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Vol. 47. Issue 5.
Pages 499-505 (September - October 2019)
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Vol. 47. Issue 5.
Pages 499-505 (September - October 2019)
Original Article
DOI: 10.1016/j.aller.2019.03.004
Assessment of vitamin D status in common variable immunodeficiency or ataxia–telangiectasia patients
J.R.S. Cruza, R. Silvab, I.G.A. Andradea, F.L.A. Fonsecac, B.T. Costa-Carvalhoa, R.O.S. Sarnia,c,
Corresponding author

Corresponding author.
a Federal University of São Paulo, São Paulo, SP, Brazil
b Faculty of Nutrition of Federal University of Alfenas, Alfenas, MG, Brazil
c ABC Faculty of Medicine, Santo André, SP, Brazil
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Tables (4)
Table 1. Biochemical markers for bone metabolism of the groups of patients with common variable immunodeficiency and ataxia–telangiectasia and controls.
Table 2. Body composition and physical activity frequency of the groups of patients with common variable immunodeficiency and ataxia–telangiectasia and controls.
Table 3. Biochemical markers of the inflammatory profile of the groups of patients with common variable immunodeficiency and ataxia–telangiectasia and controls.
Table 4. Correlation between vitamin D concentrations and biochemical and body composition variables of patients with primary immunodeficiency or patients with ataxia–telangiectasia.
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Introduction and objectives

Vitamin D plays a role in the immune system, however studies regarding this are scarce. This study aimed to evaluate the nutritional status of vitamin D in patients with Common Variable Immunodeficiency (CVID) or Ataxia–Telangiectasia (A–T) and to relate it to body composition, inflammatory and bone metabolism markers.

Patients and methods

This is a cross-sectional and controlled study involving 24 patients of both sexes (59.3% male), aged 8–56 years, with CVID (n=15) or A–T (n=9). The following variables were evaluated: body mass index (BMI), 25-hydroxyvitamin D (25 (OH) D), hepatic profile, parathormone, calcium, phosphorus, alkaline phosphatase, interleukin 6 and high-sensitivity C-reactive protein.


The median age was 26.0 years. A deficiency of 25 (OH) D was found in four A–T patients (44%) and two CVID patients (13%). Nine patients with CVI (60%) and six with A–T (66.7%) were overweight and underweight, respectively. There was a negative correlation between vitamin D and fat mass in the CVID group, and vitamin D and BMI in the A–T group. Vitamin D was negatively associated with the percentage of total fat among the patients (β – 0.842, 95% CI: −1.5–0.17, p=0.015), R2=0.21, after adjusting for sex and age.


Vitamin D deficiency occurred in a quarter of the patients although there was no difference between the patient and the control group; without association with bone and inflammation biomarkers. The percentage of fat and BMI were negatively associated with the concentrations of 25 (OH) D.

Vitamin D
Body composition
Common variable immunodeficiency


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