Buscar en
Allergologia et Immunopathologia
Toda la web
Inicio Allergologia et Immunopathologia Association between environmental exposure and CD4+CD25+ regulatory T cells
Journal Information
Vol. 47. Issue 1.
Pages 43-46 (January - February 2019)
Share
Share
Download PDF
More article options
ePub
Vol. 47. Issue 1.
Pages 43-46 (January - February 2019)
Original Article
DOI: 10.1016/j.aller.2018.04.003
Association between environmental exposure and CD4+CD25+ regulatory T cells
Visits
...
P. Fussa, K. Bala, J. Jerzyńskaa, D. Podleckaa, W. Stelmachb, I. Stelmacha,
Corresponding author
alergol@kopernik.lodz.pl

Corresponding author.
a Department of Allergology and Internal Medicine in children, Copernicus Hospital, al. Pilsudskiego 71, 90-329, Lodz, Poland
b Department of Social and Preventive Medicine, Medical University of Lodz, Lodz, Poland
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Tables (1)
Table 1. Differences between children living in farm areas and in rural areas in CD4+CD25+and CD4+CD25+Foxp3 cells expression in the presence of dust allergen.
Abstract
Background

It is considered that farm areas protect young patients from allergy and asthma due to high exposure to endotoxins.

Aim

To compare CD4+/CD25+ T-regulatory cells and forkhead transcription factor Foxp3 expression in asthmatic children allergic to house dust mites (HDM) living in rural and farm areas.

Materials and Methods

This was a prospective analysis of 35 children living in farm areas (n=19) and rural areas (n=16), aged 8–16, with allergic rhinitis (allergic to dust mites) and newly diagnosed asthma. Surface molecule CD4+CD25+Foxp3+ expression on cultured PBMCs was estimated by flow cytometry using fluorophore-conjugated monoclonal antibodies in each patient.

Results

Thirty-five children were included into the analysis: 19 children living in farm areas and 16 in rural areas. Within and between-groups (farm area vs. rural area) differences in CD4+/CD25+ and CD4+/CD25+Foxp3+ cell expression did not reach the level of significance.

Conclusion

The current analysis showed that CD4+/CD25+ and CD4+/CD25+Foxp3+ cell expression was not associated with place of living in asthmatic children sensitive to HDM.

Keywords:
Children
Environment
Regulatory cells

Article

These are the options to access the full texts of the publication Allergologia et Immunopathologia
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Allergologia et Immunopathologia

Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 22,50 €

Comprar ahora
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
Tools
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

es en pt
Política de cookies Cookies policy Política de cookies
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.