metricas
covid
Buscar en
Revista Científica de la Sociedad Española de Enfermería Neurológica
Toda la web
Inicio Revista Científica de la Sociedad Española de Enfermería Neurológica Papel del personal de enfermería especializado en el proceso de evaluación no ...
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

ORIGINAL
Papel del personal de enfermería especializado en el proceso de evaluación no motora dentro de la atención global de los pacientes con enfermedad de Parkinson
The role of nurse specialists in the evaluation of non-motor symptoms within the overall care of patients with Parkinson's disease
Teresa de Deus Fonticoba, Diego Santos García
Autor para correspondencia
diegosangar@yahoo.es

Autor para correspondencia.
Sección de Neurología, Complexo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña
Leído
4871
Veces
se ha leído el artículo
814
Total PDF
4057
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S2013524618300187"
  "issn" => "20135246"
  "doi" => "10.1016/j.sedene.2018.08.003"
  "estado" => "S300"
  "fechaPublicacion" => "2019-07-01"
  "aid" => "77"
  "copyright" => "Sociedad Española de Enfermería Neurológica"
  "copyrightAnyo" => "2018"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Rev Cient Soc Esp Enferm Neurol. 2019;50C:2-11"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2
    "PDF" => 2
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S2530299X18300177"
      "issn" => "2530299X"
      "doi" => "10.1016/j.sedeng.2018.11.001"
      "estado" => "S300"
      "fechaPublicacion" => "2019-07-01"
      "aid" => "77"
      "copyright" => "Sociedad Española de Enfermería Neurológica"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "fla"
      "cita" => "Rev Cien Enf Neur. 2019;50C:2-11"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 397
        "formatos" => array:3 [
          "EPUB" => 33
          "HTML" => 170
          "PDF" => 194
        ]
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
        "titulo" => "The role of nurse specialists in the evaluation of non-motor symptoms within the overall care of patients with Parkinson&#39;s disease"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "es"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "2"
            "paginaFinal" => "11"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Papel del personal de enfermer&#237;a especializado en el proceso de evaluaci&#243;n no motora dentro de la atenci&#243;n global de los pacientes con enfermedad de Parkinson"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "es" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0020"
            "etiqueta" => "Figure 4"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr4.jpeg"
                "Alto" => 1711
                "Ancho" => 2500
                "Tamanyo" => 180137
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Percentage of patients who answered each item of the BDI-II who present the symptom &#40;score from 1 to 3&#44; as opposed to 0&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Teresa de Deus Fonticoba, Diego Santos Garc&#237;a"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "Teresa"
                "apellidos" => "de Deus Fonticoba"
              ]
              1 => array:2 [
                "nombre" => "Diego"
                "apellidos" => "Santos Garc&#237;a"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "es" => array:9 [
          "pii" => "S2013524618300187"
          "doi" => "10.1016/j.sedene.2018.08.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "es"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013524618300187?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530299X18300177?idApp=UINPBA00004N"
      "url" => "/2530299X/000000500000000C/v1_201911060741/S2530299X18300177/v1_201911060741/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2013524618300199"
    "issn" => "20135246"
    "doi" => "10.1016/j.sedene.2018.09.002"
    "estado" => "S300"
    "fechaPublicacion" => "2019-07-01"
    "aid" => "78"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Rev Cient Soc Esp Enferm Neurol. 2019;50C:12-22"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 56
      "formatos" => array:2 [
        "HTML" => 46
        "PDF" => 10
      ]
    ]
    "es" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>"
      "titulo" => "El estr&#233;s en la enfermedad de Parkinson&#46; Biomarcadores cortisol y amilasa&#46; Revisi&#243;n sistem&#225;tica"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "12"
          "paginaFinal" => "22"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Stress in Parkinson&#39;s disease&#46; Cortisol and amylase biomarkers&#46; Systematical review"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "David Sancho Cantus, Natalia Santiesteban L&#243;pez, Mar&#237;a Cuerda Ballester, Silvia Solera G&#243;mez, Jos&#233; Enrique de la Rubia Ort&#237;"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "David"
              "apellidos" => "Sancho Cantus"
            ]
            1 => array:2 [
              "nombre" => "Natalia"
              "apellidos" => "Santiesteban L&#243;pez"
            ]
            2 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "Cuerda Ballester"
            ]
            3 => array:2 [
              "nombre" => "Silvia"
              "apellidos" => "Solera G&#243;mez"
            ]
            4 => array:2 [
              "nombre" => "Jos&#233; Enrique"
              "apellidos" => "de la Rubia Ort&#237;"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2530299X19300019"
        "doi" => "10.1016/j.sedeng.2018.09.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530299X19300019?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013524618300199?idApp=UINPBA00004N"
    "url" => "/20135246/000000500000000C/v1_201910260906/S2013524618300199/v1_201910260906/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S2013524619300236"
    "issn" => "20135246"
    "doi" => "10.1016/j.sedene.2019.10.002"
    "estado" => "S300"
    "fechaPublicacion" => "2019-07-01"
    "aid" => "93"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "edi"
    "cita" => "Rev Cient Soc Esp Enferm Neurol. 2019;50C:1"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta del presidente</span>"
      "titulo" => "Carta del presidente"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "1"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Letter from the president"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "David Iglesias Villanueva"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "David Iglesias"
              "apellidos" => "Villanueva"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2530299X19300226"
        "doi" => "10.1016/j.sedeng.2019.10.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530299X19300226?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013524619300236?idApp=UINPBA00004N"
    "url" => "/20135246/000000500000000C/v1_201910260906/S2013524619300236/v1_201910260906/es/main.assets"
  ]
  "es" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>"
    "titulo" => "Papel del personal de enfermer&#237;a especializado en el proceso de evaluaci&#243;n no motora dentro de la atenci&#243;n global de los pacientes con enfermedad de Parkinson"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "2"
        "paginaFinal" => "11"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Teresa de Deus Fonticoba, Diego Santos Garc&#237;a"
        "autores" => array:2 [
          0 => array:2 [
            "nombre" => "Teresa"
            "apellidos" => "de Deus Fonticoba"
          ]
          1 => array:4 [
            "nombre" => "Diego"
            "apellidos" => "Santos Garc&#237;a"
            "email" => array:1 [
              0 => "diegosangar@yahoo.es"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Secci&#243;n de Neurolog&#237;a&#44; Complexo Hospitalario Universitario de Ferrol &#40;CHUF&#41;&#44; Ferrol&#44; A Coru&#241;a"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Autor para correspondencia&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "The role of nurse specialists in the evaluation of non-motor symptoms within the overall care of patients with Parkinson&#39;s disease"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figura 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1822
            "Ancho" => 2510
            "Tamanyo" => 120053
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Puntuaci&#243;n por dominios de la NMSS&#44; representados como barras de cajas&#46; Cada dominio se expresa como un porcentaje &#40;sumatorio&#47;puntuaci&#243;n m&#225;xima posible&#41; para poder comparar entre ellos &#40;dado que el n&#250;mero de preguntas var&#237;a de unos a otros&#41;&#46; La mayor puntuaci&#243;n corresponde a la disfunci&#243;n sexual y la menor a las alteraciones de la percepci&#243;n&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La enfermedad de Parkinson &#40;EP&#41; es un trastorno frecuente y muchas veces complejo&#44; siendo fundamental un buen conocimiento de la misma para poder tomar las mejores decisiones en cuanto al diagn&#243;stico y tratamiento en la pr&#225;ctica cl&#237;nica habitual&#46; Los pacientes con EP presentan muchos s&#237;ntomas y el grado de afectaci&#243;n y la evoluci&#243;n as&#237; como la respuesta al tratamiento puede ser muy variable&#46; Actualmente hay muchas escalas validadas disponibles que nos permiten poder conocer con mayor detalle el grado de afectaci&#243;n del paciente con respecto a diferentes s&#237;ntomas como pueden ser los s&#237;ntomas motores &#40;temblor&#44; rigidez&#44; bradicinesia&#44; etc&#46;&#41;&#44; s&#237;ntomas no motores &#40;fatiga&#44; dolor&#44; trastornos del sue&#241;o&#44; s&#237;ntomas cognitivos&#44; depresi&#243;n&#44; ansiedad&#44; apat&#237;a&#44; trastorno del control de impulsos&#44; psicosis&#44; etc&#46;&#41; o bien su grado de autonom&#237;a y calidad de vida<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; No solo es importante detectar estos problemas sino tambi&#233;n cuantificar su severidad para poder en el seguimiento evolutivo comprobar si hay cambios en relaci&#243;n&#44; por ejemplo&#44; con la progresi&#243;n de la enfermedad o una intervenci&#243;n terape&#250;tica determinada&#46; Lo ideal es poder disponer de un equipo multidisciplinar que eval&#250;e al paciente y que as&#237; se vea facilitado el trabajo de cada una de las partes con el objetivo de poder tomar en conjunto las mejores decisiones<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">3&#44;4</span></a>&#46; En este aspecto&#44; la labor del personal de enfermer&#237;a especializado en la EP debe considerarse fundamental y se piensa que dicho personal debe desempe&#241;ar una funci&#243;n clave en el manejo asistencial global de pacientes con Parkinson<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">5&#44;6</span></a>&#46; La evaluaci&#243;n no motora rigurosamente realizada por personal de enfermer&#237;a entrenado complementar&#237;a la evaluaci&#243;n motora que realiza el neur&#243;logo en su d&#237;a a d&#237;a