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Journal Information
Vol. 42. Issue 7.
Pages 457-464 (September 2018)
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Vol. 42. Issue 7.
Pages 457-464 (September 2018)
Original article
Validation of the Spanish version of the Bladder Pain/Interstitial Cystitis-Symptom Score (BPIC-SS) questionnaire. A useful tool for the diagnosis of bladder pain syndrome
Validación de la versión española del cuestionario Bladder Pain/Interstitial Cystitis-Symptom Score (BPIC-SS). Un instrumento útil para el diagnóstico del síndrome de dolor vesical
S. Arlandisa,
Corresponding author

Corresponding author.
, A. Francob, A.M. Morac, P. Rebollod
a Hospital Universitario y Politécnico La Fe, Valencia, Spain
b Hospital Universitario Clínic, Barcelona, Spain
c Departamento Médico, Astellas Pharma S.A., Madrid, Spain
d Health Economics & Outcomes Research, Real-World Evidence Solutions, QuintilesIMS, Barcelona, Spain
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Figures (3)
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Tables (5)
Table 1. Responses to items 1–7 of the BPIC-SS questionnaire in the sample studied.
Table 2. Spearman's Rho correlation coefficients between the items of the BPIC-SS questionnaire and the PPBC questionnaire and the VAS scale of the EQ-5D-5L.
Table 3. Changes in the BPIC-SS questionnaire scores and ES according to the change perceived by PGI-C score.
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Validation of the Spanish version of the Bladder Pain/Interstitial Cystitis-Symptom Score (BPIC-SS) questionnaire to evaluate its utility for the diagnosis of bladder pain syndrome (BPS) patients in the Female and Urodynamics Urology Functional Units in Spain.

Material and methods

The Spanish adaptation of the BPIC-SS questionnaire was evaluated in 243 BPS patients. EQ-5D-5L, patient perception of bladder condition (PPBC) and global impression questionnaire (CGI-S) were collected. Consistency, test-retest reliability in patients without clinical changes at 15 days, criterion validity and sensitivity to change were assessed in BPS patients with clinical changes at 6 months. The cut-off point for discriminating BPS patients from other similar pathologies (overactive bladder or other urinary pathologies) was analyzed using ROC curve.


Mean (SD) BPIC-SS score (0–38) was 16.2 (12.0) points. Cronbach's alpha was 0.92 and intraclass coefficient correlation (ICC) was 0.82, ranging from 0.5 to 0.9 per item. Convergent validity determined a Spearman correlation of 0.63 with PPBC and −0.40 with EQ-5D-5L Visual Analogue Scale (VAS) and the effect size obtained in patients who improved their clinical status was 1.9. A score greater than or equal to 12 points in the BPIC-SS has been established as the best cut-off point for the diagnosis of BPS (87.5% sensitivity and 91.9% specificity).


The Spanish version of the BPIC-SS is a valid and reliable instrument for the diagnosis and follow-up of patients with BPS in Spain.


Evaluar las propiedades psicométricas de la versión española del cuestionario Bladder Pain/Interstitial Cystitis-Symptom Score (BPIC-SS) en el diagnóstico de pacientes con síndrome de dolor vesical (SDV) en las Unidades de Urología Funcional, Femenina y Urodinámica en España.

Material y métodos

La adaptación de la versión española del BPIC-SS fue evaluada en 243 pacientes con SDV. Los pacientes completaron los cuestionarios EQ-5D-5L, Patient Perception of Bladder Condition (PPBC) y el cuestionario de impresión global según la gravedad de la sintomatología (CGI-S). Se evaluó la consistencia, la fiabilidad test-retest en pacientes sin cambios clínicos a los 15 días, la validez de criterio y la sensibilidad al cambio en pacientes con cambios clínicos a los 6 meses. El punto de corte para discriminar pacientes con SDV de otras patologías similares se analizó mediante curva ROC.


La puntuación media (DE) del BPIC-SS (0-38) fue de 16,2 (12,0) puntos. El alfa de Cronbach fue de 0,92 y el coeficiente correlación intraclase (CCI) fue de 0,82, oscilando entre 0,5-0,9 por ítem. La validez convergente determinó una correlación de 0,63 con PPBC y –0,40 con la Escala Visual Analógica (EVA) del EQ-5D-5L, y el tamaño del efecto en pacientes que mejoraron su estado clínico fue de 1,9. Se ha establecido como punto de corte para el diagnóstico de SDV una puntuación del BPIC-SS superior o igual a 12 puntos (87,5% de sensibilidad y 91,9% de especificidad).


La versión española del cuestionario BPIC-SS es un instrumento válido, fiable y sensible al cambio para la evaluación de pacientes con SDV.

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