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Allergologia et Immunopathologia
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Inicio Allergologia et Immunopathologia IL-33 is associated with allergy in children sensitized to the cat
Journal Information
Vol. 48. Issue 2.
Pages 130-136 (March - April 2020)
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Vol. 48. Issue 2.
Pages 130-136 (March - April 2020)
Original Article
DOI: 10.1016/j.aller.2019.06.006
IL-33 is associated with allergy in children sensitized to the cat
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K. Smejdaa, A. Borkowskab, J. Jerzynskaa, A. Brzozowskaa, W. Stelmachc, I. Stelmacha,
Corresponding author
alergol@kopernik.lodz.pl

Corresponding author.
a Department of Pediatrics and Allergy, Medical University of Lodz, Copernicus Memorial Hospital in Lodz, Poland
b Department of Internal Medicine and Diabetology, Medical University of Lodz, Lodz, Poland
c Department of Social and Preventive Medicine, Medical University of Lodz, Lodz, Poland
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Tables (4)
Table 1. Baseline characteristics of the studied patients (n=51).
Table 2. Associations between IL-33 levels in the studied patients and presence of cat/dog in their domicile once in the past and during pregnancy.
Table 3. Associations between IL-33 levels in the studied patients and presence of allergy symptoms after contact with the cat.
Table 4. Associations between IL-33 levels in the studied patients and presence of co-allergy.
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Abstract
Background

Several studies suggest that early-life exposure to animal allergens constitutes a relevant risk factor for the development of allergic sensitization.

Objectives

The aim of the present study was to determine the role of interleukin-33 in children sensitive to cat allergen with allergic rhinitis and/or asthma.

Methods

The study included 51 children aged 5–18 years, both sexes, allergic to cats. Sensitization to cat allergen was confirmed by skin prick tests or specific IgE. Children were evaluated for the presence of bronchial asthma, atopic dermatitis, allergic rhinitis. A questionnaire evaluating the occurrence of allergic symptoms in children after contact with the cat and dog was performed. Mothers completed a questionnaire regarding cat exposure: during pregnancy and having a cat at home. A blood sample was taken from all children to measure the level of IL-33 in the serum.

Results

Keeping a cat in the home, once in the past, or having a cat in the home during the mother’s pregnancy, revealed a statistically significant relationship with IL-33 levels in the studied patients. Also, daily contact with a cat during pregnancy affected the level of IL-33. Higher levels of IL-33 were shown in people with hypersensitivity to cat and pollen allergens and cat and other animals. In patients with bronchial asthma higher levels of IL-33 were found than in patients without bronchial asthma.

Conclusions

Increased serum levels of IL-33 is related with keeping cats during pregnancy and in early childhood and can be associated with the development of asthma in children.

Keywords:
Children
Asthma
IL-33
Cat sensitization
Pets keeping
Allergic rhinitis
Pregnancy
Abbreviations:
IL-33
IL-1
ST2/ST2L
MDCs
ELISA
AR
AHR
AD
BMMC
ILC2s
JC
HDM

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