en la consulta&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">El objetivo del presente trabajo es describir la evaluaci&#243;n no motora llevada a cabo por la enfermera especialista en trastornos del movimiento dentro del proyecto de investigaci&#243;n Cohort of Patients with PArkinson&#39;s DIsease in Spain&#44; 2015 &#40;COPPADIS-2015&#41;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">7</span></a> en nuestro centro&#44; el Complejo Hospitalario Universitario de Ferrol &#40;CHUF&#41;&#46; COPPADIS-2015 es un estudio multic&#233;ntrico prospectivo en el que participan 35 centros de nuestro pa&#237;s y cuyo objetivo es observar en detalle la evoluci&#243;n de una cohorte de pacientes con EP a lo largo de 5 a&#241;os de seguimiento&#44; comparar dicha cohorte con un grupo control&#44; analizar la evoluci&#243;n del cuidador principal del paciente e identificar factores predictores del desarrollo de determinadas complicaciones<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">7</span></a>&#59; dicho estudio implica una evaluaci&#243;n cl&#237;nica muy completa a lo largo del seguimiento y en un subgrupo la realizaci&#243;n de estudios complementarios &#40;neuroimagen&#44; marcadores moleculares y gen&#233;tica&#41;&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Material y m&#233;todos</span><p id="par0015" class="elsevierStylePara elsevierViewall">Se trata de un estudio observacional&#44; descriptivo no intervencionista transversal en el cual se incluyeron pacientes con EP participantes del estudio COPPADIS-2015<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">7</span></a> que fueron evaluados en la Consulta de Trastornos del Movimiento del CHUF entre enero de 2016 &#40;inicio de la fase de reclutamiento para dicho estudio&#41; y octubre de 2017 &#40;final de la fase de reclutamiento&#41;&#46; Los criterios de inclusi&#243;n fueron&#58; diagn&#243;stico de enfermedad de Parkinson seg&#250;n los criterios del Banco de Cerebros de Londres<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">8</span></a>&#59; edad comprendida entre 18 y 75 a&#241;os&#59; capacidad para poder responder a los cuestionarios&#59; y deseo de participar de forma voluntaria&#46; Se excluyeron pacientes con bomba de infusi&#243;n &#40;levodopa enteral y&#47;o apomorfina&#41; y cirug&#237;a &#40;estimulaci&#243;n cerebral profunda&#41;&#44; otras causas de parkinsonismo y con demencia seg&#250;n criterios de la <span class="elsevierStyleItalic">Movement Didorder Society</span> &#40;MMSE &#60;<span class="elsevierStyleHsp" style=""></span>26&#47;30&#41;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">El neur&#243;logo experto en Parkinson &#40;DSG&#41; realizaba la evaluaci&#243;n motora que inclu&#237;a por este orden 1&#41; <span class="elsevierStyleItalic">Unified Parkinson&#39;s Disease Rating Scale</span> &#40;UPDRS&#41;-IV<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">10</span></a>&#44; 2&#41; UPDRS- III<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">10</span></a> y clasificaci&#243;n del estadio motor modificado de <span class="elsevierStyleItalic">Hoehn &#38; Yahr</span><a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">11</span></a>&#46; La evaluaci&#243;n motora se realizaba a primera hora de la ma&#241;ana a todos los pacientes en estado OFF-medicaci&#243;n y en el caso de ser fluctuantes tambi&#233;n en estado ON-medicaci&#243;n seg&#250;n protocolo del estudio COPPADIS-2015&#46; Adem&#225;s&#44; fueron recogidas diferentes variables sociodemogr&#225;ficas&#44; relacionadas con la enfermedad&#44; el tratamiento y otras comorbilidades&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">La enfermera de la Consulta de Trastornos del Movimiento &#40;TdDF&#41; realizaba la evaluaci&#243;n no motora que por este orden inclu&#237;a&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#41;</span><p id="par0030" class="elsevierStylePara elsevierViewall">Parkinson&#39;s Disease Cognitive Rating Scale &#40;PD-CRS&#41;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">12</span></a> &#40;Escala de Evaluaci&#243;n Cognitiva de la Enfermedad de Parkinson&#41;&#46; Escala validada para evaluar el estado cognitivo de los pacientes con EP&#46; La puntuaci&#243;n total es la suma de la puntuaci&#243;n frontosubcortical &#40;&#237;tem 1&#44; memoria verbal inmediata&#59; &#237;tem 3&#44; atenci&#243;n mantenida&#59; &#237;tem 4&#44; memoria de trabajo&#59; &#237;tem 5&#44; dibujo espont&#225;neo de un reloj&#59; &#237;tem 7&#44; memoria verbal diferida&#59; &#237;tem 8&#44; fluencia verbal alternante&#59; &#237;tem 9&#44; fluencia verbal de acci&#243;n&#41; y la puntuaci&#243;n cortical posterior &#40;&#237;tem 2&#44; denominaci&#243;n por confrontaci&#243;n&#59; &#237;tem 6&#44; copia de un reloj&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Resoluci&#243;n de un <span class="elsevierStyleItalic">puzle</span> sencillo de 16 piezas &#40;4 horizontales y 4 verticales&#59; 4 x 4<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#41;&#46; Se evaluaba el n&#250;mero de piezas correctamente colocadas cada minuto as&#237; como el tiempo total en resolver el mismo&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#41;</span><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Non-Motor Symptoms Scale</span> &#40;NMSS&#41;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">13</span></a> &#40;Escala de S&#237;ntomas No Motores&#41;&#46; Incluye 30 &#237;tems&#44; siendo cada &#237;tem un s&#237;ntoma no motor diferente&#46; Los s&#237;ntomas son referidos a las 4 semanas previas a la evaluaci&#243;n&#46; La puntuaci&#243;n total de cada &#237;tem es el resultado de multiplicar la frecuencia &#40;0&#44; nunca&#59; 1&#44; raramente&#59; 2&#44; a menudo&#59; 3&#44; frecuente&#59; 4&#44; muy frecuente&#41; x severidad &#40;1&#44; leve&#59; 2&#44; moderado&#59; 3&#44; grave&#41; y variar&#225; de 0 a 12 puntos&#46; La puntuaci&#243;n de la escala va de 0 a 360 puntos&#46; Los &#237;tems se agrupan en 9 dominios diferentes&#58; 1&#41; cardiovascular &#40;&#237;tems 1 y 2&#59; puntuaci&#243;n&#44; 0 a 24&#41;&#59; 2&#41; sue&#241;o&#47;fatiga &#40;&#237;tems 3&#44; 4&#44; 5 y 6&#59; puntuaci&#243;n&#44; 0 a 48&#41;&#59; 3&#41; depresi&#243;n&#47;apat&#237;a &#40;&#237;tems 7&#44; 8&#44; 9&#44; 10&#44; 11 y 12&#59; puntuaci&#243;n&#44; 0 a 72&#41;&#59; 4&#41; alteraciones de la percepci&#243;n &#40;&#237;tems 13&#44; 14 y 15&#59; puntuaci&#243;n&#44; 0 a 36&#41;&#59; 5&#41; atenci&#243;n&#47;memoria &#40;&#237;tems 16&#44; 17 y 18&#59; puntuaci&#243;n&#44; 0 a 36&#41;&#59; 6&#41; s&#237;ntomas gastrointestinales &#40;&#237;tems 19&#44; 20 y 21&#59; puntuaci&#243;n&#44; 0 a 36&#41;&#59; 7&#41; s&#237;ntomas urinarios &#40;&#237;tems 22&#44; 23 y 24&#59; puntuaci&#243;n&#44; 0 a 36&#41;&#59; 8&#41; disfunci&#243;n sexual &#40;&#237;tems 25 y 26&#59; puntuaci&#243;n&#44; 0 a 24&#41;&#59; 9&#41; miscel&#225;nea &#40;&#237;tems 27&#44; 28&#44; 29 y 30&#59; puntuaci&#243;n&#44; 0 a 48&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#41;</span><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Beck Depression Inventory</span> II &#40;BDI-II&#41;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">14</span></a> &#40;Inventario de Depresi&#243;n de Beck version II&#41;&#46; Es un instrumento de autoaplicaci&#243;n de 21 &#237;tems&#46; El sujeto evaluado tiene que elegir en cada uno de los &#237;tems entre cuatro alternativas &#40;ordenadas de menor a mayor gravedad&#41; aquella que mejor describa su estado durante las dos semanas previas&#46; La puntuaci&#243;n va de 0 &#40;m&#237;nima&#41; a 63 &#40;m&#225;ximo&#41;&#46; Puntuaciones m&#225;s altas reflejar&#225;n a priori un peor estado de &#225;nimo&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">5&#41;</span><p id="par0050" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Questionnaire for Impulsive-Compulsive Disorders in Parkinson&#39;s Disease-Rating Scale</span> &#40;QUIP-RS&#41;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">15</span></a> &#40;Cuestionario de Conductas Impulsivas y Compulsivas en la Enfermedad de Parkinson&#41;&#46; Se trata de un cuestionario que permite evaluar la presencia y severidad de trastorno de control de impulsos relacionado con juego&#44; compras&#44; comida&#44; sexo as&#237; como conductas relacionadas &#40;abuso de medicaci&#243;n&#44; <span class="elsevierStyleItalic">punding</span> y hobbismo&#41;&#46; Los s&#237;ntomas son referidos a las 4 semanas previas a la evaluaci&#243;n&#46; La puntuaci&#243;n total de cada &#237;tem es el resultado de multiplicar la frecuencia &#40;0&#44; nunca&#59; 1&#44; raramente&#59; 2&#44; a menudo&#59; 3&#44; frecuente&#59; 4&#44; muy frecuente&#41; por severidad &#40;1&#44; leve&#59; 2&#44; moderado&#59; 3&#44; grave&#59; 4&#44; muy grave&#41; y variar&#225; de 0 a 16 puntos&#46; La puntuaci&#243;n total va de 0 a 112 &#40;m&#225;ximo&#44; 7 &#215; 16&#41;&#46; Se puede expresar adem&#225;s la puntuaci&#243;n total de los 4 trastornos de control de impulsos&#44; que va de 0 a 64 puntos &#40;m&#225;ximo&#44; 4 &#215; 16&#41;&#46; Los &#237;tems relacionados con el <span class="elsevierStyleItalic">punding</span> y hobbismo se expresan como un &#250;nico trastorno que va de 0 a 32 puntos&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">6&#41;</span><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Parkinson&#39;s Disease Sleep Scale</span> &#40;PDSS&#41;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">16</span></a> &#40;Escala del Sue&#241;o de la Enfermedad de Parkinson&#41;&#46; Escala para evaluar el sue&#241;o de los pacientes con Parkinson&#46; Los s&#237;ntomas son referidos a la semana previa a la evaluaci&#243;n&#46; Son 15 &#237;tems y para cada uno la puntuaci&#243;n va de 0 a 10&#46; La puntuaci&#243;n total va de 0 a 150 &#40;m&#225;ximo&#44; 15 &#215; 10&#41;&#46; Puntuaciones m&#225;s altas reflejar&#225;n a priori una mejor calidad del sue&#241;o&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">7&#41;</span><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Neuropsychiatric Inventory</span> &#40;NPI&#41;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">17</span></a> &#40;Inventario Neuropsiqui&#225;trico&#41;&#46; Incluye 10 trastornos neuropsiqui&#225;tricos&#58; 1&#41; delirios&#59; 2&#41; alucinaciones&#59; 3&#41; agitaci&#243;n&#59; 4&#41; depresi&#243;n&#47;disforia&#59; 5&#41; ansiedad&#59; 6&#41; euforia&#47;j&#250;bilo&#59; 7&#41; apat&#237;a&#47;indeferencia&#59; 8&#41; desinhibici&#243;n&#59; 9&#41; irritabilidad&#47;labilidad emocional&#59; 10&#41; conducta motora sin finalidad&#46; Los s&#237;ntomas son referidos a las 4 semanas previas a la evaluaci&#243;n&#46; La puntuaci&#243;n total de cada &#237;tem es el resultado de multiplicar la frecuencia &#40;0&#44; nunca&#59; 1&#44; raramente&#59; 2&#44; a menudo&#59; 3&#44; frecuente&#59; 4&#44; muy frecuente&#41; &#215; severidad &#40;1&#44; leve&#59; 2&#44; moderado&#59; 3&#44; grave&#41; y variar&#225; de 0 a 12 puntos&#46; La puntuaci&#243;n total va de 0 a 120 &#40;m&#225;ximo&#44; 10 &#215; 