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Opioides" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:3 [ 0 => "es" 1 => "en" 2 => "eu" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "141" "paginaFinal" => "147" ] ] "titulosAlternativos" => array:2 [ "en" => array:1 [ "titulo" => "Advances in chronic pain pharmacotherapy. opioids" ] "eu" => array:1 [ "titulo" => "Min kronikoa botiken bidez arintzeko aurrerabideak. opioideak" ] ] "contieneResumen" => array:3 [ "es" => true "en" => true "eu" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Isla, M. Mozas, J.F. Cortázar, L. Arizmendi, P. Manuel, F. Torre, V. Ortiz, J.J. Azkue" "autores" => array:8 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Isla" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Mozas" ] 2 => array:2 [ "nombre" => "J.F." "apellidos" => "Cortázar" ] 3 => array:2 [ "nombre" => "L." "apellidos" => "Arizmendi" ] 4 => array:2 [ "nombre" => "P." "apellidos" => "Manuel" ] 5 => array:2 [ "nombre" => "F." "apellidos" => "Torre" ] 6 => array:2 [ "nombre" => "V." "apellidos" => "Ortiz" ] 7 => array:2 [ "nombre" => "J.J." "apellidos" => "Azkue" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0304485807745948?idApp=UINPBA00004N" "url" => "/03044858/0000010400000004/v1_201307161352/S0304485807745948/v1_201307161352/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0304485807745924" "issn" => "03044858" "doi" => "10.1016/S0304-4858(07)74592-4" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "74592" "copyright" => "Academia de Ciencias Médicas de Bilbao" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Gac Med Bilbao. 2007;104:135" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 976 "formatos" => array:3 [ "EPUB" => 23 "HTML" => 526 "PDF" => 427 ] ] "es" => array:8 [ "idiomaDefecto" => true "titulo" => "Dolor" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "135" ] ] "titulosAlternativos" => array:2 [ "en" => array:1 [ "titulo" => "Pain" ] "eu" => array:1 [ "titulo" => "Mina" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francisco Doñate-Oliver" "autores" => array:1 [ 0 => array:3 [ "preGrado" => "Prof. Dr." "nombre" => "Francisco" "apellidos" => "Doñate-Oliver" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0304485807745924?idApp=UINPBA00004N" "url" => "/03044858/0000010400000004/v1_201307161352/S0304485807745924/v1_201307161352/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "La Sensibilización Central en la fisiopatología del dolor" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "136" "paginaFinal" => "140" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jon Jatsu Azkue, Vicente Ortiz, Fernando Torre, Luciano Aguilera" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Jon" "apellidos" => "Jatsu Azkue" "email" => array:1 [ 0 => "jonjatsu.azkue@ehu.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">†</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Vicente" "apellidos" => "Ortiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Fernando" "apellidos" => "Torre" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Luciano" "apellidos" => "Aguilera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Neurociencias, Facultad de Medicina y Odontología, UPV / EHU. Leioa. Bizkaia. España UE." "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anestesiología y Reanimación, y Unidad de Tratamiento del Dolor, Hospital de Basurto. Bilbao. Bizkaia. España UE." "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Anestesiología y Reanimación, y Unidad de Tratamiento del Dolor, Hospital de Galdakao-Usansolo. Galdakao. Bizkaia. España UE." "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "†" "correspondencia" => "Correspondencia: Jon Jatsu Azkue-Barrenetxea. Departamento de Neurociencias. Facultad de Medicina y Odontología. Apartado 699. 