Información del artículo
Los factores de crecimiento celular representan una potente línea de investigación tanto en el dominio bioquímico como en el endocrinológico, y algunos ya son imprescindibles en el diagnóstico, pronóstico y tratamiento de ciertas enfermedades. El factor de crecimiento epidérmico (EGF) destaca entre los más estudiados. Cuarenta años después de su descubrimiento, sus principales aportaciones continúan en el campo oncológico, pero destacan numerosos trabajos en muchas otras especialidades médicas. Esta revisión se centra en los aspectos bioquímicos, moleculares y celulares del EGF, resume las aplicaciones clínicas más relevantes y orienta el camino de las investigaciones futuras.
Palabras clave:
Factores de crecimiento
EGF
The study of growth factors is an important line of investigation in the biomedical and endocrinological fields. Some growth factors are crucial in the diagnosis, prognosis and therapy of certain diseases. Epidermal growth factor (EGF) is among the most studied of these factors. Forty years after its discovery, it is especially important in oncology although studies have been published in numerous medical specialties. This review focuses on the biomedical, molecular and cellular aspects of ECF, summarizes its most important clinical applications, and suggests future investigations.
Key words:
Growth factors EGF
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