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DOI: 10.1016/j.aller.2020.02.005
Available online 22 May 2020
Antihistamines in children and adolescents: A practical update
G.F. Parisia,
Corresponding author

Corresponding author.
, S. Leonardia, G. Ciprandib, A. Corsicoc, A. Licarid, M. Miraglia del Giudicee, D. Peronif, C. Salpietrog, G.L. Marsegliad
a Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
b Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy
c Pulmonology Clinic, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
d Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
e Department of Woman, Child and of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Naples, Italy
f U.O. Pediatria, Azienda Ospedaliero-Universitaria Pisana, Scuola di Specializzazione in Pediatria, University of Pisa, Pisa, Italy
g Department of Pediatrics, Unit of Pediatric Genetics and Immunology, University of Messina, Messina, Italy
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Tables (2)
Table 1. Most common first- and second-generation oral antihistamines in alphabetic order.
Table 2. Summary of the most common antihistamines in alphabetic order.
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Histamine is a chemical mediator, released predominantly by tissue mast cells, circulating basophils, and neurons, which are activated in response to various immunological and non-immunological stimuli. Histamine has to bind to specific receptors to exert its physiological and pathophysiological functions. Endogenous histamine is the main mediator of the immediate allergic response, which moreover, performs other multiple functions, including regulation of gastric secretion, neurotransmission in the central nervous system, and immunomodulatory activity. The involvement of histamine in various disorders and the importance of receptors in the clinical features have relevant implications in clinical practice. Anti-H1 antihistamines contrast the histamine-dependent effects, mainly concerning nasal symptoms and cutaneous itching and wheal. Antihistamines are among the most prescribed drugs in pediatric care. This review updates the practical use of antihistamines in children and adolescents.

H1 receptor
Allergic disorders


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