48080 Bilbao. Bizkaia. España. UE. Tel: 946 012 867" ] ] ] ] "titulosAlternativos" => array:2 [ "en" => array:1 [ "titulo" => "Central Sensitization in the pathophysiology of pain" ] "eu" => array:1 [ "titulo" => "Erdiko sentiberatzea minaren patofisiologian" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-05-05" "fechaAceptado" => "2006-06-06" "PalabrasClave" => array:3 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec211457" "palabras" => array:3 [ 0 => "dolor neuropático" 1 => "nocicepción" 2 => "plasticidad" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec211456" "palabras" => array:3 [ 0 => "neuropathic pain" 1 => "nociception" 2 => "plasticity" ] ] ] "eu" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Gako hitzak" "identificador" => "xpalclavsec211458" "palabras" => array:3 [ 0 => "min neuropatikoa" 1 => "nozizepzioa" 2 => "plastikotasuna" ] ] ] ] "tieneResumen" => true "resumen" => array:3 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pruebas clínicas y experimentales han demostrado que un trauma tisular provoca en el Sistema Nervioso Central (SNC) un incremento de la excitabilidad neuronal, conocido como Sensibilización Central (SC), caracterizado por la presencia de dolor espontáneo o persistente, expansión de las áreas afectadas por el dolor, y trastornos sensoriales cualitativos que incluyen alodinia e hiperalgesia. La SC resulta de una serie de alteraciones funcionales y anatómicas en el SNC, algunas de ellas potencialmente irreversibles, las cuales pueden ser responsables, al menos en parte, de la persistencia del dolor tras la resolución de la lesión tisular desencadenante. Un factor clave en todos ellos parece ser la severidad del propio dolor en la fase aguda, con o sin neuropatía concomitante. Más allá del ámbito puramente experimental, la SC constituye un mecanismo relevante en la fisiopatología del dolor en una variedad de situaciones clínicas comunes.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Experimental and clinical evidence has shown that tissue injury may lead to Central Sensitization (CS), i.e. a reversible increase in the excitability of central nervous system (CNS) neurones which is characterised by spontaneous or persistent pain, expansion of painful areas, and qualitative sensory disturbances including allodynia and hyperalgesia. CS results from a series of functional and anatomical changes, some of which may be potentially irreversible, that may be at least partially responsible for the persistence of pain once the triggering tissue injury has healed. The severity of acute pain appears to be a key factor therein, irrespective of accompanying neuropathy. Beyond the experimental setting, CS arises as a clinically relevant mechanism in the pathophysiology of pain in a variety of common clinical conditions.</p>" ] "eu" => array:2 [ "titulo" => "Laburpena" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Esperimentu-arloko eta klinikako froga ugarik jakinarazi dute gorputzeko zauri edo kalte batek Erdiko Sentiberatze (ES) izena hartzen duen kitzikagarritasun-areagotze egoera leheneragarri bat sortzen duela Erdiko Nerbio Sistemako (ENS) neuronetan. Egoera honen ezaugarriak zerak dira, berezko mina edo min iraunkorra, eskualde mingarrien hedapena, eta minaren kalitate-ezaugarrien aldaketak, barne besteak beste alodinia eta hiperalgesia. ENSko neuronetan leheneraezinak ere izan daitezkeen zenbait fisiologi eta anatomi aldaketen ondorioz bilakatzen da ES, eta aldaketok omen dira, zati batez bahintzat, gorputzean hartutako kaltea sendatzearen ondoren minak oraindik ere irautea eragiten dutenak. Egoera hauetan guztietan, minak berak egoera akutuan duen larritasuna omen da gakoetako bat, duela ala ez aldi bereko neuropatia. Esperimentu-arlotik kanpo ere, ES minaren patofisiologiaren mekanismo aipagarri bat da klinikako hainbat egoera arruntetan ere.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bs0005" "bibliografiaReferencia" => array:65 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence for involvement of N-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Davies S.N." 1 => "Lodge D." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Brain Res." 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año/Mes | Html | Total | |
---|---|---|---|
2024 Octubre | 44 | 443 | 487 |
2024 Septiembre | 52 | 375 | 427 |
2024 Agosto | 32 | 365 | 397 |
