Buscar en
Allergologia et Immunopathologia
Toda la web
Inicio Allergologia et Immunopathologia The relationship between serum levels of vitamin D with asthma and its symptom s...
Journal Information
Vol. 44. Issue 6.
Pages 547-555 (November - December 2016)
Share
Share
Download PDF
More article options
ePub
Vol. 44. Issue 6.
Pages 547-555 (November - December 2016)
Original Article
DOI: 10.1016/j.aller.2016.04.016
The relationship between serum levels of vitamin D with asthma and its symptom severity: A case–control study
Visits
...
Rasoul Nasiri Kalmarzia, A. Zamanib, A. Fathallahpourd, E. Ghaderic, Ramesh Rahehaghd, W. Kootib,
Corresponding author
wesamkooti@gmail.com

Corresponding author.
a Cellular & Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
b Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
c Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
d Kurdistan University of Medical Sciences, Sanandaj, Iran
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Tables (7)
Table 1. Study population characteristics.
Table 2. Comparison of the distribution of the severity of the vitamin D deficiency in the two groups.
Table 3. Mean of various indices associated with the severity of asthma in the case group.
Table 4. Correlation between vitamin D and other study variables in the case group.
Table 5. Association between serum levels of vitamin D with IgE, FEV1 and FVC in the case group, with and without adjusting for confounders (age, sex and BMI).
Table 6. Association between serum levels of vitamin D with age, gender and IGE in the case group, with and without adjustment for confounders (FEV, FCV and BMI).
Show moreShow less
Abstract
Background

Asthma is a heterogeneous disease characterised by chronic inflammatory airways, and is affected by several immunological factors. One of the most discussed and researched hypotheses is the relationship between vitamin D serum levels with asthma. This study aimed to investigate the relationship between vitamin D serum levels with asthma and pulmonary functions in children in Kurdistan province, Iran.

Materials and methods

In this case–control study, 120 children ranging from 6 to 18 years were referred in summer for investigation. Participants were divided into two groups: asthma group, N=60; and control group, N=60. After serum separation, samples were analysed using vitamin D ELISA kit. Additionally, pulmonary function test and serum IgE levels were measured in both groups. Data were analysed using Chi-square test and multiple regression analysis in SPSS15.

Results

No difference was shown between the groups in terms of gender composition (male: 57.5; female: 42.5) (P>0.05). Average Vitamin D serum level in the case group (17.98±8.68) was less than in control group (22.35±6.26) (P<0.01). In addition, the difference of vitamin D deficiency in level of suboptimal between the asthma (17.77±6.41) and the control group (24.9±3.18) was statistically significant (P<0.0001). Positive correlation existed between vitamin D levels with FEV1, FVC, and FEV1/FVC. Multiple regression analysis showed a reverse relationship between vitamin D levels with IgE serum levels; this remained after adjustment for potential confounders (e.g. age, sex, BMI, FEV1, and FVC).

Conclusion

The results showed that serum levels of vitamin D in asthma patients were less than in healthy people, and also reduced lung function in these patients. So, the serum levels of vitamin D in asthma patients must be checked continuously.

Keywords:
Vitamin D
Asthma
Kurdistan

Article

These are the options to access the full texts of the publication Allergologia et Immunopathologia
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Allergologia et Immunopathologia

Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 22,50 €

Comprar ahora
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.