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FI 2015

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© Thomson Reuters, Journal Citation Reports, 2015

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doi: 10.1016/S0213-005X(12)70071-X
Daptomicina en las infecciones por bacterias grampositivas en pacientes oncohematológicos y en receptores de trasplante
Daptomycin in Gram-positive bacterial infections in oncohematological patients and transplant recipients
Jordi Carratalàa,, , Óscar Lenb, Julián de la Torre-Cisnerosc
a Servicio de Enfermedades Infecciosas, Hospital Universitari de Bellvitge-IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, España
b Servicio de Enfermedades Infecciosas, Hospital Universitari Vall d’Hebron-VHIR, Barcelona, España
c Unidad de Gestión Clínica de Enfermedades Infecciosas, Hospital Universitario Reina Sofía-IMIBIC, Universidad de Córdoba, Córdoba, España
Resumen

Las infecciones por bacterias grampositivas son una causa importante de morbilidad y mortalidad en los pacientes oncohematológicos y en los receptores de trasplante. Los estafilococos coagulasa negativa, Staphylococcus aureus, Enterococcus spp. y los estreptococos del grupo viridans son los organismos grampositivos aislados con mayor frecuencia. La resistencia antibiótica en estos organismos es un problema en aumento y supone un reto terapéutico. Daptomicina es un antibiótico con una rápida actividad bactericida, de amplio espectro frente a bacterias grampositivas, incluidas las cepas resistentes a otros fármacos. En este artículo se revisan algunos aspectos de las infecciones por organismos grampositivos en estos pacientes inmunodeprimidos y se analiza con detalle la experiencia con daptomicina en el tratamiento de tales infecciones.

Abstract

Gram-positive infections are a major cause of morbidity and mortality in oncohematological patients and transplant recipients. The most frequently isolated Gram-positive organisms are the coagulase-negative staphylococci, Staphylococcus aureus and Enterococcus spp., and viridans group streptococci. Antibiotic resistance in these organisms is increasing and poses a challenge to clinicians. Daptomycin is rapidly bactericidal against a broad spectrum of gram-positive bacteria, including strains resistant to other drugs. The present article reviews some aspects of Gram-positive infections in these immunocompromised patients and provides a detailed analysis of experience with daptomycin in the treatment of these infections.

Palabras clave
Neutropenia, Trasplante de progenitores hematopoyéticos, Trasplante de órgano sólido, Bacterias grampositivas, Bacteriemia, Daptomicina
Keywords
Neutropenia, Hematopoietic stem cell transplantation, Solid organ transplantation, Gram-positive bacteria, Bacteremia, Daptomycin
El Texto completo solo esta disponible en PDF
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