12&#41;&#46; Una mayor puntuaci&#243;n indicar&#225; a priori un trastorno neuropsiqui&#225;trico m&#225;s grave&#46; Se aplica al cuidador del paciente&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">8&#41;</span><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Visual Analog Scale-Pain</span> &#40;VAS-Pain&#41;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">18</span></a> &#40;Escala Visual Anal&#243;gica de Dolor&#41;&#46; Se trata de una escala visual anal&#243;gica para determinar la presencia de dolor&#46; El paciente marcar&#225; una cruz a lo largo de una l&#237;nea donde lo estime oportuno&#46; En un extremo figurar&#225; &#171;no dolor&#187; y en el otro &#171;el peor dolor posible&#187;&#46; Se le deber&#225; explicar con detalle en qu&#233; consiste la evaluaci&#243;n para asegurarnos de que lo ha comprendido y la respuesta es coherente&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">9&#41;</span><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Visual Analog Fatigue Scale</span><a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">19</span></a> &#40;Escala Visual Anal&#243;gica de Fatiga&#41;&#46; Igual que la previa pero para evaluar fatiga&#46; En este caso se consideraron dos tipos&#44; fatiga f&#237;sica y fatiga mental&#46;</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">10&#41;</span><p id="par0075" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Freezing of Gait Questionnaire</span> &#40;FOGQ&#41;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">20</span></a> &#40;Cuestionario de Bloqueos de la Marcha&#41;&#46; Es un cuestionario utilizado para evaluar los trastornos de la marcha&#46; Los s&#237;ntomas son referidos a la semana previa a la evaluaci&#243;n&#46; Incluye 6 &#237;tems&#59; el &#237;tem 1 se refiere al grado de autonom&#237;a para caminar&#44; el 2 al impacto que los trastornos de la marcha ocasionan en el desempe&#241;o de las actividades diarias y los &#237;tems 3 a 6 al fen&#243;meno de congelaci&#243;n&#46; Para cada &#237;tem la puntuaci&#243;n va de 0 a 4&#46; La puntuaci&#243;n total va de 0 a 24 puntos&#46; Una mayor puntuaci&#243;n indicar&#225; a priori un trastorno de la marcha m&#225;s grave&#46;</p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">11&#41;</span><p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Schwab &#38; England Activities of Daily Living Scale</span> &#40;ADLS&#41;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">21</span></a> &#40;Escala de Actividades de la Vida Diaria de <span class="elsevierStyleItalic">Schwab y England&#41;</span>&#46; El paciente debe indicar en una escala que va de 0 &#40;encamado&#44; no mantiene adecuadamente funciones vegetativas como la degluci&#243;n&#44; funci&#243;n vesical o intestinal&#41; a 100 &#40;totalmente independiente&#44; esencialmente normal&#41; el grado de autonom&#237;a para el desempe&#241;o de las actividades de la vida diaria&#46; Una puntuaci&#243;n &#8805; 80 indica que el paciente es totalmente independiente&#46;</p></li><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">12&#41;</span><p id="par0085" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">39-item Parkinson&#39;s disease Quality of Life Questionnaire Summary Index</span> &#40;PDQ-39SI&#41;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">22</span></a> &#40;Cuestionario de Calidad de vida de 39 &#205;tems de la Enfermedad de Parkinson&#41;&#46; Cuestionario que eval&#250;a la calidad de vida del paciente relacionada con su estado de salud&#46; Son 39 &#237;tems agrupados en 8 dominios&#58; 1&#41; movilidad &#40;&#237;tems 1 a 10&#41;&#59; 2&#41; actividades de la vida diaria &#40;&#237;tems 11 a 16&#41;&#59; 3&#41; bienestar emocional &#40;&#237;tems 17 a 22&#41;&#59; 4&#41; estigmatizaci&#243;n &#40;&#237;tems 23 a 26&#41;&#59; 5&#41; apoyo social &#40;&#237;tems 27 a 29&#41;&#59; 6&#41; cognici&#243;n &#40;&#237;tems 30 a 33&#41;&#59; 7&#41; comunicaci&#243;n &#40;&#237;tems 34 a 36&#41;&#59; 8&#41; dolor y malestar &#40;&#237;tems 37 a 39&#41;&#46; Para cada &#237;tem la puntuaci&#243;n podr&#225; ir de 0 &#40;nunca&#41; a 4 &#40;siempre&#41;&#46; Los s&#237;ntomas son referidos a las 4 semanas previas a la evaluaci&#243;n&#46; La puntuaci&#243;n total va de 0 a 156 &#40;m&#225;ximo&#44; 39 &#215; 4&#41; pero se suele expresar como un porcentaje &#40;cada dominio y la total&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">13&#41;</span><p id="par0090" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">PQ-10</span><a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">23</span></a>&#46; Es una escala verbal que va de 0 &#40;la peor posible&#41; a 10 &#40;la mejor posible&#41; en la cual el sujeto responde sobre cu&#225;l es su calidad de vida global referente a las 4 semanas previas&#46;</p></li><li class="elsevierStyleListItem" id="lsti0070"><span class="elsevierStyleLabel">14&#41;</span><p id="par0095" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">EUROHIS-QOL8 item index</span><a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">24</span></a>&#46; Es un cuestionario de calidad de vida de 8 &#237;tems &#40;calidad de vida&#44; estado de salud&#44; energ&#237;a&#44; autonom&#237;a para actividades de la vida diaria&#44; autoestima&#44; relaciones sociales&#44; capacidad econ&#243;mica y h&#225;bitat&#41; derivado del WHOQOL-100 y WHOQOL-BREF&#46; Para cada &#237;tem la puntuaci&#243;n va de 0 &#40;no del todo&#41; a 5 &#40;completamente&#41;&#46; La puntuaci&#243;n total se expresa como la media de las puntuaciones individuales&#46; Una mayor puntuaci&#243;n indicar&#225; a priori una mayor calidad de vida&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; la enfermera se encargaba tambi&#233;n de evaluar al cuidador principal del paciente cuando lo hab&#237;a y quer&#237;a participar en el estudio mediante las escalas BDI-II&#44; PQ-10&#44; EUROHIS-QOL8 item index y las escalas de sobrecarga del cuidador y estr&#233;s del cuidador <span class="elsevierStyleItalic">Zarit Caregiver Burden Inventory</span><a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">25</span></a> &#40;ZCBI&#41; y <span class="elsevierStyleItalic">Caregiver Strain Index</span><a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">26</span></a> &#40;CSI&#41;&#44; respectivamente&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">El consentimiento informado obtenido fue el firmado por todos los participantes en relaci&#243;n con el estudio COPPADIS-2015&#46; Los datos fueron analizados con el programa estad&#237;stico &#171;IBM SPSS Statistics for Windows&#44; Version 21&#46;0&#44; Armonk&#44; NY&#58; IBM Corp&#46;&#187;&#46; El an&#225;lisis estad&#237;stico fue llevado a cabo por DSG&#46; &#218;nicamente se realiz&#243; para el presente estudio an&#225;lisis descriptivo&#46; Las variables cuantitativas se expresan como media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE &#40;desviaci&#243;n est&#225;ndar&#41;&#46; Las variables cualitativas se expresan como un porcentaje &#40;&#37;&#41;&#46;</p></li></ul></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><p id="par0100" class="elsevierStylePara elsevierViewall">Un total de 102 pacientes y 62 cuidadores principales fueron incluidos en el estudio COPPADIS-2015 en nuestro centro y todos ellos resultaron v&#225;lidos para el an&#225;lisis del presente trabajo&#46; La <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a> muestra el reclutamiento secuencial por meses durante los a&#241;os 2016 y 2017&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> muestra datos sociodemogr&#225;ficos&#44; relacionados con la EP y su tratamiento&#44; otras comorbilidades y el estado motor&#46; Hubo un discreto predominio de varones&#44; el tiempo medio de evoluci&#243;n de enfermedad fue en torno a 5 a&#241;os&#44; la gran mayor&#237;a presentaba un estadio de <span class="elsevierStyleItalic">Hoehn &#38; Yahr</span> de 1 o 2&#44; el fenotipo trem&#243;rico fue el m&#225;s frecuente y hasta el 67&#37; de los pacientes recib&#237;a levodopa&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Con respecto a la evaluaci&#243;n no motora los datos vienen recogidos en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#46; El tiempo medio de evaluaci&#243;n de la parte no motora por parte de TdDF fue de 73&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#44;5 min &#40;rango&#44; de 35 min a 120 min&#41;&#46; Destacar que a pesar de presentar un MMSE medio de 29&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;7&#44; hasta casi 1 de cada 4 presentaba criterios de deterioro cognitivo &#40;PD-CRS &#8804; 84&#41;&#59; adem&#225;s un 18&#37; depresi&#243;n mayor&#44; un 14&#37; trastorno de control de impulsos&#44; un 63&#37; dolor y un 20&#37; ca&#237;das&#46; La gran mayor&#237;a result&#243; ser independiente para las actividades de la vida diaria &#40;ADLS &#8805; 80&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a> muestra el porcentaje de pacientes presentando los diferentes s&#237;ntomas no motores de la NMSS&#44; siendo la fatiga y los s&#237;ntomas urinarios los m&#225;s frecuentes&#46; La <a class="elsevierStyleCrossRef" href="#fig0015">figura 3</a> muestra las puntuaciones por dominios y expresadas como un porcentaje para poder comparar el grado de sobrecarga entre dominios&#44; resultando la disfunci&#243;n sexual y los s&#237;ntomas urinarios los de mayor puntuaci&#243;n&#46; La <a class="elsevierStyleCrossRef" href="#fig0020">figura 4</a> muestra el porcentaje de pacientes presentando cada uno de los s&#237;ntomas depresivos recogidos en el BDI-II&#44; siendo la p&#233;rdida de energ&#237;a el m&#225;s frecuente &#40;en m&#225;s del 70&#37;&#41;&#46; Finalmente&#44; en la <a class="elsevierStyleCrossRef" href="#fig0025">figura 5</a> se puede observar c&#243;mo por dominios&#44; la mayor puntuaci&#243;n en cuanto a calidad de vida &#40;PDQ-39SI&#41; correspond&#237;a al dominio dolor y malestar&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">Los datos sobre los cuidadores vienen reflejados en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#46; El porcentaje de cuidadores con sobrecarga significativa y alto &#237;ndice de estr&#233;s fue bajo&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discusi&#243;n</span><p id="par0125" class="elsevierStylePara elsevierViewall">El presente estudio describe de forma detallada el rol que la enfermera especialista en trastornos del movimiento tiene dentro del proceso de evaluaci&#243;n global del paciente con EP en nuestro centro&#46; Como se observa&#44; la evaluaci&#243;n de cada paciente es exhaustiva recogi&#233;ndose por parte de la enfermera informaci&#243;n acerca de diferentes s&#237;ntomas no motores&#44; grado de autonom&#237;a y calidad de vida mediante la aplicaci&#243;n de 13 escalas y&#47;o cuestionarios y un test cognitivo adicional &#40;test del puzle&#41; adem&#225;s de informaci&#243;n sobre el estado del cuidador del paciente&#46; M&#225;s all&#225; de la funci&#243;n que una enfermera competente puede tener en el proceso de evaluaci&#243;n de sujetos participantes en un