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Allergologia et Immunopathologia
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Inicio Allergologia et Immunopathologia Association between environmental exposure and CD4+CD25+ regulatory T cells
Journal Information
Vol. 47. Issue 1.
Pages 43-46 (January - February 2019)
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Vol. 47. Issue 1.
Pages 43-46 (January - February 2019)
Original Article
DOI: 10.1016/j.aller.2018.04.003
Association between environmental exposure and CD4+CD25+ regulatory T cells
P. Fussa, K. Bala, J. Jerzyńskaa, D. Podleckaa, W. Stelmachb, I. Stelmacha,
Corresponding author

Corresponding author.
a Department of Allergology and Internal Medicine in children, Copernicus Hospital, al. Pilsudskiego 71, 90-329, Lodz, Poland
b Department of Social and Preventive Medicine, Medical University of Lodz, Lodz, Poland
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Table 1. Differences between children living in farm areas and in rural areas in CD4+CD25+and CD4+CD25+Foxp3 cells expression in the presence of dust allergen.

It is considered that farm areas protect young patients from allergy and asthma due to high exposure to endotoxins.


To compare CD4+/CD25+ T-regulatory cells and forkhead transcription factor Foxp3 expression in asthmatic children allergic to house dust mites (HDM) living in rural and farm areas.

Materials and Methods

This was a prospective analysis of 35 children living in farm areas (n=19) and rural areas (n=16), aged 8–16, with allergic rhinitis (allergic to dust mites) and newly diagnosed asthma. Surface molecule CD4+CD25+Foxp3+ expression on cultured PBMCs was estimated by flow cytometry using fluorophore-conjugated monoclonal antibodies in each patient.


Thirty-five children were included into the analysis: 19 children living in farm areas and 16 in rural areas. Within and between-groups (farm area vs. rural area) differences in CD4+/CD25+ and CD4+/CD25+Foxp3+ cell expression did not reach the level of significance.


The current analysis showed that CD4+/CD25+ and CD4+/CD25+Foxp3+ cell expression was not associated with place of living in asthmatic children sensitive to HDM.

Regulatory cells


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