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Inicio Allergologia et Immunopathologia Interleukin-23 receptor gene polymorphisms in Iranian patients with juvenile sys...
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Vol. 48. Issue 1.
Pages 62-66 (January - February 2020)
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Vol. 48. Issue 1.
Pages 62-66 (January - February 2020)
Original Article
DOI: 10.1016/j.aller.2019.05.007
Interleukin-23 receptor gene polymorphisms in Iranian patients with juvenile systemic lupus erythematosus
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A. Rezaeia, S. Harsinia,b, M. Sadrc, V. Ziaeed, N. Rezaeia,b,e,
Corresponding author
rezaei_nima@tums.ac.ir

Corresponding author.
a Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
b Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
c Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
d Division of Pediatric Rheumatology, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
e Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
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Tables (2)
Table 1. Details of IL-23R gene single nucleotide polymorphisms (SNPs), gene polymorphisms, positions and locations, assessed in the present investigation.
Table 2. Allele and genotype distribution of IL-23R gene in JSLE patients and healthy controls.
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Abstract
Introduction and objectives

Considering the possible roles of interleukin-23 receptor (IL-23R) gene in the pathogenesis of juvenile systemic lupus erythematosus (JSLE), the objective of this study was to elucidate whether polymorphisms of the IL23R are associated with susceptibility to JSLE in an Iranian population.

Materials and methods

A case-control study on 62 patients with JSLE and 78 healthy controls was performed to investigate the associations of four single nucleotide polymorphisms (SNPs) in IL-23R gene, namely, rs7517847, rs10489629, rs11209026, and rs1343151, with susceptibility to JSLE, using real-time polymerase chain reaction Taqman genotyping technique.

Results

Analysis of allele and genotype frequency of four selected SNPs revealed statistically significant positive association between homozygous variant of rs7517847 (TT) (P, 0.02) and T allele at the same position (P, 0.01) with JSLE vulnerability. There was no significant association between other evaluated SNPs and JSLE susceptibility.

Conclusion

These findings suggest that particular IL-23R gene variants could affect individual susceptibility to JSLE.

Keywords:
Interleukin-23 receptor
Single nucleotide polymorphism
Systemic lupus erythematosus
Children

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