estudio de investigaci&#243;n&#44; cabe destacar la aplicabilidad en la pr&#225;ctica cl&#237;nica&#44; que es disponer de gran informaci&#243;n y conocer as&#237; en detalle el estado del paciente&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Recientemente ya demostramos que la enfermera entrenada puede realizar la evaluaci&#243;n motora de los pacientes con EP de forma similar a c&#243;mo la puede hacer el neur&#243;logo experto en Parkinson y en tiempo similar<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">27</span></a>&#46; En este caso no se compar&#243; la evaluaci&#243;n no motora realizada por la enfermera dado que el objetivo era simplemente describir su funci&#243;n&#46; Sin embargo&#44; la enfermera de nuestro centro tiene experiencia en Parkinson desde el a&#241;o 2013 y es obvio que personal de enfermer&#237;a entrenado est&#225; perfectamente capacitado para poder evaluar diferentes s&#237;ntomas no motores<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">27</span></a>&#46; En el presente estudio&#44; la enfermera evalu&#243; de media un paciente por semana aproximadamente entre los a&#241;os 2016 y 2017&#44; lo cual refleja la experiencia en base a la pr&#225;ctica continuada evaluando pacientes&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">En los pacientes con EP&#44; muchos s&#237;ntomas pasan desapercibidos si no se preguntan&#46; El problema es que hay poco tiempo para evaluar en la pr&#225;ctica cl&#237;nica cada paciente&#46; La media de tiempo por ejemplo de la evaluaci&#243;n no motora realizada en el presente estudio fue de una hora y cuarto&#46; Por el contrario&#44; la informaci&#243;n obtenida es de gran valor&#46; Por ejemplo&#44; m&#225;s de un 20&#37; de los pacientes cumpl&#237;an criterios de deterioro cognitivo a pesar de un valor del MMSE normal cuando se us&#243; la escala PD-CRS&#46; Igualmente&#44; un porcentaje de pacientes considerable presentaba depresi&#243;n&#44; dolor&#44; trastorno de control de impulsos o ca&#237;das&#44; resultando todo ello relevante a la hora de tomar decisiones sobre el tratamiento&#46; Gestionar el tiempo como recurso es fundamental y lo ideal es disponer de pruebas de r&#225;pida ejecuci&#243;n y fiables&#46; Precisamente el test del puzle de 16 piezas del estudio COPPADIS-2015 que tambi&#233;n realizaba la enfermera en nuestro centro podr&#237;a ser un test de screening &#250;til y r&#225;pido para detectar deterioro cognitivo en la EP como recientemente hemos comunicado<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">28</span></a>&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">El personal de enfermer&#237;a especializado en EP tiene una funci&#243;n activa y reconocida en algunos pa&#237;ses como Reino Unido desde los a&#241;os 90<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">29&#44;30</span></a> y ha ido cobrando mayor importancia en otros pa&#237;ses<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">31</span></a>&#46; Adem&#225;s de la funci&#243;n que le compete como personal de enfermer&#237;a&#44; la enfermera especializada en Parkinson debe llevar a cabo otras funciones muy importantes como informar y educar sobre la enfermedad y terapias al paciente y cuidador&#44; asegurarse de la adecuada adherencia al tratamiento&#44; resolver dudas o problemas que puedan surgir&#44; o un adecuado manejo de dispositivos en pacientes con terapias de segunda l&#237;nea<a class="elsevierStyleCrossRefs" href="#bib0350"><span class="elsevierStyleSup">32&#8211;35</span></a>&#46; La labor de la enfermer&#237;a especializada permite reducir tiempos de espera&#44; evitar hospitalizaciones innecesarias o reducir los tiempos poscirug&#237;a&#44; y as&#237; programas de teleconsulta con la enfermera experta como primer contacto est&#225;n siendo desarrollados con &#233;xito<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">36&#44;37</span></a>&#46; Incluso ensayos randomizados han demostrado un coste-efectividad similar por parte del personal de enfermer&#237;a al de los m&#233;dicos generalistas<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">38</span></a>&#46; Sin embargo&#44; el n&#250;mero de enfermeras especializadas en EP es deficitario con respecto a las recomendaciones a pesar de que se haya demostrado que su presencia reduce a largo plazo costes en el sistema y sobrecarga del neur&#243;logo&#44; siendo necesario el desarrollo de iniciativas para que los enfermos puedan acceder a este tipo de atenci&#243;n<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">36</span></a>&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Como conclusi&#243;n&#44; el presente estudio refuerza dos hechos&#46; Uno&#44; la importancia de la evaluaci&#243;n global del paciente con EP&#46; Solo haciendo una evaluaci&#243;n completa disponemos de una informaci&#243;n global del estado de la enfermedad del paciente que es relevante &#40;pron&#243;stico&#44; decisiones terap&#233;uticas&#44; etc&#46;&#41;&#46; Dos&#44; que la enfermera puede llevar a cabo esta evaluaci&#243;n o parte de ella&#46; Si el tiempo es limitado tambi&#233;n para el personal de enfermer&#237;a&#44; la evaluaci&#243;n podr&#237;a ser dirigida a aspectos concretos&#46; Al igual que en otros pa&#237;ses y especialidades&#44; el rol de la enfermera experta en trastornos del movimiento debe ir creciendo en beneficio de los pacientes&#46;<span class="elsevierStyleVsp" style="height:0.5px"></span>Autor&#237;a&#47;colaboradores</p><p id="par0150" class="elsevierStylePara elsevierViewall">Teresa de Deus Fonticoba&#44; RN&#58; evaluaci&#243;n de pacientes&#59; revisi&#243;n y cr&#237;tica del manuscrito&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Diego Santos Garc&#237;a&#44; MD&#44; PhD&#58; evaluaci&#243;n de pacientes&#59; concepci&#243;n&#44; organizaci&#243;n y ejecuci&#243;n del proyecto&#59; escritura del primer manuscrito&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicto de intereses</span><p id="par0170" class="elsevierStylePara elsevierViewall">Lo autores declaran no tener ning&#250;n conflicto de intereses</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:3 [
          "identificador" => "xres1258156"
          "titulo" => "Resumen"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introducci&#243;n"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Objetivos"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "M&#233;todos"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Resultados"
            ]
            4 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1165490"
          "titulo" => "Palabras clave"
        ]
        2 => array:3 [
          "identificador" => "xres1258155"
          "titulo" => "Abstract"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Introduction"
            ]
            1 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Objective"
            ]
            2 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Methods"
            ]
            3 => array:2 [
              "identificador" => "abst0045"
              "titulo" => "Results"
            ]
            4 => array:2 [
              "identificador" => "abst0050"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1165489"
          "titulo" => "Keywords"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introducci&#243;n"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Material y m&#233;todos"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Resultados"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discusi&#243;n"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflicto de intereses"
        ]
        9 => array:1 [
          "titulo" => "Bibliograf&#237;a"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2018-05-09"
    "fechaAceptado" => "2018-08-27"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1165490"
          "palabras" => array:8 [
            0 => "Dolor"
            1 => "Depresi&#243;n"
            2 => "Deterioro cognitivo"
            3 => "Escalas"
            4 => "Enfermedad de Parkinson"
            5 => "Enfermera"
            6 => "Neur&#243;logo"
            7 => "S&#237;ntomas no motores"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1165489"
          "palabras" => array:8 [
            0 => "Pain"
            1 => "Depression"
            2 => "Cognitive impairment"
            3 => "Scales"
            4 => "Parkinson disease"
            5 => "Nurse"
            6 => "Neurologist"
            7 => "Non-motor Symptoms"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La evaluaci&#243;n de los pacientes con enfermedad de Parkinson &#40;EP&#41; es compleja siendo fundamental para el neur&#243;logo detectar diferentes s&#237;ntomas no motores&#46; Sin embargo&#44; lleva tiempo y no es f&#225;cil en la pr&#225;ctica diaria&#46; Como alternativa&#44; una enfermera entrenada puede realizar dicha evaluaci&#243;n&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Describir la evaluaci&#243;n no motora llevada a cabo por la enfermera especialista en trastornos del movimiento dentro del proyecto de investigaci&#243;n Cohort of Patients with Parkinson&#39;s DIsease in Spain&#44; 2015 &#40;COPPADIS-2015&#41; en nuestro centro &#40;CHUF&#41;&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron pacientes con EP as&#237; como cuidadores principales que cumplieran con los criterios de participaci&#243;n del estudio COPPADIS-2015&#46; La evaluaci&#243;n llevada a cabo por la enfermera inclu&#237;a&#58; 1&#41; cognici&#243;n &#40;PD-CRS y test del puzle&#41;&#59; 2&#41; SNM en general &#40;NMSS&#41;&#59; 3&#41; estado de &#225;nimo &#40;BDI-II&#41;&#59; 4&#41; sue&#241;o &#40;PDSS&#41;&#59; 5&#41; s&#237;ntomas neuropsiqui&#225;tricos &#40;NPI&#44; QUIP-RS&#41;&#59; 6&#41; dolor y fatiga &#40;VAS-Pain y VAS-Fatigue&#41;&#59; 7&#41; alteraciones de la marcha &#40;FOGQ&#41;&#59; 8&#41; autonom&#237;a &#40;ADLS&#41;&#59; 9&#41; calidad de vida &#40;PDQ-39SI&#44; PQ-10&#44; WHOQL-8&#41;&#59; 10&#41; estado del cuidador &#40;ZCBI&#44; CSI&#44; BDI-II&#44; PQ-10&#44; WHOQL-8&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Un total de 102 pacientes &#40;65&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;2 a&#241;os&#59; 52&#37; varones&#41; con EP y 62 cuidadores fueron evaluados entre enero de 2016 y octubre de 2017&#46; El tiempo medio de evaluaci&#243;n fue de 73&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#44;5 min&#46; El 23&#44;5&#37; de los pacientes presentaba deterioro cognitivo&#44; 17&#44;6&#37; depresi&#243;n mayor&#44; 14&#44;7&#37; trastorno de control de impulsos y 66&#44;7&#37; dolor&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La evaluaci&#243;n no motora de los pacientes con EP consume tiempo pero es muy valiosa dado que proporciona gran informaci&#243;n del estado del paciente y puede ser llevada a cabo por personal de enfermer&#237;a entrenado&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objetivos"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "M&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The evaluation of patients with Parkinson&#39;s disease &#40;PD&#41; is complex and the detection of non-motor symptoms by the neurologist a very important aspect&#46; However&#44; it takes time and is not easy in daily clinical practice&#46; As an alternative&#44; a trained nurse can perform this evaluation&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To describe the non-motor evaluation of the patients from the Cohort of Patients with Parkinson&#39;s Disease in Spain&#44; 2015 study &#40;COPPADIS-2015&#41; conducted by movement disorder specialist nurse from our centre&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Patients and caregivers from the COPPADIS-2015 study were included&#46; The assessment included&#58; 1&#41; cognition &#40;PD-CRS and puzzle test&#41;&#59; 2&#41; non motor symptoms as a whole &#40;NMSS&#41;&#59; 3&#41; mood &#40;BDI-II&#41;&#59; 4&#41; sleep &#40;PDSS&#41;&#59; 5&#41; neuropsychiatric symptoms &#40;NPI&#44; QUIP-RS&#41;&#59; 6&#41; pain and fatigue &#40;VAS&#41;&#59; 7&#41; gait problems &#40;FOGQ&#41;&#59; 8&#41; disability &#40;ADLS&#41;&#59; 9&#41; quality of life &#40;PDQ-39SI&#44; PQ-10&#44; WHOQL-8&#41;&#59; 10&#41; caregiver status &#40;ZCBI&#44; CSI&#44; BDI-II&#44; PQ-10&#44; WHOQL-8&#41;&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">102 patients &#40;65&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;2 y&#59; 52&#37; males&#41; and 62 caregivers were evaluated between January 2016&#44; and October&#44; 2017&#46; Mean time of non-motor evaluation was 73&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#46;5<span class="elsevierStyleHsp" style=""></span>minutes&#46; Twenty-three point five percent of the patients had cognitive impairment&#44; 17&#46;6&#37; major depression&#44; 14&#46;7&#37; impulse control disorder&#44; and 66&#46;7&#37; pain&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The non-motor assessment of patients with PD takes a long time but is very valuable given that it provides a great deal of information about the patient&#39;s condition and can be done by trained nurses&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Objective"
          ]
          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Methods"
          ]
          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Results"
          ]
          4 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Conclusions"
          ]
        ]
      ]
    ]
    "multimedia" => array:7 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 908
            "Ancho" => 2511
            "Tamanyo" => 118900
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">N&#250;mero total de sujetos reclutados cada mes del estudio&#46; En oscuro&#44; pacientes y en claro cuidadores&#46; En verde&#44; a&#241;o 2016&#46; En azul&#44; a&#241;o 2017&#46; El color de esta figura solo puede apreciarse en la versi&#243;n electr&#243;nica del art&#237;culo&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1753
            "Ancho" => 2492
            "Tamanyo" => 268002
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Porcentaje de pacientes que contestaron en cada &#237;tem de la NMSS presentar el s&#237;ntoma &#40;puntuaci&#243;n de 1 a 12&#44; diferente de 0 que representa no presentar el s&#237;ntoma&#41;&#46; Por colores se muestran los &#237;tems de los 9 dominios de la escala&#46; El color de esta figura solo puede apreciarse en la versi&#243;n electr&#243;nica del art&#237;culo&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figura 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1822
            "Ancho" => 2510
            "Tamanyo" => 120053
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Puntuaci&#243;n por dominios de la NMSS&#44; representados como barras de cajas&#46; Cada dominio se expresa como un porcentaje &#40;sumatorio&#47;puntuaci&#243;n m&#225;xima posible&#41; para poder comparar entre ellos &#40;dado que el n&#250;mero de preguntas var&#237;a de unos a otros&#41;&#46; La mayor puntuaci&#243;n corresponde a la disfunci&#243;n sexual y la menor a las alteraciones de la percepci&#243;n&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figura 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 1711
            "Ancho" => 2500
            "Tamanyo" => 196930
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Porcentaje de pacientes que contestaron en cada &#237;tem del BDI-II presentar el s&#237;ntoma &#40;puntuaci&#243;n de 1 a 3&#44; diferente de 0&#41;&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "fig0025"
        "etiqueta" => "Figura 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
            "Alto" => 1854
            "Ancho" => 2518
            "Tamanyo" => 94238
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Puntuaci&#243;n por dominios del PDQ-39SI&#44; representados como barras de cajas&#46; Cada dominio se expresa como un porcentaje &#40;sumatorio&#47;puntuaci&#243;n m&#225;xima posible&#41; para poder comparar entre ellos &#40;dado que el n&#250;mero de preguntas var&#237;a de unos a otros&#41;&#46; La mayor puntuaci&#243;n corresponde al dolor y malestar y la menor a la comunicaci&#243;n&#46;</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">DE&#58; desviaci&#243;n est&#225;ndar&#59; ICOMT&#58; inhibidor de la catecolortometiltransferasa&#59; IMAO-B&#58; inhibidores de la monoaminooxidasa B&#59; PIGD&#58; Postural Instabillity Gait Dificulty&#59; TS-REM&#58; trastorno del sue&#241;o REM&#59; UPDRS&#58; Unified Parkinson&#39;s Disease Rating Scale&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variables demogr&#225;ficas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Evaluaci&#243;n motora&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Edad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;2 &#40;36-75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tiempo de evoluci&#243;n &#40;a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;5 &#40;0-22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Varones &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hoehn &#38; Yahr &#40;&#37;&#41;&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;5 &#40;1-4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Estadio 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Nivel sociocultural</span>&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Estadio 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Estudios primarios&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Estadio 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Estudios secundarios&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Estadio 4 o 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Estudios universitarios&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">UPDRS-III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;6 &#40;3-40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">UPDRS-IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;4 &#40;0-10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Estado civil</span>&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fluctuaciones motoras &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Casado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Discinesias &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Soltero&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Viudo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fenotipo &#40;&#37;&#41;&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Divorciado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Trem&#243;rico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Otro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- PIGD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-Indeterminado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Forma de vida</span>&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Solo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tratamiento&#58;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Con el c&#243;nyuge&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Levodopa &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Con el hijo&#47;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Agonista dopamin&#233;rgico &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Otra&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ICOMT &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IMAO-B &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">H&#225;bitat</span>&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Amantadina &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Rural &#40;&#60; 5&#46;000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anticolin&#233;rgico &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Semiurbano &#40;5&#46;000-20&#46;000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dosis eq&#46; de L-dopa &#40;mg&#47;d&#237;a&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">432&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>391&#44;8 &#40;0-1980&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Urbano &#40;&#62; 20&#46;000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antidepresivos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Comorbilidades</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ansiol&#237;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hipertensi&#243;n arterial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antipsic&#243;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Analg&#233;sico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dislipemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cardiopat&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#46;&#176; de tratamientos para la EP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;4 &#40;0-5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Arritmia cardiaca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#46;&#176; de pastillas para la EP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;7 &#40;0-11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tabaquismo activo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#46;&#176; total de tratamientos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;5 &#40;0-10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Consumo de alcohol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#46;&#176; total de pastillas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;8 &#40;0-16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TS-REM &#40;preguntas del m&#233;dico&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2151575.