2024 Julio | 22 | 320 | 342 |
2024 Junio | 36 | 325 | 361 |
2024 Mayo | 30 | 361 | 391 |
2024 Abril | 46 | 295 | 341 |
2024 Marzo | 39 | 327 | 366 |
2024 Febrero | 41 | 267 | 308 |
2024 Enero | 25 | 176 | 201 |
2023 Diciembre | 21 | 175 | 196 |
2023 Noviembre | 32 | 226 | 258 |
2023 Octubre | 42 | 209 | 251 |
2023 Septiembre | 17 | 86 | 103 |
2023 Agosto | 34 | 99 | 133 |
2023 Julio | 21 | 134 | 155 |
2023 Junio | 25 | 156 | 181 |
2023 Mayo | 69 | 195 | 264 |
2023 Abril | 56 | 150 | 206 |
2023 Marzo | 39 | 185 | 224 |
2023 Febrero | 23 | 185 | 208 |
2023 Enero | 12 | 138 | 150 |
2022 Diciembre | 42 | 111 | 153 |
2022 Noviembre | 27 | 167 | 194 |
2022 Octubre | 29 | 132 | 161 |
2022 Septiembre | 24 | 198 | 222 |
2022 Agosto | 29 | 383 | 412 |
2022 Julio | 25 | 167 | 192 |
2022 Junio | 31 | 164 | 195 |
2022 Mayo | 24 | 168 | 192 |
2022 Abril | 62 | 184 | 246 |
2022 Marzo | 41 | 244 | 285 |
2022 Febrero | 80 | 283 | 363 |
2022 Enero | 62 | 203 | 265 |
2021 Diciembre | 33 | 154 | 187 |
2021 Noviembre | 100 | 230 | 330 |
2021 Octubre | 63 | 278 | 341 |
2021 Septiembre | 36 | 261 | 297 |
2021 Agosto | 32 | 271 | 303 |
2021 Julio | 35 | 177 | 212 |
2021 Junio | 30 | 214 | 244 |
2021 Mayo | 32 | 245 | 277 |
2021 Abril | 74 | 516 | 590 |
2021 Marzo | 39 | 877 | 916 |
2021 Febrero | 57 | 719 | 776 |
2021 Enero | 42 | 524 | 566 |
2020 Diciembre | 40 | 522 | 562 |
2020 Noviembre | 51 | 691 | 742 |
2020 Octubre | 22 | 523 | 545 |
2020 Septiembre | 29 | 645 | 674 |
2020 Agosto | 27 | 667 | 694 |
2020 Julio | 38 | 499 | 537 |
2020 Junio | 20 | 433 | 453 |
2020 Mayo | 38 | 477 | 515 |
2020 Abril | 42 | 727 | 769 |
2020 Marzo | 51 | 664 | 715 |
2020 Febrero | 50 | 506 | 556 |
2020 Enero | 41 | 471 | 512 |
2019 Diciembre | 41 | 277 | 318 |
2019 Noviembre | 22 | 468 | 490 |
2019 Octubre | 38 | 791 | 829 |
2019 Septiembre | 50 | 1129 | 1179 |
2019 Agosto | 39 | 880 | 919 |
2019 Julio | 57 | 457 | 514 |
2019 Junio | 108 | 622 | 730 |
2019 Mayo | 201 | 778 | 979 |
2019 Abril | 92 | 823 | 915 |
2019 Marzo | 34 | 559 | 593 |
2019 Febrero | 21 | 428 | 449 |
2019 Enero | 21 | 432 | 453 |
2018 Diciembre | 17 | 234 | 251 |
2018 Noviembre | 22 | 389 | 411 |
2018 Octubre | 56 | 154 | 210 |
2018 Septiembre | 27 | 294 | 321 |
2018 Agosto | 7 | 635 | 642 |
2018 Julio | 5 | 421 | 426 |
2018 Junio | 2 | 458 | 460 |
2018 Mayo | 15 | 606 | 621 |
2018 Abril | 13 | 680 | 693 |
2018 Marzo | 16 | 659 | 675 |
2018 Febrero | 10 | 515 | 525 |
2018 Enero | 5 | 509 | 514 |
2017 Diciembre | 4 | 309 | 313 |
2017 Noviembre | 7 | 641 | 648 |
2017 Octubre | 14 | 688 | 702 |
2017 Septiembre | 10 | 523 | 533 |
2017 Agosto | 7 | 579 | 586 |
2017 Julio | 9 | 389 | 398 |
2017 Junio | 13 | 547 | 560 |
2017 Mayo | 19 | 631 | 650 |
2017 Abril | 16 | 627 | 643 |
2017 Marzo | 12 | 633 | 645 |
2017 Febrero | 25 | 553 | 578 |
2017 Enero | 5 | 458 | 463 |
2016 Diciembre | 22 | 310 | 332 |
2016 Noviembre | 21 | 611 | 632 |
2016 Octubre | 13 | 573 | 586 |
2016 Septiembre | 20 | 701 | 721 |
2016 Agosto | 12 | 485 | 497 |
2016 Julio | 10 | 18 | 28 |
2016 Junio | 10 | 441 | 451 |
2016 Mayo | 10 | 448 | 458 |
2016 Abril | 8 | 374 | 382 |
2016 Marzo | 12 | 379 | 391 |
2016 Febrero | 8 | 260 | 268 |
2016 Enero | 14 | 213 | 227 |
2015 Diciembre | 11 | 196 | 207 |
2015 Noviembre | 8 | 324 | 332 |
2015 Octubre | 7 | 298 | 305 |
2015 Septiembre | 4 | 227 | 231 |
2015 Agosto | 5 | 155 | 160 |
2015 Julio | 3 | 149 | 152 |
2015 Junio | 6 | 83 | 89 |
2015 Mayo | 6 | 53 | 59 |
2015 Abril | 4 | 21 | 25 |
2015 Marzo | 8 | 16 | 24 |
2015 Febrero | 6 | 5 | 11 |
2015 Enero | 13 | 4 | 17 |
2014 Diciembre | 19 | 7 | 26 |
2014 Noviembre | 14 | 4 | 18 |
2014 Octubre | 13 | 3 | 16 |
2014 Septiembre | 22 | 3 | 25 |
2014 Agosto | 20 | 3 | 23 |
2014 Julio | 19 | 4 | 23 |
2014 Junio | 32 | 4 | 36 |
2014 Mayo | 21 | 2 | 23 |
2014 Abril | 11 | 4 | 15 |
2014 Marzo | 19 | 4 | 23 |
2014 Febrero | 13 | 4 | 17 |
2014 Enero | 13 | 2 | 15 |
2013 Diciembre | 21 | 1 | 22 |
2013 Noviembre | 25 | 15 | 40 |
2013 Octubre | 18 | 19 | 37 |
2013 Septiembre | 18 | 24 | 42 |
2013 Agosto | 19 | 11 | 30 |
2013 Julio | 9 | 1 | 10 |
2007 Septiembre | 296 | 0 | 296 |