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Inicio Allergologia et Immunopathologia Estrogen and estrogen receptor signaling promotes allergic immune responses: Eff...
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Vol. 47. Issue 5.
Pages 506-512 (September - October 2019)
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Vol. 47. Issue 5.
Pages 506-512 (September - October 2019)
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DOI: 10.1016/j.aller.2019.03.001
Estrogen and estrogen receptor signaling promotes allergic immune responses: Effects on immune cells, cytokines, and inflammatory factors involved in allergy
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Z. Fan, H. Che
Corresponding author
chehuilian@cau.edu.cn

Corresponding author.
, S. Yang, C. Chen
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Qinghua Donglu, Haidian District, Beijing, PR China
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Abstract

Hypersensitivity occurs when the body is stimulated by an antigen, resulting in an immune response, and leads to a physiological disorder or abnormal tissue trauma. Various immune cells, cytokines, and inflammatory mediators are involved in the immune responses related to allergic diseases, which are the core of anaphylaxis. Estrogen receptors are widely distributed in immune cells, which combine with estrogen and participate in allergic responses by affecting immune cells, cytokines, and inflammatory factors. We aimed to summarize the association between estrogen and allergic reactions to provide a scientific basis for understanding and studying the mechanisms of allergic diseases.

Keywords:
Allergic disease
Estrogen
Estrogen receptor
Immune cells
Abbreviations:
BLN
DCs
ER
ERE
HSP-90
VH
IL-4
IL-5
IL-13
AF-1
AF-2
MHCII

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