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas de la poblaci&#243;n de pacientes incluidos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>102&#41;&#59; valores expresados en &#37; y&#47;o media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE &#40;rango&#41;</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabla 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">CSI&#58; Caregiver Strain Index&#59; DE&#58; desviaci&#243;n est&#225;ndar&#59; FOGQ&#58; Freezing of Gait Questionnaire&#59; MMSE&#58; Mini-Mental State Examination&#59; NMSS&#58; Non-Motor Symptoms Scale&#59; NPI&#58; Neuropsychiatric Inventory&#59; PD-CRS&#58; Parkinson&#39;s Disease Cognitive Rating Scale&#59; PDQ-39SI&#58; 39-item Parkinson&#39;s disease Quality of Life Questionnaire Summary Index&#59; PDSS&#58; Parkinson&#39;s Disease Sleep Scale&#59; QUIP-RS&#58; Questionnaire for Impulsive-Compulsive Disorders in Parkinson&#39;s Disease-Rating Scale&#59; TCI&#58; trastorno del control de impulsos&#59; VAS&#58; Visual Analog Scale-Pain&#59; ZCBI&#58; Zarit Caregiver Burden Inventory&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pacientes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cuidadores principales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MMSE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;7 &#40;27-30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Edad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PD-CRS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;7 &#40;61-126&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- FS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;6 &#40;32-96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Relaci&#243;n con el paciente&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- CP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;7 &#40;23-30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- C&#243;nyuge&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Deterioro cognitivo &#40;&#37;&#41;&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Hijo&#47;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; No &#40;PD-CRS<span class="elsevierStyleHsp" style=""></span>&#62; 84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Otro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; S&#237; &#40;PD-CRS &#8804; 84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tiempo puzle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ZCBI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;0 &#40;0-55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cuidadores con sobrecarga &#40;&#37;&#41;&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NMSS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>38&#44;3 &#40;0-193&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Nula o no sobrecarga &#40;0-20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Leve a moderada &#40;21-40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BDI-II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;5 &#40;0-37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Moderada a grave &#40;41-60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">S&#237;ntomas depresivos</span>&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Grave &#40;61-88&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- S&#237; criterios de depresi&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CSI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;3 &#40;0-9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- No criterios de depresi&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nivel de estr&#233;s &#40;&#37;&#41;&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tipo de depresi&#243;n</span>&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- No alto &#237;ndice de estr&#233;s &#40;0-6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Depresi&#243;n mayor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Alto &#237;ndice de estr&#233;s &#40;&#8805; 7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Depresi&#243;n menor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Depresi&#243;n subcl&#237;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BDI-II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;8 &#40;0-30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">QUIP-RS</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;5 &#40;0-21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Pacientes con TCI &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PQ-10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;6 &#40;4-10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EUROHIS-QOL8 item index&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;1 &#40;20-40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PDSS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;3 &#40;79&#44;5-149&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NPI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;9 &#40;0-46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VAS-Dolor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;9 &#40;0-9&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Pacientes con dolor &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VAS-fatiga f&#237;sica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;7 &#40;0-9&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VAS-fatiga mental&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;6 &#40;0-10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FOGQ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;3 &#40;0-18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">- Ca&#237;das &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Independencia &#40;ADLS &#8805; 80&#41; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PDQ-39SI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#44;5 &#40;0&#44;6-55&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PQ-10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;5 &#40;0-10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EUROHIS-QOL8 item index&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;5 &#40;19-37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2151574.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Datos de la evaluaci&#243;n no motora de los pacientes &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>102&#41; y de los cuidadores principales &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>62&#41; realizada por la enfermera&#59; valores expresados en &#37; y&#47;o media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE &#40;rango&#41;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:38 [
            0 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Parkinson&#39;s Disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;V&#46; Kalia"
                            1 => "A&#46;E&#46; Lang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2015"
                        "volumen" => "386"
                        "paginaInicial" => "896"
                        "paginaFinal" => "912"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Non-motor symptoms in Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;F&#46; Pfeiffer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.parkreldis.2015.09.004"
                      "Revista" => array:7 [
                        "tituloSerie" => "Parkinsonism Relat Disord"
                        "fecha" => "2016"
                        "volumen" => "22"
                        "numero" => "Suppl 1"
                        "paginaInicial" => "S119"
                        "paginaFinal" => "S122"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26372623"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interdisciplinary teamwork for the treatment of people with Parkinson&#39;s disease and their families"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46; Giladi"
                            1 => "Y&#46; Manor"
                            2 => "A&#46; Hilel"
                            3 => "T&#46; Gurevich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11910-014-0493-1"
                      "Revista" => array:5 [
                        "tituloSerie" => "Curr Neurol Neurosci Rep"
                        "fecha" => "2014"
                        "volumen" => "14"
                        "paginaInicial" => "493"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25245121"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multidisciplinary care for patients with Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;A&#46; van der Marck"
                            1 => "J&#46;G&#46; Kalf"
                            2 => "I&#46;H&#46; Sturkenboom"
                            3 => "M&#46;J&#46; Nijkrake"
                            4 => "M&#46; Munneke"
                            5 => "B&#46;R&#46; Bloem"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1353-8020(09)70819-3"
                      "Revista" => array:7 [
                        "tituloSerie" => "Parkinsonism Relat Disord"
                        "fecha" => "2009"
                        "volumen" => "15"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "S219"
                        "paginaFinal" => "S223"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20082995"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Parkinson&#39;s disease nurse specialists&#58; an important role in disease management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;G&#46; MacMahon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1999"
                        "volumen" => "52"
                        "numero" => "7 Suppl 3"
                        "paginaInicial" => "S21"
                        "paginaFinal" => "S25"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10227607"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nursing and multidisciplinary interventions for Parkinson&#39;s disease&#58; what is the evidence&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Hagell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1353-8020(08)70057-9"
                      "Revista" => array:7 [
                        "tituloSerie" => "Parkinsonism Relat Disord"
                        "fecha" => "2007"
                        "volumen" => "13"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "S501"
                        "paginaFinal" => "S508"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18267291"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "COPPADIS Study Group COPPADIS-2015 &#40;COhort of Patients with PArkinson&#39;s DIsease in Spain&#44; 2015&#41;&#44; a global--clinical evaluations&#44; serum biomarkers&#44; genetic studies and neuroimaging--prospective&#44; multicenter&#44; non-interventional&#44; long-term study on Parkinson&#39;s disease progression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Santos-Garc&#237;a"
                            1 => "P&#46; Mir"
                            2 => "E&#46; Cubo"
                            3 => "L&#46; Vela"
                            4 => "M&#46;C&#46; Rodr&#237;guez-Oroz"
                            5 => "M&#46;J&#46; Mart&#237;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12883-016-0548-9"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Neurol"
                        "fecha" => "2016"
                        "volumen" => "16"
                        "paginaInicial" => "26"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26911448"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Parkinson&#39;s Disease Society Brain Bank London&#58; overview and research"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;E&#46; Daniel"
