1 (IL-1), seem to contribute towards the pathogenesis of juvenile idiopathic arthritis (JIA), so this study was designed to evaluate the associations of IL-1 gene cluster and IL-1 receptor (IL-1R) gene single nucleotide polymorphisms (SNPs) with JIA proneness in Iranian population.

Materials and methods

Genomic DNA of 55 Iranian patients with JIA and 140 controls were extracted and typed for IL-1α gene at position −889, IL-1β gene at positions −511 and +3962, IL-1R gene at position Pst-I 1970, and interleikin-1 receptor antagonist (IL-1Ra) gene at position Mspa-I 11100, using polymerase chain reaction with sequence-specific primers method, and compared between patients and controls.

Results

The CC genotype of IL-1Ra at Mspa-I 11100 position was found to be more frequent in patients with JIA compared to healthy individuals (P=0.03), although the CT genotype at the same position was significantly higher in the control group in comparison with patients with JIA (P=0.02). No significant differences were observed between the two groups of case and control for IL-1α (−889 C/T), IL-1β (−511 C/T and +3962 C/T) and IL-1R (Pst-1 1970 C/T).

Conclusion

The results of the present investigation suggest that certain IL-1Ra gene variants are associated with individuals’ susceptibility to JIA. Nevertheless, further studies are required to establish the results of the current study.

Keywords:
Interleukin-1
Single-nucleotide polymorphism
Juvenile idiopathic arthritis

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