                            1 => "A&#46;J&#46; Lees"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neural Transm Suppl"
                        "fecha" => "1993"
                        "volumen" => "39"
                        "paginaInicial" => "165"
                        "paginaFinal" => "172"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8360656"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic procedures for Parkinson&#39;s disease dementia&#58; recommendations from the movement disorder society task force"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Dubois"
                            1 => "D&#46; Burn"
                            2 => "C&#46; Goetz"
                            3 => "D&#46; Aarsland"
                            4 => "R&#46;G&#46; Brown"
                            5 => "G&#46;A&#46; Broe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/mds.21844"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mov Disord"
                        "fecha" => "2007"
                        "volumen" => "22"
                        "paginaInicial" => "2314"
                        "paginaFinal" => "2324"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18098298"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Members of the UPDRS Development Committee&#46; Unified Parkinson&#39;s Disease Rating Scale"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Fanhn"
                            1 => "R&#46;L&#46; Elton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "editores" => "S&#46;Fahn, C&#46;D&#46;Marsden, D&#46;B&#46;Calne, M&#46;Goldstein"
                        "titulo" => "Recent developments in Parkinson&#39;s disease&#44; Vol 2&#46;"
                        "paginaInicial" => "153"
                        "paginaFinal" => "164"
                        "serieFecha" => "1987"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Parkinsonism&#58; onset&#44; progression and mortality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;M&#46; Hoehn"
                            1 => "M&#46;D&#46; Yahr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1212/wnl.17.5.427"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurology&#46;"
                        "fecha" => "1967"
                        "volumen" => "17"
                        "paginaInicial" => "427"
                        "paginaFinal" => "442"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6067254"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Parkinson&#39;s disease-cognitive rating scale&#58; a new cognitive scale specific for Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Pagonabarraga"
                            1 => "J&#46; Kulisevsky"
                            2 => "G&#46; Llebaria"
                            3 => "C&#46; Garc&#237;a-S&#225;nchez"
                            4 => "B&#46; Pascual-Sedano"
                            5 => "A&#46; Gironell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/mds.22007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mov Disord"
                        "fecha" => "2008"
                        "volumen" => "23"
                        "paginaInicial" => "998"
                        "paginaFinal" => "1005"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18381647"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The metric properties of a novel non-motor symptoms scale for Parkinson&#39;s disease&#58; Results from an international pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;R&#46; Chaudhuri"
                            1 => "P&#46; Martinez-Martin"
                            2 => "R&#46;G&#46; Brown"
                            3 => "K&#46; Sethi"
                            4 => "F&#46; Stocchi"
                            5 => "P&#46; Odin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/mds.21596"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mov Disord"
                        "fecha" => "2007"
                        "volumen" => "22"
                        "paginaInicial" => "1901"
                        "paginaFinal" => "1911"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17674410"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Beck AT&#44; Steer RA&#44; Brown GK&#46; Beck Depression Inventory-second edition&#46; Manual&#46; San Antonio&#58; The Psychological Corporation&#46; 1996&#46;"
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of the questionnaire for impulsive-compulsive disorders in Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Weintraub"
                            1 => "S&#46; Hoops"
                            2 => "J&#46;A&#46; Shea"
                            3 => "K&#46;E&#46; Lyons"
                            4 => "R&#46; Pahwa"
                            5 => "E&#46;D&#46; Driver-Dunckley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/mds.22571"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mov Disord"
                        "fecha" => "2009"
                        "volumen" => "24"
                        "paginaInicial" => "1461"
                        "paginaFinal" => "1467"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19452562"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Parkinson&#39;s disease sleep scale&#58; a new instrument for assessing sleep and nocturnal disability in Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;R&#46; Chaudhuri"
                            1 => "S&#46; Pal"
                            2 => "A&#46; DiMarco"
                            3 => "C&#46; Whately-Smith"
                            4 => "K&#46; Bridgman"
                            5 => "R&#46; Mathew"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jnnp.73.6.629"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "2002"
                        "volumen" => "73"
                        "paginaInicial" => "629"
                        "paginaFinal" => "635"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12438461"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Neuropsychiatric Inventory&#58; comprehensive assessment of psychopathology in dementia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Cummings"
                            1 => "M&#46; Mega"
                            2 => "K&#46; Gray"
                            3 => "S&#46; Rosenberg-Thompson"
                            4 => "D&#46;A&#46; Carusi"
                            5 => "J&#46; Gornbein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1212/wnl.44.12.2308"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1994"
                        "volumen" => "44"
                        "paginaInicial" => "2308"
                        "paginaFinal" => "2314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7991117"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adult measures of pain&#58; The McGill Pain Questionnaire &#40;MPQ&#41;&#44; Rheumatoid Arthritis Pain Scale &#40;RAPS&#41;&#44; Short Form McGill Pain Questionnaire &#40;SF-MPQ&#41;&#44; Verbal Descriptive Scale &#40;VDS&#41; Visual Analog Scale &#40;VAS&#41;&#44; and West Haven-Yale Multidisciplinary Pain Inventory &#40;WHYMPI&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;S&#46; Burckhardt"
                            1 => "K&#46;D&#46; Jones"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2003"
                        "volumen" => "49"
                        "paginaInicial" => "S96"
                        "paginaFinal" => "S104"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reliability&#44; responsiveness&#44; and validity of the visual analog fatigue scale to measure exertion fatigue in people with chronic stroke&#58; a preliminary study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;Y&#46; Tseng"
                            1 => "B&#46;J&#46; Gajewski"
                            2 => "P&#46;M&#46; Kluding"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Stroke Res Treat"
                        "fecha" => "2010"
                        "paginaInicial" => "Pii&#58;412964"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Construction of freezing of gait questionnaire for patients with Parkinsonism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46; Giladi"
                            1 => "H&#46; Shabtai"
                            2 => "E&#46;S&#46; Simon"
                            3 => "S&#46; Biran"
                            4 => "J&#46; Tal"
                            5 => "A&#46;D&#46; Korczyn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Parkinsonism Relat Disord"
                        "fecha" => "2000"
                        "volumen" => "6"
                        "paginaInicial" => "165"
                        "paginaFinal" => "170"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10817956"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In third symposium on parkinson&#39;s disease E&#46; And S"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;S&#46; Schwab"
                            1 => "A&#46;C&#46; England"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Livingstone&#58; Edinburgh"
                        "fecha" => "1969"
                        "paginaInicial" => "152"
                        "paginaFinal" => "157"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Parkinson&#39;s Disease Questionnaire &#40;PDQ-39&#41;&#58; development and validation of a Parkinson&#39;s disease summary index score"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Jenkinson"
                            1 => "R&#46; Fitzpatrick"
                            2 => "V&#46; Peto"
                            3 => "R&#46; Greenhall"
                            4 => "N&#46; Hyman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ageing/26.5.353"
                      "Revista" => array:6 [
                        "tituloSerie" => "Age Ageing"
                        "fecha" => "1997"
                        "volumen" => "26"
                        "paginaInicial" => "353"
                        "paginaFinal" => "357"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9351479"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of non-motor symptoms on health-related and perceived quality of life in Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Santos Garc&#237;a"
                            1 => "R&#46; de la Fuente-Fern&#225;ndez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jns.2013.07.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Sci"
                        "fecha" => "2013"
                        "volumen" => "332"
                        "paginaInicial" => "136"
                        "paginaFinal" => "140"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23890935"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The EUROHIS-QOL 8-item index&#58; comparative psychometric properties to its parent WHOQOL-BREF"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46;S&#46; Da Rocha"
                            1 => "M&#46;J&#46; Power"
                            2 => "D&#46;M&#46; Bushnell"
                            3 => "M&#46;P&#46; Fleck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jval.2011.11.035"
                      "Revista" => array:6 [
                        "tituloSerie" => "Value Health"
                        "fecha" => "2012"
                        "volumen" => "15"
                        "paginaInicial" => "449"
                        "paginaFinal" => "457"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22583455"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Application of a multidimensional caregiver burden inventory"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Novak"
                            1 => "C&#46; Guest"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Gerontol"
                        "fecha" => "1989"
                        "volumen" => "29"
                        "paginaInicial" => "798"
                        "paginaFinal" => "803"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of a Caregiver Strain Index"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46;C&#46; Robinson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/geronj/38.3.344"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Gerontol"
                        "fecha" => "1983"
                        "volumen" => "38"
                        "paginaInicial" => "344"
                        "paginaFinal" => "348"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6841931"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inter-rater variability in motor function assessment in Parkinson&#39;s disease between experts in movement disorders and nurses specialising in PD management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; De Deus Fonticoba"
                            1 => "D&#46; Santos Garc&#237;a"
                            2 => "M&#46; Mac&#237;as Arrib&#237;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Neurologia"
                        "fecha" => "2018"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Su&#225;rez Castro E&#44; Santos Garc&#237;a D&#44; de Deus Fonticoba T&#44; Tu&#241;as-Gesto C&#44; Alba Doporto A&#44; Exp&#243;sito-Ruiz I&#44; et&#46;al&#46; Test de resoluci&#243;n de un puzle como prueba de screening para la detecci&#243;n de deterioro cognitivo en la enfermedad de Parkinson&#46; Comunicaci&#243;n oral&#46; XXXII Reuni&#243;n de la Sociedad Gallega de Neurolog&#237;a&#44; A Coru&#241;a&#44; 13 y 14 de Abril de 2018&#46;"
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Support supplied by Parkinson&#39;s disease specialist nurses to Parkinson&#39;s disease patients and their spouses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Hellqvist"
                            1 => "C&#46; Berter&#246;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.apnr.2014.12.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Appl Nurs Res"
                        "fecha" => "2015"
                        "volumen" => "28"
                        "paginaInicial" => "86"
                        "paginaFinal" => "91"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25908544"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of the role of the Parkinson&#39;s disease nurse specialist"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Reynolds"
                            1 => "J&#46; Wilson-Barnett"
                            2 => "G&#46; Richardson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0020-7489(00)00013-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Nurs Stud"
                        "fecha" => "2000"
                        "volumen" => "37"
                        "paginaInicial" => "337"
                        "paginaFinal" => "349"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10760541"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nurses&#8217;responses to expert patients&#58; The rhetoric and reality of self-management in long-term conditions&#58; A grounded theory study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;M&#46; Wilson"
                            1 => "S&#46; Kendall"
                            2 => "F&#46; Brooks"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijnurstu.2005.10.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "International Journal of Nursing Studies"
                        "fecha" => "2006"
                        "volumen" => "43"
                        "paginaInicial" => "803"
                        "paginaFinal" => "818"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16343500"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of community based nurses specialising in Parkinson&#39;s disease on health outcome and costs&#58; randomised controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46; Jarman"
                            1 => "B&#46; Hurwitz"
                            2 => "A&#46; Cook"
                            3 => "M&#46; Bajekal"
                            4 => "A&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.324.7345.1072"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2002"
                        "volumen" => "324"
                        "paginaInicial" => "1072"
                        "paginaFinal" => "1075"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11991913"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Developing a nurse-led clinic for patients with Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Gow"
                            1 => "E&#46; Collins"
                            2 => "M&#46; Giles"
                            3 => "T&#46; O&#8217;Brien"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Aust Nurs Midwifery J"
                        "fecha" => "2014"
                        "volumen" => "21"
                        "paginaInicial" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24941564"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of patients with Parkinson disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;Y&#46; Shin"
                            1 => "C&#46;C&#46; Hendrix"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.NPR.0000434090.96229.5c"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nurse Pract"
                        "fecha" => "2013"
                        "volumen" => "38"
                        "paginaInicial" => "34"
                        "paginaFinal" => "43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24048348"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Understanding the role of the Parkinson&#39;s disease nurse specialist in the delivery of apomorphine therpy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Bhidayasiri"
                            1 => "K&#46; Boonpang"
                            2 => "O&#46; Jitkritsadakul"
                            3 => "S&#46;M&#46; Calne"
                            4 => "T&#46; Henriksen"
                            5 => "S&#46; Trump"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.parkreldis.2016.11.014"
                      "Revista" => array:7 [
                        "tituloSerie" => "Parkinsonism Relat Disord"
                        "fecha" => "2016"
                        "volumen" => "33"
                        "numero" => "Suppl 1"
                        "paginaInicial" => "S49"
                        "paginaFinal" => "S55"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27939324"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neurological nurse specialists&#58; a vital resource under threat"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Christodoulou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1474-4422(12)70030-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Neurol"
                        "fecha" => "2012"
                        "volumen" => "11"
                        "paginaInicial" => "210"
                        "paginaFinal" => "211"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22341030"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Implementation of an Integrative Holistic Healthcare Model for People Living with Parkinson&#39;s Disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "I&#46; Pretzer-Aboff"
                            1 => "A&#46; Prettyman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/geront/gnv004"
                      "Revista" => array:7 [
                        "tituloSerie" => "Gerontologist"
                        "fecha" => "2015"
                        "volumen" => "55"
                        "numero" => "Suppl1"
                        "paginaInicial" => "S146"
                        "paginaFinal" => "S153"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26055776"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomised controlled trial comparing cost effectiveness of general practitioners and nurse practitioners in primary care"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Venning"
                            1 => "A&#46; Durie"
                            2 => "M&#46; Roland"
                            3 => "C&#46; Roberts"
                            4 => "B&#46; Leese"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.320.7241.1048"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2000"
                        "volumen" => "320"
                        "paginaInicial" => "1048"
                        "paginaFinal" => "1053"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10764367"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/20135246/000000500000000C/v1_201910260906/S2013524618300187/v1_201910260906/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "13744"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20135246/000000500000000C/v1_201910260906/S2013524618300187/v1_201910260906/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013524618300187?idApp=UINPBA00004N"
]
Información del artículo
ISSN: 20135246
Idioma original: Español
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Octubre 87 8 95
2024 Septiembre 84 29 113
2024 Agosto 34 12 46
2024 Julio 55 12 67
2024 Junio 91 7 98
2024 Mayo 104 9 113
2024 Abril 93 13 106
2024 Marzo 68 7 75
2024 Febrero 101 7 108
2024 Enero 58 11 69
2023 Diciembre 120 13 133
2023 Noviembre 129 14 143
2023 Octubre 107 9 116
2023 Septiembre 40 1 41
2023 Agosto 48 3 51
2023 Julio 63 7 70
2023 Junio 95 12 107
2023 Mayo 141 6 147
2023 Abril 194 5 199
2023 Marzo 96 12 108
2023 Febrero 84 30 114
2023 Enero 47 9 56
2022 Diciembre 60 17 77
2022 Noviembre 74 14 88
2022 Octubre 126 17 143
2022 Septiembre 100 31 131
2022 Agosto 70 14 84
2022 Julio 86 14 100
2022 Junio 89 22 111
2022 Mayo 92 29 121
2022 Abril 121 10 131
2022 Marzo 214 25 239
2022 Febrero 162 14 176
2022 Enero 130 20 150
2021 Diciembre 78 16 94
2021 Noviembre 90 14 104
2021 Octubre 66 33 99
2021 Septiembre 41 19 60
2021 Agosto 48 12 60
2021 Julio 23 13 36
2021 Junio 22 17 39
2021 Mayo 76 27 103
2021 Abril 71 16 87
2021 Marzo 49 26 75
2021 Febrero 42 31 73
2021 Enero 33 26 59
2020 Diciembre 28 15 43
2020 Noviembre 31 18 49
2020 Octubre 17 18 35
2020 Septiembre 21 15 36
2020 Agosto 32 15 47
2020 Julio 26 18 44
2019 Abril 0 2 2
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos